• 한국환경보건학회지
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• 제50권1호
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• pp.6-15
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• 2024

Background: People's activities have been restricted due to the COVID-19 pandemic. These changes in activity patterns may lead to a decrease in fine particulate matter (PM_2.5) concentrations. Additionally, the level of population exposure to PM_2.5 may be changed. Objectives: This study aimed to analyze the impact of population movement and meteorological factors on the distribution of PM_2.5 concentrations before and after the outbreak of COVID-19. Methods: The study area was Guro-gu in Seoul. The research period was selected as January to March 2020, a period of significant population movement changes caused by COVID-19. The evaluation of the dynamic population was conducted by calculating the absolute difference in population numbers between consecutive hours and comparing them to determine the daily average. Ambient PM_2.5 concentrations were estimated for each grid using ordinary kriging in Python. For the population exposure assessment, the population-weighted average concentration was calculated by determining the indoor to outdoor population for each grid and applying the indoor to outdoor ratio to the ambient PM_2.5 concentration. To assess the factors influencing changes in the ambient PM_2.5 concentration, a statistical analysis was conducted, incorporating population mobility and meteorological factors. Results: Through statistical analysis, the correlation between ambient PM_2.5 concentration and population movement was positive on both weekends and weekdays (r=0.71, r=0.266). The results confirmed that most of the relationships were positive, suggesting that a decrease in human activity can lead to a decrease in PM_2.5 concentrations. In addition, when population-weighted concentration averages were calculated and the exposure level of the population group was compared before and after the COVID-19 outbreak, the proportion of people exceeding the air quality standard decreased by approximately 15.5%. Conclusions: Human activities can impact ambient concentrations of PM_2.5, potentially altering the levels of PM_2.5 exposure in the population.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7179-7186
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• 2013

Background and Aims: Scutellaria is one of the most popular traditional Chinese herbal remedies against various human diseases, including cancer. In this study, we examined the active effects of Scutellaria extract and its main flavonoid constituents on the proportion of side population cells within human multiple myeloma cell line RPMI8226 in vitro and explored the potential molecular mechanisms involved. Materials and Methods: The contents of flavonoids in ethanolic extract of Scutellaria baicalensis Georgi were determined using high performance liquid chromatography. The antiproliferative effect of the ethanolic extract on RPMI-8226 was determined by CCK assay. Apoptosis was measured by annexin combining with propidium iodide in a flow cytometer. Cell cycle analysis was performed by propidium iodide staining in combination with flow cytometry analysis. Hoechst 33342 exclusion assay was used for the identification of side population within RPMI8226 cells. The expression of ABCG2 protein was assessed by Western blotting assay. Results: The content of major flavonoids constitutents of Scutellaria extract was baicalin (10.2%), wogonoside (2.50%), baicalein (2.29%), and wogonin (0.99%), respectively. The crude Scutellaria extract did not show significant anti-proliferative effect, apoptosis induction and cell cycle arrest in RPMI-8226 within the concentrations of $1-75{\mu}g/mL$. However, the ethanolic extract, baicalein, wogonin and baicalin reduced the side population cells in RPMI-8226, and data showed that baicalein and wogonin had stronger inhibitory effects. Correspondingly, they also exhibited significant effects on decreasing the expression level of ABCG2 protein in RPMI-8226 in vitro. Conclusions: Our results for the first time demonstrated a novel mechanism of action for Scutellaria extract and its main active flavonoids, namely targeting SP cells by modulating the expression of ABCG2 protein. This study provides an insight for new therapeutic strategies targeting cancer stem cells of multiple myeloma.

• 경제분석
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• 제25권1호
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• pp.66-122
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• 2019

우리 경제가 성장하면서 경제활동인구가 늘고 고용률이 높아지는 등 고용이 양적으로 꾸준히 성장하였다. 그러나 생산가능인구가 2017년부터 감소하기 시작하였고 여성 및 청년층의 고용은 부진한 상황이다. 비임금 근로자의 비중이 다른 나라나 소득 수준에 비해 크게 높은 수준이다. 또한 임금근로자 중 비정규직 비중과 소규모 기업 종사 근로자의 비중이 높은 것으로 나타났다. 이와 같은 고용구조의 특징에 비추어 우리나라 고용구조의 과제는 노동시장 이중구조심화, 청년실업 증가, 여성 고용의 부진, 저생산성의 과도한 자영업 비중 등으로 정리할 수 있다. 노동시장 이중구조가 심화된 데는 글로벌화에 따른 경쟁 심화, 대기업 우위의 원·하청관계, 대·중소기업 간 생산성 격차, 기업규모별 노동조합의 교섭력 격차 및 기업단위 노사협상 등의 제도적 요인이 복합적으로 작용하였다. 청년실업은 대학진학률 상승으로 대졸자들이 크게 증가한 반면 노동시장 이중구조화로 1차 노동시장 규모가 늘지 않은 데다 대졸자들의 2차 노동시장 기피현상이 심화된 것을 주된 배경으로 한다. 낮은 여성 고용률과 고용의 질적 수준은 결혼·출산 이후의 뚜렷한 경력단절에 기인하며 가정과 직장생활을 병행하기 어렵게 하는 제도 및 문화가 근본적인 원인으로 보인다. 생산성이 낮은 자영업자가 과다한 데에는 임금근로자 일자리가 충분하지 않고 노동시장 이중구조로 인해 양질의 임금근로자 일자리에 취업하기 힘들다는 점이 주요한 배경으로 작용하였다. 우리나라의 고용 확대를 제약하고 고용구조를 악화시킨 주된 구조적 요인은 이중구조 심화인 것으로 판단되는 만큼 공정거래 질서 확립과 중소기업의 생산성 향상 등 노동시장 이중구조 완화에 정책 역량을 집중할 필요가 있다. 아울러 청년 노동시장의 효율성을 제고할 수 있도록 직업훈련 및 고용지원서비스 제도를 개선하는 한편 보육시설 확충 등 여성들이 일과 가정이 병행할 수 있도록 하는 제도적 보완을 지속해 나가는 것도 중요하다.

• Asian-Australasian Journal of Animal Sciences
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• 제24권12호
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• pp.1660-1665
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• 2011

This study presents a linkage disequilibrium (LD) analysis and effective population size ($N_e$) for the entire Hanwoo Korean cattle genome, which is the first LD map and effective population size estimate ever calculated for this breed. A panel of 4,525 markers was used in the final LD analysis. The pairwise $r^2$ statistic of SNPs up to 50 Mb apart across the genome was estimated. A mean value of $r^2$ = 0.23 was observed in pairwise distances of <25 kb and dropped to 0.1 at 40 to 60 kb, which is similar to the average intermarker distance used in this study. The proportion of SNPs in useful LD ($r^2{\geq}0.25$) was 20% for the distance of 10 and 20 kb between SNPs. Analyses of past effective population size estimates based on direct estimates of recombination rates from SNP data demonstrated that a decline in effective population size to $N_e$ = 98.1 occurred up to three generations ago.

• 한국인구학
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• 제26권2호
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• pp.111-145
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• 2003

이 연구는 개혁개방정책 이후 중국 내 조선족이 보인 사회인구학적 행태의 변화를 설명하기 위한 것이다. 시장경제체제의 도입과 한중 국교수립 이후 조선족사회는 출산력수준의 급격한 저하와 인구구조의 고령화로 매우 급격한 변화를 겪고 있다. 조선족의 인구행태와 인구구조의 이러한 변화는 한족에 비해 두드러지게 나타난다. 중국 내 조선족인구가 가장 밀집되어 거주하고 있는 연변지역의 조선족사회는 최근 절대인구규모의 감소추세를 보이고 있다. 아울러 시장경제의 도입 이후 이동성향이 높아지고 통혼권과 거주지역이 확산되며. 조선족학교를 통한 민족교육이 급격히 위축되는 추세를 보인다. 그리고 이에 따라 조선족사회의 사회적 통합과 문화정체성이 약화되고 중국 내 소수민족사회로서의 위상도 점차 약화되는 과정에 있다. 연변 조선족사회의 사회인구학적 변화와 위기상황에 대한 설명을 위해 이 연구는 연변조선족자치주의 1990년과 2000년 인구센서스 자료와 각종 통계자료를 활용하였다. 또한, 이 연구에서는 인구센서스를 통하여 드러난 조선족인구의 연령구조가 매우 불규칙적이라는 점을 감안하여 1990년과 2000년 인구센서스 자료의 신뢰성과 정확도를 재검토하는 작업도 이루어졌다.

• Environmental Engineering Research
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• 제21권1호
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• pp.74-83
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• 2016

The purpose of this study is to identify the driven factors affecting the changes in energy-related $CO_2$ emissions in Hebei Province of China from 1995 to 2013. This study confirmed that energy-related $CO_2$ emissions are correlated with the population, urbanization level, economic development degree, industry structure, foreign trade degree, technology level and energy proportion through an improved STIRPAT model. A reasonable and more reliable outcome of STIRPAT model can be obtained with the introducing of the Ridge Regression, which shows that population is the most important factor for $CO_2$ emissions in Hebei with the coefficient 2.4528. Rely on these discussions about affect abilities of each driven factors, we conclude several proposals to arrive targets for reductions in Hebei's energy-related $CO_2$ emissions. The method improved and relative policy advance improved pointing at empirical results also can be applied by other province to make study about driven factors of the growth of carbon emissions.

• Journal of Information Processing Systems
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• 제16권1호
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• pp.210-223
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• 2020

Since constrained optimization algorithms are easy to fall into local optimum and their ability of searching are weak, an improved symbiotic organisms search algorithm with mixed strategy based on adaptive ε constrained (ε_SOSMS) is proposed in this paper. Firstly, an adaptive ε constrained method is presented to balance the relationship between the constrained violation degrees and fitness. Secondly, the evolutionary strategies of symbiotic organisms search algorithm are improved as follows. Selecting different best individuals according to the proportion of feasible individuals and infeasible individuals to make evolutionary strategy more suitable for solving constrained optimization problems, and the individual comparison criteria is replaced with population selection strategy, which can better enhance the diversity of population. Finally, numerical experiments on 13 benchmark functions show that not only is ε_SOSMS able to converge to the global optimal solution, but also it has better robustness.

• 품질경영학회지
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• 제21권1호
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• pp.35-43
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• 1993

The principal objective of a sampling plan is to make efficient use of the budget allocated and to obtain as precise an estimate of a population parameter as possible. In order to estimate the proportion of defectives produced or to determine some measure of product Quality, it is necessary to select random samples which represent a population parameter of the process. In this case, the two stage sampling is more efficient and convenient than simple random sampling. Therefore this paper aims to propose the design procedures of two stage sampling plan to obtain a representative samples in considering the sampling precision under the restricted sampling unspection cost.

• Journal of Multimedia Information System
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• 제6권1호
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• pp.31-35
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• 2019

The Socialist Republic of Vietnam has become one of the top ten nations with the highest aging rate. The proportion of their aging population increased from 7.2% to 10.95% from 1989 to 2017 and entered into the aging society six years earlier than what had been anticipated in 2011. The main issues in such a society are the problems associated with the elderly living by themselves and their solitary deaths. This study attempts to find a solution which would mitigate the burdens of aging or aged population who are living in a lonely and solitary living condition focusing on the system used for the purpose of managing or monitoring of their daily lives to prevent any undesirable outcomes including solitary deaths. The study also discusses the possibility of introducing the system into Vietnam.

• Anatomy and Cell Biology
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• 제56권3호
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• pp.367-373
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• 2023

One of the main parameters in the analysis of skeletal remains in forensic anthropological cases is the estimation of age. This study aimed to investigate the correlation between age and the fusion status of the sternal junction. This cross-sectional study was carried out on 184 sterna from 94 females and 90 males obtained from known-age cadavers in the Thai population. By direct observation, the fusion stage of the manubrio-sternal and sterno-xiphoidal junctions was studied and divided into unfused and fused joints. The results showed that a large proportion of the sterna remain unfused throughout adulthood, with fusion observed in both young and old cadavers. Insignificant differences in the rate of fusion, the sexes and ages were observed. None of the sterna under 30 years of age in females and 32 years of age in males showed fusion of the manubrio-sternal and sterno-xiphoidal junctions. Based on the variability of the sternal fusions observed in this study, we highlighted a very limited role of the sternum alone in the estimation of age in the Thai population.