• 한국자기공명학회논문지
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• 제8권2호
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• pp.96-107
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• 2004

We prepared two oligonucleotides containing same base pairing, but different base sequence in the middle region, d(CGAATTCG) and d(CGTATACG). NMR and UV absorbance data represented that such variation in base sequence could cause a significant difference in melting temperature and dynamics between d(CGAATTCG)$_2$ and d(CGTATACG)$_2$ duplexes, which are regarded to be associated with the stacked structure and the width of the minor groove of them. The latter showed poor stability compared to the former, because of poor stacking of bases. And berenil could bind to the minor groove of d(CGAATTCG)$_2$ which is relatively narrow, more strongly than d(CGTATACG)$_2$ and this gave rise to large improvement in thermal stability of the d(CGAATTCG)$_2$ duplex, compared to d(CGTATACG)$_2$.

• 구강회복응용과학지
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• 제25권4호
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• pp.391-401
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• 2009

임플란트의 성공은 식립 후의 초기 안정성 (Initial stability)의 결과가 중요한 영향을 준다. 이 연구의 목적은 연질 골에서 두 종류의 테이퍼 형태 임플란트가 임플란트의 디자인과 self-tapping blade의 유무에 따라서 초기 안정성에 주는 영향을 알아보는 것이다. Self-tapping blade를 가지고 있는 것과 가지고 있지 않은 두 종류의 테이퍼 형태 임플란트가 사용되었다. Solid Rigid Polyurethane Form으로 연질 골 상태인 D4 골 모형을 재현하였다. 임플란트 고정체를 식립하면서 초기 안정성 값을 기록하고, 식립 직후 implant stability quotient (ISQ)을 측정하여 Resonance frequency Analysis (RFA)를 평가하였다. 마지막으로 임플란트가 식립된 모형골을 만능 시험기에 부착하여 장축 방향으로의 pull-out force를 측정하였다. 초기 안정성 값과 최대 pull-out torque 값은 non self-tapping implants가 self-tapping group에 비하여 통계학적으로 유의하게 큰 평균값을 나타냈다 (P = 0.008). 공진 주파수 분석 결과인 ISQ 값은 거의 비슷한 평균값을 보였으면 통계학적으로 차이가 없었다. 각 임플란트 시스템에서 식립 토크와 pull-out 최대 토크 그리고 공진 주파수 간에는 상관관계를 나타내지 않았다. Non self-tapping 임플란트의 높은 식립 토크는 임상적으로 우수한 초기 안정성을 의미한다. 결론적으로 연질 골에서 self-tapping blade가 없는 임플란트가 있는 것 보다 더 우수한 초기 안정성을 보였다.

• 한국표면공학회지
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• 제48권1호
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• pp.11-22
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• 2015

Pd alloy hydrogen membranes for hydrogen purification and separation need thermal stability at high temperature for commercial applications. Intermetallic diffusion between the Pd alloy film and the porous metal support gives rise to serious problems in long-term stability of Pd alloy membranes. Ceramic barriers are widely used to prevent the intermetallic diffusion from the porous metal support. However, these layers result in poor adhesion at the interface between film and barrier because of the fundamentally poor chemical affinity and a large thermal stress. In this study, we developed Pd alloy membranes having a dense microstructure and saturated composition on modified metal supports by advanced DC magnetron sputtering and heat treatment for enhanced thermal stability. Experimental results showed that Pd-Cu and Pd-Ag alloy membranes had considerably enhanced long-term stability owing to stable, dense alloy film microstructure and saturated composition, effective diffusion barrier, and good adhesive interface layer.

• 한국자동차공학회논문집
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• 제21권4호
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• pp.135-143
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• 2013

In this study, we suggested effective countermeasure of biodiesel oxidation problems by investigating the oxidation degradation of biodiesels derived from variable resources and the level of oxidation stability of current distributing biodiesel blended fuels (2%) in Korea, and oxidation stability change according to storage time (for 3 month) and biodiesel blending ratio (2, 5, 7, 10%). By the composition analysis results of biodiesel from various resources which are possible to distribute in Korea, the biodiesel from animal fat has poor oxidation stability and cold performance, while the biodiesel from coconut and palm kernel which are considered as future potential raw material showed good oxidation stability and cold performance. The oxidation stability level of current distributing biodiesel blended fuels in Korea was excellent with showing over 30 hours (average 68 hours) stability, but the oxidation stability of the blended fuel with animal fat biodiesel having poor oxidation property (1.22 hours) was rapidly decreased to below 32 hours by mixing only 2%. Therefore, we have to pay attention to quality control of oxidation property, because the oxidation stability problem can be caused by increasing biodiesel blending ratio and diversifying raw materials those have worse property.

• 수산해양기술연구
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• 제51권4호
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• pp.512-519
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• 2015

A historical tragic disaster happened by capsizing the passenger ship Sewol at South Western Sea of Korea in 16, April 2014. The ship which left Incheon harbour to bound for Jeju port passed Maengol strait and reached to approach of Byung Pung island, and then capsized and sank with a sudden inclination to the portside in the mean time of starboard the helm. In this time, the ship which has very poor stability without sufficient ballast waters and with over loading cargo listed port side caused by the centrifugal force acting to the outside of turning. A lot of cargoes not fastened moved to the port side consequently, and the ship came to beam end to capsize and sank in the end. No crews including especially captain would offer their own duties in a such extremely urgent time, as a result, enormous number of victims broke out including a lot of student. In this report, author carried out some calculation on the factors which influenced on the stability of the ship, i.e. the ship's speed, the rudder angle, the weight of cargoes and distance of movement, the surface effect of liquid in the tank. We found out that the most causes of capsize were the poor stability with heavy cargoes and insufficient amount of ballast water against the rule, and the cargoes unfastened moved one side to add the inclination as well. Above all, the owner be blamable because of the illegally operating the ship without keeping the rule.

• 대한치과교정학회지
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• 제34권3호
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• pp.205-218
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• 2004

III급 부정교합을 조기에 치료했을 때, 치료 후 retention 기간 중에 교합이 안정적으로 유지되는 경우와, 재발되어 성장 완료시기에 악교정수술을 해야 하는 경우를 경험하게 된다. 어린 년생부터 장기간에 걸쳐 교정치료를 했음에도 재발되어 악교정수술을 하는 경우에, 환자와 보호자는 소모된 시간과 경비에 대해 많은 실망을 하는 경우를 볼 수 있다. 교정치료 후 보정기간 중에 있는 30증례를 조사했다. 치료 완료된 교합상태를 교합안정 정도에 따라 good, fair, relapse군으로 나누어 치료 전 골격형태를 관찰한 결과, AB-MP 항목이 유의성 있는 차이를 보였다. 조기에 III급 부정교합을 치료하는 경우에, 치료 후 안정에 관한 예후를 평가하는데 AB-MP를 활용할 수 있다. AB-MP이 65이상인 경우에 조기치료가 권장되고, 60이하인 경우에는 성장이 완료될 때까지 연기할 수 있다.

• 한국전문물리치료학회지
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• 제18권4호
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• pp.1-10
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• 2011

This study compared the stability of the cervical spine according to the presence of neck pain and deep neck flexor performance. Thirty subjects with neck pain, and thirty subjects without neck pain were recruited for this study. The Cranio-cervical flexion (CCF) test was applied using a pressure biofeedback unit to classify the subjects into four subgroups; no cervical pain and good deep neck flexor performance (NG group), no cervical pain and poor deep neck flexor performance (NP group), cervical pain and good deep neck flexor performance (PG group), and cervical pain and poor deep neck flexor performance (PP group). The head sway angle was measured using a three-dimensional motion analysis system. A 3-kg weight was used for external perturbation with the subject sitting in a chair in the resting and erect head positions with voluntary contraction of the deep neck flexors. A one-way analysis of variance (ANOVA) was performed with a Bonferroni post hoc test. The deep neck flexor performance differed significantly among the four groups (p<.05). The NG group had significantly greater deep neck flexor performance than NP and PP groups. The stability of the cervical spine also differed significantly among the four groups in the resting head position (p<.05). The head sway angle was significantly smaller in NG group as compared with the other groups. The PP group had the greatest head sway angle in the resting head position. However, there was no significant difference in the stability of the cervical spine among the groups in the erect head position with voluntary contraction of deep neck flexors (p=.57). The results of this study suggest that the deep neck flexor performance is important for maintaining the stability of cervical spine from external perturbation.

• Journal of Pharmaceutical Investigation
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• 제41권2호
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• pp.75-82
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• 2011

LB71350 is an HIV protease inhibitor with poor aqueous solubility and extensive first pass effect. The purpose of the present study was to test the feasibility of solid dosage form of LB71350 with improved bioavailability utilizing solid dispersion. Three different compositions with varying ratio of (LB71350: Gelucire 44/14: Tween 20) were studied. Capsule filling of these solid dispersion compositions was tested using a semi-automatic capsule filling system. Oral bioavailability in dog was tested. Chemical and physical stability at 4, 25 and $40^{\circ}C$ was monitored by HPLC assay, dissolution test, powder XRD and microscopy. The capsule filling system yielded uniform products of drug loading up to 10%. Oral bioavailability in dog was improved compared to the aqueous suspension of crystalline LB71350. Capsules were chemically stable for up to 6 months at $40^{\circ}C$. However, there were temperature and composition dependent physical changes. Decrease in dissolution rates after storage at $40^{\circ}C$ was due to the polymorphic change. In conclusion, manufacturing process, bioavailability, and physico-chemical stability have been considered to propose a solid dispersion capsule formulation for the HIV protease inhibitor with poor physico-chemical properties. A new less soluble crystalline form identified during the physical stability test warrants further study.

• 한국지반환경공학회 논문집
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• 제22권11호
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• pp.39-47
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• 2021

우리나라는 국토 전체 면적 중 70% 이상 산악지형으로 철도공사 시 주행성능 확보를 위해 터널 공사가 매년 증가하고 있다. 터널공사가 증가함에 따라 터널굴착 방법 또한 다양해지고 있다. 굴착부의 지반이 풍화암으로 구성되어있으면 다양한 터널굴착 공법이 적용될 수 있지만 굴착부가 파쇄대를 지나거나 저토피의 계곡부를 지나는 경우 터널 굴착 시 붕괴의 위험성을 지니고 있다. 따라서 본 연구에서는 다양한 지반에서의 보강공법을 제시하고자 저토피 및 암질불량구간의 굴착 중인 대표터널을 선정하였다. 수치해석은 암질불량구간일 때 강관을 미적용한 경우와 적용한 경우, 저토피 구간일 때 터널 상부에 고화토를 성토한 경우 강관보강을 적용하여 수치해석을 통해 안정성 분석을 수행하였다.

• 한국안전학회지
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• 제30권2호
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• pp.1-8
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• 2015

Forklift truck is a very convenient transportation vehicle and widely used in industries. However, a lot of overturn accidents occur during operation because of poor understanding on the stability of forklift trucks. The stability of a forklift is defined by the minimum slope of the ramp where a forklift truck overturns. According to the KS BISO 22915-2 code, the stability is determined from the four kinds of stability tests. The equations for the stability of a forklift truck were proposed already in several published literatures and the equations can be used conveniently to estimate the stability and examine the effects of design parameters in forklift trucks. However, because the detail derivation procedure was omitted, it is very difficult to examine the accuracy of the proposed equations and to modify the equations for other types of forklift trucks. In this paper the stability equations were derived again with detail derivations for the four kinds of stability tests. And the effects of acceleration or centrifugal forces were also additionally included in the equations and minor corrections were also made.