• Title/Summary/Keyword: Poor Limit

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Preparation and Characterization of Alumina Thin Film by Sol-Gel Method (II); Synthesis of Alumina Sol for Coating and Preparation of Coating Films (졸겔법에 의한 알루미나 박막의 제조 및 특성(II);코팅용 알루미나 졸의 합성 및 박막 제조)

  • 이재호;최세영
    • Journal of the Korean Ceramic Society
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    • v.31 no.8
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    • pp.911-919
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    • 1994
  • As the study for preparation of single-layer anti-reflective coating on glass, the conditions of synthesis of sol for coating and of reproducible coating procedure were investigated. In case of water-based sol, coating was impossible because of poor wettability of sol. The Substitution of solvent with ethanol improved the wettability of sol on the glass surface, and optimum amount of ethanol for substitution was 70 vol%. Maximum specific surface area and total pore volume of water-based sol were 268.7$m^2$/g and 0.315 cc/g, but after substitution, those values increased to 404.1 $m^2$/g and 0.376 cc/g, respectively. The upper limit withdrawl speed of coating in order to get clean coated films without aggregations or stains was 7 cm/min. In case of addition of 0.1 mol HNO3 and substitution with 70 vol% ethanol and heat-treatment at 40$0^{\circ}C$ for 1 hour, thin film with thickness of 94 nm was obtained at withdrawl speed of 4 cm/min. The thickness of thin film was independent of drying time.

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Early Biologic Treatment in Pediatric Crohn's Disease: Catching the Therapeutic Window of Opportunity in Early Disease by Treat-to-Target

  • Kang, Ben;Choe, Yon Ho
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.21 no.1
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    • pp.1-11
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    • 2018
  • The emergence of mucosal healing as a treatment goal that could modify the natural course of Crohn's disease and the accumulating evidence showing that biologics are most effective in achieving mucosal healing, along with the success of early treatment regimens for rheumatoid arthritis, have led to the identification of early Crohn's disease and development of the concept of catching the therapeutic window during the early disease course. Thus, an increasing number of pediatric gastroenterologists are adopting an early biologic treatment strategy with or without an immunomodulator. Although early biologic treatment is effective, cost and overtreatment are issues that limit its early use. Currently, there are insufficient data on who will benefit most from early biologics, as well as on who will not need early or even any biologics. For now, top-down biologics should be considered for patients with currently known high-risk factors of poor outcomes. For other patients, close, objective monitoring and accelerating the step-up process by means of a treat-to-target approach seems the best way to catch the therapeutic window in early pediatric Crohn's disease. The individual benefits of immunomodulator addition during early biologic treatment should be weighed against its risks and decision on early combination treatment should be made after comprehensive discussion with each patient and guardian.

Development of a Matrix-prespotted Plate for Enhancing the Reproducibility of Serum Glycan Analysis by MALDI-TOF-MS

  • Ha, Mi-Young;In, Young-Ha;Maeng, Hye-Sun;Zee, Ok-Pyo;Lee, Jong-Sik;Kim, Yang-Sun
    • Mass Spectrometry Letters
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    • v.2 no.3
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    • pp.61-64
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    • 2011
  • Matrix Assisted Laser Desorption/Ionization-Time-of-Flight mass spectrometry (MALDI-TOF-MS) is the most widely used MS technique for glycan analysis. However, the poor point-to-point and sample-to-sample reproducibility becomes a limit in glycan biomarker research. A prespotted MALDI plate which overcomes the large crystal formation of 2,5-dihydroxybenzoic acid (DHB) has been developed and applied for glycan analysis. A homogeneous matrix coated surface without a crystal structure was formed on a hydrophilic/ hydrophobic patterned surface using a piezoelectric device. The reproducible MALDI-TOF-MS data have been presented using MALDI imaging of beer glycan as well as serum glycan eluted from 10% and 20% ACN elution fractions. The glycan profile from the serum glycan by MALDI-TOF-MS with a DHB prespotted plate was highly conserved for 10 different spectra and the coefficient of variations of significant ion peaks of MALDI data varies from 3.59 to 19.95.

Screening Analysis of 10 Adrenal Steroids by Matrix-Assisted Laser Desorption Ionization-Tandem Mass Spectrometry

  • Kim, Sun-Ju;Jung, Hyun-Jin;Chung, Bong-Chul;Choi, Man-Ho
    • Mass Spectrometry Letters
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    • v.2 no.3
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    • pp.69-72
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    • 2011
  • Defective synthesis of the steroid hormones by the adrenal cortex has profound effects on human development and homeostasis. Due to the time-consuming chromatography procedure combined with mass spectrometry, the matrix-assisted laser desorption ionization method coupled to the linear ion-trap tandem mass spectrometry (MALDI-LTQ-MS/MS) was developed for quantitative analysis of 10 adrenal steroids in human serum. Although MALDI-MS can be introduced for its applicability as a high-throughput screening method, it has a limitation on reproducibility within and between samples, which renders poor reproducibility for quantification. For quantitative MALDI-MS/MS analysis, the stable-isotope labeled internal standards were used and the conditions of crystallization were tested. The precision and accuracy were 3.1~35.5% and 83.8~138.5%, respectively, when a mixture of 10 mg/mL ${\alpha}$-cyano-4-hydroxycinnamic acid in 0.2% TFA of 70% acetonitrile was used as the MALDI matrix. The limit of quantification ranged from 5 to 340 ng/mL, and the linearity as a correlation coefficient was higher than 0.988 for all analytes in the calibration range. Clinical applications include quantitative analyses of patients with congenital adrenal hyperplasia. The devised MALDI-MS/MS technique could be successfully applied to diagnosis of clinical samples.

Geoengineering Characteristics of the Cretaceous Rock Cut Slopes in Jinju area (진주지역 중생대 암반절토사면 지반특성)

  • Kim, Seung-Hyun;Lee, Jung-Yup;Rhee, Jong-Hyun;Koo, Ho-Bon
    • Proceedings of the Korean Geotechical Society Conference
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    • 2006.03a
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    • pp.652-661
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    • 2006
  • The cut slopes in Jinju area constitute the Cretaceous Sedimentary rock which is one of the most poor ground conditions. The geological rocks of the cut slopes are correlated with Jinju Formation. Most of the rocks consist of Black Shale layer, but the lower parts consist of Alkorsic White Sandstone. So, It is characteristic of the differential weathering due to the difference of rock species. Moreover, vertical joints which concentrate on the released rock and weak rock fragments are accompanied with minor faults. We make out face mapping about each slopes through the detailed field-study and deduce RMR and SMR from the field data. The strength properties of rocks were obtained from references, indoor tests, and Back Analysis method. And, choosing properties were used in the stability analysis as stereographic projection and limit equilibrium analysis and we establish the countermeasures for the cut slopes.

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Novel Optical Properties of Si Nanowire Arrays

  • Lee, Munhee;Gwon, Minji;Cho, Yunae;Kim, Dong-Wook
    • Proceedings of the Korean Vacuum Society Conference
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    • 2014.02a
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    • pp.179.1-179.1
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    • 2014
  • Si nanowires have exhibited unique optical characteristics, including nano-antenna effects due to the guided mode resonance, significant optical absorption enhancement in wide wavelength and incident angle range due to resonant optical modes, graded refractive index, and scattering. Since Si poor optical absorption coefficient due to indirect bandgap, all such properties have stimulated proposal of new optoelectronic devices whose performance can surpass that of conventional planar devices. We have carried out finite-difference time-domain simulation studies to design optimal Si nanowire array for solar cell applications. Optical reflectance, transmission, and absorption can be calculated for nanowire arrays with various diameter, length, and period. From the absorption, maximum achievable photocurrent can be estimated. In real devices, serious recombination loss occurring at the surface states is known to limit the photovoltaic performance of the nanowire-based solar cells. In order to address such issue, we will discuss how the geometric parameters of the array can influence the spatial distribution of the optical field (resulting optical generation rate) in the nanowires.

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Lubricity Characterization of Hydrogenated Biodiesel as an Alternative Diesel Fuel (경유 대체연료로서 수첨바이오디젤의 윤활 특성 연구)

  • Kim, Jae-Kon;Jeon, Cheol-Hwan;Yim, Eui-Soon;Chung, Choong-Sub
    • Tribology and Lubricants
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    • v.28 no.6
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    • pp.321-327
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    • 2012
  • Paraffin bio-based hydrotreated biodiesel(HBD) is originated from vegetable oil(the process can also be applied to animal fat) with the the chemical structure $C_nH_{2n+2}$. In the number of process of the oil or fat, the hydrogenation is significantly important to create a bio-based diesel fuel. This study is focused on lubricity characteristics of BTL diesel blends to use alternative diesel fuel in Korea. The BTL diesel are blended the different volume ratios (HBD 5(5 vol.% HBD - 95 vol.% diesel), HBD 10, HBD 20, HBD 30, HBD 40 and HBD 50. HBD with paraffin compounds showed a very high centane number, low sulfur content and free aromatic compound. Especially, the wear scar of HBD showed poor lubricity compared to automotive diesel due to the fuel composition, low sulfur content and free aromatic compound. Also, the lubricity specification of automotive diesel with different six HBD blends is within the limit by the Korean standards. Finally, HBD as an alternative diesel fuel is challengeable in transportation sector of Korea.

Effect of Low-Temperature Conditions on Expansion of Choux (슈의 팽화에 대한 저온 조건의 영향)

  • Kim, Myoung Ae
    • Journal of the Korean Society of Food Culture
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    • v.33 no.3
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    • pp.276-282
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    • 2018
  • This study examined the effects of low temperature conditions on the expansion of choux when mixing the dough with egg fluid. The egg fluid was tested at 5 and $17^{\circ}C$, and the dough temperature was 20, 30, 40, 50, 60 or $70^{\circ}C$. The expansion decreased with decreasing temperature of the egg fluid and dough, with the concomitant formation of membranes in the cavities of choux because of the poor emulsion stability of the choux paste. In addition, the structure of the choux pastry was not dense and the cracks in the surface were partial and narrow. The shape, expansion and cracks of choux were the best at a dough temperature of 60 and $70^{\circ}C$ added with egg fluid at $17^{\circ}C$. The temperature of the choux paste in these two samples was higher than the melting point of the butter used to produce the paste. Therefore, the practical limit temperature when mixing the egg fluid and dough is 20 and $60^{\circ}C$, respectively, and care should ve taken to maintain a low temperature when making choux in confectionary.

Characteristics of Zr-base Passivation Layers of Tinplate (전기주석도금강판의 Zr계 화학처리 피막 특성)

  • Bae D.C.;Kim T.Y.;Cho K.
    • Journal of the Korean institute of surface engineering
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    • v.36 no.3
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    • pp.251-255
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    • 2003
  • With increasing environmental demands in surface treatment of steel sheets, the passivation layers containing hexavalent chromium $(Cr^{+6})$ are being replaced by non-chromium or trivalent chromium compounds. After review on the various types of inorganic compounds, the zirconates was chosen as the candidate for alternative to sodium dichromate in the aspect of its barrier properties with excellent adhesion to organics. The ammonium zirconium carbonate (AZC) and sodium hexafluorozirconate (SFZ) could be reach $70-80\%$ level of CDC (cathodic dichromate) treatment by their single applications. But high porosity in the AZC layer and poor electrical conductivity of SFZ solution limit the single application of zirconate. Mixed composition of zirconates to compensate their inferiorities or incorporation of organic compounds to seal the porosity seems to be inevitable to match up the target level of Cr-free passivation of tinplate.

Underwater image quality enhancement through Rayleigh-stretching and averaging image planes

  • Ghani, Ahmad Shahrizan Abdul;Isa, Nor Ashidi Mat
    • International Journal of Naval Architecture and Ocean Engineering
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    • v.6 no.4
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    • pp.840-866
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    • 2014
  • Visibility in underwater images is usually poor because of the attenuation of light in the water that causes low contrast and color variation. In this paper, a new approach for underwater image quality improvement is presented. The proposed method aims to improve underwater image contrast, increase image details, and reduce noise by applying a new method of using contrast stretching to produce two different images with different contrasts. The proposed method integrates the modification of the image histogram in two main color models, RGB and HSV. The histograms of the color channel in the RGB color model are modified and remapped to follow the Rayleigh distribution within certain ranges. The image is then converted to the HSV color model, and the S and V components are modified within a certain limit. Qualitative and quantitative analyses indicate that the proposed method outperforms other state-of-the-art methods in terms of contrast, details, and noise reduction. The image color also shows much improvement.