• Title/Summary/Keyword: Poncirus trifoliata ext

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Antihyperlipidemic and Antioxidant Effects of Poncirus trifoliata (탱자 열매 추출액의 항산화 및 지질저하효과)

  • Lee Eun
    • Korean Journal of Plant Resources
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    • v.19 no.2
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    • pp.273-276
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    • 2006
  • Lipid-lowering and antioxidant effects of Poncirus trifoliata extract were investigated in hyperlipidemic rat. Concentrations of FFA and triglyceride in plasma were decreased in Poncirus trifoliata extract treatment groups. Plasma total cholesterol and LDL-cholesterol were lower in Poncirus trifoliata extract treatment groups. However HDL-cholesterol showed no significant difference in all treatment groups. Concentrations of liver total cholesterol and triglyceride were decreased in Poncirus trifoliata extract treatment groups. Concentrations of plasma and liver TBARS showed a low values in Poncirus trifoliata extract treatment groups. The values of GSH-Px and CAT activities were increased in the Poncirus trifoliata extract treatment groups. However the values of SOD activity showed no significant difference in all treatment groups.

Inhibitory Effects of Medicinal Herbs on Cytochrome P450 Drug Metabolizing Enzymes (생약추출물의 Cytochrome P450 약물대사 효소계 저해활성)

  • Jeong, Hye-Gwang;You, Ho-Jin;Chang, Young-Su;Park, Sung-Jun;Moon, Young-Hee;Woo, Eun-Rhan
    • Korean Journal of Pharmacognosy
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    • v.33 no.1 s.128
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    • pp.35-41
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    • 2002
  • The MeOH ext., $CH_2Cl_2$ Frac., EtOAc Frac., n-BuOH Frac., and $H_2O$ Frac. of 23 Korean medicinal herbs were prepared and were tested the inhibitory effects on Cytochrome P450 (Cyp) 1A1/2, 2B1/2, 2E1. Among the tested samples, the extracts of Selaginella tamariscina, Euonymus alatus, Salvia miltiorhiza, Angelica acutiloba, Rheum palmatum, Paeonia moutan, Scutellaria barbata, Tribulus terrestris, Hedyotis diffusa, Curcuma zedoaria, Rehmania glutinosa, Trogopterus xanthipes, Melandryum firmum, Achyranthes bidentata, Leonurus sibricus, Panax ginseng, Paeonia lactiflora, Poncirus trifoliata, Cnidium officinale, Cyperus rotundus, Corydalis ternata showed significant inhibitory effects on Cyp 1A1/2, 2B1/2, 2E1. The $IC_{50}$ values of those extracts were found to be below $50\;{\mu}g/ml$.