• Proceedings of the Ginseng society Conference
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• 1988.08a
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• pp.19-24
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• 1988

We have isolated two new cytotoxic polyynes against $L_{1210}$ cell from the root of Panax ginseng. namely acetylpanaxydol and panaxydolchorhydrin. The epoxy group in C-9 and the heptyl group on C-10 of the panaxydol-analogues potentiate the activity. Panaxydol has cis-configuration in epoxy group. There is no diffrernce in activity between cis-. trans- and cis/trans-configurational isomers. The essential structure for the cytotoxicity of panaxydol and its isomers is hept-l-en-4.6-diyn-3-ol.