• Journal of Veterinary Clinics
• /
• v.32 no.2
• /
• pp.180-182
• /
• 2015

A 3 year-old pregnant female Yorkshire terrier dog was presented with major complaints of polyuria and polydipsia. Laboratory tests found persistent hyperglycemia and glucosuria. Abdominal ultrasound study found 2 dead fetuses. Ovarian hysterectomy was performed to remove the dead fetuses. After ovarian hysterectomy, the level of blood glucose was returned to normal range. In addition, the clinical signs and urine glucose were all disappeared. Based on findings on laboratory tests and follow-up study, the case was diagnosed as gestational diabetes mellitus. To our best knowledge, this is the first case report describing a gestational diabetes mellitus of dog in Korea.

• The Journal of Korean Medicine
• /
• v.21 no.1
• /
• pp.99-102
• /
• 2000

Central diabetes insipidus(CDI) results from deficient vasopressin(antidiuretic hormone) secretion and causes polydipsia and polyuria. Its etiologic diagnosis is confirmed with an increase of urine osmolality by administering desmopressin(DDAVP) after water restriction. Because cm is caused by deficiency of vasopressin, up to now, desmopressin, a synthetic analog of vasopressin, has been the drug of choice in the treatment of CDI. However, under such treatment, CDI patients suffer from the continual administration of DDAVP throughout one's life and high cost of the treatment We administrated oriental herb medicine on a cm patient in a state of discontinuance of DDAVP. Prior to the study, brain sella MRI was scanned to exclude germinoma. In addition, urine analysis, serum and urinary osmolality, daily urinary volume, serum electrolyte levels were measured. Chungsimyunjatang was administered for 15 days, and urine analysis, urine osmolality, daily urinary volume, serum Na were measured several times again during the therapy, As a result, urinary frequency increased, serum Na slightly elevated, but specific gravity of urine, urinary osmolality severely decreased and daily urinary volume substantially increased. However, the frequency of DDAVP treatment was reduced from four times per day to once or twice a day with the continual administration of the Chungsimyunja-tang for two months after the discharge.

• The Journal of Pediatrics of Korean Medicine
• /
• v.19 no.2
• /
• pp.229-241
• /
• 2005

Objective : This study was designed to investigate causes, symptoms and treatments for the diabetes insipidus with oriental medical literatures. Methods : We surveyed the oriental and western medical books from to recent published bocks that have articles on diabetes insipidus Results and Conclusions : The symptoms of diabetes insipidus are polyuria and polydipsia, these are similar symptoms of Pae-so(肺消), Gouk-so, So-gal(消渴), Sang-so(上消), Sin-so(腎消), So-sin(消腎), Ha-so(下消) and Sin-jung(腎中) of kinds of So-gal(消渴) in the oriental medicine. The major causes of diabetes insipidus are the deficiency of the yin of the kidney, the heat of the heart and the dryness of the pulmonary. The methods of treatment are tonifying the yin of the kidney(滋補腎陰), tonifying qi and arrest discharges(益氣固澁), removing heat to moisten dryness (淸熱潤燥) and promoting fluid production to quench thirst(生津止葛). The herbal-medications for treatment are So-galbang and Yidongtang(消渴方合二冬湯), Ryoumijihawangtang gamibang(六味地黃湯加味方).

• The Journal of Internal Korean Medicine
• /
• v.18 no.2
• /
• pp.40-52
• /
• 1997

1. Xiaoke(消渴) had been defined symptoms as polyuria with polydysia in Han and Dang Dynasty(漢唐時代), diagnosed variable disease as to the region of typical symptoms in Jin and Yuan Dynasty(金元時代) and classified into Upper-jiao(上消), Middle-jiao(中消), Lower-jiao(下消) by typical symptoms in Ming and Qing Dynasty(明淸時代). 2. The complications of Xiaoke(消渴) consist of carbuncle and phlegmon(癰疽), hemorrhoid and diarrhea(痔疾), an eye disease(眼病) such as nyctalopia(雀目) and cataract(內障) without Zhongman and Guzhang(中滿鼓脹) resulted from wrong medical treatmentis considered the pathology of Huore(火熱) 3. The pathology of Xiaoke(消渴) has been taken an instance of Shen-zao(腎燥), Five zang-organs's ganzao(五臟乾燥), Zao-re(燥熱), Shi-huo(實火) and Xu-huo(虛火), and since Jin and Yuan Dynasty(金元時代) generally cosidered Zao-re(燥熱). 4 The complications of Xiaoke(消渴) are explained the pathology of Huore(火熱), in the an opinion that the the pathology of Huore(火熱) changed into Zao-re(燥熱), and then Zao(燥), the pathology of Xiaoke(消渴) is similar to Huo(火), the pathology of Jungpung(中風).

• Natural Product Sciences
• /
• v.25 no.3
• /
• pp.261-267
• /
• 2019

The rhizomes of Dioscorea japonica Thunb. are widely consumed as food and also used to treat diabetes and polyuria in Korea. This study was undertaken to study the anti-atopic dermatitis effects of a 95% ethanolic extract (DJE) of D. japonica in an oxazolone-stimulated murine model of atopic dermatitis (AD). The therapeutic effects of DJE on AD-like skin lesions were assessed on both ears. DJE (1%) or dexamethasone (0.5%; the positive control) were applied to skin lesions for three weeks. Serum levels of IgE and IL-4 were assessed by ELISA (enzyme-linked immunosorbent assay). Histopathological examinations were performed by hematoxylin and eosin (H&E) and toluidine blue staining and revealed DJE significantly reduced dermal thickness and inflammatory cell infiltration when applied to oxazolone-treated ear skin. DJE-treated AD mice also showed lower serum levels of IgE and IL-4 than oxazolone-stimulated controls. Our findings demonstrate DJE might be a useful safe, topical agent for the treatment of atopic diseases.

• Brain Tumor Research and Treatment
• /
• v.6 no.2
• /
• pp.73-77
• /
• 2018

Germinoma is the most common type of intracranial germ cell tumors (GCTs). Pineal gland and suprasellar region are the most frequent sites of central nervous system (CNS) involvement. Intracranial masses caused by Langerhans cell histiocytosis (LCH) mimics features of CNS GCTs. LCH frequently involve spine and is the most common cause of vertebra plana in children. A 15-year-old boy presented with progressing symptoms of polydipsia, polyuria, general headache, nausea and severe back pain. Brain MRI showed brain tumor with simultaneous involvement of suprasellar region and pineal gland. An excisional biopsy of suprasellar mass was done. The pathologic assessment confirmed the diagnosis of germinoma. Patient's treatment continued accordingly. A spine MRI, done due to persistent backache, showed a vertebra plana. We reevaluated the primary diagnosis suspecting LCH. Germinoma of CNS was confirmed and a biopsy of vertebral lesion resulted in hemangioma. Thus we report a case of CNS germinoma with co-occurrence of vertebra plana. We emphasized the importance of histopathologic diagnosis of pineal/suprasellar masses and primary investigation of other CNS regions including spine for possible metastasis or comorbidities.

• Journal of Veterinary Clinics
• /
• v.37 no.6
• /
• pp.360-362
• /
• 2020

A 12-year-old intact female Pomeranian dog was presented with vulvar discharge, lethargy, polyuria, and polydipsia. A complete blood count revealed leukocytosis and anemia. The serum biochemical analyses showed elevated serum alkaline phosphatase activity and blood urea nitrogen. Survey abdominal radiography revealed an enlarged left kidney. Abdominal ultrasonography identified multiple rounded hypoechoic subcapsular lesions in the left kidney. The bilateral uterine horn was enlarged, and contained echogenic fluid. Percutaneous ultrasonographic-guided aspiration of the renal subcapsular lesions was performed on the left kidney. Cytological examination revealed bacterial cocci, degenerated neutrophils, and suppurative inflammation. Bacterial culture produced growth of Escherchia coli. Left nephrectomy and ovariohysterectomy were performed. Dilated uterine fluid was also evaluated for bacterial culture, and showed growth of E. coli. Urine was examined by bacterial culture, and showed negative results. The treatment consisted of antibiotic therapy according to the antibiotic sensitivity test. Based on these findings, the diagnosis was renal subcapsular abscess associated with pyometra. This study suggests that pyometra should be considered as the cause of renal abscess.

• Childhood Kidney Diseases
• /
• v.25 no.1
• /
• pp.40-43
• /
• 2021

Enuresis is intermittent urinary incontinence during sleep at night in children aged 5 years or older. The main pathophysiology of enuresis involves nocturnal polyuria, abnormal sleep arousal, and low functional bladder capacity. In rare cases, enuresis is an early symptom of endocrine disorders such as diabetes or thyroid disorders. Herein, we report a case of a 12-year-old girl with enuresis as a rare initial presentation of Graves' disease. She complained of nocturnal enuresis from a month before visiting our clinic. She also complained of urinary frequency, headache, and weight loss. On physical examination, she had tachycardia, intention tremors, and a diffuse goiter on her anterior neck with bruit on auscultation. Her thyroid function test results revealed hyperthyroidism, and Graves' disease was diagnosed as the thyroid stimulating hormone receptor autoantibody was positive. After treatment for Graves' disease with methimazole, symptoms of enuresis resolved within 2 weeks as she became clinically and biochemically euthyroid. In children with secondary enuresis, Graves' disease should be considered as a differential diagnosis, and signs of hyperthyroidism should be checked for carefully.

• The Journal of the Society of Stroke on Korean Medicine
• /
• v.10 no.1
• /
• pp.68-73
• /
• 2009

Type 2 diabetes mellitus (T2DM) is a progressive disorder caused by a combination of insulin resistance and 𝛽 cell dysfunction. Sogal(消渴) is a traditional Korean medical term referring to a condition pertaining 3 major symptoms - thirst, polyphasia, polyuria. Sogal has been reported to have similar characteristics with DM. This case report demonstrates a patient with T2DM complaining of typical Sogal symptoms. We diagnosed him as So-yang person Sogal and treated him with acupuncture and herbal medicine.

• The Journal of Internal Korean Medicine
• /
• v.44 no.5
• /
• pp.979-986
• /
• 2023

Objective: The purpose of this study is to report the case of intracranial germ cell tumor-induced central diabetes insipidus (CDI) in a child treated with Korean herbal medicine. Methods: A nine-year-old female patient diagnosed with intracranial germ cell tumor-induced CDI suffering from polyuria, polydipsia, and headache was hospitalized. Nocturia frequency and 24-hour urine volume were assessed. Results: The patient was treated with Korean medicine, including Nokyong-hwan. As a result of the 6-day inpatient treatment, nocturia frequency was decreased 3-4 times to 0-1 time, and 24-hour urine volume was decreased. Conclusion: Korean medicine, including Nokyong-hwan, may be considered an optional treatment for releasing the symptoms of intracranial germ cell tumor-induced CDI. Further studies are needed to confirm this finding.