• 폴리머
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• 제29권5호
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• pp.468-474
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• 2005

약물 전달체로서 캬비톨에 의해 개시된 PLGA와 PCL은 락타이드, 글라이콜라이드, 그리고 카프로락톤의 개환 중합에 의해서 합성되었다. 이들 합성고분자를 이용한 이식형 웨이퍼는 합성고분자와 모델 단백질 약물로서 소혈청알부민의 물리적 혼합 후에 성형 압축법에 의해서 간단히 제조되었다. 웨이퍼로부터 알부민의 방출량은 형광측정기를 사용하여 형광 강도에 의해서 측정되었다. 또한 웨이퍼에서 알부민의 방출거동은 콜라겐, 소장점막하조직, 폴리비닐피롤리돈, 그리고 폴리에틸렌글리콜과 같은 첨가제를 통해 조절되었다. PLGA와 PCL로만 준비된 웨이퍼에서의 알부민의 방출은 30일 동안 $10\%$ 미만의 느린 방출거동을 보였다. 그러나 첨가제를 함유한 웨이퍼는 첨가제 함량에 따라서 다양한 서방형의 방출거동을 보였다. 더욱이 콜라겐과 소장점막하조직과 같은 천연재료를 함유한 웨이퍼는 폴리비닐피롤리돈, 폴리에틸렌글리콜과 같은 합성재료를 함유한 웨이퍼보다 0차 방출의 거동을 보였다. 이러한 이식형 웨이퍼로부터 알부민의 방출은 천연재료의 첨가를 통해 쉽게 조절할 수 있음을 확인하였다.

• 한국해양공학회지
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• 제27권5호
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• pp.99-104
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• 2013

Recently, various nanoparticles have been used for filler in polymer matrices. The particles of nano size are whether high or not cross-link density in polymer affects the thermal and mechanical properties of one. The properties change as a result of chemical reactions between the nanoparticles and the surface of the polymer. There are two models for nanocomposites: "repulsive interaction" and "attractive interaction" between the nanoparticles and matrix. In this study, the variation in the curing mechanism was examined when nano-size $TiO_2$ was dispersed into an epoxy (Bisphenol A, YD-128) with different curing agents. The results of this study showed that the exothermic temperature and Tg in the case of the nanoparticles used (Jeffamine) (D-180) at room temperature were reduced by an increase in the $TiO_2$ contents because of the "repulsive interaction" between the nanoparticles and the matrix. The tensile strengths were increased by increasing amounts of $TiO_2$ until 3 wt% because of a dispersion strengthening effect caused by the nanoparticles, because of the repulsive interaction. However, such tensile properties decreased at 5 wt% of $TiO_2$, because the $TiO_2$ was agglomerated in the epoxy. In contrast, in the case of the nanoparticles that used NMA and BDMA, the exothermic temperature and Tg tended to rise with increasing amounts of $TiO_2$ as a result of the "attractive interaction." This was because the same amounts of $TiO_2$ were well dispersed in the epoxy. The tensile strength decreased with an increase in the $TiO_2$ contents. In the general attractive interaction model, however, the cross-link density was higher, and tensile strength tended to increase. Therefore, for the nanoparticles that used NMA, it was difficult to conclude that the result was caused by the "attractive model."

• 한국에너지공학회:학술대회논문집
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• 한국에너지공학회 2008년도 춘계학술 발표회
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• pp.101-108
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• 2008

Polymer electrolyte membrane (PEM) fuel cells are promising power generation devices which are ideal for residential and automobile applications, thanks to their fast transient characteristics. However, liquid water produced in PEM fuel cells should be properly managed to enhance the performances and durabilities of the cells. In this study, a visualization experiment was conducted to investigate the flow behavior of water droplets in cathode channels. The visualization experiment was done with four different model flow channels which were made by varying the material (Acrylic and Teflon) and the channel width (1 mm and 2 mm). Acrylic is hydrophilic (contact angle is about $80^{\circ}$) while Teflon is hydrophobic (contact angle is about $120^{\circ}$). A computational fluid dynamics (CFD) analysis was also performed to compare the observed and the simulated two-phase water/air flow characteristics in cathode channels. The computational models were made to be consistent with the geometries and surface properties of the model flow channels. Both the experimental and numerical results showed that the Teflon cathode channel with 1 mm width has the best water management performance among four model flow channels considered. A close correlation was found between the experimental visualization results and the numerical CFD simulation results.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2008년도 추계 학술발표회 제20권2호
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• pp.133-136
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• 2008

염해에 노출이 심한 구조물이나 교량의 상판의 보강철근 부식으로 인한 콘크리트 구조물의 구조성능 및 내구성능의 저하가 큰 문제로 대두되고 있다. 이에 최근 활발히 연구가 진행 중인 유리섬유 보강근(Glass Fiber Reinforced Polymer Bar, 이하 GFRP 보강근)은 높은 화학적 내구성, 고강도, 경량성 등에 의하여 철근을 대체할 콘크리트 보강재로 그 가치를 인정받아 미국, 유럽, 캐나다 등에서는 이미 GFRP 보강근의 설계지침서가 발표되었다. 하지만 아직 GFRP 보강근을 이형철근과 같이 높은 신뢰성을 가지는 보강재로 사용하기에는 파악해야할 구조적 문제가 많이 있는데 그 중 하나가 콘크리트와의 부착성능이다. GFRP 보강근의 부착성능은 콘크리트 압축강도에 크게 영향을 받는 이형철근과 달리 섬유종류, 외피 표면 상태 등 여러 가지 요소에 의한 복합적 영향을 받는 부착특성을 보인다. 이에 본 연구에서는 외피 표면 상태, 콘크리트 압축강도 등을 변수로 하는 GFRP 보강근으로 보강된 일 방향 인장-인발 시편의 부착실험을 통하여 GFRP 보강근의 부착특성을 관찰하였다. 또한 이를 통하여 단조하중을 받는 GFRP 보강근의 부착응력-미끄럼 관계를 제안하고자 한다.

• 대한토목학회논문집
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• 제40권2호
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• pp.197-208
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• 2020

본 연구에서는 콘크리트 원형 교각의 동적거동 특성을 향상시키기 위하여 최적의 탄소섬유강화 플라스틱 설치 방법에 대해서 해석적 기법을 적용하여 평가하였다. 범용구조해석 프로그램인 ABAQUS가 해석연구에 사용되었으며, 소성 및 손상 콘크리트 재료특성을 적용하여 구조물의 비선형해석을 실시하였다. CFRP 적용에 따른 내진성능 향상도를 분석하고자 교각높이와 보강된 높이 비율, 교각 지름 대비 CFRP 보강 두께를 해석변수로 고려하여 거동특성과 연성도를 비교 분석하였다. 해석결과를 토대로 보강에 따른 정량적인 성능향상을 확인할 수 있었으며, 보강 재료 두께 증가보다는 교각높이 대비 보강높이 비율이 보다 성능에 큰 영향을 미치는 것을 알 수 있었다.

• Steel and Composite Structures
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• 제26권3호
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• pp.347-360
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• 2018

The aim of this paper is to evaluate the accuracy and reliability of the available bond-slip laws which are being used for the numerical modeling of Fiber Reinforced Polymer (FRP)/concrete interfaces. For this purpose, a set of Reinforced Concrete (RC) beams retrofitted with external FRP were modeled using the 3D nonlinear Finite Element (FE) approach. All considered RC beams have been previously tested and the corresponding experimental data are available in the literature. The failure modes of these beams are concrete crushing, steel yielding and FRP debonding. Through comparison of the numerical and experimental results, the effectiveness of each FRP/concrete bond-slip model for the prediction of the structural behavior of externally retrofitted RC beams is assessed. The sensitivity of the numerical results against different modeling considerations of the concrete constitutive behavior and bond-slip laws has also been evaluated. The results show that the maximum allowable stress of FRP/concrete interface has an important role in the accurate prediction of the FRP debonding failure.

• Journal of Pharmaceutical Investigation
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• 제31권1호
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• pp.1-5
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• 2001

The aggregation behavior of nystatin (NYS) in the presence of pluronic F127, triblock copolymer of poly (ethylene oxide) (PEO) and poly (propylene oxide) (PPO), was measured and correlated with hemolytic activity. Antifungal activity was also studied using Saccharomyces cerevisiae as a model strain. The critical aggregation concentrations (CAC) of the drug were 50.1, 108.0, 134.2, 154.3, and $217.9\;{\mu}M$ at 0.1%, 0.5%, 1.0%, 1.5%, and 2.0% pluronic F127 solution, respectively. The levels of NYS required to start lysis of erythrocytes were about 80, 100, 125, 150, and $200\;{\mu}M$ at 0.1%, 0.5%, 1.0%, 1.5%, and 2.0% pluronic F127 solution, respectively. It was $50\;{\mu}M$ in the absence of the polymer. Minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) of NYS-pluronic F127 lyophilizate were same at $3\;{\mu}g/ml$, while MIC and MFC of pure NYS are $3\;{\mu}g/ml$ and $12\;{\mu}g/ml$, respectively. By modulating the aggregation behavior of NYS, pluronic F127 was able to reduce the toxicity of the drug without compromising the MIC and MFC.

• Computers and Concrete
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• 제16권5호
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• pp.759-774
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• 2015

This study simulates the flexural behavior of ultra-high-performance fiber-reinforced concrete (UHPFRC) beams reinforced with steel and glass fiber-reinforced polymer (GFRP) rebars. For this, micromechanics-based modeling was first carried out on the basis of single fiber pullout models considering inclination angle. Two different tension-softening curves (TSCs) with the assumptions of 2-dimensional (2-D) and 3-dimensional (3-D) random fiber orientations were obtained from the micromechanics-based modeling, and linear elastic compressive and tensile models before the occurrence of cracks were obtained from the mechanical tests and rule of mixture. Finite element analysis incorporating smeared crack model was used due to the multiple cracking behaviors of structural UHPFRC beams, and the characteristic length of two times the element width (or two times the average crack spacing at the peak load) was suggested as a result of parametric study. Analytical results showed that the assumption of 2-D random fiber orientation is appropriate to a non-reinforced UHPFRC beam, whereas the assumption of 3-D random fiber orientation is suitable for UHPFRC beams reinforced with steel and GFRP rebars due to disorder of fiber alignment from the internal reinforcements. The micromechanics-based finite element analysis also well predicted the serviceability deflections of UHPFRC beams with GFRP rebars and hybrid reinforcements.

• Structural Engineering and Mechanics
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• 제39권2호
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• pp.207-221
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• 2011

This paper aims to study the behavior of short reinforced concrete columns confined with external glass Fiber Reinforced Polymers (GFRP) sheets under eccentric loads. The experimental part of the study was achieved by testing 9 specimens under eccentric compression. Three eccentricity ratios corresponding to e/t = 0, 0.10, 0.50 in one direction of the column were used. Specimens were divided into three groups. The first group was the control one without confinement. The second group was fully wrapped with GFRP laminates before loading. The third group was wrapped under loading after reaching 75% of failure loads of the control specimens. The third group was investigated in order to represent the practical case of strengthening a loaded column with FRP laminates. All specimens were loaded until failure. The results show that GFRP laminates enhances both failure load and ductility response of eccentrically loaded column. Moreover, the study also illustrates the effect of confinement on the first crack load, lateral deformation, strain in reinforcement and failure pattern. Based on the analysis of the experimental results, a simple model has been proposed to predict the improvement of load carrying capacity under different eccentricity ratios. The predicted equation takes into consideration the eccentricity to cross section depth ratio, the ultimate strength of GFRP, the thickness of wrapping laminate, and the time of wrapping (before loading and under loading). A good correlation was obtained between experimental and analytical results.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2006년도 추계 학술발표회 논문집
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• pp.365-368
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• 2006

RBSN Method, Rigid-Body-Spring Network Method, is a structural analysis method that overcomes the problems faced in FEM analysis of concrete or crack forming structures. In RBSN, irregular lattices are used to model structural components consisting of bulk material, curvilinear reinforcements, and their interfaces. Because reinforcements and their interfaces in the bulk material are freely positioned, meshing is irrespective of the geometry of the representing bulk material. In this paper, RBSN method of 3D is applied in simulating the pull-out test of FRP (Fiber Reinforced Polymer) embedded in concrete. The comparison of analysis results to experimental results shows that RBSN method simulates the shear-slip behavior very precisely. From the analysis results, 3D RBSN method is proven to be an effective and accurate analysis method for concrete structural analysis. Also, the results show that RBSN method can be a potential analysis method for concrete structures that can replace the current FEM analysis.