• Journal of Pharmaceutical Investigation
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• 제30권4호
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• pp.295-297
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• 2000

A new method to evaluate erosion of biodegradable polymer, polyanhydrides, was developed. The polymer devices were prepared with the melt-casting method and weight loss was accurately measured after agitating the devices in buffers (pH 1-9), and removing the device at selected time intervals and freeze-drying the device. The erosion rate was estimated from the plot of the weight loss(%) of device as a function of time. The freeze-drying technique used in this study is particularly useful for estimating the erosion rate of biodegradable polymer.