• 재활복지
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• 제18권4호
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• pp.257-277
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• 2014

본 연구의 목적은 국외에서 중추청각처리장애의 선별도구로 널리 사용되고 있는 Fisher's 청각행동문제 체크리스트(Fisher's auditory problems checklist, FAPC)와 청각행동특성척도(Scale of Auditory Behaviors, SAB)를 한국어로 번역하여 학령기 아동을 대상으로 실시하므로 국내의 학령기 아동의 청각행동특성을 파악하고, 두 검사 간의 특성을 비교하므로 국내에서 중추청각처리장애 선별을 위한 기초 자료를 제공하는데 있다. 한국어로 번역된 FAPC와 SAB 검사도구를 1~6학년 223명의 학생의 부모나 양육자에게 실시한 결과, FAPC와 SAB 검사 도구는 모두 학년별로 유의미한 점수 차이를 보이지 않았고, 학년 증감에 따른 수행 점수 간에 특정 유형이 관찰되지 않았으므로 본 설문지들은 학년에 상관없이 사용하여도 무방하다고 여겨진다. 그러나 두 검사의 유의미한 상관관계에도 불구하고 공통위험군 범위의 아동 수가 적어 서로 다른 특성을 포함하고 있으므로 선별검사 및 청각행동특성을 기초로 한 진단검사의 선정 및 재활 계획 수립시 서로 보완적으로 사용하는 것이 바람직하다고 여겨진다. 더하여 두 검사의 중추청각처리장애와의 관련성 검증과 표본 집단을 확대한 규준 제시를 통한 후속 표준화 연구가 요구된다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6283-6286
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• 2014

In patients with microscopic hematuria there is a need for better identification of those who are at greater risk of harbouring bladder tumors. The RisikoCheck(C) questionnaire has a strong correlation with the presence of urothelial carcinoma (UC) of the bladder and in combination with other available tests may help identify patients who require detailed clinical investigations due to increased risk of presence of bladder tumors. This study aimed to evaluate the efficacy of RisikoCheck(C) questionnaire together with NMP-22(R) (BladderChek(R)) as a point-of-care urine test in predicting the presence of bladder tumors in patients presenting with microscopic hematuria as the sole finding. In this multi-institutional prospective evaluation of 303 consecutive patients without a history of urothelial carcinoma (UC), RisikoCheck(C) risk group assessment, urinary tract imaging and cystourethroscopy as well as urine cytology and Nuclear Matrix Protein-22 (NMP-22 BladderChek) testing were performed where available. The sensitivity, specificity, negative predictive value (NPV), and positive predictive values (PPV) for the risk adapted approach were calculated. All patients underwent cystoscopy, and tumors were detected in 18 (5.9%). Urine cytology and NMP-22 was positive for malignancy in 9 (3.2%) and 12 (7.5%) of patients, respectively. A total of 43 (14%) patients were in the high risk group according to the RisikoCheck(C) questionnaire. The sensitivity and specificity of the questionnaire in detecting a bladder tumor was 61.5 % and 84.0 % in the high risk group. In patients with either a positive NMP-22 test or high risk category RisikoCheck(C), 23.6% had bladder tumors with a corresponding sensitivity of 54.2% and specificity of 88.6%. If both tests were negative only 3.3% of the patients had bladder tumors. The results of our study suggest that the efficacy of diagnostic evaluation of patients with microscopic hematuria may be further enhanced by combining RisikoCheck(C) questionnaire with NMP-22.

• Parasites, Hosts and Diseases
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• 제52권5호
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• pp.501-505
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• 2014

In recent years, rapid diagnostic tests (RDTs) have been widely used for malaria detection, primarily because of their simple operation, fast results, and straightforward interpretation. The Asan $EasyTest^{TM}$ Malaria Pf/Pan Ag is one of the most commonly used malaria RDTs in several countries, including Korea and India. In this study, we tested the diagnostic performance of this RDT in Uganda to evaluate its usefulness for field diagnosis of malaria in this country. Microscopic and PCR analyses, and the Asan $EasyTest^{TM}$ Malaria Pf/Pan Ag rapid diagnostic test, were performed on blood samples from 185 individuals with suspected malaria in several villages in Uganda. Compared to the microscopic analysis, the sensitivity of the RDT to detect malaria infection was 95.8% and 83.3% for Plasmodium falciparum and non-P. falciparum, respectively. Although the diagnostic sensitivity of the RDT decreased when parasitemia was ${\leq}500\;parasites/{\mu}l$, it showed 96.8% sensitivity (98.4% for P. falciparum and 93.8% for non-P. falciparum) in blood samples with parasitemia ${\geq}100\;parasites/{\mu}l$. The specificity of the RDT was 97.3% for P. falciparum and 97.3% for non-P. falciparum. These results collectively suggest that the accuracy of the Asan $EasyTest^{TM}$ Malaria Pf/Pan Ag makes it an effective point-of-care diagnostic tool for malaria in Uganda.

• 대한임상검사과학회지
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• 제48권2호
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• pp.49-53
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• 2016

급성 심 질환 환자는 트로포닌(troponin)과 같은 생물학적 표지자(biomarker)가 등장하면서 진단과 치료에 많은 개선이 있었다. 콩팥 질환에서는 많은 치료약제 개발이 꾸준하게 진전해 왔음에도 불구하고 실제 사망률이나 이환률은 별로 개선되지 않았다. 급성 콩팥 손상 환자를 대상으로 응급의료센터에서 측정한 NGAL의 측정치는 NGAL이 증가할수록 Creatinine이 유의하게 증가 하였다. 그러나, AST, ALT, BUN, Na, K, Cl 과의 상관관계는 통계적으로 유의하지 않았다. NAGL kit와 ELISA의 민감도는 ${\geq}300$ (92.2%), ${\geq}200$ (95.6%), ${\geq}100$ (99.6%), 특이도는 ${\geq}300$ (95.1%), ${\geq}200$ (97.3%), ${\geq}100$ (99.4%)로 조사되었으며 양성예측도는 ${\geq}300$ (93.3%), ${\geq}200$ (93.4%), ${\geq}100$ (99.2%), 음성예측도는 ${\geq}300$ (96.7%), ${\geq}200$ (97.7%), ${\geq}100$ (98.1%)로 조사되었으며, 급성 콩팥 손상의 정도를 평가하는 검사로써 조기 진단 및 예후를 예측함에 있어서 환자의 치료의 결정에 유용하게 이용 될 수 있다. 향후 응급의료센터에서 콩팥 질환 환자의 중증도를 평가하고 치료 방향을 결정하며, 예후를 예측하는데 있어서 NGAL kit 검사가 도움이 될 수 있다고 생각한다.

• 농촌의학ㆍ지역보건
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• 제40권4호
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• pp.221-227
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• 2015

본 연구는 관절염 환자들의 신체활동에 대한 제한, 이러한 활동에 대한 상대적 의존성 그리고 우울감 사이의 관련성을 매개효과를 밝히고자 연구를 실시하였다. 연구대상자는 지역사회에 거주하는 여성 농업인 중 관절염을 앓고 있다고 응답한 자 중 209명을 임의로 추출하여 설문조사 방식으로 조사하였다. 결과적으로 관절염으로 인한 세 개의 활동영역(개인의 신변활동, 집안일, 거주지에서의 이동성 등)은 활동제한이 우울감에 직접 관련이 있다기 보다는 활동제한으로 인해 의존성이 발생되고 결과적으로 우울감이 발생되는 경로를 보여 의존성을 개선하였을 경우 우울감이 줄어들거나 극복될 수 있으며, 여가생활에 대한 활동제한은 우울감에 직접적인 효과가 있어 관절염환자들의 활동제한 중에서 무엇보다도 여가생활의 제한은 우울감에 직접적인 영향을 주므로 환자들에게서 여가생활을 적극 장려할 수 있는 프로그램 개발이 필요하다. 결론적으로 관절염환자들의 자기관리능력 함양, 보조 기구 지급을 통한 의존성의 개선은 이들 환자들의 우울감 개선이 될 것이다.

• 성인간호학회지
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• 제12권1호
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• pp.17-29
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• 2000

The purpose of this study is to find out the effects of depression on older adults' metamemory and memory performances. The subjects of the study consisted of 103 older adults over the age of 60 who are living in Kangwon Province. Some data were collected by means of the interview method, using questionnaires for metamemory (MIA questionnaire by Hultsch, et al., 1988), and depression(GDS by Yesavage and Sheikl, 1986). Other data were collected by a testing method on the memory performance, such as the immediate word recall task, the delayed word recall task, the word recognition task(Elderly Verbal Learning Test by Kyung Mi Choi, 1998), and the face recognition task(Face Recognition Task tool developed by this study). The results of this study were as follows: 1) The average point of depressed older persons' metamemory is 3.2 on a 5 point scale and was significantly lower than nondepressed older persons' point of 3.6. Looking into each sub-concept of metamemory, depressed persons' points are higher in terms of task(4.1), but are lower in terms of change(2.3), locus(2.6), and strategy(2.9) in comparison with nondepressed persons' points. 2) Depressed older persons' memory performances are all significantly lower than nondepressed person's, especially in terms of face recognition task(t=7.26, p<.0082) and word recognition task(t=6.58, p<.01). 3) In both depressed and nondepressed persons, metamemory has a close correlation with all memory tasks. In particular, depressed older persons' correlation is higher across the board, especially in memory self-efficacy of metamemory(r=.36 - .49) in comparison with nondepressed persons. 4) According to the results of analysis on the relations between metamemory and memory performances of each memory task using canonical analysis, in the case of depressed older persons, strategy, locus, capability and task have high correlation with word recognition task and delayed word recall task. Also in the case of nondepressed persons, achievement, strategy, change and locus variable have high correlation with face recognition task and immediate word recall task. As mentioned above, depression variables have a negative effect on older persons' metamemory and memory performance. In conclusion, when we care for depressed older persons with less memory ability, we have to consider the outcomes of this study are relevant. In addition, it is necessary to develop nursing intervention in order to prevent memory loss and improve memory performance in depressed older persons.

• Journal of mucopolysaccharidosis and rare diseases
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• 제4권1호
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• pp.26-36
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• 2018

Mucopolysaccharidosis IIIA is a heritable neurodegenerative disorder resulting from the dysfunction of the lysosomal hydrolase sulphamidase. This leads to the primary accumulation of the complex carbohydrate heparan sulphate in a wide range of tissues and CNS degeneration. Characterization of animal model is the beginning point of the therapeutic clinical trial. Mouse model has a limitation in that it is not a human and does not have all of the disease phenotypes. Therefore, delineate of the phenotypic characteristics of MPS IIIA mouse model prerequisite for the enzyme replace treatment for the diseases. We designed 6-month duration of phenotypic characterization of MPS IIIA mouse biochemically, behaviorally and histologically. We compared height and weight of MPS IIIA mouse with wild type from 4 weeks to 6 months in both male and female. At 6 months, we measured GAG storage in urine kidney, heart, liver, lung and spleen. The brain GAG storage is presented with Alcian blue staining, immunohistochemistry, and electron-microscopy. The neurologic phenotype is evaluated by brain MRI and behavioral study including open field test, fear conditioning, T-maze test and Y-maze test. Especially behavioral tests were done serially at 4month and 6month. This study will show the result of the MPS IIIA mouse model phenotypic characterization. The MPS IIIA mouse provides an excellent model for evaluating pathogenic mechanisms of disease and for testing treatment strategies, including enzyme or cell replacement and gene therapy.

• 대한간호학회지
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• 제16권3호
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• pp.67-77
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• 1986

The research was carried out in order to assess, at an early stage, the potential barrier in mother-child relationship in the childs' development by using the screening tool. Consequently, after modifying the Neonatal Perception Inventory developed by Broussard and testing its reliability. It has been applied to 152 mothers at the hospital of three universities in Seoul from August 1 to September 30, 1986. The data was analyzed by S.P.S.S. pro-gram and the results were as follows: 1) Mothers perceived the newborn as an individual, and evaluated their baby higher than other babies. 2) Mothers indicated difficulties in their role performance in the fellowing order-bathing, safety, detecting pain or suffering, and feeding. 3) Mothers' perception of a newborn was positive for 75% of the mothers. 4) The factor analysis of the modified tool using principal components analysis and Varimax rotation resulted in the two factors: Factor 1, Baby as an individual: Factor Ⅱ, Performances are required to meet the new-born's needs. 5) The difference in mothers' individual characteristics such as the number of childbirth, the desire to get pregnant or not, the type of deli-very, and the sex of the newborn did not influence on a mothers' perception of her newborn. As seen above, most of the mothers perceived their newborns as able individuals and expressed difficulties involved in taking care of the newborn. Also most of the mothers perceived their babies positively. My point here is, we ought to observe those mothers who perceive their babies negatively, and then compare them with those mothers who perceive their babies extremely positive or extremely negative. In the future, for more comprehensive assessment tool for maternal perception of the newborn, a repetitive verification and modification of this tool is demanded. At the same time, father's perception of the newborn should be included.

• IMMUNE NETWORK
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• 제21권1호
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• pp.11.1-11.10
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• 2021

Coronavirus causes an infectious disease in various species and crosses the species barriers leading to the outbreak of zoonotic diseases. Due to the respiratory diseases are mainly caused in humans and viruses are replicated and excreted through the respiratory tract, the nasal fluid and sputum are mainly used for diagnosis. Early diagnosis of coronavirus plays an important role in preventing its spread and is essential for quarantine policies. For rapid decision and prompt triage of infected host, the immunochromatographic assay (ICA) has been widely used for point of care testing. However, when the ICA is applied to an expectorated sputum in which antigens are present, the viscosity of sputum interferes with the migration of the antigens on the test strip. To overcome this limitation, it is necessary to use a mucolytic agent without affecting the antigens. In this study, we combined known mucolytic agents to lower the viscosity of sputum and applied that to alpha and beta coronavirus, porcine epidemic diarrhea virus (PEDV) and Middle East respiratory syndrome coronavirus (MERS-CoV), respectively, spiked in sputum to find optimal pretreatment conditions. The pretreatment method using tris(2-carboxyethyl)phosphine (TCEP) and BSA was suitable for ICA diagnosis of sputum samples spiked with PEDV and MERS-CoV. This sensitive assay for the detection of coronavirus in sputum provides an useful information for the diagnosis of pathogen in low respiratory tract.

• Journal of Periodontal and Implant Science
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• 제48권4호
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• pp.251-260
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• 2018

Purpose: The aim of this retrospective cross-sectional study was to evaluate whether salivary findings of active matrix-metalloproteinase 8 (aMMP-8) chairside (point of care; POC) tests were associated with periodontal risk assessment parameters in patients receiving supportive periodontal therapy (SPT). Methods: A total of 125 patients receiving regular SPT were included, and their records were examined. The following inclusion criteria were used: a diagnosis of chronic periodontitis, at least 1 non-surgical periodontal treatment (scaling and root planning) with following regular SPT (minimum once a year), at least 6 remaining teeth, and clinical and aMMP-8 findings that were obtained at the same appointment. In addition to anamnestic factors (e.g., smoking and diabetes), oral hygiene indices (modified sulcus bleeding index [mSBI] and approximal plaque index), periodontal probing depth simultaneously with bleeding on probing, and dental findings (number of decayed, missing, and filled teeth) were recorded. Salivary aMMP-8 levels were tested using a commercial POC test system (Periomarker, Hager & Werken, Duisburg, Germany). Statistical analysis was performed using the t-test, Mann-Whitney U test, Fisher's exact test, and ${\chi}^2$ test, as appropriate (P<0.05). Results: Only the mSBI was significantly associated with positive salivary aMMP-8 findings (aMMP-8 positive: $27.8%{\pm}20.9%$ vs. aMMP-8 negative: $18.0%{\pm}14.5%$; P=0.017). No significant associations were found between aMMP-8 and smoking, diabetes, periodontal parameters, or parameters related to the maintenance interval (P>0.05). Conclusions: Salivary aMMP-8 chairside findings were not associated with common parameters used for periodontal risk assessment in patients receiving SPT. The diagnostic benefit of POC salivary aMMP-8 testing in risk assessment and maintenance interval adjustment during SPT remains unclear.