• Title/Summary/Keyword: Pleomorphic

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Carcinoma ex pleomorphic adenoma of the parotid gland: Case report (이하선에 발생한 다형선종유래암종의 치험례)

  • Jung, Jin-Hwan;Lee, Sang-Chil;Kim, Dong-Woo;Park, Dae-Song;Lee, Seul-Ki;Park, Chul-Hui;Yeom, Hak-Ryul;Kim, Hyeon-Min;Song, Min-Seok
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.36 no.1
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    • pp.53-56
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    • 2010
  • Carcinoma ex pleomorphic adenoma is transformed at the incidence of 1-20% in pleomorphic adenoma and frequently recurred. It accounts for 10% of all malignant salivary tumors and its average age of occurrence is 60s. It will present in a large, long-standing pleomorphic adenoma or in one that was previously treated but has recurred. According to cell composition in malignant cell carcinoma, and clear cell adenocarcinoma. Most (75%) occur in parotid gland, while about 20% occur in the minor gland of the oral mucosa. The metastasis rate to regional lymph node is about 25%, and to distant organs about 33% and the 5-year survival rates are 40%. Though the treatment of the carcinoma ex pleomorphic adenoma is not established, it is treated ideally with and extensive resection, neck dissection, postoperative radiotherapy, and chemotherapy. When occurred in parotid gland, facial paralysis is reported. With a review of literatures, we report a case of carcinoma ex pleomorphic adenoma which operated with total parotidectomy and supraomohyoid neck dissection.

A Case of Giant Pleomorphic Adenoma Arising in the Deep Lobe of the Parotid Gland (이하선 심부엽에 발생한 거대 혼합종(Giant Pleomorphic Adenoma) 1예)

  • Yoon Jong-Ho;Chang Hang-Seok;Chung Woung-Youn;Park Cheong-Soo
    • Korean Journal of Head & Neck Oncology
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    • v.14 no.1
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    • pp.103-106
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    • 1998
  • Pleomorphic adenoma is the most common tumor in the parotid gland and a parotidectomy with preservation of the facial nerve is a widely accepted treatment. With the advanced imaging methods such as CT scan or MRI and the developed surgical technique, the incidence of complications in parotid surgery declined considerably. However, when the tumor forms a huge mass after a prolonged period, surgeons tend to hesitate surgical treatment regarding the possibility of facial nerve injury and incomplete resection due to a malignant transformation of the tumor. And this is more likely when the huge tumor arised in the deep lobe of the parotid gland. We present a case of 39-year old man with a giant pleomorphic adenoma arising in the deep lobe of the parotid gland who was treated successfully by total parotidectomy without any complications. The size and weight of the tumor were 20x15x15cm and 1,100gm, respectively. In our experience, because pleomorphic adenoma is well encapsulated and not invasive to the adjacent tissue, even a giant pleomorphic adenoma arising in the deep lobe of the parotid gland can be treated by careful surgical resection with the preservation of the facial nerve.

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A Case of Parotid Carcinoma Ex Pleomorphic Adenoma with Mixture of Malignant Subtypes (이하선에 발생한 혼합 아형의 암종들로 구성된 다형선종 유래 암종 1예)

  • Youn Jin Cho;Young Rok Jo;Sang-Yeop Lee;Hye Ran Lee
    • Korean Journal of Head & Neck Oncology
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    • v.40 no.1
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    • pp.37-41
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    • 2024
  • Carcinoma ex pleomorphic adenoma is an uncommon malignant salivary gland tumor that arises from a long-standing pleomorphic adenoma. The carcinomatous component of carcinoma ex pleomorphic adenoma can possess virtually any histologic subtype of salivary gland cancer. We experienced a case of a 61-year-old patient who presented with a right parotid mass that was initially palpated 20 years ago, with a sudden increase in size in the last few months. Radiological and cytological findings from fine needle aspiration biopsy could not exclude malignancy. Total parotidectomy and selective neck dissection were performed for treatment, and carcinoma ex pleomorphic adenoma with mixed carcinoma components of salivary duct carcinoma and myoepithelial carcinoma was diagnosed. After receiving postoperative radiation of 6000 cGy over 6 weeks, there has been no recurrence up to the 18-month follow-up. We report this rare case of carcinoma ex pleomorphic adenoma with mixed malignancy subtypes, accompanied by a review of literature.

GLYCOSAMINOGLYCAN EXPRESSION IN PLEOMORPHIC ADENOMAS OF THE SALIVARY GLAND (타액선 다형성 선종에서 Glycosaminoglycan의 발현)

  • Kim, Seong-Joo;Kim, Chul-Hwan;Kim, Kyung-Wook
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.28 no.1
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    • pp.1-12
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    • 2006
  • Pleomorphic adenoma is the most common benign tumor in salivary glands, and occurred in frequency of 60% in parotid gland tumors, and 50% in submandibular gland tumors, and 25% in sublingual gland tumors. Histopathologically, pleomorphic adenoma is composed of epithelial cells and mesenchymal tissues, and called 'mixed tumor' because of morphological divergency. The cell structures of luminal area are composed of polyhedral and cuboidal secretory epithelial cells and modified myoepithelial cells around it, and mesenchymal tissue is composed of some myoepithelial cells and stromal tissue. In stromal tissue, myxoid change, chondroid change, or hyalinization can be seen even if bone tissue. In many studies, tumor cells of pleomorphic adenoma containing modified myoepithelial cell participate in synthesis of glycosaminoglycans. In this study, tissue sample of pleomorphic adenoma of human salivary gland were obtained from 20 surgical specimens, and all specimens were routinely fixed in 10% formalin and embedded. Serial 4-8${\mu}m$ thick sections were cut from paraffin blocks. The histopathologic evaluation was done with light microscopy. And, with immunohistochemical staining, characteristics of glycosaminoglycan were observed. And, for biochemical analysis of glycosaminoglycan, isolation of crude glycosaminoglycan from tumor tissue and immuno-blot analysis were carried out. With transmission electromicroscopy, tumor cells and biologic behavior of pleomorphic adenoma were observed with distribution and expression of glycosaminoglycan in tumor cells, The results were obtained as follows: 1. In immunohistochemical study, chondroitin 4-sulfate is highly postively stained in myxoid stromal tissue, and chondroitin 6-sulfate is highly positively stained in chondroid mesenchymal tissue, both glycosaminoglycans are positively stained in non-luminal cell of ductal area. 2. Dermatan sulfate and keratan sulfate is positively stained in periductal non-luminal tumor cells. 3. In immunohistochemical study, heparan sulfate is weakly stained in luminal cells and non-luminal cells around duct, and chondroid mesenchymal tissue. 4. In transmission electromicroscopic view, the tumor cells are composed of modified myoepithelial cells, and contain many microfilaments and well developed rough endoplasmic reticulum. 5. In Immuno-Blot analysis, the expression of glycosaminoglycans is expressed mostly in chondroitin 6-sulfate and chondroitin 4-sulfate. From the results obtained in this study, tumor cells of pleomorphic adenoma are composed of modified myoepithelial cells, and glycosaminoglycans of chondroitin 4-sulfate and chondroitin 6-sulfate mostly participate in the development of pleomorphic adenoma, but dermatan sulfate, keratan sulfate and heparan sulfate glycosaminoglycans were expressed variably.

A Case of Adenocarcinoma Ex Pleomorphic Adenoma with Tumor Thrombus of Submandibular Gland (악하선에 발생한 종양 혈전을 동반한 다형선종유래 선암종)

  • Kwon, Chul;Park, Choel-Eon;Shin, Il-Ho;Eun, Young-Gyu;Kwon, Kee-Hwan
    • Korean Journal of Head & Neck Oncology
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    • v.26 no.2
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    • pp.216-220
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    • 2010
  • Carcinoma ex pleomorphic adenoma is rare, aggressive, poorly understood malignancy that occurs in the salivary glands. The patient was 70-year-old male presenting ovoid elevated submandibular mass that has been present for 30 years and rapid growing for 6 months. The initial cytologic finding by fine needle aspiration biopsy showed highly malignant cells and the radiologic finding revealed a $3.6{\times}3.7{\times}4.8cm$ sized mass with cervical lymphadenopathy. After wide excision of submandibular gland and modified radical neck dissection, the histologic examination revealed that tumor was composed partly of a benign pleomorphic adenoma and partly of an adenocarcinoma component with areas of calcification and frequent angiolymphatic invasion. We present a rare case of adenocarcinoma ex pleomorphic adenoma with tumor thrombus in the submandibular gland.

Single Small Bowel Metastasis after Curative Operation in a Pleomorphic Lung Carcinoma (근치적 수술 후 소장으로 단독 전이된 폐의 다형성 암종 1예)

  • Kim, Ki-Won;Lee, Ho-Sung;Choi, Jae-Sung;Seo, Ki-Hyun;Oh, Mee-Hye;Jou, Sung-Shick;Kim, Yong-Hoon;Na, Ju-Ock
    • Tuberculosis and Respiratory Diseases
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    • v.71 no.2
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    • pp.139-143
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    • 2011
  • Small bowel metastasis of pleomorphic carcinoma of the lung is very rare. A 58-year-old man was admitted to our hospital with abdominal palpable mass in the right upper quadrant area. He underwent right middle and lower lobectomy for early stage pleomorphic carcinoma of the lung approximately 3 months ago. USG-guided biopsy was performed for abdominal mass. Pathologic examination revealed a metastatic pleomorphic carcinoma from the lung. He received chemotherapy followed by radiation therapy but died due to septic shock caused by intestinal stenosis and adhesion. We report the first case of small bowel metastasis by pleomorphic carcinoma of the lung after curative surgery.

PLEOMORPHIC ADENOMAS WHICH OCCURED IN THE SUBMANDIBULAR GLAND AND HARD PLATE;REPORTS OF TWO CASES (악하선(顎下腺)과 경구개(硬口蓋)에 발생한 다형성(多形性) 선종(腺腫)의 치험례)

  • Ha, Jong-Woon
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.16 no.2
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    • pp.163-166
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    • 1994
  • Pleomorphic adenoma(benign mixed tumor) is the most common tumor of the major salivary glands, constituting approximately 70 per cent of benign tumors of these glands. The term mixed tumor was introduced in the nineteenth century to stress the dual origin of this neoplasm from epithelial and mesenchymal elements, and the designation pleomorphic adenoma is preferred because it emphasizes both the epithelial origin and the variety of histological patterns found in this common salivary gland lesion. Rauch, in a review of 4245 pleomorphic adenomas, found 92.5 per cent in the major salivary glands and 6.5 per cent in the minor salivary glands, 8 per cent arose in the submandibular glands, and in another large series of over 6,000 cases, approximately 4 per cent arose in the hard and soft palates with equal frequency in each. The prognosis of pleomorphic adenoma depends more upon the choice and adequacy of treatment than upon histological appearances. The accepted treatment for this tumor is excision. With adequate surgery recurrence rates of less than 1 per cent can be obtained. In this hospital, I experienced two patients who were identified PMA which occurred in the hard palate and submandibular gland. The lesions were successfully treated by surgery.

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Metastasizing Pleomorphic Adenoma in Right Lung -A case report - (우측 폐로 전이된 전이성 다형태 선종 -증례 보고-)

  • Chung, Won-Sang;Nam, Seung-Hyuk;Kang, Jeong-Ho;Kim, Young-Hak;Kim, Eung-Soo;Kim, Hyuck
    • Journal of Chest Surgery
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    • v.40 no.2 s.271
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    • pp.143-146
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    • 2007
  • A metastasizing pleomorphic adenoma originating from the parotid gland is a rare form of neoplasm. The neoplasm is a histologically benign, but clinically controversial entity. Herein, a case report of a pleuro-pneumonectomy of a metastasizing pleomorphic adenoma in the right lung is described. A 57-year-old man, who underwent resection of parotid gland due to a pleomorphic adenoma, presented with multiple metastases on the right lung, mediastinum, pericardium and intercostal muscle. The metastatic lesions were composed of a benign pleomorphic structure.

A Case of Pleomorphic Hyalinizing Angiectatic Tumor of Neck Mimicking Neurogenic Tumor (신경성 종양으로 오인된 경부에 발생한 다형성 유리질 혈관확장성 종양 1례)

  • Yoo, Seok Chan;Yeo, Chang Ki;Shin, Hyeong Chan
    • Korean Journal of Head & Neck Oncology
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    • v.36 no.2
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    • pp.37-40
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    • 2020
  • Pleomorphic hyalinizing angiectatic tumor (PHAT) is a rare, low grade neoplasm which usually occurs in subcutaneous soft tissue. Histologically, it features ectatic blood filled vessels surrounded by hyalinized stroma and pleomorphic spindle cells. Clinically and histologically, PHAT could be misdiagnosed as such tumor as neurogenic tumor, malignant fibrous histiocytoma. About 100 cases of PHAT have been reported so far, and it is even rarer in head and neck area. We experienced a case of PHAT in 41-year-old male with several months of history of gradually enlarging neck mass which was surgically removed by wide excision.

Rapid Progression of Early Delayed Radiation Effect in Pleomorphic Xanthoastrocytoma

  • Park, Kyung-Jae;Kang, Shin-Hyuk;Lee, Hoon-Kap;Chung, Yong-Gu
    • Journal of Korean Neurosurgical Society
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    • v.46 no.6
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    • pp.564-567
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    • 2009
  • Early delayed radiation effects are known to occur within several months after completing radiotherapy for brain tumors. We present marked changes of magnetic resonance imaging (MRI) scan that occurred one month after radiotherapy in a patient with a pleomorphic xanthoastrocytoma, which was eventually diagnosed as an early delayed radiation effect. Such an early development of dramatic MRI change has not been reported in patients treated with radiotherapy for pleomorphic xanthoastrocytomas.