• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5675-5680
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• 2013

Background: Preexisting type 2 diabetes mellitus (T2DM) affects the prognosis and mortality of patients with some cancers. Insulin like growth factor (IGF) and insulin receptor (IR) signaling axes play important roles in both cancer and diabetes development. We aimed to explore the expression characteristics of proteins in IGF/IR axis in non-small cell lung cancer (NSCLC) cases with preexisting T2DM. Methods: Fifty-five NSCLC patients with preexisting T2DM were retrospectively included and matched by 55 NSCLC without diabetes at a 1:1 ratio. The expression of proteins in IGF/IR axis was detected by immunohistochemical staining. Clinicopathological data were collected to analyze their relationship with the protein expression. Results: Both IGF 1 receptor (IGF-1R) and insulin receptor substrate 2 (IRS-2) showed higher expression in the NSCLC with T2DM group, compared with those without T2DM. The high expression of IGF-1R and IRS-2 were found to be negatively associated with lymph node metastases and T staging in the T2DM group, respectively, and IRS-2 expression was also found more in the subgroup whose T2DM duration was more than 4 years. No difference was detected in the expression of IRS-1, IGF-1, IGF-2, IGFBP3, IR and mTOR between groups with or without T2DM. Conclusion: Our study found higher expression of IGF-1R and IRS-2 proteins in NSCLC patients with preexisting T2DM, and that there was an association with early stage NSCLC, which suggested that IGF signaling may play an important early event in development of NSCLC associated with diabetes.

• Korean Journal of Community Nutrition
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• v.15 no.2
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• pp.253-265
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• 2010

The purpose of this study was to examine the designs of the menu books as an important tool of marketing and then present its improvement strategies. For this, the investigator comparatively examined the current status of menu book designs of the restaurants in Incheon area with 295 managers and then analyzed menu book designs by its designers. Menu book designers were printing houses (42.0%), specialized business (31.9%) and managers/employees (26.1%). 51.5% of menu books were impossible to substitute partially. Even there were seasonal menus or event menus, 27.5% of them were impossible to replace menu books partially; therefore, it was impossible to take a prompt action for seasonal or event menus. The easiness of understanding the terminology in menu books was average $2.74{\pm}0.45$(3-point scale). The harmony of menu book design with restaurants was average $2.46{\pm}0.51$ (3-point scale). Comparing to the menu books designed in specialized business, the menu books designed in printing houses or by managers/employees were uniform in type sizes (p < 0.001), had no menu photos (p < 0.001) and explanations (p < 0.001), and did not classify menus by groups (p < 0.001) in general. In addition, profit-making menus were not properly emphasized (p < 0.001), thus making the design of menu books a little improper. Therefore, it is necessary to educate managers in the restaurants to understand the importance of menu books and thus improve it. In addition, by maintaining close communication with designers of menu books, managers in the restaurants must ensure for their menu books to be designed appropriately, thus making their menu books play the role of an important marketing tool.

• Proceedings of the Korea Society for Simulation Conference
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• 2001.10a
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• pp.9-10
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• 2001

Simulation has been evolved with the advance of computer and technique of modeling application systems. Early simulations were numerical analysis of engineering models known as continuous simulation, analysis of random events using various random number generators thus named as Monte Carlo simulation, iud analysis o(\\\\`queues which are prevalent in many real world systems including manufacturing, transportation, telecommunication. Discrete-event simulation has been used far modeling and analyzing the systems with waiting lines and inefficient delays. These simulations, either discrete-event, continuous, or hybrid, have played a key role in industrial age by helping to design and implement the efficient real world systems. In the information age which has been brought up by the advent of Internet, e-business has emerged. E-business, any business using Internet, can be characterized by the network of extended enterprises---extended supply and demand chains. The extension of value chains spans far reaching scope in business functions and space globally. It also extends to the individual customer, customer preferences and behaviors, to find the best service and product fit for each individual---mass customization. Simulation should also play a key role in analyzing and evaluating the various phenomena of e-business where the phenomena can be characterized by dynamics, uncertainty, and complexity. In this tutorial, applications of simulation to e-business phenomena will be explained and illustrated. Examples are the dynamics of new economy, analysis of e-business processes, virtual manufacturing system, digital divide phenomena, etc. Partly influenced by e-business, a new trend of simulation has emerged called agent-based simulation, Agent-based simulation is a technique of simulation using software agent that have autonomy and proactivity which are useful in analyzing and integrating numerous individual customer's behavior. One particular form of agent-based simulation is swarm. This tutorial concludes with the illustration of swarm or swarm Intelligence applied to various e-business applications, and future directions and implications of this new trend of simulation.

• Journal of Korean Society on Water Environment
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• v.25 no.5
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• pp.682-688
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• 2009

A plane field and a sloped field located at low-land plane and alpine areas, respectively, were monitored with respect to runoff, water quality and fertilizer uses from March to December, 2008. Runoff volume and Non-Point Source (NPS) loads were estimated and analyzed with respect to fertilizer uses. Total TN and TP loads from the sloped field were higher than those from plane field because of larger chemical uses in the alpine field than in the plane field. Organic matter load from plane field was higher than that from sloped field because more organic compost was applied to plane field than to sloped field. Event Mean Concentration (EMC) of measured water quality indices were relatively higher in both fields. Organic matter load per 1 mm rainfall were higher in plane field and TN and TP loads per 1 mm rainfall were higher in sloped field than those in respective comparing field. It was concluded that the type and application method of fertilizer could play an important role in the estimation of NPS pollution loads and the development of Best Management Practices (BMPs). However, it was recommended that long-term monitoring is necessary to better describe the relationship between fertilizer uses and water quality from agricultural fields because numerous natural and management factors other than fertilizer also affect runoff quality.

• Journal of Korea Society of Industrial Information Systems
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• v.17 no.3
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• pp.35-42
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• 2012

The database for driving patterns can be utilized in various system such as automatic driving system, driver safety system, and it can be helpful to monitor driving style. Therefore, we propose a driving pattern recognition system in which the sensor streams from a smartphone are recorded and used for recognizing driving events. In this paper we focus on the driving pattern recognition that is an essential and preliminary step of driving style recognition. We divide input sensor streams into 7 driving patterns such as, Left-turn(L), U-turn(U), Right-turn(R), Rapid-Braking(RB), Quick-Start(QS), Rapid-Acceleration (RA), Speed-Bump(SB). To classify driving patterns, first, a preprocessing step for data smoothing is followed by an event detection step. Last the detected events are classified by DTW(Dynamic Time Warping) algorithm. For assisting drivers we provide the classified pattern with the corresponding video stream which is recorded with its sensor stream. The proposed system will play an essential role in the safety driving system or driving monitoring system.

• Journal of Auto-vehicle Safety Association
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• v.9 no.4
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• pp.26-31
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• 2017

The current autonomous vehicle competitions are dominated by a few leading research institutions and universities. Since the leading research groups have been able to accumulate their knowledge and to develop their own algorithms for autonomous vehicle for many years, the technology gap seems too big for other followers to catch up with. On the other hand, recent researches predict that there would be a sharp rise in demand for engineers with background in autonomous vehicle technology. Therefore, it would be warranted to further expand the base of the academia and autonomous vehicle industry. In an effort to achieve this goal, it would be beneficial to hold a new format of autonomous vehicle competition event where undergraduate students can play a leading role. So, this study is to analyze the current autonomous vehicle competitions and thus to establish a strategic plan to develop a unique and improved competition event. This study investigates the pros and cons of the domestic and international autonomous vehicle competitions. Based on the analysis for the current autonomous vehicle competitions, the authors suggest a strategic plan to initiate an autonomous vehicle competition. To implement the aforementioned strategic plan, it is necessary to develop a systematic environment where the education and communication are actively available. Through the strategic plan the authors propose, the newly launching autonomous vehicle competition will able to encourage the undergraduate students and professors to dive in the cutting-edge technology thereby increasing technology competitiveness.

• Management & Information Systems Review
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• v.31 no.4
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• pp.639-661
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• 2012

The purpose of the paper is to examine sidedness effects of comparative advertising and moderating roles of the emotions of customer and product type. To test the research hypotheses, this study conducted experimental designs. One hundred ninety-two undergraduate students were assigned to one of the four experimental groups. Comparative Advertising message type and product type were manipulated as between-subject factors. There was a surprising event situation(free gift event) when participants came to laboratory for experiment, which is for the emotion manipulation. If a participant in a positive emotion group, he or she gets a free gift. The data demonstrate that comparative message type have a significant effect on both attitude toward the advertising and acceptance intention. In addition, consumers' emotion and product type play a significant moderating role between the message types and the dependent variables. The results of this study contribute to the literature as a new attempt to examine the sidedness effect of the comparative advertising message. We suggested that message types and consumer's emotion is one of very important aspects for a comparative advertising and marketers should consider people's emotion when they release a comparative advertising, which can help when marketers make their strategy for a comparative advertising.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.41 no.4
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• pp.59-69
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• 2018

This study deals with the case study on the pallet quantity determination problem for the flexible manufacturing system producing 32 different types of aircraft wing ribs which are major structures of an aircraft wings. A Korean company has constructed the WFMS (wing rib flexible manufacturing system) that is composed of several automated equipments such as the 5-axis machining centers, the RGV (rail guided vehicles)s, the AS/RS (automated storage and retrieval system), the loading/unloading stations, and so on. Pallets play a critical role in the WFMS to maintain high system utilization and continuous work flow between 5-axis machining machines and automated material handling devices. The discrete event simulation method is used to evaluate the performance of the WFMS under various pallet mix alternatives for wing rib manufacturing processes. Four performance measures including system utilization, throughput, lead-time and work in process inventory level are investigated to determine the best pallet mix alternative. The best pallet mix identified by the simulation study is adopted in setting up and operating a real Korean aircraft parts manufacturing shop. By comparing the real WFMS's performances with those of the simulation study, we discussed the cause of performance difference observed and the necessity of developing the CPS (cyber physical system).

• The Bulletin of The Korean Astronomical Society
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• v.44 no.1
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• pp.61.3-61.3
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• 2019

We report the status of KMTNet (Korea Microlensing Telescope Network) microlensing. From KMTNet event-finder, we are annually detecting over 2500 microlensing events. In 2018, we have carried out a real-time alert for only the Northern bulge fields. It was very helpful to select Spitzer targets. Thanks to the real-time alert, KMT-only events for which OGLE and MOA could not detect have been largely increased. The KMTNet event-finder and alert-finder algorithms are being upgraded every year. From these, we found 18 exoplanets and various interesting events, such as an exomoon-candidate, a free-floating candidate, and brown dwarfs, which are very difficult to be detected by other techniques including radial velocity and transit. In 2019, the KMTNet alert will be available in real-time for all bulge fields. As before, we will continue to collaborate with Spitzer team to measure the microlens parallaxes, which are required for estimating physical parameters of the lens. Thus, the KMTNet alert will be helpful to select Spitzer targets again. Also we plan to do follow-up observations for high-magnification events to study the planet multiplicity function. The KMTNet alert will play an important role to do follow-up observations for high-magnification events. Also, we will search for free-floating planets with short timescale (< 3 days) to study the planet frequency in our Galaxy.

• BLOOD RESEARCH
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• v.53 no.4
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• pp.276-280
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• 2018

Background Chronic lymphocytic leukemia (CLL) exhibits profound heterogeneity in its clinical course. Its clinicohematological and cytogenetic features play a significant role in determining the clinical course and in predicting the treatment response and prognosis. In this context, 17p deletion is known to predict a poor prognosis, as these cases are refractory to conventional therapy. This study aimed to evaluate the clinicohematological characteristics, outcomes, and prognostic factors among CLL patients with and without del 17p in Pakistan. Methods This prospective observational study was conducted at the Department of Haematology, Armed Forces Institute of Pathology (Rawalpindi, Pakistan) between January 2013 and December 2017. Patients were diagnosed based on the International Workshop on Chronic Lymphocytic Leukaemia IWCLL criteria, their clinicohematological parameters were recorded, and cytogenetic analyses were performed. The time from diagnosis to treatment and the 2-year overall survival rate were also evaluated. Results We evaluated 130 CLL cases, including 24 patients (18.5%) with del 17p, who included 18 men (75%) and 6 women (25%). The median age was 68 years. Binet stage C was detected at the presentation in 16 patients (67%). Treatment was administered to 14 patients (70%) at a median interval of 11 months (range, 0-28 mo) after diagnosis. The overall response rate was 64.3%, the median event-free survival was 9 months (range, 1-23 mo), and the 2-year overall survival rate was 65%. Conclusion Del 17p is relatively common in Pakistan, and patients harboring this deletion had poor treatment response and survival outcomes.