• Title/Summary/Keyword: Platycodon grandiflorum

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Development of a Natural Surfactant from Extracts of Platycodon Grandiflorum (도라지 추출물로부터 천연계면활성제의 개발)

  • Kim, Hee Jin;Park, Suk Kyong;Kim, Bo Young;Hong, Seul-Ki;Cho, Sung Ki;Kim, Donguk
    • Korean Chemical Engineering Research
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    • v.46 no.2
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    • pp.227-232
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    • 2008
  • In this research, organic extracts from roots of platycodon grandiflorum was tested to see the possibility for cosmetic natural surfactant. Interfacial properties of extracts of Platycodon grandiflorum was checked for interfacial tension, forming force, dispersion force, emulsion force, emulsion activity, and emulsion stability. At 0.005 wt% concentration, the interfacial tension against the caster oil was 11.5 dyn/cm which was lower than that of Tween 40 and quillaja bark. Extracts of Platycodon grandiflorum showed excellent emulsification activity and stability for cosmetic oils such as olive oil, soybean oil, and canola oil. In patch test using 2-5% of the extract and glycerin, the extract showed mild skin irritation. From the experiment, the extracts of platycodon grandiflorum root showed good interfacial properties as a cosmetic agent with minor skin irritation.

Physio-chemical impacts on efficient germination in Platycodon grandiflorum for. duplex pollen culture

  • Kwon, Soo Jeong;Hwang, Ha Nule;Moon, Young Ja;Cho, Gab Yeon;Woo, Sun Hee;Boo, Hee Ock;Koo, Jin-Woog;Kim, Hag Hyun
    • Proceedings of the Korean Society of Crop Science Conference
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    • 2017.06a
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    • pp.170-170
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    • 2017
  • The highly valued ornamental plant, Platycodon grandiflorum for. duplex was generated by petaloidy of a calyx of Platycodon grandiflorum. The present investigation was executed to explore the several factors having effects on the germination of pollens with a view to acquire the underlying data for the artificial crossing to cultivate the species of Platycodon grandiflorum for. duplex. Both low and high temperature impaired the germination of Platycodon grandiflorum for. duplex pollens. The good germination rate was observed at the temperature of $25^{\circ}C$. The types and concentrations of carbon sources induced the differences in germination rate. The germination rate increased with the increasing concentration of sucrose and glucose except for fructose. Sucrose and glucose showed the highest results at the concentration of 20%. While fructose demonstrated the similar tendency to sucrose and glucose, it reduced the germination rate at the concentration of 20%. The highest germination rate was observed at the concentration of 15%. The appropriate carbon course for germination of pollens of Platycodon grandiflorum for. duplex was glucose of which germination rate was twice as high as that of sucrose and fructose. The germination rate was reduced substantially when the pH was close to alkali, and the potential germination rate was obtained at pH 6. Boric acid enhanced the germination rate at a lower concentration than the higher concentration.

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Effect of Saponin Fraction from Platycodon grandiflorum on Clinical Chemical Changes in TCDD (2,3,7,8-Tetrachlorodibenzo-ρ-dioxin)-induced Rat Toxicity

  • Kwak, Yi-Seong;Moon, You-Jin;Kyung, Jong-Soo;Kim, Tae-Hwan;Rhee, Man Hee
    • Biomedical Science Letters
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    • v.26 no.2
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    • pp.66-74
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    • 2020
  • This study was carried out to investigate the protective effect of crude saponin from Platycodon grandiflorum on Clinical chemical parameters in male rats acutely exposed to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD). Crude saponin was prepared from Korean Platycodon grandiflorum with Diaion HP-20 adsorption chromatography after extraction of 80% ethanol at 75℃. The crude saponin was confirmed by thin layer chrmatography. When compared with ginseng saponins, the crude saponin had both a few number of saponins and a broad distribution. Forty male rats (200±20 g) were divided into 4 groups. Normal control (NC) group received vehicle and saline; TCDD-treated (TT) group received TCDD (40 ㎍/kg, single dose) intraperitoneally; Platycodon grandiflorum saponin (PG5 and PG10) groups received crude saponin 5 mg/kg and 10 mg/kg (p.o), respectively, for 2 weeks before 1 week of TCDD-exposure. Increase of body weight was retarded greatly by TCDD-exposure. Body weight of animals in TT group was significantly decrease after 2 days of TCDD-exposure. However, body weights of animals in PG groups increased through the experimental perimental period, although the increasing rate was slower than that of NC group. Increases in contents of blood glucose, total cholesterol and triglyceride (TG) and activities of amylase, lipase, AST, ALT and LDH by toxic action of TCDD were significantly attenuated by crude saponin from Platycodon grandiflorum (P<0.05). In conclusion, these results suggest that crude saponin prepared from Korean Platycodon grandiflorum might be a member of useful protective agents against TCDD, which is one of the environmental hormones.

The Effect of Femented Platycodon grandiflorum on the Memory Impairment of Mice (발효에 의한 길경추출물의 인지기능 개선 효능)

  • Kim, Tae-Yeon;Shin, Yong-Wook
    • The Korea Journal of Herbology
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    • v.28 no.2
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    • pp.25-31
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    • 2013
  • Objectives : The purpose of this study was to characterize the effect of the Ethanolic extracts of Platycodon grandiflorum and its permented production the learning and memory impairments induced by scopolamine. Methods : The cognition-enhancing effect of Platycodon grandiflorum and its permented production were investigated using a passive avoidance test, the Morris water maze test and Y-maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). Results : The results showed that the Permented Platycodon grandiflorum extract-treated group (100 mg/kg, p.o.) and the tacrine-treated group (10 mg/kg, p.o.) significantly ameliorated scopolamine-induced amnesia based on the Passive avoidance Y-maze test and Water maze test. And these results are same manner in DPPH radical scavenger effect and Acetylcholineseterase inhibition effect. Conclusions : These results suggest that 80% Ethanol extract of fermented P.grandiflorum showed significant anti-amnestic and cognitive-enhancing activities related to the memory processes, and these activities were parallel to treatment duration and dependent of the learning models.

Effects of an Extract from the Roots of Platycodon grandiflorum on the Growth and Gene Expression of Human Lung Carcinoma NCI-H460 Cells (DNA chip에 의한 연구에 따른 길경 수용액 추출물이 NCI-H460 인체 폐암세포의 성장 및 유전자 발현에 미치는 영향)

  • Kim, Hoon;Park, Dong-Il
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.19 no.2
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    • pp.77-87
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    • 2006
  • Objectives : We studied Effect of Platycodon grandiflorum on Lung carcinoma Methods : By using cDNA microarray technique, we analyzed the effects of AEPG(aqueous extract of Platycodon grandiflorum) on the gene expression profile. Results : Out of 384 genes screened associated with growth inhibition of carcinoma cell, 9 genes were founded to be affected in their expression levels by more than 1.2-fold after treatment with AEPG. And 67 genes were changed the expression level 0.5 times more than that of reference RNA after treatment of AEPG. Conclusions: These findings suggest that P. grandiflorum has strong potential for development as an agent for prevention and treatment against human lung cancer.

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Vasodilatory Effect of Complex Saponin Extracted from Platycodon grandiflorum and Glycyrrhiza uralensis Mixture Extract

  • Jung-Hwan Nam
    • Korean Journal of Plant Resources
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    • v.35 no.6
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    • pp.713-719
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    • 2022
  • Platycodon grandiflorum and Glycyrrhiza uralensis contain several bioactive compounds, such as saponin, oleanolic acid, and flavone. P. grandiflorum and G. uralensis have traditionally been used to treat disorders related to blood pressure, diabetes, and counteracting poison, and they have antinociceptive and antiinflammatory properties. However, the validity of complex saponin's vasodilatory effect has not been scientifically investigated. Therefore, this study explores the vasodilatory effect of complex saponin extracted from P. grandiflorum and G. uralensis mixture extract on rabbit carotid arteries. To this end, arterial rings with intact or damaged endothelium were used in an organ bath experiment and contracted by endothelin. Complex saponins, the major active constituents of P. grandiflorum and G. uralensis mixture extract, exhibited a moderate vasodilatory effect on the rabbit's basilar arteries. Therefore, treatment with complex saponin extracted from P. grandiflorum and G. uralensis mixture extract may selectively accelerate cerebral blood flow through basilar arterial dilation. Overall, the findings suggest that the extracted complex saponins can serve as vasodilator sources.

Effect of Platycodon grandiflorum DC Extract on the Growth of Cancer Cell Lines (도라지(Platycodon grandiflorum DC) 추출 성분의 암세포 증식 억제효과)

  • Lee, Ji-Young;Hwang, Woo-Ik;Lim, Seung-Taik
    • Korean Journal of Food Science and Technology
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    • v.30 no.1
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    • pp.13-21
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    • 1998
  • To investigate the cytotoxic effect of Platycodon grandiflorum DC, petroleum ether extract of Platycodon grandiflorum DC was partially purified by a silica gel column chromatography. Among several fractions, fraction D which was obtained under the elution with a 7:3 mixture of petroleum ether and ethyl ether, showed patent cytotoxicity against mouse leukemia cell line (L1210), human rectum cancer cell line (HRT-18) and human colon cancer cell lint (HCT-48).

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Culture of Hairy Roots Induced by Agrobacterium rhizogenes in Platycodon grandiflorum DC. (Balloon Flower) (Agrobacterium rhizogenes 에 의하여 유도된 도라지 (Platycodon grandiflorum DC.) Hairy Root 의 배양)

  • 김병노
    • Journal of Plant Biology
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    • v.33 no.3
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    • pp.183-188
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    • 1990
  • Induction and culture of hairy roots by Agrobacterium rhizogenes A4 were carried out in Platycodon grandiflorum DC. After 2-4 weeks of inoculation with Agrobacterium rhizogenes hairy roots were formed at root segments in the balloon flower. Optimized growth of hairy roots was obtained in hormone-free MS medium, 6% sucrose and pH 5.8. The pattern of ginsenoside in the transformed roots was not different with that in the ordinary roots.

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도라지(Platycodon grandiflorum A. DC) 추출성분이 기관지 질환 세균에 미치는 효과

  • Lee, In-Sun;Choe, Myeong-Cheol;Mun, Hye-Yeon
    • 한국생물공학회:학술대회논문집
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    • 2000.04a
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    • pp.305-308
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    • 2000
  • This study was observed to the effect of the feeding Platycodon grandiflorum A. DC (3 years) extract on the bronchus diseases bacteria ( C. diphtheriae, S. aureus, Mycobacterium sp., F. nucleatum, S. pygogenes, K. pneumoniae and N. gonorrhoeae) and fungi(A. fumicatus). Platycodon grandiflorum A. DC was extracted ethanon, water, ethyl ether and petroleum ether. The extraction rate of Platycodon grandiflorum A. DC to the extract solution was identified 71.8%, 100%, 15.4% and 14.1%. Each extract solution was injected culture media into several concentrations and then investigated the bacteria cell growth during 32 hours. As a result antimicrobial activity was excellent an extract by ethyl ether and petroleum ether. Among several concentrations, bacteria cell growth inhibition was observed from 0.06% to 0.14%. The rate of antimicrobial activity was over 70%. The cell growth inhibition rate of each bacteria was appeared in order of ethyl ether > petroleum ether > water > ethanol.

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Effect of Platycodon Grandiflorum Aqueous Extract on Lipid Levels in Rats

  • Kim Jeong-Seon
    • Nutritional Sciences
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    • v.9 no.3
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    • pp.167-172
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    • 2006
  • This study investigated the effects of Platycodon grandiflorum aqueous extract on lipid concentration of serum and liver in rats fed high cholesterol diet Male Sprague-Dawley rats were assigned to three groups (control, low dose of extract, high dose of extract) for four weeks. The serum total cholesterol concentration was significantly lower in the low and high doses of extract groups than in the control group. There was a significant decrease in the free cholesterol, cholesterol ester, LDL-cholesterol, and triglycerides concentrations in serum, and the total cholesterol and the triglycerides contentin liver in the low and high doses of extract groups compared to the control group. When the serum phospholipid concentration was compared among the groups, it was significantly lower in high dose of extract group than in control and low dose of extract group. It can be postulated that Platycodon grandiflorum aqueous extract may possess substantial hypolipidemic properties in rats.