• Journal of Industrial and Engineering Chemistry
• /
• v.67
• /
• pp.469-477
• /
• 2018

We describe surgical sutures enabled with the local, sustained delivery of a TGF-${\beta}$ inhibitory drug, tranilast. To fabricate drug-delivery sutures, we separately prepared a tranilast-loaded strand using poly (lactic-co-glycolic acid), which was then physically braided with a surgical suture already in clinical use. By this method, the drug-delivery sutures maintained the mechanical strength and allowed the modulation of drug release profiles by simply altering the tranilast-loaded strand. The drug-delivery sutures herein released tranilast for up to 14 days. When applied to animal models, scarring was indeed reduced with diminished TGF-${\beta}$ expression and fibroblast numbers during the entire 21 day testing period.

• Archives of Plastic Surgery
• /
• v.42 no.6
• /
• pp.686-694
• /
• 2015

Background Rosa damascena, a type of herb, has been used for wound healing in Eastern folk medicine. The goal of this study was to evaluate the effectiveness of rose placenta from R. damascena in a full-thickness wound model in mice. Methods Sixty six-week-old C57BL/6N mice were used. Full-thickness wounds were made with an 8-mm diameter punch. Two wounds were made on each side of the back, and wounds were assigned randomly to the control and experimental groups. Rose placenta ($250{\mu}g$) was injected in the experimental group, and normal saline was injected in the control group. Wound sizes were measured with digital photography, and specimens were harvested. Immunohistochemical staining was performed to assess the expression of epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), transforming growth factor-${\beta}1$ (TGF-${\beta}1$), and CD31. Vessel density was measured. Quantitative analysis using an enzyme-linked immunosorbent assay (ELISA) for EGF was performed. All evaluations were performed on postoperative days 0, 2, 4, 7, and 10. Statistical analyses were performed using the paired t-test. Results On days 4, 7, and 10, the wounds treated with rose placenta were significantly smaller. On day 2, VEGF and EGF expression increased in the experimental group. On days 7 and 10, TGF-${\beta}1$ expression decreased in the experimental group. On day 10, vessel density increased in the experimental group. The increase in EGF on day 2 was confirmed with ELISA. Conclusions Rose placenta was found to be associated with improved wound healing in a mouse full-thickness wound model via increased EGF release. Rose placenta may potentially be a novel drug candidate for enhancing wound healing.

• Archives of Plastic Surgery
• /
• v.35 no.4
• /
• pp.360-366
• /
• 2008

Purpose: Botulinum toxin type A(BoTA) can block the release of vasoconstriction cotransmitters as well as acetylcholine in nerve terminal. The authors observed that BoTA increases flap survival by preventing sympathetic collapse of peripheral vessels. Methods: 10 Sprague Dawley rats were divided into control(n=5), and BoTA group(n=5). $3{\times}10cm$ sized random pattern cutaneous flaps were elevated on the dorsal side in both groups. In BoTA group, BoTA was injected into the flap via intradermal to subdermal route, 7 days before the flap elevation. Flap survival rates (survival area/total area) were measured 7 days after the elevation. Cutaneous blood flow was measured in proximal, middle and distal compartments of the flap using laser Doppler flowmetry initially, preoperatively, at immediate postoperation, and 7 days after flap elevation, respectively. Histological examination was performed 7 days after the flap elevation. The number and shape of the vessels were evaluated under microscope. Results: Mean flap survival was $53.18{\pm}6.58%$ in control group and $93.79{\pm}6.06%$ in BoTA group, displaying statistically significant difference(p=0.0008, p<0.05). In the control group, blood flow to the middle and distal compartments of the flap decreased significantly immediately after flap elevation. In the BoTA group, blood flow to the middle compartment did not decrease(p=0.002) and slightly decreased in the distal compartment(p=0.001). Cutaneous blood flow was significantly higher in all compartments of the flap in BoTA group than in control group, 7 days after the flap elevation. In histopathologic examination, greater number of vessels were noted in the BoTA group than in the control group. Conclusion: Botulinum toxin A can increase the survival of the random pattern cutaneous flap in rats by preventing the sympathetic collapse of peripheral vessels.

• Korean Journal of Soil Science and Fertilizer
• /
• v.43 no.5
• /
• pp.565-571
• /
• 2010

One of the disadvantages of flooding treatment for desalting from soils is that salts move to deep soils after flooding and at the end reaccumulate at the soil surface through capillary movements. This study was carried out to remove salts from soils in plastic film houses by a modified flooding method, drainage after flooding. The method successfully removed salts at the soil surface and salts did not move to the deep soil. Drained water containing N, P and K could be reused as fertilizer. By applying small amount of MgO, turbidity of water flooded decreased in 30 min by 95%. Struvite should be formed since the flooded water contain ammonia and phosphorous and their concentrations were decreased. This could be utilized as fertilizer which provides a slow-release source of phosphorus, magnesium and nitrogen that features low inherent water solubility.

• Computational Structural Engineering
• /
• v.9 no.1
• /
• pp.65-76
• /
• 1996

The initiation and growth of microcracks or microvoids inside concrete results in the progressive degradation of concrete. This damage processing along processing along with plastic deformation is main cause of nonlinear behavior of concrete. In this study, a continuum damage model of concrete is developed for the analysis of the nonlinear behavior of concrete due to damage and elasto-plastic deformation. Anisotropic damage tensor is used to describe the anisotropy of concrete and hypothesis of equivalent elastic energy is used to define the effective elastic tensor. The damage model including the damage evolution law and constitutive equation is derived with damage variable and damage surface which is defined by damage energy release rate by using the Helmholtz free energy and dissipation potential based on the thermodynamic principles. By adopting a typical plasticity model of concrete, plasticity of concrete is included to this model. Afinite element analysis program implemented with this model was developed and finite element analysis was performed for the analyses of concrete subjected to uniaxial and biaxial loadings. Comparison of the results of analysis with those of experiments and other models shows that the model successfully predicts the nonlinear behavior of concrete.

• Fire Science and Engineering
• /
• v.32 no.3
• /
• pp.8-13
• /
• 2018

It was conceived from the realization that there was a lack of studies on the fire risk compared to utility and importance of plastic which is widely used. In this study, the fire hazard of five types of plastic products was measured by Cone Calorimeter (ISO 5660-1). As a result, the time to ignition (TTI) of polyvinyl Chloride (PVC) plate delayed TTI (196 s), and polystyrene (PS) plate had the shortest TTI of 19 s. The total heat release (THR) of PS plate was measured at 213.07 % higher than the lowest measured PVC plate. Also, the PS plate will have 1.45 to 4.21 times higher $CO_2$ than other plastics, resulting in the highest incomplete combustion and the greatest possible damage of life. Thus, assessing the risk of fire revealed that PS plate is the most dangerous and PVC is the safest.

• Archives of Plastic Surgery
• /
• v.36 no.4
• /
• pp.432-436
• /
• 2009

Purpose: Negative pressure therapy has been used in various conditions to promote wound healing. It has also been used to secure a skin graft by improving microcirculation and improving tight adhesion between the graft and the recipient bed. To reduce post burn scar contracture and improve aesthetical result, many types of dermal substitutes have been invented and used widely. The goal of this study was evaluate usefulness of the VAC (Kinetic concepts Inc., San Antonio, TX) in improving the take rate and time to incorporation of Integra$^{(R)}$ in reconstruction of burn scar contracture. Methods: A retrospective study was performed from October, 2006 to December, 2008. The VAC was utilized for 11 patients. The average patient's age was 19.7 years (range 5 - 27) and average surface area was $785cm^2$ (range 24 - 1600). The burn scars were excised deep into normal subcutaneous tissue to achieve complete release of the scar, Integra$^{(R)}$ was sutured in place with skin staple와 Steri - strip$^{(R)}$. Then slit incisions were made on silicone sheet only with No.11 blade for effective drainage. The VAC was used as a bolster dressing over Integra$^{(R)}$. Negative - Pressure ranging from 100 to 125 mm Hg was applied to black polyurethane foam sponge trimmed to the appropriate wound size. An occlusive seal over the black polyurethane foam sponge was maintained by a combination of the occlusive dressing, OP - site$^{(R)}$. The VAC dressing changes were performed every 3 or 4 days until adequate incorporation was obtained. The neodermis appeared slightly yellow to orange color. When the Integra$^{(R)}$ deemed clinically incorporated, The VAC was removed and take was estimated with visual inspection. Very thin STSG(0.006 ~ 0.008 inches) was performed after silicone sheet removal. Result: The mean time for clinically assessed incorporation of Integra$^{(R)}$ was 10.00 days (range 9 - 12). The mean dressing change was 3.5 times until take was obtained. In All patients, Integra$^{(R)}$ had successful incorporation in tissue without serious complications. Conclusion: Integra$^{(R)}$ in combination with Vacuum - Assisted Closure(VAC) may be incorporated earlier than conventional dressing method.

• Advances in environmental research
• /
• v.2 no.3
• /
• pp.179-202
• /
• 2013

Bisphenol A and other alkylphenols are widely used in plastic and other industrial consumer products. Release of these compounds into the aquatic environment during their manufacture, use and disposal has been a great scientific and public concern due to their toxicity at high concentrations and endocrine disrupting effects at low concentration on aquatic wildlife and human beings. This paper reviews the published data and researches on the environmental occurrence, distribution, health effects and analytical techniques of bisphenol A and alkylphenols. The aim is to provide an overview of the current understanding about bisphenol A and alkylphenols in the environment and the difficulties faced today in order to establish standard and systematic environmental analysis and assessment process for these endocrine disruptor compounds.

• Proceedings of the Korean Society for Technology of Plasticity Conference
• /
• 2004.05a
• /
• pp.47-52
• /
• 2004

Springback comes from the release of residual stress after forming. The control of phenomenon is especially important in the sheet metal forming since there are no other practical methods available to correct the dimensional inaccuracy from springback. Therefore the accurate predication before the die machining has been a long goal in the Held of sheet metal forming. The aim of the present study is to enhance the prediction capability of finite element(FE) analysis for the springback phenomenon. For this purpose FE analysis for V-bending has been carried out with the commercial programs, LS-DYNA. The FE analysis results have been validated through the comparison of experimental. The experimental results measured directly by the strain gauge have given the confidence to FEA.

• Proceedings of the Korean Society for Technology of Plasticity Conference
• /
• 1999.03b
• /
• pp.237-240
• /
• 1999

The elastic stress analysis of the die for helical gear forging has been calculated by using the nodal force at the final stage obtained from the rigid-plastic finite element analysis. In order to obtain more precise gear products. the elastic analysis of the die after release of punch and the elastic spring-back analysis of product after ejection have been performed and the final dimension of the computational product has been in good agreement with that of the experimental product.