• Earthquakes and Structures
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• 제23권2호
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• pp.183-196
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• 2022

Reduced beam section (RBS) moment connections used in special moment resisting frames are currently limited to beam sections that are not larger than nominal depths of 920 mm, weight of 447 kg/m and flange thickness of 44 mm. Due to the higher demand for structural components with jumbo sections, which can potentially be applied in the transfer girders in long-span building structures, the newly available steel heavy members are promising. To address this issue, advanced numerical models are developed to fully evaluate the distribution of stresses and concentrations of plastic strains for such jumbo RBS connections. This paper first presents a brief overview of an experimental study on four specimens with large beam and column sections. Then, a numerical model that includes initial imperfections, residual stresses, geometric nonlinearity, and explicitly modeled welds is presented. The model is used to further explore the behavior of the test specimens, including distribution of stresses, distribution of plastic strains, stress triaxiality and potential for fracture. The results reveal that the stresses are highly non-uniform across the beam flange and, similarly, the plastic strains concentrate at the extreme fiber of the bottom flange. However, neither of these phenomena, which are primarily a function of beam flange thickness, is reflected in current design procedures.

• BMB Reports
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• 제52권3호
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• pp.202-207
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• 2019

Keloids are the most common pathological form of trauma healing, with features that seriously affect appearance and body function, are difficult to treat and have a high recurrence rate. Emerging evidence suggests that miRNAs are involved in a variety of pathological processes and play an important role in the process of fibrosis. In this study, we investigated the function and regulatory network of miR-152-5p in keloids. The miRNA miR-152-5p is frequently downregulated in keloid tissue and primary cells compared to normal skin tissue and fibroblasts. In addition, the downregulation of miR-152-5p is significantly associated with the proliferation, migration and apoptosis of keloid cells. Overexpression of miR-152-5p significantly inhibits the progression of fibrosis in keloids. Smad3 is a direct target of miR-152-5p, and knockdown of Smad3 also inhibits fibrosis progression, consistent with the overexpression of miR-152-5p. The interaction between miR-152-5p and Smad3 occurs through the Erk1/2 and Akt pathways and regulates collagen3 production. In summary, our study demonstrates that miR-152-5p/Smad3 regulatory pathways involved in fibrotic progression may be a potential therapeutic target of keloids.

• 소성∙가공
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• 제7권3호
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• pp.233-245
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• 1998

A new approach has been proposed for the incremental analysis of the nonsteady state large deformation of planar anisotropic elastic-plastic sheet forming. A mathematical brief review of a constitutive law for the incremental deformation theory has been presented from flow theory using the minimum plastic work path for elastic-plastic material. Since the material embedded coordinate system(Lagrangian quantity) is used in the proposed theory the stress integration procedure is completely objective. A new return mapping algorithm has been also developed from the general midpoint rule so as to achieve numerically large strain increment by successive control of yield function residuals. Some numerical tests for the return mapping algorithm were performed using Barlat's six component anisotropic stress potential. Performance of the proposed algorithm was shown to be good and stable for a large strain increment, For planar anisotropic sheet forming updating algorithm of planar anisotropic axes has been newly proposed. In order to show the effectiveness and validity of the present formulation earing simulation for a cylindrical cup drawing and front fender stamping analysis are performed. From the results it has been shown that the present formulation can provide a good basis for analysis for analysis of elastic-plastic sheet metal forming processes.

• 한국지반공학회논문집
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• 제21권4호
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• pp.31-40
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• 2005

본 연구에서는 이방성을 가지는 현장지반의 비배수 전단거동을 예측하기 위해 한계상태 간격비를 고려한 새로운 항복함수식을 제안하였다. 또한 수정 Cam-clay모델의 항복면 식을 이방압밀 조건에 적용할 수 있도록 수정한 새로운 소성포텐셜 함수를 적용하는 비관련 구성모델을 제안하였다. 제안모델을 적용하여 등방 및 이방압밀된 재성형 포항 이암풍화토의 비배수 전단거동을 예측하였으며, 신뢰성을 평가하기 위해 등방정규압밀된 Bankok clay 및 $K_0$ 압밀된 Drammen clay의 비배수 전단거동을 예측하였다. 그 결과 제안된 모델은 전반적인 거동을 잘 예측하는 것으로 나타났다.

• Archives of Plastic Surgery
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• 제44권2호
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• pp.124-135
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• 2017

Background In cases of total knee arthroplasty (TKA) threatened by potential hardware exposure, flap-based reconstruction is indicated to provide durable coverage. Historically, muscle flaps were favored as they provide vascular tissue to an infected wound bed. However, data comparing the performance of muscle versus fasciocutaneous flaps are limited and reflect a lack of consensus regarding the optimal management of these wounds. The aim of this study was to compare the outcomes of muscle versus fasciocutaneous flaps following the salvage of compromised TKA. Methods A systematic search and meta-analysis were performed to identify patients with TKA who underwent either pedicled muscle or fasciocutaneous flap coverage of periprosthetic knee defects. Studies evaluating implant/limb salvage rates, ambulatory function, complications, and donor-site morbidity were included in the comparative analysis. Results A total of 18 articles, corresponding to 172 flaps (119 muscle flaps and 53 fasciocutaneous flaps) were reviewed. Rates of implant salvage (88.8% vs. 90.1%, P=0.05) and limb salvage (89.8% vs. 100%, P=0.14) were comparable in each cohort. While overall complication rates were similar (47.3% vs. 44%, P=0.78), the rates of persistent infection (16.4% vs. 0%, P=0.14) and recurrent infection (9.1% vs. 4%, P=0.94) tended to be higher in the muscle flap cohort. Notably, functional outcomes and ambulation rates were sparingly reported. Conclusions Rates of limb and prosthetic salvage were comparable following muscle or fasciocutaneous flap coverage of compromised TKA. The functional morbidity associated with muscle flap harvest, however, may support the use of fasciocutaneous flaps for coverage of these defects, particularly in young patients and/or high-performance athletes.

• Geomechanics and Engineering
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• 제22권1호
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• pp.11-23
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• 2020

In this study, a new analytical-numerical procedure is developed to give the stresses and strains around a circular tunnel in rock masses exhibiting different stress-strain behavior. The calculation starts from the tunnel wall and continues toward the unknown elastic-plastic boundary by a finite difference method in the annular discretized plastic zone. From the known stresses in the tunnel boundary, the strains are calculated using the elastic-plastic stiffness matrix in which three dimensional Hoek-Brown failure criterion (Jiang and Zhao 2015) and Mohr-Coulomb potential function with proper dilation angle (i.e., non-associated flow rule) are employed in terms of stress invariants. The illustrative examples give ground response curve and show correctness of the proposed approach. Finally, from the results of a great number of analyses, a simple relationship is presented to find out the closure of circular tunnel in terms of rock mass strength and tunnel depth. It can be valuable for the preliminary decision of tunnel support and for prediction of tunnel problems.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 1997년도 고액공존금속의 성형기술 심포지엄
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• pp.5-15
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• 1997

It is the objective of this study that by conducting the serni-solid extrusion using A12024, the effect of various process variables on the quality of extruded product and extrusion force is understood. The results of experiment are compared with those of finite element simulation in order to verify the effectiveness of the developed FE-simulation code. In order to simulate densification in the deformation of serni-solid material, the semi-solid material is assumed to be composed of solid region as porous skeleton following compressible visco-plastic model and liquid region following Darcy's equation for the liquid flow saturated in the interstitial space. Then the flow and deformation of the semi-solid alloy are analyzed by coupling the deformation of the porous skeleton and the flow of the eutectic liquid. It is assumed that initial solid fraction is homogeneous. Yield and plastic potential function presented by Kuhn and constitutive model developed by Gunasekera are used for solid skeleton.

• 한국환경복원기술학회지
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• 제9권1호
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• pp.1-13
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• 2006

The recent environmental protection issue has diminished the supply of sand for soft ground improvements so much that the prices of sand have shown a sudden rise. Plastic material is one of substitutes for sand material, but plastic is nonperishable and doubtable if it has potential environmental hormone disrupting substances. Moderate-priced natural fiber drain board made with coconut coir and jute filter are in the spotlight recently as an alternative material for sand and plastic drain board etc. Natural fiber drain has not only competitive price but also a characteristic of assimilation into the soils after finishing of its own function. Discharge capacity of the fiber drain board evaluated by triaxial type discharge capacity test was relatively lower than that of plastic drain board. Nevertheless, settlement and pore pressure dissipation behaviors of the fiber drain board and the plastic drain board which were installed in the clayey soil during the composite discharge capacity test were almost similar. It was also found that biodegradation of the fiber drain board was in progress until 18 month after installation in the clayey soil, but they had still enough engineering properties to use at field.

• 대한기계학회논문집A
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• 제24권2호
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• pp.472-480
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• 2000

A macroscopic yield criterion for porous solids with pressure-sensitive matrices modeled by Coulomb's yield criterion was obtained by generalizing Gurson's yield criterion with consideration of the hydrostatic yield stresses for a spherical thick-walled shell and by fitting the finite element results of a voided cube. The macroscopic yield criterion is valid for negative mean normal stresses as well as for positive mean normal stresses. From the yield criterion, a plastic potential function for the porous solids was derived either for plastic normality flow or for plastic non-normality flow of pressure- sensitive matrices. In addition, the elastic relation, an evolution equation of the plastic flow stress of the matrices and an evolution equation of the void volume fraction were presented to complete a set of constitutive relations. The set of constitutive relations was implemented into a finite element code ABAQUS to analyze the material behavior of rubber-toughened epoxies. The cavitation and the deformation behavior were analyzed around a crack tip under three-point bending and around notch tips under four-point bending. In the numerical analyses, the cavitation of rubber particles was considered via a stress-controlled nucleation model. The numerical results indicate that a reasonable cavitation zone can be obtained with void nucleation controlled by the macroscopic mean normal stress, and a plastic zone is smaller around a notch tip under compression than under tension. These numerical results agree well with corresponding experimental results on the cavitation and plastic zones.

• Archives of Plastic Surgery
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• 제37권1호
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• pp.31-36
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• 2010

Purpose: The primary goal of palatoplasty is to enable normal speech with harmonious growth of face. Some children who had palatoplasty display typical findings of transverse maxillary deficiency requiring orthodontic widening of the maxilla. Levi (2009) described a cleft palate repair coupled with pedicled buccal fat pad flaps to cover bone exposed areas of the hard palate. Hence we report clinical experiences of cleft palate repair using pedicled buccal fat pad flap. Methods: Four Veau class II and a Veau class I cleft palate patients underwent palatoplasty with buccal fat pad flap by single surgeon from April 2009 to August 2009. Two patients received 2-flap palatoplasty and three patients 1-flap palatoplasty, respectively. After the cleft palate repair, sharp mosquito scissors was placed in the superior buccal sulcus just lateral to the maxillary tuberosity and inserted directly through the mucosa resulting in buccal fat pad extrusion. The elevated flap was moved to cover mucoperiosteal defect in hard palatal area. Results: Five patients underwent primary palatoplasty using buccal fat pad flap. Flap harvest and inset took on average 9 minutes per flap. Mucosal epithelization took 18 days on average. No patients had complications related to the buccal fat pad flap. Conclusion: Buccal fat pad pedicled flap has significant potential to function as an added vascularized tissue layer in cleft palate repair and we can expect better growth of maxilla with this method although longer duration of follow-up was unavailable.