• Archives of Pharmacal Research
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• v.28 no.12
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• pp.1350-1357
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• 2005

Nuclear factor kappa B (NF-$\kappa$B) regulates the expression of multiple cytokines, chemokines, and cell adhesion molecules that are involved in the pathogenesis of asthma. We investigated the anti-asthmatic effects and the mechanism of action of DA-9201, an extract of the black rice, in a mouse model of asthma. Mice immunized with ovalbumin (OVA) were administered with DA-9201 (30, 100 or 300 mg/kg) or dexamethasone (DEXA, 3 mg/kg) for 2 weeks and challenged with aerosolized OVA during the last 3 days. Anti-asthmatic effects were assessed by means of enhanced pauses, level of total lgE and Th2 cytokines in plasma or bronchoalveolar lavage fluid (BALF), the percentage of eosinophils in BALF, and histopathological examination. The expression of NF-$\kappa$B in nuclear and cytoplasmic fraction and its DNA-binding activity in lung tissues were analyzed by means of Western blotting and electrophoretic gel mobility shift assay (EMSA), respectively. DA-9201 significantly reduced airway hyperrespon-siveness (AHR), total lgE level in plasma and BALF, IL-4, IL-5, and IL-13 levels in BALF, and the percentage of eosinophils in BALF. Tissue inflammation was significantly improved by DA­9201 treatment. In addition, DA-9201 dramatically suppressed the expression of NF-$\kappa$B and its DNA-binding activity. These results suggest that DA-9201 may be useful for the treatment of asthma and its efficacy is related to suppression of NF-$\kappa$B pathway.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.56 no.7
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• pp.1275-1281
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• 2007

The discharge phenomena in a flat fluorescent lamp for the backlight unit of liquid crystal displays are simulated by sung a two-dimensional fluid model. The numerical methods for the calculation of plasma dynamics and the radiation transport are introduced for the discharge simulation and for the transmission of the vacuum ultraviolet lights. The simulation results are presented to compare the luminance and the luminance efficacy with the variation of gas pressure, gas mixture ratio, driving voltage, and frequency.

• Nuclear Engineering and Technology
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• v.30 no.1
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• pp.17-25
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• 1998

Transport of carbon and boron impurity ions parallel to magnetic field lines in the tokamak SOL (scrape-off layer) is numerically investigated for a one-dimensional steady state. The spatial distributions of density and velocity of the impurity ions in a steady state are calculated by finite difference method for a single-fluid model. The calculated results show that among forces acting on SOL particles thermal force produced tv plasma temperature gradient is a principal force determining the feature of impurity distribution profiles in the tokamak edge. However, strong collisional friction forces appearing dominant in front of the diverter plate restrain impurity ion flows due to temperature gradients from moving toward the midplane. Consequently, the stagnation point develops in the impurity flow by these two forces near the diverter region, in which ion flows change their directions. Impurity ions turn out to be accumulated at the stagnation points, where peaked profiles of highly-ionized state ions are relatively predominant over those of low-ionized state ions.

• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.225-225
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• 2014

일반적인 Cosine law를 이용한 증착 두께의 분포에 대한 계산은 적분의 형태로 이루어져있다. LCD 8G 급의 경우 마그네트론 스퍼터링 타겟의 크기가 깊이 3 m, 폭 25 cm정도인데 대략 6~8개를 설치하여 공정 시간을 줄이고 있다. 이 때 한 쪽 방향으로 이동하는 기판이 타겟 표면과 이루는 각도는 아주 작은 각에서 수직으로 다시 음의 각도로 변화한다. 이 때 발생하는 박막의 미세 조직 변화는 박막 특성에 많은 영향을 준다. 이에 대한 연구를 위한 1단계로 타겟 표면과 기판 표면을 모두 미소 면적소로 구분하고 각각의 면적소 간에 이루어지는 증착 원자의 비행을 충돌이 없다는 가정하에 direct flux 알고리즘으로 처리하였다. 이 때 소요되는 계산 시간은 매우 길어서 single core CPU에서 serial job으로 처리하는 경우 여러 시간이 소요된다. 이에 대한 대안으로 OpenMP를 이용한 작업의 병렬화를 시도하였다. 4 core machine에서 최대 96%의 병렬 효율을 달성하였다.

• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.216.2-216.2
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• 2014

플라즈마의 연속 운전 조건은 플라즈마 발생원의 기하적, 전기적 특성에 의한 공정 특성을 갖는다. RF power를 pulsing하는 경우 off시간에 하전 입자와 중성 라디칼의 소멸 특성의 차이로 인하여 나노 미세 구조의 식각에 유리한 측면이 있다. 유도 결합 플라즈마원을 주발생원으로 이용하는 건식 식각장비의 기판 바이어스를 rf pulsing하는 경우 유체 모델을 이용한 계산 방법에서 rf off 시간 중의 2차 전자 발생 계수를 rf on time시와 동일 하게 계산하거나 입사 이온의 에너지와 무관하게 0.05 등의 상수로 처리하는 경우가 많은데 본 연구에서는 rf bias off 시간 동안의 SEC(secondary electron coefficient)를 변화시키는 조건이 플라즈마의 특성에 어떤 영향을 미치는지 CFD-ACE+에 user subroutine을 이용하여 조사하였다.

• 한국정보디스플레이학회:학술대회논문집
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• 2009.10a
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• pp.177-180
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• 2009

Here is presented the measurement on SrO- and SrCaO-PDP operated at lower voltage. SrO- and SrCaO-PDP attain high luminous efficacy at low voltage, where the breakdown voltage is 30 % lower than that of the ordinary MgO-PDP. A one-dimensional fluid model is applied for the simulation of PDP discharge. High VUV radiation efficiency is confirmed at high ${\gamma}_i$ and both low and high $V_s$ as in the experiment. Discharge analysis in simulation also shows that the high ${\gamma}_i$ protective layer leads to high plasma density especially near the cathode electrode, being responsible for high efficiency.

• 한국가시화정보학회:학술대회논문집
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• 2002.11a
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• pp.73-76
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• 2002

A one-dimensional fluid model has been established for Raman amplification of a short laser pulse in a plasma by a counter-propagating pump. The laser pulse is amplified with a large gain and also may be compressed by nonlinear three-wave Interactions. The spatiotemporal evolutions of the seed and the pump pulses were visualized for linear and nonlinear regimes, and the transition from regular to chaotic behavior of subsidiary pulses was investigated with variation of pump intensity.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.40 no.4
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• pp.221-226
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• 2016

Since arterial disease in the upper extremity is less common than that in the lower extremity, experimental and numerical investigations related to upper extremity have been rarely performed. We created a three-dimensional model of the arteries, larger than approximately 1 mm, in a Korean adult's left hand (from brachial to digital arteries), from 3T magnetic resonance imaging (MRI) data. For the first time, a three-dimensional computational fluid dynamic method was employed to investigate blood flow velocity, blood pressure variation, and wall shear stress (WSS) on this complicated artery system. Investigations were done on physiological blood flows near the branches of radial and deep palmar arch arteries, and ulnar and superficial palmar arch arteries. The flow is assumed to be laminar and the fluid is assumed to be Newtonian, with density and viscosity properties of plasma.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.2
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• pp.1375-1380
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• 2015

Nowadays, the technique to deal with the waste gas of perfluorinated compounds using plasma has been developed. As the effective decomposition techniques at many research centers and companies were investigated at home and abroad, the products have been improved with various methods. This study aims to guess the distributions of pressure and temperature through the thermal and fluid analyses inside the decomposition equipment model of waste gas. As the analysis result, the maximum pressure and the minimum pressure are 0.975Pa and -1.037Pa individually on the whole. It is shown that the pressure of air decreases gradually as the air flows from inlet to plane 1 and the pressure increases as the air flows from plane 1 to outlet. And the maximum temperature and the mimum temperature are $1718^{\circ}C$와 $26.07^{\circ}C$ individually on the whole. It is shown that the temperature of air increases gradually as the air flows from inlet to plane 4 and the temperature decreases as the air flows until outlet. It is thought that the data necessary to develop the real system can be applied by using the thermal and fluid analyses.

• Coupled systems mechanics
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• v.6 no.2
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• pp.113-125
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• 2017

This paper proposes the idea to enhance the heat transfer in Gas Tungsten Arc Welding (GTAW) by using the azimuthal magnetic field. The azimuthal magnetic field generated by the external currents makes the Lorentz force stronger, and consequently improves the heat transfer by the faster flow movement. The enhanced heat transfer might improve the welding performance by increasing the temperature at the workpiece. To validate the proposed idea, a two-dimensional axi-symmetric model of GTAW is built, and the multiphysics simulation of GTAW is carried out. As the analysis result, the distributions of electric current, electromagnetic fields, arc flow velocity, and temperature are investigated. Then, the proposed idea for heat transfer enhancement is validated by comparing the Lorentz force, flow velocity, and temperature distribution with and without azimuthal magnetic fields.