• Archives of Pharmacal Research
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• v.16 no.3
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• pp.219-226
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• 1993

For the analysis of structure relationship of ar-turmerone analogues, the compounds containing the various substituents on the phenyl ring and 1(or 2)-naphthyl group in the place of phenyl of ar-turmerone were prepared and tested their cytotoxicity against HL-60, K-562, and L1210 leukemia cells in vitro. The substituents at para position are methoxy, phenoxy, methyl, trifluoromethyl, fluoro, and chloro. At meta position methoxy, methyl, trifluoromethyl, or chloro groups at ortho position mathoxy or chloro group were introduced. Against HL-60 and K-562 cells, $ED_{50}$ values of the analogues are ranged from 0.8 to $30.0\;\mu{g/ml}$. Againste L1210 cell, these are located more than $20.0\;\mu{g/ml}$. However, 5-carbone-thoxy-2-methyl-6(1-naphthyl)-2-octen-4-one (5n)possesses $ED_{50}$ valuses 0.8, 2.1, $6.5\;\mu{g/ml}$ against HL-60, L1210 cells, respectively. The electronic nature of the substituents on phenyl ring of ar-tumerone dose not affect the biological activity. Therefore the flat structure of aromatic potion of ar-tumerone analogues is the more important factor for their activity rather than its electronic nature. The potentiation of the cytotoxicity with the enlargement of aromatic ring region also supports the importance of the plane structure of this area. The restriction of the single bond rotation between C-6 and aromatic ring through the introduction of substituents at the ortho position of phenyl ring and the increment of size of alkyl group at C-6 position enhances the activity. Therefore the effective conformation should by the one having the orthogonal arrangement between the aromatic ring and the side chain.

• International Journal of Control, Automation, and Systems
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• v.4 no.3
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• pp.325-332
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• 2006

The dynamic responses of human standing postural control were investigated when subjects were exposed to long-term horizontal vibration. It was hypothesized that the motion of standing posture complexity mainly occurs in the mid-sagittal plane. The motor-driven support platform was designed as a source of vibration. The AC Servo-controlled motors produced anterior/posterior (AP) motion. The platform acceleration and the trunk angular velocity were used as the input and the output of the system, respectively. A method was proposed to identify the complexity of the standing posture dynamics. That is, during AP platform motion, the subject's knee, hip and neck were tightly constrained by fixing assembly, so the lower extremity, trunk and head of the subject's body were individually immovable. Through this method, it was assumed that the ankle joint rotation mainly contributed to maintaining their body balance. Four subjects took part in this study. During the experiment, the random vibration was generated at a magnitude of $0.44m/s^2$, and the duration of each trial was 40 seconds. Measured data were estimated by the coherence function and the frequency response function for analyzing the dynamic behavior of standing control over a frequency range from 0.2 to 3 Hz. Significant coherence values were found above 0.5 Hz. The estimation of frequency response function revealed the dominant resonance frequencies between 0.60 Hz and 0.68 Hz. On the basis of our results illustrated here, the linear model of standing postural control was further concluded.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.4C
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• pp.494-504
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• 2004

The researches about gaze detection have been much developed with many applications. Most previous researches only rely on image processing algorithm, so they take much processing time and have many constraints. In our work, we implement it with a computer vision system setting a IR-LED based single camera. To detect the gaze position, we locate facial features, which is effectively performed with IR-LED based camera and SVM(Support Vector Machine). When a user gazes at a position of monitor, we can compute the 3D positions of those features based on 3D rotation and translation estimation and affine transform. Finally, the gaze position by the facial movements is computed from the normal vector of the plane determined by those computed 3D positions of features. In addition, we use a trained neural network to detect the gaze position by eye's movement. As experimental results, we can obtain the facial and eye gaze position on a monitor and the gaze position accuracy between the computed positions and the real ones is about 4.2 cm of RMS error.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.16 no.1
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• pp.43-52
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• 2003

The present study is to investigate the ultimate behavior and limit state design of 2-I) R/C structures, with the changing of crack direction, and the yielding of the reinforcing steel bars, and Is to introduce an algorithm for the limit state design and analysis of 2-D R/C structures, directly from the finite element model. For the design of reinforcement in concrete the limit state design equation is incorporated into finite element algorithm to be based on the pointwise elemental ultimate behavior. It is also introduced a simplified nonlinear analysis algorithm for stress-strain relationship of R/C plane stress problem considering the cracking and its rotation in concrete and the yielding of the reinforcing steel bar. The algorithm is incorporated into the nonlinear finite element analysis. The analysis model is compared with the experimental model of R/C shear wall. In a simple design example for a shear wall, the required reinforcement ratios in each finite element is obtained from the limit state design equations.

• Journal of rehabilitation welfare engineering & assistive technology
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• v.7 no.1
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• pp.21-27
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• 2013

Manual wheelchair propulsion can lead to pain and injuries of users due to mechanical inefficiency of wheelchair propulsion motion. The kinetic analysis of the upper limbs during manual wheelchair propulsion needs to be studied. A two dimensional inverse dynamic model of upper limbs was developed to compute the joint torque during manual wheelchair propulsion. The model was composed of three segments corresponding to upper arm, lower arm and hand. These segments connected in series by revolute joints constitute open chain mechanism in sagittal plane. The inverse dynamic method is based on Newton-Euler formalism. The model was applied to data collected in experiments. Kinematic data of upper limbs during wheelchair propulsion were obtained from three dimensional trajectories of markers collected by a motion capture system. Kinetic data as external forces applied on the hand were obtained from a dynamometer. The joint rotation angles and joint torques were computed using the inverse dynamic model. The developed model is for upper limbs biomechanics and can easily be extended to three dimensional dynamic model.

• Journal of the Korean Institute of Telematics and Electronics D
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• v.35D no.12
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• pp.83-91
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• 1998

Fiber Bragg grating which has a blazed ang1e to the plane of incident wave generates a side-mode as well as main-mode. The side-mode has an identical characteristics with a long period grating that couples with a cladding mode, so rejects the special wavelength. We experimented on the side-mode characteristics with two fibers which Ge doped depressed index fiber and very high photosensitive H$_2$ loaded step index fiber according to the tilted angle. Also, using a phase mask equipped with rotation plate which has 0.02$^{\circ}$ resolution, we can control the bandwidth and the peak value of a total loss spectrum by aligned tilted grating in a fiber and using this, tried to compose the ASE band rejection filter of the Erbium doped fiber amplifier.

• Journal of the Earthquake Engineering Society of Korea
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• v.16 no.4
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• pp.37-52
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• 2012

In this study, a new 4-node general shell element with 6 DOFs per node is presented. Drilling rotational degrees of freedom are introduced by the variational principle with an independent rotation field. In formulation of the element, substitute transverse shear strain fields are used to avoid shear locking, while four nonconforming modes are applied in the in-plane displacement fields as a remedy for membrane locking. In addition, a direct modification method for nonconforming modes is employed in the numerical implementation of nonconforming modes to represent constant strain states. A 9-points integration rule is adopted for volume integration in the computation of the element stiffness matrix. With the combined use of these techniques, the developed shell element has no spurious zero energy modes, and can represent a constant strain state. Several numerical tests are carried out to evaluate the performance of the new element developed. The test results show that the behavior of the elements is satisfactory.

• Computational Structural Engineering
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• v.7 no.4
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• pp.103-111
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• 1994

Based on a variational principle of the consistent shear deformable discrete laminate theory derived in the companion paper Part I, a finite element procedure for the vibration analysis of laminated composite plates is presented. The present formulation takes the in-plane displacements of an arbitrary layer, the rotations of the cross section of each layer and transverse displacement of the plate as the state variables at a nodal point of finite element, resulting in total nodal degree of freedom of 2(n+l) +1 for the n-layered laminate. Thus, it allows to specify displacement boundary conditions of layer stretching and/or rotation of layer cross sections around the plate edge and/or lateral displacement. The developed procedure is applied to the free vibration problem for sandwich-type hybrid laminates composed of layers with drastically different material properties whose elasticity solutions are known. Comparison of analysis results with other FEM solutions showed that the present formulation yields better accuracy.

• Journal of Elementary Mathematics Education in Korea
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• v.21 no.1
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• pp.161-194
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• 2017

The aim of this study is to look into sub-factors of spatial sense that can be contained in spatial sense of solid figure of mathematics curriculum and offer suggestions to improve teaching spatial sense of solid figures in the future. In order to attain these purposes, this study examined the meaning and sub-factors of spatial sense and the relations between spatial sense of solid figure and sub-factors of spatial sense through a theoretical consideration regarding various studies on spatial sense. Based on such examination, this study compared and analyzed textbooks used in South Korea, Finland and the Netherlands with respect to contents of mathematics curriculum and textbooks in grades, sub-factors of spatial sense, and realistic contexts for spatial sense of solid figure. In the light of such theoretical consideration and analytical results, this study provided suggestions for improving teaching spatial sense of solid figures in elementary schools in Korea as follows: extending contents regarding spatial sense of solid figures in mathematics curriculum and considering continuity between grades in textbooks, emphasizing spatial orientation as well as spatial visualization, underlining not only construction with blocks but also mental activities in mental rotation and mental transformation, comparing strength and weakness of diverse plane representations of three dimensional objects, and utilizing various realistic situations and objects in space.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2010.05a
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• pp.205-208
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• 2010

We introduce a novel feature extraction scheme for online handwritten digit based on utilizing Zernike moment and angulation feature. The time sequential signal from mouse movement on the writing pad is described as a sequence of consecutive points on the x-y plane. So, we can create data-set which are successive and time-sequential pixel position data by preprocessing. Data preprocessed is used for Zernike moment and angulation feature extraction. this feature is scale-, translation-, and rotation-invariant. The extracted specific feature is fed to a BP(backpropagation) neural network, which in turn classifies it as one of the nine digits. In this paper, proposed method not noly show high recognition rate but also need less learning data for 200 handwritten digit data.