• World Technopolis Review
• /
• 제7권2호
• /
• pp.74-81
• /
• 2018

The concept of Smart Specialization represents a major shift in EU structural policy. It recognizes place-specific qualities and particularly locally embedded knowledge to stimulate innovative economic performance. Although there have been debates about the role of universities as innovation incubator, deliberations about their influence in regional innovation strategies (RIS3) in the context of smart specialization approaches are still under-represented. This paper therefore aims at discussing the potential role of universities and related incubator environments in smart specialization strategies, which is illustrated with the help of a German state, Mecklenburg-Vorpommern.

• 건축역사연구
• /
• 제8권3호
• /
• pp.39-51
• /
• 1999

The purpose of this study is to establish the theory of the spatial composition that is 'The Structure of Relation' in Korean traditional houses. This study has been focused on the spatial composition of Hyangdan. The form composition is an element defining primitive functions and space and producing aesthetical effects, where 'quality as a substance' is not important but 'quality as a relation' is essential. Quality as a meaningful relationship comes from realization and regulation of visual attributes among form elements. Each form compositional element establishes the hierarchical structure logically with the entire order, In order for the quality of all form compositional elements to be clarified as a meaningful relationship logically, 'compositional concept' which combines a series of form elements into the grammatical dependence to a specific direction, has to be assumed. If the intrinsic relationship among a series of form compositional elements fails to confront with the 'contextual concept' which eventually indicates unique conditions for a place according to the refined compositional concept, the result of form composition never leads to a specific solution

• 해양환경안전학회:학술대회논문집
• /
• 해양환경안전학회 2001년도 추계학술발표회
• /
• pp.17-24
• /
• 2001

The sludge oils were produced necessarily in the ships operation, so that it will be the best way to manage the sludge oils inside ship itself from a viewpoint of the prevention of marine oil pollution from ship. The present study deal with the ultrasonic breaking systems which recycle the sludge oil from ships into usable oil to be burnt. The first place, experimental studies were carried out to investigate the homogenizing effect of the marine oils by repeated vibration of ultrasonic transducer. Variation of the properties(viscosity, specific gravity and pH) and the matrix structures for the environment of various marine oils were interpreted to analyze the breaking, dispersion effects by cavity. The experimental results can be useful to the development of sludge oil disposing systems.

• Nuclear Engineering and Technology
• /
• 제40권7호
• /
• pp.527-532
• /
• 2008

As therapeutic uses of radionuclides in nuclear medicine increases, the use of patient-specific methods for calculation of radiation dose becomes more important. In this manuscript basic methods and resources for internal dose calculations are outlined, with a focus on how current changes and advances are making more accurate and detailed, patient-individualized dose calculations possible. Most current resources make use of standardized models of the human body representing median individuals, but the use of image-based and more realistic models will soon take their place, and will permit adjustments to represent individual patients and tailor therapy planning uniquely for each subject.

• 한국컴퓨터정보학회논문지
• /
• 제22권11호
• /
• pp.49-55
• /
• 2017

Recently, for safety of people, there are proposed so many technologies which detect density of people at the specific place or space. The representative technology for crowd density estimation was using image analysis method from CCTV images. However, this method had a weakness which could not be used and which's accuracy was lower at the dark or smog space. Therefore, in this paper, to solve this problem, we proposed a user density estimation system at closed space using high frequency and smart device. The system send inaudible high frequencies to smart devices and it count the smart devices which detect the high frequencies on the space. We tested real-time user density with the proposed system and ten smart devices to evaluate performance. According to the testing results, we confirmed that the proposed system's accuracy was 95% and it was very useful. Thus, because the proposed system could estimate about user density at specific space exactly, it could be useful technology for safety of people and measurement of space use state at indoor space.

• Archives of Pharmacal Research
• /
• 제26권4호
• /
• pp.258-263
• /
• 2003

Colon-specific delivery of glucocorticoids is highly desirable for the efficient treatment of inflammatory bowel disease. We synthesized prednisolone 21-sulfate sodium (PDS) as a colon-specific prodrug of prednisolone (PD) and investigated its properties using rats as test animals. We expected that introduction of sulfate ester as a sodium salt might increase the hydrophilicity and restrict the absorption in the GI tract. If PDS is stable and nonabsorbable in the upper intestine, it will be delivered to the colon as an intact form, where it hydrolyze by the sulfatase to release PD. Compared with PD, the solubility of PDS increased and the apparent partition coefficient decreased greatly. PDS was stable on incubation with pH 1.2 and 6.8 buffer solutions and with the contents of the stomach and small intestine. On incubation with the cecal contents, PDS decreased to 9.6％ of the dose in 10 h producing PD. The amount of PD increased to give a maximum 54％ of the dose and decreased. As a control, when PD was incubated with the cecal contents, it decreased to 29％ of the dose in 8 h, which implied that reduction of PD proceeded under such conditions. These results suggested that hydrolysis of PDS took place to produce and accumulate PD, which decreased by reduction as the incubation period extended. Our results suggested that PDS can be a promising colon-specific prodrug of PD, and sulfate ester group might serve as a potential colon-specific promoiety, especially for the drugs which are resistant to reduction in the colon.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권12호
• /
• pp.7133-7136
• /
• 2013

Background: We studied Surveillance, Epidemiology and End Results (SEER) breast cancer data of Georgia USA to analyze the impact of socio-economic factors on the disparity of breast cancer treatment outcome. Materials and Methods: This study explored socio-economic, staging and treatment factors that were available in the SEER database for breast cancer from Georgia registry diagnosed in 2004-2009. An area under the receiver operating characteristic curve (ROC) was computed for each predictor to measure its discriminatory power. The best biological predictors were selected to be analyzed with socio-economic factors. Survival analysis, Kolmogorov-Smirnov 2-sample tests and Cox proportional hazard modeling were used for univariate and multivariate analyses of time to breast cancer specific survival data. Results: There were 34,671 patients included in this study, 99.3% being females with breast cancer. This study identified race and education attainment of county of residence as predictors of poor outcome. On multivariate analysis, these socio-economic factors remained independently prognostic. Overall, race and education status of the place of residence predicted up to 10% decrease in cause specific survival at 5 years. Conclusions: Socio-economic factors are important determinants of breast cancer outcome and ensuring access to breast cancer treatment may eliminate disparities.

• 한국응용과학기술학회지
• /
• 제31권2호
• /
• pp.329-336
• /
• 2014

The conductive polymer composites have attracted considerable attention in the field of industry due to their electrical properties. To understand electrical properties of the composites, their volume specific resistance was measured. Electrical conductivity results showed percolation phenomena. Percolation theories are frequently applied to describe the insulator-to-conductor transitions in the composites composed of conductive filler and insulating matrix. It was found that the percolation threshold strongly depends on the aspect ratio of filler particles. The critical concentration of percolation formed is defined as the percolation threshold. The purpose of this study was to examine electrical properties of the epoxy resins filled with nickel. The sample was prepared using vehicle such as epoxy resin replenished with nickel powder, and the evaluation on their practical use was performed in order to apply them to electric and electronic industry as well as general field. The volume specific resistance of epoxy resin composites was 4.666~13.074 when using nickel powder. Weight loss of the conductive composites took place at $350^{\circ}C{\sim}470^{\circ}C$.

• 설비공학논문집
• /
• 제27권2호
• /
• pp.103-111
• /
• 2015

In general, no particularly well-established standards have been in place so far, for the method of evaluating the deteriorated level of pipes and ducts of industrial facilities. For that reason, the evaluation depends upon various studies which are based on the analysis of the residual life, thickness thinning, closure rate, and scale thickness that measure a few specific positions of pipes. It also depends upon the expertise in business operation and the specific techniques conducted by the inspection companies and institutions. This research introduces the concept of measuring units per section and the selection method of measurement points per section. Furthermore, specific methodologies were developed to plan and analyze deterioration level of industrial pipes and ducts by engineers and managers using a section map. Consequently, applying the outcomes from this study to the plant equipment of the incineration facility resulted in saving 42% of the repairing and remodeling cost.

• Archives of Pharmacal Research
• /
• 제23권2호
• /
• pp.139-146
• /
• 2000

7- Bromomethylbenz[a]anthracene is a known mutagen and carcinogen. The two major DNA adducts produced by this carcinogen, i.e., $N^2$-(benz[a]anthracen-7-yl methyl)-2'-deoxyguanosine (2, b[a]$a^2$G) and $N^6$-(benz[a]anthracen-7-ylmethyl)-2'-deoxyadenosine (4, b[a]$a^6$/A), as wel 1 as the simpler benzylated analogs,$N^2$-benzyl-2'deoxyguanosine (1, $bn^2$G) and $N^6$-benzyl-2'-deoxyadenosine (3, $bn^6$/A), were prepared by direct aralkylation of 2'-deoxyguanosine and 2'-deoxyadenosine. To determine the site-specific mutagenicity of these bulky exocyclic amino-substituted adducts, the suitably protected nucleosides were incorporated into 16-base oligodeoxyribonucleotides in place of a normal guanine or adenine residues which respectively are part of the ATG initiation codon for the lac Z' \alpha-complementation gene by using an in situ activation approach and automated phosphite triester synthetic methods. The base composition and the incorporation of the bulky adducts into synthetic oligonucleotides were characterized after purification of the modified oligonucleotides by enzymatic digestion and HPLC analysis.