• Title/Summary/Keyword: Pituitary-dependent hyperadrenocorticism(PDH)

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Use of selegiline in 3 Cases of Canine Pituitary-dependent Hyperadrenocorticism (개의 뇌하수체 의존성 부신 피질 기능 항진증에서의 selegiline 적용)

  • 김주민;황철용;윤정희;윤화영;한홍율
    • Journal of Veterinary Clinics
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    • v.19 no.4
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    • pp.455-460
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    • 2002
  • Pituitary-dependent hyperadrenocorticism (PDH) was diagnosed with history taking, physical examination, complete blood count, serum chemistry profiles, abdominal radiology, ultrasonography and adrenal function tests in 3 dogs. Their clinical signs were polyuria, polydipsia, polyphagia, bilateral symmetrical truncal alopecia and secondary infection in skin or urinary tract. Especially one dog showed severe clinical signs such as calcinosis cutis and delayed wound healing. These 3 dogs were diagnosed as PDH, and treated with selegiline 1-2 mg/kg /ay sid PO. 2 dogs with clinical signs of PDH were disappeared and improved, but 1 dog with severe illness progressed gradually despite of selegiline and mitotane application, and eventually died.

Mitotane Therapy and Management of Naturally Occurring Pituitary Dependent Hyperadrenocorticism (PDH) in a Dog (개에서 자연발생한 뇌하수체 의존성 부신피질기능 항진증의 치료 및 관리)

  • Song, Jae-won;Park, Hee-Myung
    • Journal of Veterinary Clinics
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    • v.20 no.2
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    • pp.233-236
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    • 2003
  • A 10 year old, intact female Yorkshire terrier was referred to the Veterinary Teaching Hospital of Konkuk University. Upon admission, the patient had severe necrotic skin disease on face and abdominal wall, and also showed polyuria, polydipsia (PUPD), and polyphagia. A tentatative diagnosis of hyperadrenocorticism was made on the basis of history takings, physical examination, and results of CBC and serum biochemistry. Hyperadrencorticism was confirmed by ACTH stimulation test and pituitary-dependent hyperadrenocorticism (PDH) was diagnosed according to the results of high dose dexamethasone suppression test (HDDST). After initiating mitotane therapy, severe skin problem and clinical signs including PUPD were improved. And we determined whether or not mitotane therapy well controlled serum cortisol level with ACTH stimulation test. This case was presented to show that the patient misdiagnosed and treated for more than 1 year as other dermatologic problem in 3 local animal clinics was treated and managed sucessfully with mitotane administration.

Trilostane Treatment in a Dog with Pituitary-Dependent Hyperadrenocorticism (뇌하수체 의존성 부신피질기능항진증 이환견의 Trilostane 치료 1례)

  • Lim Young-Hwan;Lee Jung-Youn;Cho Sung-Nam;Park Seong-Jun;Choi Ho-Jung;Lee Young-Won;Song Kun-Ho
    • Journal of Veterinary Clinics
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    • v.23 no.2
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    • pp.202-206
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    • 2006
  • A 7-year-old, spayed female, Yorkshire terrier dog with polyuria/polydipsia (PU/PD), interdigital edema, pruritus and abdominal enlargement was referred to the Veterinary Medical Teaching Hospital of the present university. Pituitary-dependent hyperadrenocortisim (PDH) was diagnosed by clinical signs, physical examination, laboratory examination (complete blood count, serum chemistry, urinalysis, ACTH stimulation test and high dose dexamethasone suppression test) and diagnostic imaging (radiography, ultrasonography and computed tomography). Clinical signs were improved after trilostane treatment, and maintenance therapy with trilostane still continued after successful induction therapy. Trilostane can be used as an alternative to mitotane therapy in hyperadrenocortisim in dogs.