• Title/Summary/Keyword: Pilot trial

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Ultrasound-guided superficial cervical plexus block under dexmedetomidine sedation versus general anesthesia for carotid endarterectomy: a retrospective pilot study

  • Do, Wangseok;Cho, Ah-Reum;Kim, Eun-Jung;Kim, Hyae-Jin;Kim, Eunsoo;Lee, Heon-Jeong
    • Journal of Yeungnam Medical Science
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    • v.35 no.1
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    • pp.45-53
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    • 2018
  • Background: Carotid endarterectomy (CEA) has been performed under regional and general anesthesia (GA). The general anesthesia versus local anesthesia for carotid surgery study compared the two techniques and concluded that there was no difference in perioperative outcomes. However, since this trial, new sedative agents have been introduced and devices that improve the delivery of regional anesthesia (RA) have been developed. The primary purpose of this pilot study was to compare intraoperative hemodynamic stability and postoperative outcomes between GA and ultrasound-guided superficial cervical plexus block (UGSCPB) under dexmedetomidine sedation for CEA. Methods: Medical records from 43 adult patients who underwent CEA were retrospectively reviewed, including 16 in the GA group and 27 in the RA group. GA was induced with propofol and maintained with sevoflurane. The UGSCPB was performed with ropivacaine under dexmedetomidine sedation. We compared the intraoperative requirement for vasoactive drugs, postoperative complications, pain scores using the numerical rating scale, and the duration of hospital stay. Results: There was no difference between groups in the use of intraoperative antihypertensive drugs. However, intraoperative inotropic and vasopressor agents were more frequently required in the GA group (p<0.0001). In the GA group, pain scores were significantly higher during the first 24 h after surgery (p<0.0001 between 0-6 h, p<0.004 between 6-12 h, and p<0.001 between 12-24 h). The duration of hospital stay was significantly more in the GA group ($13.3{\pm}4.6days$ in the GA group vs. $8.5{\pm}2.4days$ in the RA group, p<0.001). Conclusion: In this pilot study, intraoperative hemodynamic stability and postoperative outcomes were better in the RA compared to the GA group.

Micronutrients and superoxide dismutase in postmenopausal women with chronic periodontitis: a pilot interventional study

  • Daiya, Sunita;Sharma, Rajinder Kumar;Tewari, Shikha;Narula, Satish Chander;Sehgal, Paramjeet Kumar
    • Journal of Periodontal and Implant Science
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    • v.44 no.4
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    • pp.207-213
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    • 2014
  • Purpose: The study was aimed at investigating changes in periodontal parameters and superoxide dismutase activity triggered by root surface debridement with and without micronutrient supplementation in postmenopausal women. Methods: Forty-three postmenopausal chronic periodontitis patients were divided into two groups: group 1 (n=22) were provided periodontal treatment in the form of scaling and root planing (SRP) and group 2 (n=21) patients received SRP along with systemic administration of micronutrient antioxidants. Patients in both groups were subjected to root surface debridement. Group 2 patients also received adjunctive micronutrient antioxidant supplementation. Serum and salivary superoxide dismutase (SOD) activity along with periodontal parameters were recorded at baseline and 3 months after therapy. Results: Salivary and serum SOD values significantly (P<0.05) improved with periodontal treatment. Improvement in systemic enzymatic antioxidant status along with reduction in gingival inflammation and bleeding on probing (%) sites was significantly greater in group 2 as compared to group 1. Conclusions: Adjunctive micronutrient supplements reduce periodontal inflammation and improve the status of systemic enzymatic antioxidants in postmenopausal women.

Inclusion of Home-based Rehabilitation Services in the Long-Term Care Insurance - Review on the Home-based Physical Therapy in the OECD - (노인장기요양보험제도를 통한 방문재활 서비스 도입방안 -서비스 공급주체로서 OECD국가 가정방문물리치료의 고찰-)

  • Yoon, Tae-Hyung
    • The Korean Journal of Health Service Management
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    • v.5 no.4
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    • pp.161-175
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    • 2011
  • The purpose of this study was to expand the home-based rehabilitation services in the long term care insurance. This study was reviewed on the home-based physical therapy in the OECD. The way of this study was literature search and review. This was to reviewed Proquest, Sciencedirect, SpingerLink, Pubmed. Kew word is "home-based therapy". This was collected 71 articles and final analyzed article was 49. The results were as follows; The article number is seven in Canada, fifteen in USA, five in UK, six in Australia, three in Sweden, five in New Zealand, two in Netherlands, one in Turkey, South Korea, Japan, France, Spain, Italy respectively. Randomized controlled trial is fifty, case-control study is eleven, interview is three, literature review is two, and case report, cost-analysis, cost-effectiveness, pilot study, single blinded parallel design, demonstrative study, survey is one respectively. Physical therapist played an important role in home-based rehabilitation among OECD than nurse. Therefore, we must introduce home-based physical therapy in long term care insurance in South Korea.

Development of Questionnaires for Pathogenesis Analysis of Yukmijiwhang-tang Symptom (육미지황탕증(六味地黃湯證)의 병인논(病因論)적 분석을 위한 설문문항(說問問項) 개발(開發))

  • Cho, Sang-Won;Park, Young-Jae;Kim, Min-Yong;Oh, Hwan-Sup;Park, Young-Bae
    • The Journal of the Society of Korean Medicine Diagnostics
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    • v.12 no.2
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    • pp.61-73
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    • 2008
  • Background: Yukmijiwhang-tang is one of the most common herbal formulas in Oriental Medicine. Yukmijiwhang-tang has been widely used as a herbal medicine to replenish Yin and tonify the kidneys for hundred years in Asian countries. Because of insufficiency in data, objective judgements about remedial effects have been difficult. In order to make objectivity diagnostic data, this research is developed. Purpose: The aim of the research is to make a pilot questionnaire for clinical use of Yukmijiwhang-tang. Methods: The questionnaire which includes symptoms and signs for Yukmijiwhang-tang is studied by the Delphi method. Results: By the Delphi method and score evaluation, 30 items of the initial copy of questionnaire are chosen for the research. Conclusions: By the Delphic survey among clinicians, a reference questionnaire for Yukmijiwhang-tang applications was suggested. Further research is necessary for modification of questionnaire by statistics and certification by clinical trial. research.

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The effects of vibration stimulation applied to the left forearm on unilateral neglect in patients with stroke: A pilot randomized controlled trial

  • Park, Jin-hyuck;Park, Ji-hyuk
    • Therapeutic Science for Rehabilitation
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    • v.4 no.2
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    • pp.63-71
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    • 2015
  • Objective : The purpose of this study was to investigate the effects of vibratory stimulation applied to the left forearm on unilateral neglect in patients with stroke. Methods : The subjects were 11 unilateral neglect patients with stroke. They were divided into 2 groups; 6 experimental subjects and 5 control subjects. Both groups received standardized rehabilitation program and occupational therapy for the intervention of unilateral neglect in a day. In random order, line bisection test (LBT), Albert test, and star cancellation test (SCT) were conducted at baseline, the next day. During the process of all assessments of the next day, vibration stimulation was provided for the 6 subjects in the experimental group (EG), while the 5 subjects in CG carried out all assessments without vibration stimulation. Result : No significant differences were found between groups on any demographic variable or baseline assessments scores. In the next day, there was significant improvement in the EG for the LBT(p<0.05), Albert's test(p<0.05), and SCT(p<0.05). However, there was no significant improvement in the CG for the LBT(p<0.05), Albert's test(p<0.05), and SCT(p<0.05). Conclusion : These result indicate that vibratory stimulation has a positive effect on the unilateral neglect, and may be considered as alternative choice in clinical occupational therapy for reducing unilateral neglect.

Proposal of Checklists for Patient Safety in Miniscalpel Acupuncture Treatment of Cervical and Lumbar Spine: Pilot Trial (환자 안전을 위한 경추 및 요추부 도침시술 전후 체크리스트 제안: 예비연구)

  • Jo, Hee-Geun;Song, Min-Yeong;Yoon, Sang-Hoon;Jeong, Sin-Yeong;Kim, Jong-Hwan;Baek, Eun-Hye;Leem, Jungtae
    • Journal of Korean Medicine Rehabilitation
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    • v.28 no.1
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    • pp.61-72
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    • 2018
  • Objectives The authors propose a new checklist model adapted for safety miniscalpel acupuncture procedure of cervical and lumbar spine. Methods On the basis of available literature and expert opinion, a prototype checklist was developed. The checklist was adapted on the basis of observation of daily practice. Results The checklist has three parts: 1. prevention and management of healthcare associated infections, 2. verification list before and after miniscalpel acupuncture treatment, 3. adverse event monitoring after procedure. We presented a summary checklist based on the above contents. Conclusions We propose the first patient safety checklist for minicalpel acupuncture treatment of cervical and lumbar spine. The checklist will be complemented using further research methodologies.

The effect of obstacle gait training on balance, gait and ADL of the stroke patient - pilot study (장애물 보행훈련이 뇌졸중 환자의 균형, 보행 및 일상생활활동에 미치는 영향 - 예비연구)

  • Kim, Soo Jin;Oh, Gku Bin;Lee, Hyo Jeong
    • Journal of Korean Physical Therapy Science
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    • v.27 no.2
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    • pp.1-12
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    • 2020
  • Background: The purpose of this study is intended to evaluate the effectiveness and analyse the change on balance, gait and ADL of the stroke patient by obstacle gait training. Design: Randomized controlled trial. Methods: Ten subjects with stroke patient are recruited from C rehablitation hospital located Chungbuck. The subjects which are divided to 2 group as experimental group (N=5) conducted the obstacle gait training and control group (N=5) conducted the general gait training. The gait (10mWT), balance (BBS) and ADL (FIM) were measured before and after intervention. Results: There were no significant differences (p>.05) in sex, age, height, weight and K-MMSE among subjects. There were significant differences (p<.05) in balance and gait between of the experimental group and control group. But there was no significant difference (p>.05) in the ADL between of the experimental group and control group. There were significant differences (p<.05) gait and balance in the experimental group. But there were no significant difference (p>.05) gait, balance and ADL in the control group. Conclusion: Obstacle gait training showed positive effects on the gait, balance of the stroke patient.

Setting-Up of a Fischer-Tropsch Catalyst Testing Apparatus (Fischer-Tropsch 觸媒試驗裝置의 試作)

  • Lee, Chai-Sung;Koh, Kwang-Gook
    • Journal of the Korean Chemical Society
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    • v.5 no.1
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    • pp.66-72
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    • 1961
  • A small size Fischer-Tropsch Catalyst testing apparatus, designed for an operating pressure of 150 psig, was test fabricated from ordinary schedule 40 iron pipes. The operability of the apparatus was tested by charging the reactor tube with the Lurgi Fischer-Tropsch iron Catalyst and passing through it the water gas obtained by gasifying the Korean anthracite using steam and oxygen. With the kind of catalyst charged, the apparatus was proven to daily produce about 50c.c. of synthetic greasy product, water and water soluble compounds, by running at a temperature of $250^{\circ}C$ and at a space velocity of 180 volume of gas per volume of catalyst/hr. About 20 consecutive days of operation is claimed to be sufficient for gathering an enough amount of synthetic products for such ordinary tests as distillation analysis, density measurement, iodine value determination etc. This trial fabrication of apparatus may be the first case of its kind in Korea in that the work has been conducted out in much a pilot plant scheme rather than a routine laboratory way which depends on small glass ware apparatus.

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RELIABILITY ANALYSIS OF DIGITAL SYSTEMS IN A PROBABILISTIC RISK ANALYSIS FOR NUCLEAR POWER PLANTS

  • Authen, Stefan;Holmberg, Jan-Erik
    • Nuclear Engineering and Technology
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    • v.44 no.5
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    • pp.471-482
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    • 2012
  • To assess the risk of nuclear power plant operation and to determine the risk impact of digital systems, there is a need to quantitatively assess the reliability of the digital systems in a justifiable manner. The Probabilistic Risk Analysis (PRA) is a tool which can reveal shortcomings of the NPP design in general and PRA analysts have not had sufficient guiding principles in modelling particular digital components malfunctions. Currently digital I&C systems are mostly analyzed simply and conventionally in PRA, based on failure mode and effects analysis and fault tree modelling. More dynamic approaches are still in the trial stage and can be difficult to apply in full scale PRA-models. As basic events CPU failures, application software failures and common cause failures (CCF) between identical components are modelled.The primary goal is to model dependencies. However, it is not clear which failure modes or system parts CCF:s should be postulated for. A clear distinction can be made between the treatment of protection and control systems. There is a general consensus that protection systems shall be included in PRA, while control systems can be treated in a limited manner. OECD/NEA CSNI Working Group on Risk Assessment (WGRisk) has set up a task group, called DIGREL, to develop taxonomy of failure modes of digital components for the purposes of PRA. The taxonomy is aimed to be the basis of future modelling and quantification efforts. It will also help to define a structure for data collection and to review PRA studies.

Effect of Multi-Sensorimotor Training on Gait Ability and Fall Risk in Subacute Stroke Patients: A Randomized Controlled Pilot Trial (다발성감각운동자극 치료가 뇌졸중 환자의 보행과 낙상위험도에 미치는 효과: 무작위배정예비임상시험)

  • Lim, Chaegil
    • Journal of The Korean Society of Integrative Medicine
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    • v.7 no.2
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    • pp.19-29
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    • 2019
  • Purpose : To determine whether an advanced rehabilitation therapy combined with conventional rehabilitation therapy consisting of sensorimotor exercises that would be superior to a usual treadmill training in gait ability and fall risk in subacute stroke patients. Methods : Thirty subjects randomly assigned to either multi-sensorimotor training group (n=19) or treadmill training group (n=18). Both groups first performed conventional physical therapy for 30 min, after which the multi-sensorimotor training group performed multi-sensorimotor training for 30 min, and the treadmill training group performed treadmill gait training for 30 min. Both groups performed the therapeutic interventions 5 days per week for 8 weeks. Gait ability was evaluated using the GAITRite system and Fall risk was measured using the Biodex Balance system before intervention and after 8 weeks. Results : There were no intergroup differences between demographic and clinical characteristics at baseline (p>.05). Both groups showed a significant improvement in gait ability (p<.05) and Fall risk (p<.05). In particular, the multi-sensorimotor training group showed more significant differences in gait velocity (p=.05), step length (p=.01) and stride length (p=.014) than the treadmill training group. Conclusion : The multi-sensorimotor training program performed on multiple types of sensory input had beneficial effect on gait ability. A large-scale randomized controlled study is needed to prove the effect of this training.