• Title/Summary/Keyword: Phytochemical investigation

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NMR Assignment and Antimicrobial/Antioxidant Activities of 1${\beta}$-Hydroxyeuscaphic acid from the Seeds of Butyrospermum parkii

  • Nyaa, Laurentine Bouquet Tankeu;Tapondjou, Leon Azefack;Barboni, Luciano;Tamokou, Jean De Dieu;Kuiate, Jules Roger;Tane, Pierre;Park, Hee-Juhn
    • Natural Product Sciences
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    • v.15 no.2
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    • pp.76-82
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    • 2009
  • Phytochemical investigation of the EtOAc and n-BuOH fractions obtained from the crude methanol extract of the seeds of Butyrospermum parkii led to the isolation of seven compounds including 1${\beta}$,2${\alpha}$,3${\alpha}$-trihydroxyurs-12-en-28-oic acid (1${\beta}$-hydroxyeuscaphic acid) which full NMR assignment is herein reported for the first time. The above extract, fractions and some of the isolated compounds were screened for antimicrobial and antioxidant activities; 1${\beta}$-hydroxyeuscaphic acid was the more potent.

Bauhinia variegata Linn. (Mountain Ebony): a review on ethnobotany, phytochemistry and pharmacology

  • Mali, Ravindra G;Dhake, Avinash S
    • Advances in Traditional Medicine
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    • v.9 no.3
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    • pp.207-216
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    • 2009
  • Bauhinia variegata Linn (Mountain Ebony) is a medium-sized, deciduous tree, found throughout India, ascending to an altitude of 1,300 m in the Himalayas. The plant is widely used by the tribals throughout India and popular in various indigenous systems of medicine like Ayurveda, Unani and Homoeopathy. Following the various traditional claims on utility of this plant in curing number of diseases, considerable efforts have been made by researchers to verify its utility through pharmacological screenings. The notable biological activities reported are anthelmintic, antiulcer, antitumour, antimicrobial, anti-inflammatory, antigoitrogenic, hepatoprotective and haemagglutination. Industrially, the plant is widely used for the manufacture of wood wool board, production of tannin, oil, gum and fibre. The plant is also utilized for afforestation to conserve the nature. In this article, a comprehensive account of the cultivation, microscopy, phytochemical investigation, traditional and biologically evaluated medicinal uses of B variegata is presented.

A New Naphthoquinone with Anti-inflammatory Activity from An Egyptian Collection of Echiochilon fruticosum

  • Fathy, Hoda M.;Aboushoer, Mohamed I.;Baraka, Azza;Abdel-Kader, Maged S.;Omar, Abdallah A.
    • Natural Product Sciences
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    • v.15 no.1
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    • pp.22-26
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    • 2009
  • Phytochemical investigation of the roots of Echiochilon fruticosum resulted in the isolation of two naphthoquinone derivatives. Compound 1 was identified as anhydroalkanin while compound 2 was identified as a new derivative 5-hydroxy 8-methoxy 2-(4-methylpent-1,3-dienyl) naphthalene-1,4-dione named as echiochiloquinone. In addition, caffeic acid 3, caffeic acid methyl ester 4 were isolated. The structures were determined by physical, chemical and spectral methods. The anti-inflammatory activity of the root extracts and compound 2 was evaluated utilizing both cotton pellet-induced and carragenin-induced rat paw edema. The ulcerogenic effect was also studied.

A New Steroidal Glycoside from Allium macrostemon Bunge

  • Kim, Yun Sik;Cha, Joon Min;Kim, Dong Hyun;Lee, Tae Hyun;Lee, Kang Ro
    • Natural Product Sciences
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    • v.24 no.1
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    • pp.54-58
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    • 2018
  • A phytochemical investigation of Allium macrostemon Bunge (Liliaceae) afforded the new pregnane steroidal glycoside, named allimacroside F (1), along with three known glycosides, benzyl-O-${\alpha}-{\text\tiny{L}}$-rhamnopyranosyl-($1{\rightarrow}6$)-${\beta}-{\text\tiny{D}}$-glucopyranoside (2), phenylethyl-O-${\alpha}-{\text\tiny{L}}$-rhamnopyranosyl-($1{\rightarrow}6$)-${\beta}-{\text\tiny{D}}$-glucopyranoside (3), (Z)-3-hexenyl-O-${\alpha}-{\text\tiny{L}}$-rhamnopyranosyl-($1{\rightarrow}6$)-${\beta}-{\text\tiny{D}}$-glucopyranoside (4). The identification and structural elucidation of a new compound (1) was carried out based on spectral data analyses ($^1H-NMR$, $^{13}C-NMR$, $^1H-^1H$ COSY, HSQC, HMBC, and NOESY) and HR-FAB-MS.

A New Pyrrole Constituent from the Fruits of Lycium chinense

  • Jeon, Wan-Soo;Kim, E. Ray;Chin, Young-Won;Kim, Jin-Woong
    • Natural Product Sciences
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    • v.17 no.3
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    • pp.181-182
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    • 2011
  • Phytochemical investigation of Lycium chinense fruits led to isolation of a new pyrrole compound. The structure of this compound was confirmed as a 5-methoxymethyl-lH-pyrrole-2-carbaaldehyde, a new natural product, by interpretation of 1D ($^1H$, $^{13}C$) and 2D (HMQC, HMBC) spectroscopic data along with HRMS and IR spectroscopic data.

Phenolic Compounds from Phyllanthus ussuriensis (여우주머니의 Phenol성 화합물)

  • 함인혜;왕도미나;조은선;조형권;황완균
    • YAKHAK HOEJI
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    • v.45 no.3
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    • pp.237-244
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    • 2001
  • The herbaceous species of phyllanthus in this genus are used as hyperglycemic, diuretic, and malaria agent in the world. For the phytochemical studies and the investigation of medicinal resources in the Phyllanthus species, Phyllanthus ussuriensis (Euphorbiaceae) were used and the studies of constituents in this plant were carried out. From the aqueous fraction of methanolic extract, one flavonoid (quercetin-3-O-rutinoside), two gallotannins (gallic acid, methyl gallate), and two ellagitannins (corilagin, geraniin) were isolated through fractionation and repeated column chromatography using Amberlite XAD-4, ODS gel, and sephadex LH-20. The structures of these compounds were identified on the basis of spectroscopic evidences.

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Flavonoids of Crotalaria sessiliflora

  • Yoo, Hun-Sung;Lee, Ji-Suk;Kim, Chul-Young;Kim, Jin-Woong
    • Archives of Pharmacal Research
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    • v.27 no.5
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    • pp.544-546
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    • 2004
  • Phytochemical investigation of the whole plants of Grata/aria sessiliflora L. led to the isolation of four flavonoids. The structures of these compounds were identified as 2',4',5,7-tetrahydroxy-isoflavone (1), 2',4',7-trihydroxyisoflavone (2), 4',7-dihydroxyflavone (3), and isovitexin (4) using spectroscopic analysis. Among these, compounds 2, and 3 have not been reported from Crotalaria species, whereas compounds 1, and 4 were reported from this plant for the first time.

Phenolic Compounds Isolated from Opuntia ficus-indica Fruits

  • Kim, Jung Wha;Kim, Tae Bum;Yang, Heejung;Sung, Sang Hyun
    • Natural Product Sciences
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    • v.22 no.2
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    • pp.117-121
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    • 2016
  • On the phytochemical investigation of a 70% ethanol extract of the fruits of Opuntia ficus-indica, (Cacataceae), we could result in the isolation of thirteen phenolic compounds including seven flavonoids (1 - 9) and four simple phenolic glycosides (10 - 13) by column chromatographic methods. Among the isolated compounds, picein (11), androsin (12), and $1-O-feruloyl-{\beta}-{\small{D}}-glucopyranoside$ (13) were isolated for the first time from O. ficus-indica; additionally, this is the first report $benzyl-O-{\beta}-{\small{D}}-glucopyranoside$ (10) from the genus Opuntia. The structures of the compounds were determined by spectral data analysis which included 1D, 2D NMR spectrum and ESIMS.

Chemical Composition of Clausena lansium (Lour.) Skeels Leaves and Antifungal Activity

  • Vu, Duc Nam;Teruhisa, Fujimatsu;Hirofumi, Takigawa;Hiroshi, Kusuoku;Nguyen, Minh Khoi;Le, Viet Dung;Do, Thi Ha;Hiroshi, Hashimoto
    • Natural Product Sciences
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    • v.22 no.1
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    • pp.35-40
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    • 2016
  • The first study on chemical constituents and biological activities of Clausena lansium (Lour.) Skeels (Rutaceae) growing in Vietnam has been done. Phytochemical investigation of n-hexane extract led to the isolation of five compounds: dihydroindicolactone (1), 8-geranyloxy psoralen (2), imperatorin (3), heraclenol (4) and indicolactone (5), in which this is the first report on the presence of dihydroindicolactone (1). Their structures were elucidated based on LC/MS/NMR hyphenated techniques as well as comparison with those of literature data. The n-hexane extract and its subfractions, ethanol 95% extract and several isolated compounds were evaluated for antifungal activity.

Antioxidant and antimicrobial constituents of Crucianella maritima L.

  • Badr, Jihan M.
    • Natural Product Sciences
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    • v.14 no.4
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    • pp.227-232
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    • 2008
  • Phytochemical further investigation of the chloroform extract of the aerial parts of Crucianella maritima L. (Rubiaceae) growing in Egypt resulted in the isolation of a new anthraquinone; 3-formyl-1-hydroxy-2-methoxy anthraquinone (3) along with the four known compounds isolated for the first time from the genus Crucianella; alizarin-1-methyl ether (2), 1,4-dihydroxy-2-methoxy anthraquinone (5), 1, 3, 6-trihydroxy-2-methoxy anthraquinone (7) and the flavonol kaempferol (8), beside four known compounds previously isolated from the same plant. The structures of the isolated compounds were established based on different spectroscopic data including UV, IR, EIMS, 1D and 2D-NMR. Moreover, the antioxidant and antimicrobial activities of the isolated compounds were evaluated.