• 한국식품영양학회지
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• 제36권5호
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• pp.341-353
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• 2023

In this study, we aimed to develop a fermented green rice beverage with a unique flavor and physiological function activity. With glutinous green rice and rice nuruk as independent variables, we modeled the antioxidant characteristics and α-glucosidase, α-amylase inhibitory activity of glutinous green rice fermented beverage to verify its significance. The total flavonoid content and α-glucosidase inhibitory activity were selected as Quadratic models, and DPPH radical scavenging ability and α-amylase inhibitory activity were selected as linear models. For the sensory characteristics of glutinous green rice fermented beverage, sweetness, sourness, savory taste, bitterness, throat feel, nuruk scent, and overall preference increased in preference as the amount of glutinous green rice and rice nuruk increased, but significantly decreased after the center point (p<0.01). A blending ratio of 180.00 g of glutinous green rice and 400.00 g of rice nuruk had the highest preference among all the sensory items. Based on these results, we developed a green rice fermented beverage with unique flavor and physiological function activity of rice using glutinous green rice and rice nuruk, and the optimal blending ratio was determined to be 164.04 g of white rice, 195.96 g of glutinous green rice, and 414.61 g of rice nuruk.

• Toxicological Research
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• 제30권1호
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• pp.1-5
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• 2014

Xenograft models of human cancer play an important role in the screening and evaluation of candidates for new anticancer agents. The models, which are derived from human tumor cell lines and are classified according to the transplant site, such as ectopic xenograft and orthotopic xenograft, are still utilized to evaluate therapeutic efficacy and toxicity. The metastasis model is modified for the evaluation and prediction of cancer progression. Recently, animal models are made from patient-derived tumor tissue. The patient-derived tumor xenograft models with physiological characters similar to those of patients have been established for personalized medicine. In the discovery of anticancer drugs, standard animal models save time and money and provide evidence to support clinical trials. The current strategy for using xenograft models as an informative tool is introduced.

• Asian-Australasian Journal of Animal Sciences
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• 제17권9호
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• pp.1315-1328
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• 2004

Conjugated linoleic acid (CLA) is a mixture of positional and geometric isomers of octadecadienoic acid with two conjugated double bonds. Of more than a dozen isomers of CLA found naturally in dairy and meat products from ruminants, c-9, t-11 and t-10, c-12 are the two isomers with known physiological importance, including anticarcinogenic, antidiabetic, antilipogenic, and antiatherosclerotic effects. Positive effects of CLA on immune function and bone modeling have also been reported. In spite of the compelling findings in tissue cultures and experimental animal models, its effect, dose, and mechanism of action vis-à-vis specific isomers remains speculative. Results obtained from animal models are inconclusive and conflicting at times in humans, where the research data is limited. It appears that there is a long way to go before CLA could be accepted unequivocally as having definite effects in any or all of these physiological states and how such effects actually occur in humans. The objective of this review is to critically examine the available literature on potential health benefits of CLA observed in cell culture, animal models, and human subjects, wherever possible and to a certain extent the mechanism of action associated with these biological activities.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.1479-1483
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• 2008

The three main physiological functions of nose are air-conditioning, filtering and smelling. Knowledge of airflow characteristics in nasal cavities is essential to understand the physiological and pathological aspects of nasal breathing. Several studies have utilized physical models of the healthy nasal cavity to investigate the relationship between nasal anatomy and airflow. In our laboratory, there have been a series of experimental investigations on the nasal airflow in normal and deformed nasal cavity models by PIV under both constant and periodic flow conditions. In this time, airflow inside normal nasal cavity is investigated numerically by the FVM general purpose code. The comparisons with PIV measurement are appreciated. Heat and humidity transfer is dealt numerically. Dense CT data and careful treatment of model surface under the ENT doctor’s advice provide more sophisticated cavity models for both PIV experiment and numerical grid system. Average and RMS velocity distributions have been obtained for inspirational and expirational nasal. Temperature distribution, heat and humidity transfer through the mucosa are obtained.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2008년도 춘계학술대회논문집
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• pp.498-501
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• 2008

Knowledge of airflow characteristics in nasal cavities is essential to understand the physiological and pathological aspects of nasal breathing. Several studies have utilized physical models of the healthy nasal cavity to investigate the relationship between nasal anatomy and airflow. In our laboratory, there have been a series of experimental investigations on the nasal airflow in normal, abnormal, and deformed nasal cavity models cavity models by PIV under both constant and periodic flow conditions. In this time normal and several deformed nasal cavity models, which simulate surgical operation, Turbinectomy, are investigated numerically by the FVM general purpose code and PIV analysis. The comparisons of these results are appreciated. Dense CT data and careful treatment of model surface under the ENT doctor's advice provide more sophisticated cavity models. The Davis (LaVision Co.) code is used for PIV flow analysis. Average and RMS distributions have been obtained for inspirational and expirational nasal airflows in the normal and deformed nasal cavities.

• 대한인간공학회지
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• 제27권2호
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• pp.1-7
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• 2008

This study quantified 7 trunk muscles' physiological cross-sectional areas (PCSAs) and developed prediction equations for the physiological cross-sectional area as a function of anthropometic variables for Korean people. Nine females and nine males were participated in the magnetic resonance imaging (MRI) scans approximately from S1 through T8. Muscle fiber angle corrected cross-sectional areas (anatomical cross sectional areas: ACSAs) were recorded at each vertebral level and maximum value of ACSAs were determined as physiological cross sectional area (PCSA). There was a significant gender difference in PCSAs of all muscles (p<0.05). Stepwise linear regression techniques using anthropometric measures (e.g., height, weight, trunk depths and widths) as independent variables were conducted to develop prediction equations for the PCSA for each muscle. For males, six muscles' significant prediction equations (p<0.05) were developed except quadratus lumborum. For females, three prediction equations were developed for psoas, quadratus lumborum, and erector spinae muscles (p<0.05).

• 대한인간공학회지
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• 제16권3호
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• pp.23-36
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• 1997

The objective of this study was to make a comparison of the oxygen consumption rates during the lifting activities and the physiological criteria of the recommended weights of RWL, AL, and MPL by NIOSH Guideline. The physical Work Capacity (PWC) based on the bicycle ergometer was 2562.71ml/min, and the one based on the treadmill was 2874.89ml/min for the college male students of Korea. Lifting activities with four different lifting frequencies(2, 5, 8, 11 lifts/min) for one lifting range from floor to 76cm height were studied. The oxygen consumption rates and the heart rates were measured or recorded while subjects were lifting the weight of RWL, AL, and MPL. The heart rates and the oxygen consumption rates increased as the frequency increased from 2 to lifts/min. However, those slightly decreased at the frequency of 11 lifts/ min. The measured oxygen consumption rates were ranging from 2.3% to 29.6% higher than the physiological criteria 620, 700, and 1000ml/min, respectively, of the RWL, AL, and MPL for all the lifting frequencies (5, 8, 11 lift/min) except 2 lifts/min. It si suggested that the physiological criteria of NIOSH Guideline should be based on the lifting PWC, which can consider the type of lifting activity and the frequency of the task, rather than using the PWC by ergometer or treadmill. The measured oxygen consumption rates were ranging from 13.26% to 40.11% higher than the values estimated using the models by Garg and Kim. From these findings it is suggested that the NIOSH Equation should not be directly applied to Korean without resonable modifications.

• Korea-Australia Rheology Journal
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• 제20권4호
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• pp.197-211
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• 2008

The purpose of this study is mainly directed towards present of viewpoints on critical and commentary analysis on blood rheology, blood viscosity models, and physiological flow conditions. Understanding these basics is fundamental to meet the need for a sufficient and reliable CFD model of blood. Most of the used viscosity models on this manner have determined from parameter fitting on experimental viscosity data. Availability of experimental data from literature to define viscosity models of CFD analysis should be accurately chosen and treated in order to avoid any errors. Several basic gaps that limit the CFD model results are identified and given opportunities for future research.

• 말소리와 음성과학
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• 제1권1호
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• pp.9-22
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• 2009

This paper first presents the author's personal view on the importance of modeling in scientific research in general, and then describes two of his works toward modeling certain aspects of human speech communication. The first work is concerned with the physiological and physical mechanisms of controlling the voice fundamental frequency of speech, which is an important parameter for expressing information on tone, accent, and intonation. The second work is concerned with the cognitive processes involved in a discrimination test of speech stimuli, which gives rise to the phenomenon of so-called categorical perception. They are meant to illustrate the power of models based on deep understanding and precise formulation of the functions of the mechanisms/processes that underlie observed phenomena. Finally, it also presents the author's view on some models that are yet to be developed.

• BMB Reports
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• 제56권4호
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• pp.225-233
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• 2023

Hepatocellular carcinoma (HCC) is a very common form of cancer worldwide and is often fatal. Although the histopathology of HCC is characterized by metabolic pathophysiology, fibrosis, and cirrhosis, the focus of treatment has been on eliminating HCC. Recently, three-dimensional (3D) multicellular hepatic spheroid (MCHS) models have provided a) new therapeutic strategies for progressive fibrotic liver diseases, such as antifibrotic and anti-inflammatory drugs, b) molecular targets, and c) treatments for metabolic dysregulation. MCHS models provide a potent anti-cancer tool because they can mimic a) tumor complexity and heterogeneity, b) the 3D context of tumor cells, and c) the gradients of physiological parameters that are characteristic of tumors in vivo. However, the information provided by an multicelluar tumor spheroid (MCTS) model must always be considered in the context of tumors in vivo. This mini-review summarizes what is known about tumor HCC heterogeneity and complexity and the advances provided by MCHS models for innovations in drug development to combat liver diseases.