• 대한의용생체공학회:의공학회지
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• 제43권1호
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• pp.19-26
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• 2022

The Comprehensive in vitro Proarrhythmic Assay(CiPA) project was launched for solving the hERG assay problem of being classified as high-risk groups even though they are low-risk drugs due to their high sensitivity. CiPA presented a protocol to predict drug toxicity using physiological data calculated based on the in-silico model. in this study, features calculated through the in-silico model are analyzed for correlation of changing action potential in the near future, and features are verified through predictive performance according to drug datasets. Using the O'Hara Rudy model modified by Dutta et al., Pearson correlation analysis was performed between 13 features(dVm/dtmax, APpeak, APresting, APD90, APD50, APDtri, Ca_peak, Ca_resting, CaD90, CaD50, CaDtri, qNet, qInward) calculated at 100 pacing, and between dVm/d_{tmax_repol} calculated at 1,000 pacing, and linear regression analysis was performed on each of the 12 training drugs, 16 verification drugs, and 28 drugs. Indicators showing high coefficient of determination(R²) in the training drug dataset were qNet 0.93, AP resting 0.83, APDtri 0.78, Ca resting 0.76, dVm/dt_max 0.63, and APD90 0.61. The indicators showing high determinants in the validated drug dataset were APDtri 0.94, APD90 0.92, APD50 0.85, CaD50 0.84, qNet 0.76, and CaD90 0.64. Indicators with high coefficients of determination for all 28 drugs are qNet 0.78, APD90 0.74, and qInward 0.59. The indicators vary in predictive performance depending on the drug dataset, and qNet showed the same high performance of 0.7 or more on the training drug dataset, the verified drug dataset, and the entire drug dataset.

• 동의생리병리학회지
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• 제22권6호
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• pp.1378-1382
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• 2008

This study is aim to evaluate pulse diagnosis as indicators for classification of the pattern identifications in stroke patients. To get the clinical information, we recruited the onset 1 month stroke patients through the multicenter network which consists of 13 oriental hospitals. The clinical informations about three pairs of pulse wave form and levels of their significancy based on the case report form (CRF) were collected and their distribution in each pattern identification were analyzed. The results are as follows Fire-Heat group shows high portions of floating pulse, rapid pulse and solid pulse. Qi Defficiency group has a greater portion of deep pulse, slow pulse, deficient pulse. The well-defined character of Phlegm-Retained Fluid, Yin Defficiency, Static Blood groups cannot be explained by pulse wave form. These results show a rough relationship between the pulse diagnosis and pattern identifications of stroke therefore, further studies are required to determine the pulse diagnosis as significant indicators of stroke pattern identification.

• 대한간호학회지
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• 제49권6호
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• pp.748-759
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• 2019

Purpose: This study aimed to examine the effect of spouses participating in health coaching on stage of the change, health behaviors, and physiological indicators among male office workers with cardiocerebrovascular disease (CVD) risk factors and compare the findings with trainers who provided health coaching only to workers. Methods: A quasi-experimental pretest-posttest design was used. Convenience sampling was used to recruit participants from a manufacturing research and development company in the city of Gyeonggi province. The health coaching program for the experimental group (n=26) included individual counseling sessions according to workers' stage of change, and provision of customized health information materials on CVD prevention to workers and their spouses for 12 weeks through mobile phone and email. Results: After 12 weeks of intervention, the total score for health behavior, and scores on the sub-areas of exercise and health checkups significantly improved in the experimental group, but there were no significant differences in the scores of stage of the change and physical indicators. The results of a paired t-test showed a significant decrease in the body mass index, abdominal circumference, systolic blood pressure, diastolic blood pressure, total cholesterol and triglyceride values, and a significant increase in the high-density lipoprotein cholesterol value in the experimental group after the intervention. Conclusion: To improve the health of male workers with CVD risk factors in the workplace, sharing health information with their spouses has proven to be more effective than health coaching for only workers. Therefore, it is important to develop strategies to encourage spousal participation when planning workplace health education for changing health-related behaviors.

• 문화기술의 융합
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• 제8권1호
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• pp.157-166
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• 2022

본 연구는 심뇌혈관질환 예방을 위한 생활습관 중재 프로그램의 특성을 파악하기 위하여 프로그램 중재 연구논문을 분석한 문헌분석 연구이다. 연구대상 논문은 Pubmed 등 전자 데이터베이스를 통해 "심뇌혈관질환", "중재" 등의 검색어를 적용하여 최종 18편의 논문이 선정되었다. 대상 문헌에서의 프로그램 참여 대상자 선정기준은 주로 신체생리학적 기준이 이용되었고, 신체활동과 식습관 생활습관 영역을 중재한 프로그램이 많았다. 중재유형은 교육이 가장 많이 이용되었고, 여러 중재를 병합하여 적용하는 연구가 많은 것으로 나타났다. 중재기간은 평균 22주 이상의 장기개입이 많았고, 중재효과를 측정하는 효과지표는 신체생리학적 지표가 가장 많이 활용되었다. 본 연구를 통해 여러 생활습관의 상호관련성을 고려한 중재 프로그램의 개발과 건강한 생활습관을 유지하기 위한 환경 및 사회적 지원이 필요함을 제언한다.

• 동의생리병리학회지
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• 제35권3호
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• pp.87-96
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• 2021

The purpose of this study was to investigate the effect of single herbal medicines and Korean herbal medicine complex prescriptions for osteoporosis in Korea. We targeted studies published in domestic journals from January 1, 2013 to April 1, 2021. For domestic databases, RISS, NDSL, OASIS, DBpia, KISS, KISTI, and Korean Traditional Knowledge Portal were used. Words such as "osteoporosis", "herbal medicine", "herbal combination prescription" and "herbal" were combined and searched. A total of 32 studies were selected. Among them, 8 studies were conducted exclusively for animal studies, 18 studies were conducted on cell experiments, and 6 studies were conducted on both animal and cell experiments. There were 18 studies using a single herb and 14 studies using a combination of Herbal medicine. As a result of the investigation of a single herb, it was found that 補陽藥 was most widely used, and it was found that it was mainly used in the herbal combination prescription, mainly for 補陽藥, 補氣藥, and 補陰藥. Studies in animal experiments revealed significant results mainly in bone mineral density, serological indicators, and morphological indicators of bone tissue. In the study of cell experiments, the effects were found in factors related to the differentiation of osteoclasts and inhibitors of inflammation. Through the results of this study, we are able to confirm the effective single herbal medicines and herbal medicine complex prescriptions for the treatment of osteoporosis, and it is expected that they will contribute to clinical treatment.

• 동의생리병리학회지
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• 제36권5호
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• pp.193-208
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• 2022

In this study, we proposed a mathematical model that can explain the source of the observed variability of repeated measurement data collected in Korean medicine clinical practice, and conducted a pilot analysis to infer the source of these variability based on our model. Mathematical model was constructed by dividing the observed variations into three components: common time-dependent variations, signal shift, and measurement error. To show the applicability of our model in real data, we analyzed 20 repeated measurement data of Korean clinical indicators in graduate students of Pusan National University Graduate School of Korean Medicine. We showed how to infer each source of variations based on our model and also showed the limitation of inference given the acquired the dataset. On the basis of objective recognition of these source of the variability, we hope that quantitative investigations on these sources for each Korean medicine clinical indicator are made in the future, so that they can be used in the clinical and educational areas of Korean medicine.

• 한국환경과학회지
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• 제33권3호
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• pp.217-226
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• 2024

Manufacturing workers face increased fatigue and stress due to environmental factors in workplace such as noise and vibration. Addressing this issue requires creating conducive rest spaces; however, the existing conditions of rest spaces in manufacturing workplace are subpar and lack sufficient scholarly evidence. This study investigated the effect of nature-based rest spaces on the physical and emotional recovery from fatigue on manufacturing workers. Three manufacturing complexes with nature-friendly rest spaces were selected, and 63 manufacturing workers participated in the study. The measurement tools included the Multidimensional Fatigue Scale (MFS) for fatigue levels, physiological indicators (blood pressure and heart rate), and emotional indicators (Zuckerman Inventory of Personal Reaction Scale; ZIPERS, Perceived Restorativeness Scale; PRS, Profile of Mood States; POMS and State-Trait Anxiety Inventory; STAI). The study compared recovery levels during a 7-minute rest between a space without plants and a space with natural elements. The results indicated a significant reduction in systolic and diastolic blood pressure of participants in green rest spaces compared with those in conventional rest spaces. Regarding fatigue levels, green rest spaces showed a decrease in systolic blood pressure in the middle-fatigue and high-fatigue groups. Positive feelings increased in green spaces, whereas negative emotions decreased, suggesting that short breaks in nature-friendly environments effectively promote workers' physical and emotional recovery. Furthermore, this study emphasizes the importance of green space in various work environments to promote well-being in workers.

• 한국산림과학회지
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• 제103권4호
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• pp.664-669
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• 2014

본 연구는 도시림에서의 경관감상과 산책이 인체의 생리적 안정에 미치는 영향을 규명하기 위해 수행되었다. 실험은 대전광역시에 위치한 한밭수목원에서 실시하였으며, 대조실험은 대전시청 앞에서 실시하였다. 20대 남자 대학생 24명(평균나이 $21.1{\pm}2.5$세)이 피험자로 참여하였고, 피험자를 세 그룹으로 나누어 수목원 내 소나무 숲, 수목원 내 연못, 도시 세 장소에 무작위 배치하였으며, 자리에 앉아 10분간 경관을 감상한 후 15분 동안 산책을 실시하였다. 측정지표로써 HRV, 혈압, 맥박수를 이용하여 생리적 변화를 측정하였다. 그 결과 도심 수목원 내에서 경관감상과 산책을 했을 때 도심과 비교하여 통계적으로 유의한 HF 성분의 증가와 수축기 혈압의 감소를 확인할 수 있었다. 본 연구를 통해 도심 수목원에서의 경관감상 또는 산책과 같은 활동이 도시민의 생리적 안정감을 향상시키는데 효과가 있음을 알 수 있었다.

• 동의생리병리학회지
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• 제23권1호
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• pp.97-103
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• 2009

The status and the property of a tongue are the important indicators to diagnose one's health like physiological and clinicopathological changes of inner organs. However, the tongue diagnosis is affected by examination circumstances like a light source, patient's posture, and doctor's condition. To develop an automatic tongue diagnosis system for an objective and standardized diagnosis, classifying tongue coating is inevitable but difficult since the features like color and texture of the tongue coatings and substance have little difference, especially in the neighborhood on the tongue surface. The proposed method has two procedures; the first is to acquire the color table to classify tongue coatings and substance by automatically separating coating regions marked by oriental medical doctors, decomposing the color components of the region into hue, saturation and brightness and obtaining the 2nd order discriminant with statistical data of hue and saturation corresponding to each kind of tongue coatings, and the other is to apply the tongue region in an input image to the color table, resulting in separating the regions of tongue coatings and classifying them automatically. As a result, kinds of tongue coatings and substance were segmented from a face image corresponding to regions marked by oriental medical doctors and the color table for classification took hue and saturation values as inputs and produced the classification of the values into white coating, yellow coating and substance in a digital tongue diagnosis system. The coating regions classified by the proposed method were almost the same to the marked regions. The exactness of classification was 83%, which is the degree of correspondence between what Oriental medical doctors diagnosed and what the proposed method classified. Since the classified regions provide effective information, the proposed method can be used to make an objective and standardized diagnosis and applied to an ubiquitous healthcare system. Therefore, the method will be able to be widely used in Oriental medicine.

• 복식문화연구
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• 제21권4호
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• pp.606-611
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• 2013

It has been reported that tight sportswear could have complicated influence on physiological function of human body. The purpose of this present study was to investigate the effect of wearing gradient compression tights (GCT) on muscle strength and EMG activity during repeated isokinetic muscle contractions. Four healthy male undergraduate students performed maximal voluntary isokinetic concentric muscle contractions on biomechanical test and training systems with GCT and loose pants as control (Cont) respectively. During each test, the peak torque of extensor and flexor contractions and the surface electromyography (sEMG) of the rectus femoris and medial gastrocnemius was recorded simultaneously, the peak torque was recorded as an indicator of muscle strength, and the average amplitude and mean power frequency of sEMG were calculated as indicators of EMG activity. The results showed that: the peak torque decreased gradually during continuous muscle contractions both when the Cont and GCT were worn, average sEMG and mean power frequency declined along with the repetitions of muscle contractions for both wearing conditions, and the change tendency was consistence with that of peak torque. There was no obvious difference between the peak torque recorded wearing the Cont or wearing GCT, but when GCT were worn, average sEMG was lower and mean power frequency was higher than the Cont condition. In 24 samples obtained from four subjects, 80% of results showed the same trend. So we could make a conclusion that wearing GCT had no obvious effect on the improvement of muscle strength, but it would affect the EMG activity positivly.