• Toxicological Research
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• v.34 no.4
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• pp.297-302
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• 2018

Cells are constantly exposed to endogenous and exogenous chemical and physical agents that damage their genome by forming DNA lesions. These lesions interfere with the normal functions of DNA such as transcription and replication, and need to be either repaired or tolerated. DNA lesions are accurately removed via various repair pathways. In contrast, tolerance mechanisms do not remove lesions but only allow replication to proceed despite the presence of unrepaired lesions. Cells possess two major tolerance strategies, namely translesion synthesis (TLS), which is an error-prone strategy and an accurate strategy based on homologous recombination (homology-dependent gap repair [HDGR]). Thus, the mutation frequency reflects the relative extent to which the two tolerance pathways operate in vivo. In the present paper, we review the present understanding of the mechanisms of TLS and HDGR and propose a novel and comprehensive view of the way both strategies interact and are regulated in vivo.

• Journal of the Korean Institute of Navigation
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• v.25 no.4
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• pp.417-422
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• 2001

Every ship might be exposed to collision, grounding and/or various accidents. They may make some underwater holes on the hull. An underwater damage would cause her loss of buoyancy, trim, and inclination. Although a ship has some provisions against these accidents, if the circumstance is serious, she would be sunk or upsetted. Because of varieties of type of accidents, one could not prepare all of them. Many subdivision could prevent them, but it is difficult to realize it due to rising costs. This paper deals with physical phenomena of sinkage and an application on box type ship, and some results are earned as follows； 1. sinkage speed up to the level of the damage hole is increased proportionally, and is decreased proportionally after filling the level. 2. the curve of draft shows cup type of second order polynomial up to the damage hole level, and shows cap type of second order polynomial after filling the level. 3. if damage occurs beneath half of the draft, changes of head and displacement, and sinking speed follow almost straight lines. 4. by careful observation, sinkage speed could be predicted.

• Structural Engineering and Mechanics
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• v.39 no.2
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• pp.287-301
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• 2011

This paper is focused on the residual capacity of steel columns, as a damage criterion. Load-Impulse (P-I) diagrams are frequently used for analysis, design, or assessment of blast resistant structures. The residual load carrying capacity of a simply supported steel column was derived as a damage criterion based on a SDOF computational approach. Dimensionless P-I diagrams were generated numerically with this quantitative damage criterion. These numerical P-I diagrams were used to show that traditional constant ductility ratios adopted as damage criteria are not appropriate for either the design or damage assessment of blast resistant steel columns, and that the current approach could be a much more appropriate alternative.

• Journal of the Korean Society for Precision Engineering
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• v.13 no.10
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• pp.130-138
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• 1996

In general, the scattler is observed in fatigue test data due to the nonhomogeneity of a material. Consequently. It is necessary to use the statistical method to describe the fatigue crack growth process precisely. Bogdanoff and Kozin suggested and developed the B-model which is the probabilistic models of cumulative damage using the Markov process in order to describe the damage process. But the B-model uses only constant probability ratior(r), so it is not consistent with the actual damage process. In this study, the r-decreasing model using a monotonic decreasing function is introduced to improve the B-model. To verify the model, thest data of fatigue crack growth of A12024-T351 and A17075-T651 are used. Compared with the empirical distribution of test data, the distribution from the r-decreasing model is satisfactory and damage process is well described from the probabilistic and physical viewpoint.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.25 no.2
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• pp.296-303
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• 2001

Kachanov-Rabotnov(K-R) creep damage theory was reviewed, and applied to design a creep curve for type 316LN stainless steel. Seven coefficients used in the theory, i.e., A, B, k, m, λ, r, and q were determined, and their physical meanings were analyzed clearly. In order to quantify a damage parameter ($\omega$), cavity amount was measured in the crept specimen taken from interrupted creep test with time variation, and then the amount was reflected into K-R damage equations. Coefficient λ, which is regarded as a creep tolerance feature of a material, increased with creep strain. Mater curve with λ=2.8 was well coincided with an experimental one to the full lifetime. The relationship between damage parameter and life fraction was matched with the theory at exponent ${\gamma}$=24 value. It is concluded that K-R damage equation was reliable as the modelling equation for type 316LN stainless steel. Coefficient data obtained from type 316LN stainless steel can be utilized for life prediction of operating material.

• Computers and Concrete
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• v.13 no.2
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• pp.209-220
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• 2014

Vibration based damage detection is very popular in the civil engineering area. Especially, special structures like dams, long-span bridges and high-rise buildings, need continues monitoring in terms of mechanical properties of material, static and dynamic behavior. It has been stated in the International Commission on Large Dams that more than half of the large concrete dams were constructed more than 50 years ago and the old dams have subjected to repeating loads such as earthquake, overflow, blast, etc.,. So, some unexpected failures may occur and catastrophic damages may be taken place because of theloss of strength, stiffness and other physical properties of concrete. Therefore, these dams need repairs provided with global damage evaluation in order to preserve structural integrity. The paper aims to show the effectiveness of the model updating method for global damage detection on a laboratory arch dam model. Ambient vibration test is used in order to determine the experimental dynamic characteristics. The initial finite element model is updated according to the experimentally determined natural frequencies and mode shapes. The web thickness is selected as updating parameter in the damage evaluation. It is observed from the study that the damage case is revealed with high accuracy and a good match is attained between the estimated and the real damage cases by model updating method.

• Structural Engineering and Mechanics
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• v.36 no.5
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• pp.643-667
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• 2010

The classical flexibility difference method detects damage by observing the difference of conventional deflection flexibility matrices between pre- and post-damaged states of a structure. This method is not able to identify multiple damage scenarios, and its criteria to identify damage depend upon the boundary conditions of structures. The key point behind the inability and dependence is revealed in this study. A more feasible flexibility for damage detection, the Angle-between-String-and-Horizon (ASH) flexibility, is proposed. The physical meaning of the new flexibility is given, and synthesis of the new flexibility matrix by modal frequencies and translational mode shapes is formulated. The damage indicators are extracted from the difference of ASH flexibility matrices between the pre- and post-damaged structures. One feature of the ASH flexibility is that the components in the ASH flexibility matrix are associated with elements instead of Nodes or DOFs. Therefore, the damage indicators based on the ASH flexibility are mapped to structural elements directly, and thus they can pinpoint the damaged elements, which is appealing to damage detection for complex structures. In addition, the change in the ASH flexibility caused by damage is not affected by boundary conditions, which simplifies the criteria to identify damage. Moreover, the proposed method can determine relatively the damage severity. Because the proposed damage indicator of an element mainly reflects the deflection change within the element itself, which significantly reduces the influence of the damage in one element on the damage indicators of other damaged elements, the proposed method can identify multiple damage locations. The viability of the proposed approach has been demonstrated by numerical examples and experimental tests on a cantilever beam and a simply supported beam.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.28 no.3
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• pp.105-113
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• 2010

This study is for the preservation plan of the tradition space which is performed by the damage status analysis through performing the value assessment. Especially, it is an experimental study for finding the process and methods by analyzing the major element for the value assessment of the selected object's damage status through the expert group who are systematized in their interest to conserve the traditional structure in traditional space. For that purpose, this study should be performed by the fundamental understanding of the physical property of the Supyo-bridge and the condition of the selected site's environment. Meanwhile, this study has been done that 'map of the damage status distribution' for making records of damage status of the Supyo-bridge on the property utilized field measurement adapted by photogrammetry and assessment guidelines, which are for investigation on damage status of objects that are standardized 'Raccomandazioni Normal' which could be said construction culture assets management guidelines of Italian government. As the result of investigation, damage status of each part in the Supyo-bridge was mostly composed of damage by sediment and corrosion and in case of 9 damage types including corrosion, in consideration of physical and chemical properties and distribution status of those elements, it is made an judgement that is not working as a threatened factor regarding security of the Supyo-bridge. On the contrary, for the improvement landscape, in case of 'Thermoclastism' phenomenon observed in 'upper floor', 'Myungae stone' and 'bridge pier' is that when taking it into consideration that is widely distributed concentrated on the bridge pier, surface reinforcement job along with elimination of damage part will be judged to be requested for earliest treatment.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.9
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• pp.299-305
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• 2019

As the damage factors of the three­storey stone pagoda of the Bulguksa Temple in Gyeongju could cause a reduction in the historical and artistic value and accelerate the deterioration of the stone, an appropriate solution is needed. The aim of stone conservation is to conserve the original shape and convey originality from the ancestors to their descendants. This procedure includes a record of the condition, being available in the future. In particular, the damage assessment could be used in conservational research, educational data, conservational treatment, and preventive data. As a result of quantitative damage assessment, biological damage indicated 159 %, chemical damage 114 %, and physical damage 16 %. The west direction revealed 95 % because of the amount of sunshine, moisture, and expansion of rock. Complex factors and high range damage were observed on the foundation and body of the pagoda. Since the top of pagoda was restored in the 1970s, the state presented a good condition. By doing this, the number of organisms could be reduced by cleaning and the physical damage could be minimized by bonding. On the other hand, continuous monitoring will be needed because there is a possibility of reforming the damage in the future.

• Physical Therapy Korea
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• v.13 no.3
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• pp.24-32
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• 2006

Theoretical framework of motor learning is used to enhance perceptual motor skill in physical therapy intervention, which can be subdivided into two main types-explicit and implicit. The purpose of this study was to examine whether stroke patients with unilateral brain damage learn implicitly a motor skill using the arm ipsilateral to the damaged hemisphere. Speculation then followed as to the formation of therapeutic plans and instructions provided to patients with stroke. 20 patients with stroke and 20 normal participants were recruited. All the subjects practiced serial reaction time tasks for 30 minutes a day and retention tests on the following day. The tasks and tests involved pressing the corresponding buttons to 4 colored circles presented on a computer screen as quickly and accurately as possible. Patients with stroke responded more slowly than controls. However, both groups showed decreased reaction time in the experimental and retention periods. Also, there was no significant difference between both groups regarding explicit knowledge of consecutive order. Therefore, patients with stoke had the ability to learn implicitly a perceptual motor skill. Prescriptive instruction using implicit and explicit feedback may be beneficial for motor skill learning in physical therapy intervention for patients with brain damage.