• Journal of Photoscience
• /
• 제3권1호
• /
• pp.29-31
• /
• 1996

Psoralens are metabolized in the liver and thus can produce liver damage in laboratory animals when given in excessive doses. However, in humans, reports of the effects of psoralens on liver functions during photochemotherapy have been contradictory. We studied 311 patients t o observe the effects of various phototoxic drugs: 8-methoxypsoralen (8-MOP), 5-methoxypsoralen (5-MOP), 4,5,8-trimethylpsoralen (TMP)-on liver function during photochemotherapy. Of the 311 patients, only seven had transient elevations of transaminases. Incidence of hepatotoxicity of 8-MOP, TMP and 5-MOP showed 0.6%, 6% and 3%, respectively. Although the effects of psoralens on liver functions during photochemotherapy have been contradictory in humans and there have been few cases showing transient elevated values of liver transaminases during photochemotherapy, it is advisable to obtain serial liver function tests before and during photochemotherapy.

• 한국전문물리치료학회지
• /
• 제3권1호
• /
• pp.73-79
• /
• 1996

Photochemotherapy(UVA with 8-methoxypsoralen) was given to 30 patients with systemic psoriasis. The results of clearing and long-term(6-month) interval maintenance were reported. Clearing requirements were in general similar to these reported by Melski and Burger. The skin of the 14 patients (46.6%) recovered good skin condition by a once weekly maintenance dose. This result was better than that reported by other authors. 1. During initial treatment period, average number of treatment was 27.3 and average duration treatment was 24.8 weeks. 2. The factors to quit treatment were motion decrease, moving to the remote area, complications, etc. 3. Number of patient who received maintenance treatment was 14. 4. The complications reported from the patients were hyperpigmentation, nausea, headache, pruritis, vomiting, gastritis.

• Journal of Photoscience
• /
• 제2권1호
• /
• pp.37-45
• /
• 1995

INTRODUCTION : Psoralens are planar tricyclic furocoumarins present in numerous plants and fungi found throughout the world.' Naturally occurring and synthesized psoralen derivatives(see Figure 1) are photosensitizers of UVA especially from 320 nm to 400 nm, a range at which cellular nucleic acids and proteins are weakly absorbing if any at all. Because of their skinphotosensitizing properties, these compounds have been used in the photochemotherapy of psoriasis and vitiligo. However, undesirable side effects such as carcinoma development in hairless mice as well as possible liver damage from the use of 8-methoxypsoralen(8-MOP) have been reported. The other photobiological effects include inactivation of DNA viruses, killing and mutagenesis of bacteria, inhibition of tumor transmitting capacity of various cells, and hyperpigmentation on human and guinea pig skin. PUVA(psoralen+UVA) photochemotherapy is in fact thousands of years old, having been used in Egypt and India since B.C. 1200-2000. Photochemotherapy for a common disfiguring disease, vitiligo, was practiced in the ancient world by physicians and herbalists who used boiled extracts of the fruits of certain umbelliferous plants, e.g. Ammi majus Linnaeus in Egypt or the leguminous plants, Psoralea corylifolia L. in India. It was first described by Kuske in 19388 that photosensitization of skin by plants was related to the presence of psoralen. He identified natural psoralens in plants as photosensitizers and isolated bergapten(5methoxypsoralen) from the oil of bergamot. The scientific interest in photosensitizing psoralens, however, has grown considerably after the introduction into clinics of the psoralen photochemotherapy for the treatment of psoriasis and of other skin (abbreviation)

• 대한소아치과학회지
• /
• 제42권2호
• /
• pp.151-157
• /
• 2015

할로겐 광중합기를 광원으로, 치면세균막 착색제인 erythrosine을 광감각제로 사용하여 S. mutans biofilm에 대한 광역동 치료를 시행할 때의 최적조건을 알아보기 위해서 erythrosine의 농도와 광조사 시간 및 광감각제의 접촉시간에 따른 광역동 치료의 효과를 비교하였다. erythrosine의 농도를 0, 10, 20, 40, $80{\mu}M$로 변화시킨 결과 농도가 증가할수록 항균효과가 증가하는 경향을 보였으며 $40{\mu}M$과 $80{\mu}M$의 두 군에서 통계적 유의성이 나타났다. 광 조사 시간을 0, 5, 15, 30, 60, 75초로 변화시킨 결과 조사 시간이 길어질수록 항균효과가 증가하는 경향을 보였으며 30초, 60초, 75초의 세 군에서 통계적 유의성이 나타났다. erythrosine 처리시간을 0분, 1분, 2분30초, 5분으로 변화시킨 결과 erythrosine과의 접촉시간이 늘어날수록 항균효과가 증가하는 경향을 보였으며 2분30초 군과 5분 군에서 통계적 유의성을 보였다. 이상의 결과로 광감각제로 사용한 erythrosine의 농도를 $20-40{\mu}M$, 광원으로 사용한 할로겐 광중합기의 광 조사시간을 30초 이상, 광감각제인 erythrosine을 2분30초 이상 처리하여 사용하는 것이 치아우식 예방을 위한 광역동 치료에 효과적임을 알 수 있다.

• Bulletin of the Korean Chemical Society
• /
• 제12권5호
• /
• pp.554-559
• /
• 1991

The photophysical and photochemical properties of khellin were compared with those of 8-methoxypsoralen (8-MOP). Quantum yields of fluorescence and triplet formation decreases as solvent polarity increases, which is opposite to 8-MOP, and photocycloadditivity of khellin to olefins is much lower than that of 8-MOP. Electron ejection from khellin by laser flash was not observed, but observed from 8-MOP. As models of 4',5'-monoadducts of khellin or 8-MOP with thymine base, khellin<>dimethylfumarate 4',5'-monoadduct (KDF) was also compared with 8-MOP<>thymidine 4',5'-monoadduct (F-2) in those properties to give some insight on the second-step biadduct formation resulting in cross-links of DNA duplex. KDF and F-2 were very similar to khellin and 8-MOP in photophysical properties, respectively. However, KDF did not form adducts with various olefins, and thus it is thought that 2,3-double bond of chromone moiety in khellin is hardly reactive in contrast with 3,4-double bond of coumarin moiety in 8-MOP. These results indicate that khellin is fairly photostable compound, a poor type Ⅰ photodynamic sensitizer and producer of ${O_2}^{-}$ which is some cause of phototoxic erythemal reactions and undesirable side effects. Therefore khellin is safer to use than 8-MOP in photochemotherapy of some skin diseases. Although khellin is much less reactive than 8-MOP, khellin must be also a monofunctional drug. Since khellin is, however, as effective as 8-MOP in photochemotherapy of some skin diseases, it is suggested that khellin may be different from 8-MOP in the action mechanism.

• Journal of Chest Surgery
• /
• 제53권5호
• /
• pp.317-320
• /
• 2020

Pulmonary carcinoids are relatively rare tumors with low metastatic potential. Pleural carcinomatosis of a bronchial carcinoid has only been reported in 4 cases. Due to the rarity of this condition, there are no guidelines for its treatment or management. We report a case of atypical carcinoid with local recurrence and pleural metastases treated by video-assisted thoracoscopic surgery lobectomy and total pleurectomy with photodynamic therapy after non-radical wedge resection.

• 한방안이비인후피부과학회지
• /
• 제29권3호
• /
• pp.168-176
• /
• 2016

Objectives : The purpose of this study is to report the effect of combination therapy of photodynamic therapy (PDT) with Korean medical treatments on scalp folliculitis, which has been difficult to treat by using antibiotic.Methods : A 32-year-old male patient with scalp folliculitis, received treatment with acupuncture, herbal medicine and PDT and so on. We used Visual Anologue Scale(VAS) to evaluate recovery from erythema, pruritus and pain. Also, the photos of patient were taken before and after treatments.Results : Visible symptoms to the naked eye and VAS scale effectively decreased after Korean medicine treatments for two months.Conclusions : It is expected that Korean medical treatments and PDT were thouht to be effective for scalp folliculitis.

• Journal of Chest Surgery
• /
• 제36권10호
• /
• pp.794-797
• /
• 2003

광역동치료는 흉부외과 영역에서 조기 식도암, 기관 및 기관지 종양, 위장관 점막 내 종양 및 바레트식도 등에서 광감작물질의 광파장 및 광선의 암세포에 대한 선택적이고 직접적인 독성 효과를 이용한 비수술적 치료로 안전하고 효과가 있으며, 기타 진행된 폐암이나 식도암에서 보존적 요법으로도 이용될 수 있다고 여겨지고 있다. 그러나 광역동치료 후 광독성에 의한 피부 독성이 흔하여, 직사 광선의 차단 및 약물 요법이 병행되어야 한다. 저자들은 식도암 수술 후 흘곽 내에 거치된 위장에 발생한 원발성 위암에 대한 광역동치료(Photodynamic tharapy)로 좋은 결과를 얻었기에 문헌 고찰과 함께보고하고자 한다.

• Journal of Periodontal and Implant Science
• /
• 제48권3호
• /
• pp.164-173
• /
• 2018

Purpose: The aim of this study was to evaluate the antimicrobial effect of a newly devised toothbrush with light-emitting diodes (LEDs) on Porphyromonas gingivalis attached to sandblasted and acid-etched titanium surfaces. Methods: The study included a control group, a commercial photodynamic therapy (PDT) group, and 3 test groups (B, BL, and BLE). The disks in the PDT group were placed in methylene blue and then irradiated with a diode laser. The B disks were only brushed, the BL disks were brushed with an LED toothbrush, and the BLE disks were placed into erythrosine and then brushed with an LED toothbrush. After the different treatments, bacteria were detached from the disks and spread on selective agar. The number of viable bacteria and percentage of bacterial reduction were determined from colony counts. Scanning electron microscopy was performed to visualize bacterial alterations. Results: The number of viable bacteria in the BLE group was significantly lower than that in the other groups (P<0.05). Scanning electron microscopy showed that bacterial cell walls were intact in the control and B groups, but changed after commercial PDT and LED exposure. Conclusions: The findings suggest that an LED toothbrush with erythrosine treatment was more effective than a commercial PDT kit in reducing the number of P. gingivalis cells attached to surface-modified titanium in vitro.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권5호
• /
• pp.3351-3355
• /
• 2013

Photodynamic therapy (PDT) is a promising cancer treatment modality that uses dye-sensitized photooxidation of biologic matter in target tissue. This study explored effects of the photosensitizer BCPD-17 during PDT for osteosarcoma. LM-8 osteosarcoma cells were treated with BCPD-17 and cell viability after laser irradiation was assessed in vitro with the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay. The effects of BCPD-17 during PDT recurrence were then examined on tumor-bearing mice in vivo. BCPD-17 had dosedependent cytotoxic effects on LM-8 osteosarcoma cells after laser irradiation which also had energy-dependent effects on the cells. The rate of local recurrence was reduced when marginal resection of mice tumors was followed by BCPD-17-mediated PDT. Our results indicated BCPD-17-mediated PDT in combination with marginal resection of tumors is a potentially new effective treatment for osteosarcoma.