• Title/Summary/Keyword: Phenylpropanoids

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The Chemistry of Secondary Products from Acanthopanax Species and their Pharmacological Activities

  • Shin, Kuk-Hyun;Lee, Sang-Hyun
    • Natural Product Sciences
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    • v.8 no.4
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    • pp.111-126
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    • 2002
  • The chemistry of secondary products from Acanthopanax species and their pharmacological activities were reviewed. A nitrogenous compound, a furan compound, a quinoid, benzoids, coumarins, phenylpropanoids, lignans, flavonoids, terpenoids, phytosterols, polyacetylenes, a pyrimidine, cyclitols, monosaccharides and an aliphatic alcohol have been isolated from Acanthopanax species and have been shown to have various levels of activities such as anti-bacterial, anti-cancer, anti-gout, anti-hepatitis, anti-hyperglycemic, anti-inflammatory, anti-leishmanicidic, anti-oxidant, anti-pyretic, anti-xanthine oxidase, choleretic, hemostatic, hypocholesterolemic, immunostimulatory and radioprotectant effects, etc.

Pharmacological Evaluation of the Glycosidated Phenylpropanoids Containing Fraction from Orobanche crenata

  • El-Shabrawy, O.A.;Melek, F.R.;Ibrahim, M.;Radwan, A.S.
    • Archives of Pharmacal Research
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    • v.12 no.1
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    • pp.22-25
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    • 1989
  • Ethylacetate fraction from Orobanche crenata, contained two phenylpropanoid glycosides, exhibited some pharmacological properties. It was found to be non-toxic to rats in oral doses up to 500mg/100gm body weight. In large doses, it lowered the arterial blood pressure of anaethetised rats, and produced significant analgesic effect in mice and diuretic effect in rats. It further showed smooth muscle relaxant and antispasmodic effects in the isolated rabbit intestine and guinea-pig ileum respectively.

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Bioactive Phenylpropanoids from Asiasarum sieboldi Roots (세신(細辛)의 생리활성물질(生理活性物質) Phenylpropanoids의 분리(分離))

  • Kim, Geum-Sook;Park, Chang-Kie;Baek, Nam-In;Seong, Jae-Duck;Kwack, Young-Ho
    • Korean Journal of Medicinal Crop Science
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    • v.5 no.2
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    • pp.126-130
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    • 1997
  • Treatment of ethylacetate extract of Asiasarum sieboldi inhibited the germination and the growth of radish seeds. Two phenylpropanoids were isolated from ethylacetate extract. Their structures were identified as safrole and o-methyleugenol by spectroscopic evidence. From the test to inhibitory effect, o-methyleugenol had inhibited the germination and the growth of radish seeds, while safrole did not. The germination rate and radicle length of radish seeds were decreased to 63.0%, 31.5 % of control at 5mg/ml of o-methyleugenol, respectively. At the same concentration, o-methyleugenol inhibited the hypocotyl growth up to 100%.

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Cytotoxic Compounds from the Stem Bark of Magnolia obovata

  • Min, Byung-Sun;Youn, Ui-Joung;Bae, Ki-Hwan
    • Natural Product Sciences
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    • v.14 no.2
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    • pp.90-94
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    • 2008
  • Two sesquiterpenes (1 - 2), a tetralone (3), and two phenylpropanoids (4 - 5) were isolated from the stem bark of Magnolia obovata Thunberg (Magnoliaceae) through repeated column chromatography. Their structures were identified as ${\beta}-eudesmol$ (1), cryptomeridiol (2), 4R-4,8-dihydroxy-${\beta}-tetralone$ (3), trans-pcoumaryl aldehyde (4), and p-coumaric acid (5) on the basis of spectroscopic analysis including two dimensional NMR and mass. Compounds 1 - 3 were tested in vitro for their cytotoxic activity against the K562, HeLa, A549, and HCT116 cancer cell lines. However, compounds 1 - 3 were inactive in this assay system.

Anti-complement Activity of Phenolic Compounds from the Stem Bark of Magnolia obovata

  • Min, Byung-Sun
    • Natural Product Sciences
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    • v.14 no.3
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    • pp.196-201
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    • 2008
  • Five neolignans (1 - 4, 8), two sesquiterpene-lignans (5 - 6), and two phenylpropanoids (7, 9) were isolated from the stem bark of Magnolia obovata Thunberg (Magnoliaceae) by repeated column chromatography. The structures of isolated compounds were identified as 4-methoxyhonokiol (1), obovatol (2), magnolol (3), honokiol (4), eudeshonokiol B (5), eudesobovatol B (6), coumaric acid (7), magnaldehyde B (8), and ${\rho}-coumaric$ acid (9) on the basis of spectroscopic analysis including 2D-NMR and MS data. Compounds 1 - 9 were evaluated for their anti-complement activities against the classical pathway of the complement system. Of them, compound 8 showed significant anti-complement activity on the classical pathway with $IC_{50}$ value of 102.7 ${\mu}M$, whereas compounds 1 - 7 and 9 were inactive. This result indicated that an aldehyde group in the neolignan is important for the anti-complement activity against the classical pathway.