• Journal of Korean Traditional Oncology
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• v.20 no.1
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• pp.11-21
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• 2015

Objectives : The cancer incidence and cancer burden is increasing. In addition, the use of botanical agents in cancer care is increasing. This article aims to review a research strategy for botanical agents. Methods : The clinical studies of anticancer botanical agents and the papers about clinical research methodology of botanical agents were reviewed. Results : In phase I study, safety confirmation, optimal dose determination and drug interaction study are important. Most botanical agents have low toxicity and some have non-monotone dose response. Therefore, dose-response curve must be evaluated separately from the dose-toxicity curve to determine optimal dose. Although anticancer botanical agents can't shrink tumor size rapidly, they do extend survival. So, in phase II study, response should be evaluated by the survival. Conclusions : Clinical research of botanical agents in cancer is different from traditional methods and strategies. Considering the characteristics of botanical agents and experimental mechanism is necessary in conducting botanical based clinical trials.

• International Journal of Fluid Machinery and Systems
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• v.2 no.4
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• pp.431-438
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• 2009

A Large Eddy Simulation (LES) of the flow in an inducer is carried out under flow rate oscillations. The present study focuses on the dynamic response of the backflow and the unsteady pressure performance to the flow rate fluctuations under non-cavitation conditions. The amplitude of angular momentum fluctuation evaluated by LES is larger than that evaluated by RANS. However, the phase delay of backflow is nearly the same as RANS calculation. The pressure performance curve exhibits a closed curve caused by the inertia effect associated with the flow rate fluctuations. Compared with simplified one dimensional evaluation of the inertia component, the component obtained by LES is smaller. The negative slope of averaged performance curve becomes larger under unsteady conditions. From the conservations of angular momentum and energy, an expression useful for the evaluation of unsteady pressure rise was obtained. The examination of each term of this expression show that the apparent decrease of inertia effects is caused by the response delay of Euler's head and that the increase of negative slope is caused by the delay of inertial term associated with the delay of backflow response. These results are qualitatively confirmed by experiments.

• Geomechanics and Engineering
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• v.30 no.4
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• pp.363-372
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• 2022

One of the most frequent issues in tunnel excavation is the collapse of rock blocks and the dropping of rock fragments from the tunnel face. The tunnel face can be reinforced using a number of techniques. One of the most popular and affordable solutions is the use of face longitudinal dowels, which has benefits including high strength, flexibility, and ease of cutting. In order to examine the reinforced face, this work shows the longitudinal deformation profile and ground response curve for a tunnel face. This approach is based on assumptions made during the analysis phase of problem solving. By knowing the tunnel face response and dowel behavior, the interaction of two elements can be solved. The rock element equation derived from the rock bolt method is combined with the dowel differential equation to solve the reinforced ground response curve (GRC). With a straightforward and accurate analytical equation, the new differential equation produces the reinforced displacement of the tunnel face at each stage of excavation. With simple equations and a less involved computational process, this approach offers quick and accurate solutions. The FLAC3D simulation has been compared with the suggested analytical approach. A logical error is apparent from the discrepancies between the two solutions. Each component of the equation's effect has also been described.

• Structural Engineering and Mechanics
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• v.58 no.2
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• pp.327-345
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• 2016

Many experimental and analytical studies have been conducted with beam-column subassemblages composed of a two-span beam to investigate the progressive collapse resistance of RC frames. Most study results reveal a strength-decreased transition phase in the nonlinear static load-deflection curve, which may induce dynamic snap-through response and increase the chord rotation demand for effective catenary action (ECA). In this study, the nonlinear static response is idealized as a piecewise linear curve and analytical pseudo-static response is derived for each linearized region to investigate the rotation demands for the ECA of the two-span RC beams. With analytical parameters determined from several published test results, numerical analysis results indicate that the rotation demand of 0.20 rad recommended in the design guidelines does not always guarantee the ECA. A higher rotation demand may be induced for the two-span beams designed with smaller span-to-depth ratios and it is better to use their peak arch resistance (PAR) as the collapse strength. A tensile reinforcement ratio not greater than 1.0% and a span-to-depth ratio not less than 7.0 are suggested for the two-span RC beams bridging the removed column if the ECA is expected for the collapse resistance. Also, complementary pseudo-static analysis is advised to verify the ECA under realistic dynamic column loss even though the static PAR is recovered in the nonlinear static response. A practical empirical formula is provided to estimate an approximate rotation demand for the ECA.

• Geotechnical Engineering
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• v.13 no.1
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• pp.111-122
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• 1997

The calculation of phase velocities in Spectral-Analysis -of-Surface -Waves (SASW) meas urements requires unwrapping phase angles. In case of layered systems with strong stiffness contrast like a pavement system, conventional phase unwrapping algorithm to add in teger multiples of 2n to the principal value of a phase angle may lead to wrong phase volocities. This is because there is difficulty in counting the number of jumps in the phase spectrum especially at the receiver spacing where the measurements are in the transition Bone of defferent modes. A new phase interpretation scheme, called "Impulse Response Fil traction ( IRF) Technique," is proposed, which is based on the separation of wave groups by the filtration of the impulse response determinded between two receivers. The separation of a wave group is based on the impulse response filtered by using information from Gabor spectrogram, which visualizes the propagation of wave groups at the frequency -time space. The filtered impulse response leads to clear interpretation of phase spectrum, which eliminates difficulty in counting number of jumps in the phase spectrum. Verification of the IRF technique was performed by theoretical simulation of the SASW measurement on a pavement system which complicates wave propagation.opagation.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.56 no.2
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• pp.396-406
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• 2007

In this paper, we proposed development of improved model reduction and design of hierarchical controller using reduction model. The model reduction is considered that it is the transient response and the steady-state response through the use of nyquist curve. The hierarchical controller selected tuning of PID controller to ensure specified gain and phase margin and hybrid smith-predictor fuzzy controller using reduction model. Simulation examples are given to show the better performance of the proposed method than conventional methods.

• The Korean Journal of Zoology
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• v.35 no.4
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• pp.509-517
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• 1992

LiCl (0.047 M)은 Goldhamster의 활동주기 (T)를 평균 1.6시간 연장시키고, 동물 중 20%엑서 단축되는 것으로도 관찰되었다. 1시간 통안의 빛자극(75 Lux)에 의해 주기현상 시점 변화가 나타나는 데 LICI에 의해서 0.3 h 더욱 delav되었고 advance 현상은 1.5 h 감소되었으며 delay엔h advance 전환시기는 1시간 늦게 나타났다. 반면에 7 Lux의 빛 자극에서는 delay가 2.4시간으로 더 증가되었으며 advance 현상은 2.6시간으로 저하되었고, 30분 늦게 delay에서 advance로 전환되었다. subjective day 동안에는 빛자극에 의한 LiCl 효과가 전혀 보이지 않았다. Phase-Response-Curve(PRC)는 Circadian Time에서 delay-advance로 전환되는 mid-subjective night에 점진적으로 변화되는 weak phase curve로 형성되었다. 이 PRC에서 Li이 빛에 대한 민감성을 둔화시키는 효과를 볼 수 있다.

• Physical Therapy Korea
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• v.9 no.3
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• pp.39-46
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• 2002

In this study, vertical acceleration of center of mass was observed along normal gait phases in 9 healthy male volunteers (aged $25.7{\pm}2.18$). The developed wireless accelerometric device was attached on the intervertebral space between L3 and L4 using a semi-elastic waist belt. A three-dimensional motion analysis system, synchronized with the accelerometry, was used for detecting gait phases. There was no significant correlation between the body weight and the acceleration. The first peak curve covered loading response phase. The second downward peak point was matched accurately with the opposite toe-off. In mid-stance and terminal stance, the acceleration curve highly resembled the vertical ground reaction force curve. There was no significant difference in timing between the final upward peak point and the initial contact. Therefore, the developed accelerometry system would be helpful in determining determine temporal gait pattems in patients with gait disorders.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.23 no.5
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• pp.1372-1383
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• 1998

In this paper, modeling for DC and AC characteristics analysis of DFB-LD was performed considering effects of .lambda./4-shifted gratingandspatial hole burning within a laser diode cavity. From the simulation for DC characteristics, Light-Current curve, optical power distribution and carrier density distribution within the cavity can be obtained. The simulation for AC characteristics porovides IM response and the amplitude and phase and the amplitude and phase response of FM with excellent accuracy.

• Transactions of the Korean Society of Mechanical Engineers
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• v.13 no.1
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• pp.67-76
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• 1989

Although the standard 2-CR network filter, one of the filters used for measuring surface roughness, is being used widely in the field of industry it possesses a weak point of causing Phase-distortion when the wavelength is passing through. Phase-corrected filter is used for eliminating these phase-distortion and the difference of phase characteristics between these two filters is thought to have considerable amount of effect on the surface roughness value. Moveover, the definition on this is as yet unclear. Therefore, the Rt and Rz value, obtained when the wavelength are passed through the standard and phase-corrected filters from the same random machine-processed surface, and its standard deviation are compared and experimented in this paper. Also, the ratio of relative bearing curve complying to the phase characteristics of these two filters are acquired. As a result, the use of phese-corrected filter is appropriate in experiments where the form of wavelength is important, and the standard deviation on the same experimented values appeared greater with when using the standard filter. The rate of relative bearing curve became greater as .lambda.$_{c}$, the cut-off value of filter, became smaller.r.