• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1997.11a
• /
• pp.35-39
• /
• 1997

Recent development of human genetics and techniques of gene transfer and expression have opened the way for investigating novel approaches based on the genetic modification of cells to treat both inherited and acquired diseases. This approach is referred to as gene therapy. Over the past few years, gene therapy has moved from the laboratory to phase I clinical trials. Although the clinical performance of gene transfer experiments is still in an early phase of development, the NIH of Health Recombinant DNA Advisory Comittee (RAC) has approved more than 150 protocols that involve gene transfer or putative gene therapy procedures in clinical settings. Many sectors of society in United States have participated in the design and formulation of these clinical trials through local Institutional Review Boards, the National Institutes of Health (NIH) RAC, the Chemotherapy Evaluation Program of the National Cancer institute, and the FDA. Currently, clinical trials involving gene modification are under way at many medical centers throughout the United Slates. The goals of these trials are as follows. (1) The design should be directed to short-term achievable goals. (2) Each clinical trial is best considered as an intermediate step in a multistep process. (3) The design should identify evaluable proximate endpoints for toxicity and for efficacy, (4) The potential benefits and possible risks for patients participating in these trial should be defined.

• Proceedings of the KIEE Conference
• /
• 1991.07a
• /
• pp.47-50
• /
• 1991

LPM(Linear Pulse Motor) provide direct and precise position control of bidirectional linear motion. LPM is not subject to the same linear velocity and acceleration limitations inherent in systems converting rotary to linear motion such as lead screws, rack and pinion, belt and pulley drives. With LPM, all the thrust force generated by the motor is efficiently applied directly to the load. And speed, distance, and acceleration are easily programmed in a highly repeatable fashion. Potential industrial and application fields of LPM include PCB assembly, industrial sewing machines, automatic inspection, coil winder, medical uses, conveyer system, laser cut and trim systems, semiconductor wafer processing, OA instruments etc. This paper describes various design parameter of LPM such as magnetic ciucuit construction methods, phase number and tooth number per pole, permanent magnet and coil mmf, tooth geometries. And to solve the problems of existing control methods, in this paper, a new control method of the LPM is proposed throughout modern control theory.

• Interaction and multiscale mechanics
• /
• v.1 no.4
• /
• pp.397-409
• /
• 2008

The interfacial thermal resistance of pristine and defective carbon nanotubes (CNTs) embedded in low-density polyethylene matrix is studied in this paper. Interface thermal resistance in nanosystems is one of the most important factors that lead to the large variation in thermal conductivities in literature and the novelty of this paper lies in the estimation of the interfacial thermal resistance for defective nanotubes-systems. Thermal properties of CNT nanostructures are estimated using molecular dynamics (MD) simulations and the simulations were carried out for various temperatures by rescaling the velocities of carbon atoms in the nanotube. This paper also deals with the mesoscale thermal conductivities of composite systems, using effective medium theories by considering the size effect in the form of interfacial thermal resistance and also using the conventional micromechanical methods like Hashin-Shtrikman bounds and Wakashima-Tsukamoto estimates.

• Proceedings of the KOSOMBE Conference
• /
• v.1997 no.05
• /
• pp.253-256
• /
• 1997

KESF-1 foot conceptually provides storage of potential energy and is converted to kinetic energy throughout the weight - bearing phase of the gait cycle. This stored energy is progressively released as the foot continues through the toe-off phase to rebound and propel the body forward. A weight deflects the keel through a predetermined range, then the keel "springs back" as weight is removed. Foot designs criteria were selected to guide development beyond the proof-of concept composite material keels; 1) store and return energy (1-3/4 " metatarsal deflection at 435 pounds vertical load), 2) natural feel and stability; 3) useful life of 3-years: 4) lightweight; 5) reduced production costs. The purpose of this study is developed the comfortable stable foot that fitted with Korean lifestyle and road condition. The results produced the realistic cosmetic foot cover with polyurethane form and the keel composed with composite materials of both glass fiber and carbon fiber.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.18 no.3
• /
• pp.425-438
• /
• 1993

Due to the producer-consumer dependency of shared variables, the potential parallelism embeded in the logic programming language has not been fully examined. The method proposed in this paper eliminates the dependency of shared variables by introducing number-sequenced variables in expanding an AND-OR proof tree. Basically, the execution of a logic program can be divided into two phases : expanding an AND-OR tree and proving the tree by matching facts with leaf nodes. In the course of the first phase, a set of number-sequenced variables are produced by expanding an AND-OR tree in the breadth-first searching. Based on the information of number-sequence, each of them is verified in the second phase in order to prove the tree. Consequently, the proposed algorithm can explore more parallelism without the dependency of shared variables.

• Journal of the Korean Ceramic Society
• /
• v.53 no.2
• /
• pp.178-183
• /
• 2016

Ferroelectric relaxor ceramics with $BaTiO_3-NaNbO_3-Bi(Mg_{1/2}Ti_{1/2})O_3$ ternary compositions (BT-NN-BMT) have been prepared by sol-gel powder synthesis and consequent bulk ceramic processing. Through the modified chemical approach, fine and single-phase complex perovskite compositions were successfully obtained. Temperature and frequency dependent dielectric properties indicated typical relaxor characteristics of the BT-NN-BMT compositions. The ferroelectric-paraelectric phase transition became diffusive when NN and BMT were added to form BT based solid solutions. BMT additions to the BT-NN solid solutions affected the high temperature dielectric properties, which might be attributable to the compositional inhomogeneity of the complex perovskite and resulting weak dielectric coupling of the Bi-containing polar nanoregions (PNRs). The temperature stability of the dielectric properties was good enough to satisfy the X9R specification. The quasi-linear P-E response and the temperature- stable dielectric properties imply the high potential of this ceramic compound for use in high temperature capacitors.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 2008.11a
• /
• pp.231-232
• /
• 2008

The coupling between electric, magnetic, and structural order parameters results in the so-called multiferroics, which possess ferroelectricity, ferromagnetism, and/or ferroelasticity. The simultaneous ferroelectricity and ferromagnetism (magnetoelectricity) allow potential applications in information storage, spintronics, and in magnetic or electric field sensors. Perovskite compound $BiFeO_3$ (BFO) is antiferromagnetic below Neel temperature of 647K and ferroelectric with a high Curie temperature of 1043K. It exhibits weak magnetism at room temperature(RT) due to the residual moment from a canted spin structure. It is likely that non-stoichiometry and second-phase formation are the factors which cause leakage in BFO. It has been suggested that oxygen non-stoichiometry leads to valence fluctuations of Fe ions in BFO, resulting in high conductivity. To reduce the large leakage current of BFO, one attempt is fabricating donor doped BFO compounds and thin films. We report here the successful fabrication of the Nd, Ti co-doped $BiFeO_3$ ceramics and thin films by pulsed laser deposition technique.

• Journal of the Institute of Electronics and Information Engineers
• /
• v.49 no.12
• /
• pp.249-255
• /
• 2012

A cochlear implant system uses charge-balanced biphasic pulses that are known to reduce tissue damage than monophasic pulses. In this study, we investigated effect of pulse pattern on neural responses using a computer model, based on the Hodgkin-Huxley equation. Electric pulse phase, pulse duration, and phase gap have been systematically varied to characterize auditory nerve responses. The results show that neural responses, dynamic range and threshold are represented as a function of stimulus patterns and duration. The results could greatly extend to develop more efficient cochlear implant stimulation.

• 한국가시화정보학회:학술대회논문집
• /
• 2004.11a
• /
• pp.40-43
• /
• 2004

The effects of free surface on wake behind a rotating propeller were investigated experimentally in a circulating water channel with the variation of water depth. Instantaneous velocity fields were measured using two-frame PIV technique at tow different blade phases and ensemble-averaged to investigate the phase-averaged flow structure in the wake region. For an isolated propeller, the flow behind the propeller is influenced by the propeller rotation and the free surface. The phase-averaged mean velocity fields show that the potential wake and the viscous wake are formed by the boundary layers developed on the blade surfaces. The interaction between the tip vortices and the slipstream causes the oscillating trajectory of tip vortices. Tip vortices are generated periodically and the slipstream contracts in the near-wake region. The presence of free surface affects the wake structure largely, when the water depth is less than 0.6D. The free surface modifies the vortex structure, especially the tip and trailing vortices and flow structure in slipstreams of the propeller wake behind X/D = 0.3.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.37 no.1
• /
• pp.37-42
• /
• 2011

The rheological properties of the aqueous solution of scleroglucan industrially produced by Sclerotium rolfsii at concentrations ranging from 0.1 % to 2 % (w/w) were determined by using brookfield viscometer and rheometer. Gel matrices of scleroglucans were stable over a wide range of pH and ionic strength in the aqueous medium. In the oil dispersion with phytosqualane in oil phase and three kinds of thickening agent in aqueous phase, scleroglucan showed the highest dispersion properties. The synergistic effect between scleroglucan and locust bean gum was also examined. The highest viscosity was obtained for the solution mixture at scleroglucan/locust bean gum weight ratio of 5 : 5. The results of this study suggest the potential of scleroglucan as thickner for a wide variety of cosmetic formulations.