• 한국임상수의학회지
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• 제37권6호
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• pp.355-359
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• 2020

Contrast-enhanced ultrasonography (CEUS) has been applied to evaluate parenchymal organs in human and veterinary medicine. However, to our knowledge, there is no report on the identification of active bleeding and the bleeding site in veterinary clinical patients. Herein, we describe the use of CEUS in two cases of abdominal bleeding caused by ruptured lesions with malignant abdominal tumors. One dog had a splenic hemangiosarcoma, which had metastasized to the liver; the other dog had hepatic cell carcinomas in the left hepatic lobe, which were lobectomized, and another nodule was identified in the right hepatic lobe. Immediately after the rupture of these oncogenic lesions was suspected, CEUS was performed to identify the bleeding sites. The active bleeding sites were confirmed by hyperechoic pooling signs in the arterial phase, and extravasation could be observed within the defects showing hypoechoic perfusions in the delayed phase of the CEUS. Microbubbles were also observed in the ascites; thus, CEUS could detect the presence of hemorrhage and accurately identify the bleeding site. Collectively, the study findings suggest the usefulness of CEUS in emergent situations as it enables rapid and noninvasive evaluation of bleeding points in case of active bleeding in dogs.

• 국제학술발표논문집
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• The 2th International Conference on Construction Engineering and Project Management
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• pp.160-168
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• 2007

Conflicts of interest and independent agenda of the parties brought together for implementation of a construction project often leads to dispute in Contract and claim situations. Construction Industry is notorious for claim that is managed on its arising and there lacks an endeavor to minimize the breeding grounds through efficient planning and alignment to purpose, of all contract-documents. There failure of a concerted effort entails wastage of resources, delayed completion of facilities and stained relationships of parties when collide in mistrust in contract to win over the other. There needs a focus on the claim breeding issue and establish an effective mechanism to deal with disputes in urgency. Claim occurs mostly during the construction phase. But the seeds of claim and nutrients essential for development are contained in the contract documentation and the information supplied or not in pre-contract phase. Opportunity to prevent nutrients for seed of Claim comes to an end once tender-documents are finalized, the contract is awarded and established or not a mechanism for dealing with claim situation. The processes presented here would help in minimizing the breeding grounds and emergence of disputes during progression of works and dealing with eventualities in forceful manners for finding a resolution most effectively in relevant time.

• 한국건설관리학회논문집
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• 제12권5호
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• pp.146-154
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• 2011

국내 건설기업은 1960년대 처음으로 해외건설시장에 진출한 이래 지속적으로 성장해왔으며 2010년에는 해외건설시장에서 716억 달러를 수주하는 등 국가 경제에 많은 기여를 해왔다. 특히 플랜트산업의 경우 2010년에 사상 최대인 574억 달러를 수주하여 전제 해외건설 수주금액의 80% 이상을 차지하였다. 그럼에도 불구하고 국내 건설기업은 해외 선전기업에 비해 설계단계의 기술경쟁력 부족 및 사업관리 능력의 부족으로 해외 플랜트 사업을 수행하는데 있어 어려움이 크다. 본 연구는 최근 국제 유가의 상승, 에너지 수요의 증가, 친환경 건설에 대한 관심의 증가로 시장규모가 확대되고 있는 해외 LNG 플랜트사업의 수익률 안정을 위해 설계단계의 리스크를 규명하고, 이를 보다 합리적으로 평가하기 위한 방법을 제시하였다. 본 연구의 결과로서 첫째, 기존문헌의 분석, 기업 설계보고서, 전문가 인터뷰를 통해 해외 플랜트 설계단계에서 총 57개 리스크 요인을 도출하였다. 둘째 기존의 우선순위 평가방법(이축, PI)에 플랜트의 특성을 반영 할 수 있는 조정지수(Coordination Index, CI)를 추가하여 해외 LNG 플랜트 설계단계에 보다 적합한 삼축(PIC)우선순위 평가방법을 제시하였다. 마지막으로 전문가 설문조사 및 인터뷰를 통해 삼축 평가방법의 적절성 및 실무 적용성을 확인하였다. 따라서 국내 건설기업이 자신의 경험을 바탕으로 본 연구에서 제시된 리스크 요인과 평가방법을 해외 LNG 플랜트 설계단계에 적용한다면, 보다 합리적이고 객관적인 리스크 관리가 가능할 것으로 기대된다.

• Bulletin of the Korean Chemical Society
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• 제27권6호
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• pp.909-917
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• 2006

2,2-Dimethyl-3,4-dialkoxy-substituted 6-aminobenzopyran analogues (eg., 7 and 8) were identified as prolyl 4-hydroxylase inhibitors via a screening process using HSC-T6 and LI 90 cells that express an immortalized rat hepatic stellate cell line and as part of a test of the type I collagen contents employing the ELISA method. A subsequent lead optimization effort based on solid-phase parallel synthesis led to the identification of 2,2-dimethyl-3,4-dialkoxy-substituted 6-aminobenzopyrans as potent inhibitors of prolyl 4-hydroxylase.

• 한국결정학회지
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• 제4권1호
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• pp.18-24
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• 1993

백금-안티모니갔의 상평형 및 안정 화합물에 대한 연구를 위해 합성실험을 실시하였다. 반응생성물은 반 사현미경, X-선 회절분석, 전자현미분석 등으로 규명하 였다. 백금-안티모니계에는 Pt5Sb, Pt3Sb, Pt3Sb2, PtSb, PtSb5등 5종류의 화합물이 존재하며 Pt5Sb2는 존재하지 않는 것으로 밝혀졌다. Pt5Sb는 처음 발견된 화합물로서 83at.%Pt의 화학성분을 가지며, 정방정계와 격자상수 a=3.948(3), c=16.85(1)차를 가진다. Ptssb 의 X-선회절 분말자료는 a=3.9455(7), c=16.959(5) A 인 정방정계의 구조로 격자지수화가 가능하다. PtSb의 화학성분은 800연까지 50at.% Pt이나 10반종에서는 49at.%정 회이다. 백금속의 안티모니 고용한계는 1000°, 800°, 600°에서 각각 7.5, 10.0, 6.1at.%이다. Ptsb2와 Sb를 잇는 액상곡선의 형태도 수정되었다.

• 산업공학
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• 제19권2호
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• pp.140-152
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• 2006

Today, many companies realize that the effort to develop new products / services faster that customers want and continue to purchase is crucial for their survival. As the service sector is rapidly growing, one of the challenges faced by the service industries is the lack of effective methodologies for new service development. This paper proposes a systematic framework for developing new service concepts, with an emphasis on generating innovative, convergence-type service concepts from the customer‘s perspective. The framework consists of three phases-identification of customer needs (Phase I), extraction of new service opportunities (Phase II), and generation of new service concepts (Phase III). The proposed framework is demonstrated through a case study in the telecommunications industry. In the case study, a survey was conducted on ten customers to identify the latent customer needs; 61 new service opportunities were extracted; and 129 new service concepts were generated.

• Asian-Australasian Journal of Animal Sciences
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• 제22권4호
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• pp.492-499
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• 2009

A Silkie Bantam embryo fibroblast line (named SBF59 line) was successfully established by using direct explant culture and cryopreservation techniques. Cell morphology, viability, dynamic growth and contamination were tested and the karyotype and levels of isoenzymes of lactic dehydrogenase and malic dehydrogenase were analyzed. Four kinds of fluorescent protein extrogenes, including $pEGFP-N_3$, $pECFP-N_1$, $pEYFP-N_1$ and $pDsRed1-N_1$ were transfected into the cells. The results showed that the cells were healthy and possessed a fibrous structure without a change in morphology. The average viability of the cells was 96% before freezing and 90.5% after thawing. The growth curve appeared as typical "S" shape and the cell growth passed through a detention phase, a logarithmic phase and a platform phase; the estimated population doubling time (PDT) was 38.5 h; assays for the presence of bacteria, fungi, viruses and mycoplasmas were negative; the cell line showed no cross contamination when assessed by isoenzyme analysis; the chromosome number was 2n = 78 on more than 88% of occasions; four kinds of fluorescent protein extro-genes appeared to be expressed effectively with a high transfection efficiency between 18.3% and 42.3%. The cell line met the required quality control standard. It not only preserves the genetic resources of the important Silkie Bantam at the cellular level but also provides valuable materials for genomic, post-genomic, somatic cell cloning research and other applications.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2329-2336
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• 2016

Background: Despite the existence of established guidelines advocating the use and value of chemotherapy order templates, chemotherapy orders are still handwritten in many hospitals in Lebanon. This manuscript describes the implementation of standardized chemotherapy order templates (COT) in a Lebanese tertiary teaching hospital through multiple steps. Initial Assessment: An initial assessment was conducted through a retrospective appraisal of completeness of handwritten chemotherapy orders for 100 adult patients to serve as a baseline for the project and identify parameters that might afford improvement. Choice of solution: Development of over 300 standardized pre-printed COTs based on the National Comprehensive Cancer Network templates and adapted to the practice culture and patient population. Implementation: The COTs were implemented, using Kotter's 8-step model for leading change, by engaging health care providers, and identifying and removing barriers. Evaluation: Assessment of physicians' compliance with the new practice (122 orders assessed) was completed through two phases and allowed for the identification of areas of improvement. Lessons Learned: Overall, COT implementation showed an average improvement in order completion from 49.5% (handwritten orders) to 77.6% (phase 1-COT) to 87.6% (phase 2-COT) reflecting an increase of 38.1% between baseline and phase 2 and demonstrating that chemotherapy orders completeness was improved by pre-printed COT. As many of the hospitals in Lebanon are moving towards standardized COTs and computerized physician order entry (CPOE) in the next few years, this study provides a prototype for the successful implementation of COT and demonstrates their role in promoting quality improvement of cancer care.

• 대한전자공학회논문지
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• 제27권2호
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• pp.55-64
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• 1990

직류 전동기의 위치 및 속도 제어를 위해 그동안 주로 사용해 왔던 고전적인 선형 PID 제어 알고리듬을 사용하여 왔으나, 주위환경의 변화나 부하의 변경 또는 외란과 같은 비션형 요소들로 인해 실제 시스템의 모델링에는 많은 제한이 따랐다. 이 문제를 해결하기 위해 시스템의 모델링 없이 매개변수들을 온라인으로 추정하여 식별할 수 있는 PID 자기 동조기의 설계 방법을 제안하였다. 본 논문에서는 극 배치 PID 자기 동조 제어기의 설계 기법을 제안하고, 각각의 제어기 매개변수들을 추정하기 위하여 순환 최소자승 알고리듬을 사용하야T으며, Diophantine 방정식의 도입으로 인한 4개의 추가매개 변수들을 추정된 제어기 매개변수들을 이용하여 새롭게 유도된 방정식에서 구하였다. 제안된 제어기의 성능을 평가하기 위하여 최소, 비최소 위상 시스템에 대한 시뮬레이션을 하였고 실제 로보트 매니플레이터용 DC 서어보 전동기에 대하여 무부하와 부하 실험을 거쳐 그 특성이 양호함을 검증하였다.

• 한국축산식품학회지
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• 제36권6호
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• pp.719-728
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• 2016

The aim of this study was to explore the volatile compounds of hind leg, foreleg, abdomen and Longissimus dorsi in both male and female Hyla rabbit meat by solid phase microextraction tandem with gas chromatography mass spectrometry, and to seek out the key odorants via calculating the odor activity value and principal component analysis. Cluster analysis is used to study the flavor pattern differences in four edible parts. Sixty three volatile compounds were detected, including 23 aldehydes, 4 alcohols, 5 ketones, 11 esters, 5 aromatics, 8 acids and 7 hydrocarbons. Among them, 6 aldehydes and 3 acids were identified as the potential key odorants according to the ratio of concentration and threshold. The contents of volatile compounds in male Hyla rabbit meat were significantly higher than those in female one (p<0.05). The results of principal component analysis showed that the first two principal component cumulative variance contributions reach 87.69%; Hexanal, octanal, 2-nonenal, 2-decenal and decanal were regard as the key odorants of Hyla rabbit meat by combining odor activity value and principal component analysis. Therefore volatile compounds of rabbit meat can be effectively characterized. Cluster analysis indicated that volatile chemical compounds of Longissimus dorsi were significantly different from other three parts, which provide reliable information for rabbit processing industry and for possible future sale.