• Journal of Pharmacopuncture
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• v.14 no.3
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• pp.81-90
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• 2011

Objectives : Angelicae Gigantis Radix has been known traditional medicine with antimicrobial activities and it has been widely used for treatment of blood and inflammatory diseases. In the present study, some studies examined anti-inflammation effects of Angelicae Gigantis Radix but they usually were performed by ethanol extracted Angelicae Gigantis Radix pharmacopuncture. So We investigated the inhibitory effects of Angelicae Gigantis Radix pharmacopuncture by hot water and ethanol extract on Nitric oxide(NO) and Prostaglandin $E_2$($PGE_2$) production in lipopolysaccharide(LPS) induced macrophage cell. Methods : Angelicae Gigantis Radix was extracted by ethanol and hot water. Cell viability was determined by MTT assay. To evaluate anti-inflammation effects of Angelicae Gigantis Radix pharmacopuncture, we examined NO and $PGE_2$ production in LPS induced macrophages. The concentrations of NO and $PGE_2$ were measured by Griess assay and Enzyme Immuno-Assay. Results : 1) The MTT assay demonstrated that cytotoxic effect of Angelicae Gigantis Radix pharmacopuncture by hot water extract and ethanol extract in RAW 264.7 macrophage cells were not appeared. 2) Angelicae Gigantis Radix pharmacopuncture by ethanol extract and hot water extract inhibited NO production in LPS induced macrophages significantly. 3) Angelicae Gigantis Radix pharmacopuncture by ethanol extract tended to inhibiting $PGE_2$ production in LPS induced macrophages. And Angelicae Gigantis Radix pharmacopuncture by hot water extract inhibited LPS induced production of $PGE_2$ in RAW 264.7 macrophage cells significantly. Conclusions : This study suggests that Angelicae Gigantis Radix pharmacopuncture may have an anti-inflammatory property through the inhibition of NO and $PGE_2$ production in LPS induced macrophages. It may have a therapeutic potential for the treatment of various inflammatory diseases.

• Journal of Korean Medicine Rehabilitation
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• v.20 no.1
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• pp.1-12
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• 2010

Objectives : Cool Pharmacopuncture for static blood is a famous pharmacopuncture treatment that treated disease caused by static blood. Hyolhae(Sp10) is also a famous point of acupuncture that treated that. This study was designed to evaluate the effects of Cool Pharmacopuncture for static blood into Hyolhae(Sp10) on BAX and BCL-2 expression in the experimental traumatic brain injury(TBI) rats. Methods : Male rats were divided into 3 groups. I was no treatment after TBI. II was treatment with needle-prick acupuncture after TBI. III was treatment with Cool Pharmacopuncture for static blood into Hyolhae(Sp10) after TBI. The author carried out neurological motor behavioral test, histological assessment test. Neurological motor behavior tests consist of rotarod test, beam-walking test and postural reflex test. In the histological assessment test, BAX and BCL-2 expression, hematoxylin & eosin staining were experimented. Results : In neurological motor behavior tests, motor and cognitive function recovery was significantly increased in the II, III as compared with I (p<0.05). Especially III was significantly increased as compared with II (p<0.05). BAX expression was significantly decresed in order of the III, II, I after 7 and 14 days later. BCL-2 expression was investigated in the III, II as compared with I. Especially Most incresed expression was experimented in the III. Conclusions : According to the above results, Cool Pharmacopuncture for static blood can inhibit apoptosis of cells after TBI in rats by contol of BAX and BCL expression.

• Journal of Pharmacopuncture
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• v.14 no.4
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• pp.71-80
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• 2011

Objectives: The purpose of this research was to examine the effect of Carthami-Flos Pharmacopuncture on posterior neck pain of menopausal women. Methods: We treated 20 female patients with neck pain patient(45-60 yr) into two groups and treated Group A with Carthami-Flos Pharmacopuncture and common acupuncture and Group B with common acupuncture. The efficacy of treatment was measured by VAS, NDI and MENQOL scores of before and after 30 days to start treatment. Results: Both group A and B represented effective improvement in VAS and NDI of neck pain and MENQOL scores. And group A was more effective than B group statistically. Conclusions: It was suggested that Carthami-Flos Pharmacopuncture treatment might have effect on posterior neck pain treatment of menopausal women.

• Journal of Pharmacopuncture
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• v.12 no.1
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• pp.99-102
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• 2009

This study was to evaluate a case of foot drop treated with placenta pharmacopuncure. After thirteen times of treatment, I evaluated this case by the angle of dorsiflexion, the total sum of gaiting points, the time of heel standing. As a result of evaluation, the angle of dorsiflexion, total sum of gaiting points, time of heel standing were improved. The placenta pharmacopuncture can be used for foot drop and other peripheral nerve palsy.

• Journal of Pharmacopuncture
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• v.13 no.2
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• pp.67-73
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• 2010

Objective : The purpose of this study is to determine the efficacy and safely of Hwangryunhaedok-tang Pharmacopuncture (HHT-PA) therapy on post-stroke depression (PSD) in stroke patients. Methods : Fifteen PSD patients has been recruited and evaluated with liver function test (LFT) and renal function lest (RFT) and depression scales, Beck Depress ion Inventory (BDI) and Hamilton Depression Rating Scale (HAM-D) before and after HHT-PA treatment. Results : HAM-D score significantly decreased after HHT-PA treatment regard less of improving of motor function. But BDI score did not decrease significantly. All results of LFT and RFT were in normal range before and after HHT-PA treatment Conclusion : These results showed that HHT-PA decrease PSD symptoms and has safety on stroke patients, although has no effect on improving of motor impairment.

• Journal of Pharmacopuncture
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• v.17 no.2
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• pp.27-33
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• 2014

Objectives: The main objective of this study was to evaluate the anti-depressant effects of pharmacopuncture using sumsu (Bufonis venenum). Methods: Animals were divided into three groups (control, sham, and experimental), with eight mice per group. The sham and the experimental groups were exposed to 2 hours of immobilization stress daily for 14 days. They were also injected with normal saline (sham) or subjected to pharmacopuncture with sumsu at the acupoints HT7, SP6, and GV20 (experimental). The depression or anxiety-like behaviors of the mice in each group were evaluated 1 day after treatment. Results: There was no difference in locomotor activity between the groups during the open-field test; i.e., all groups had normal motor function. However, the open-field and the forced-swimming tests revealed that depression and anxiety-like behaviors were decreased significantly in the group treated with sumsu pharmacopuncture. Conclusion: Sumsu pharmacopuncture attenuated depressive or anxiety-like behavior in mice stressed with chronic immobilization. These results suggest that sumsu pharmacopuncture has therapeutic potential for treating neuropsychiatric disorders such as anxiety or depression disorder.

• Journal of Acupuncture Research
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• v.26 no.6
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• pp.41-49
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• 2009

Objectives : This study was designed to evaluate the effect of Soyeom Pharmacopuncture on postauricular pain accompanied acute peripheral facial paralysis. Methods : We observed thirty peripheral facial palsy inpatients with postauricular pain at Cheonan oriental hospital of Daejeon university from Jan. 1st, 2009 to July 31th, 2009. These inpatients were divided into two groups; Group A was treated using general treatment and Group B was treated using general treatment and Soyeom Pharmacopuncture on the posterior ear area. Results : 1. Postauricular pain was significantly decreased in Group B. 2. Duration of postauricular pain was significantly reduced in Group B. 3. Improvement of facial paralysis was not significantly different between Group A and Group B. Conclusions : Soyeom Pharmacopuncture has significant effects on a postauricular pain accompanied with peripheral facial paralysis.

• Journal of Pharmacopuncture
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• v.14 no.1
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• pp.97-104
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• 2011

Objective : This study is to report the effect that taken by using oriental treatment on the patient with Fibromyalgia Syndrome(FMS). Methods : We have observed this case of patient treated by Acupuncture therapy, pharmacopuncture therapy and herbal medication. Results : There was improvement in condition of the patient who had Fibromyalgia Syndrome(FMS) after treated by using oriental treatment. Conclusion : Oriental treatments such as Acupuncture therapy, Pharmacopuncture therapy and herbal medication can be effective for the Fibromyalgia Syndrome(FMS).

• Journal of Pharmacopuncture
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• v.24 no.4
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• pp.206-212
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• 2021

The aim of this study was to report on the improvement of shoulder pain resulting from disorders of the rotator cuff such as impingement syndrome and adhesive capsulitis, by manual acupuncture (MA) and pharmacopuncture (PA) following origin/insertion technique (OIT) of applied kinesiology (AK). Two patients were treated with MA and PA after OIT on shoulder muscles. The Numerical Rating Scale and the assessment of the Japanese Orthopedic Association scores were used to assess the pain, and ultrasound images were taken to compare treatment outcome. This study showed that MA and PA following OIT may be an effective treatment for impingement syndrome and adhesive capsulitis.

• The Journal of Korean Medicine
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• v.44 no.1
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• pp.117-127
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• 2023

Objectives: The purpose of this study is to report the effect of hominis placenta pharmacopuncture and chuna manual therapy in patients with frozen shoulder. Methods: Frozen shoulder was treated with hominis placenta pharmacopuncture and chuna manual therapy, and the overall shoulder pain was measured by visual analog scale (VAS), and the range of motion (ROM) of shoulder movement was evaluated by measuring passive abduction and external rotation and active hand to shoulder blade test. Results: After the treatment, overall shoulder pain was reduced, and ROM of passive abduction and external rotation was increased. Conclusions: The above results show that hominis placenta pharmacopuncture and chuna manual therapy can be used as an effective treatment for frozen shoulder.