• Journal of Acupuncture Research
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• v.32 no.1
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• pp.23-36
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• 2015

Objectives : This study was designed to investigate the neuroprotective effects of Hominis-Placenta (HP)on dopaminergic neurons. Methods : We examined the effect of invitro administration of HP against 1-methyl-4-phenylpyridinium( MPP+)-induced dopaminergic cell loss in primary mesencephalic culture and also used behavioral tests and performed analysis in the striatum and the substantia nigra of mouse brain, to confirm the effect of HP on dopaminergic neurons in an invivo 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced PD mouse model. Animals were assigned to four groups: (1) Group 1(vehicle-treatedgroup), (2) Group 2(MPTPonlytreated group), (3) Group 3(MPTP+ saline-treated/$ST_{36}$ group), and (4) Group 4(MPTP+HP-treated/$ST_{36}$ group). HP at $20{\mu}L$ of 48 mg/kg dose was injected at $ST_{36}$ for 4 weeks at 2-day intervals. MPTP in saline was injected intraperitoneally each day for 5 days from the $8_{th}$ treatment of HP. We performed the pole test and rota-rod test on the first and seventh day after the last MPTP injection. To investigate the effect of HP on dopaminergic neurons, we performed analysis in the striatum and the substantia nigra of mouse brain after treatment with HP and/or MPTP. Results : Treatment with HP had no influence on cell proliferation and caused no cell toxicity in $PC_{12}$ and $HT_{22}$ cells. Our study showed that HP significantly prevented cell loss and protected neurites against MPP+ toxicity. Although the invivo treatment of HP herbal acupuncture at $ST_{36}$ showed a tendency to improve movement ability and protected dopaminergic cells and fibers in the substantia nigra and the striatum, it did not show significant changes compared with the MPTP treated group. Conclusions : These data suggest that HP could be a potential treatment strategy in neurodegenerative diseases such as Parkinson's disease.

• The Journal of Internal Korean Medicine
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• v.40 no.5
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• pp.901-911
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• 2019

Objective: The aim of this case report is to describe three clinical cases that indicate positive effects of traditional Korean medicine for the treatment of acute headache attributed to whiplash injury. Method: Three patients were treated with a series of Korean medicine treatment, including Chuna treatment, acupuncture, pharmacoacupuncture, and herbal medicine, during the inpatient treatment period. Results: All patients showed decreases in the numerical rating scale (NRS) and headache impact test (HIT) scores. Conclusion: Traditional Korean medicine has potential benefits for the treatment of acute headache attributed to whiplash injury.

• Journal of Korean Traditional Oncology
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• v.21 no.1
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• pp.15-25
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• 2016

Objective : The purpose of this study is to report the possibility of treatment of Cancer of Unknown Primary Site (CUPS) patient with Traditional Korean Medicine based Samchilchoongcho-jung and Gunchilgyebok-Jung following chemotherapy. Methods : The patient is a female, who was diagnosed with CUPS, suffering from left flank pain, abdominal discomfort, nausea, vomiting and fatigue after chemotherapy. The patient was treated with acupuncture, pharmacoacupuncture, moxibution, herbal medicine and enema used with herbal decoction for 15 days. The clinical outcomes were measured by numeric rating scale(NRS). Results : After treatment, left flank pain had disappeared and nausea and vomiting was decreased from NRS 4 to NRS 1 respectively. Fatigue was also improved. Conclusion : This case study suggests that Traditional Korean Medicine is effective for treatment of CUPS patients and can improve the quality of life.

• Journal of Pharmacopuncture
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• v.20 no.4
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• pp.280-286
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• 2017

Objective: This case series aims to report the efficacy and the safety of using snake venom pharmacopuncture (SVP) for chemotherapy-induced peripheral neuropathy (CIPN). Methods: Three heterogeneous cancer (1 endometrium, 1 cervix, and 1 prostate cancer) patients were referred to the East-West Cancer Center (EWCC), Dunsan Korean Medicine Hospital of Daejeon University, from August 02, 2017, to September 15, 2017, for treatment with SVP, and they were treated with SVP 4 times, 6 times, and 8 times, respectively. During the treatment period, the efficacy of SVP therapy was assessed by using the Numerical Rating Scale (NRS) and the Common Terminology Criteria for Adverse Events (CTCAE), and the stability was evaluated by using blood tests. Following each session, all patients were examined closely for any allergenic responses or adverse effects. Results: All patients showed noticeable improvements of their NRS and CTCAE scores. Except for bleeding and bruising at the SVP injection site, no major side effects were noted. One of the patients reported mild chilling and a sore throat after receiving the second treatment; those symptoms went away after a few hours. No hematologic toxicity, hepatotoxicity, or nephrotoxicity was found on the blood test. Conclusion: The results of this research suggest positive potential benefits of using SVP for treating patients with CIPN. Also, the excellent safety results of SVP seen in this research should lead to larger clinical trials aimed at developing SVP into a potential intervention for managing patients with the symptoms of CIPN.

• The Journal of Internal Korean Medicine
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• v.42 no.5
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• pp.939-948
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• 2021

Objectives: This study considered the effectiveness of Korean medicine for the treatment of eyelid edema post craniotomy. Methods: The patient was diagnosed with Taeumin-one of the four constitution types in Korean medicine-and treated with herbal medicines: Cheongsimyeunja-tang, Chungpyesagan-tang, and Hwangryunhaedok-tang pharmacoacupuncture treatment. The severity of eyelid edema was assessed using Kara and Gokalan's scale, daily imaging of the patient's eyelids, and the ratio of the length of the left eye to that of the right. Results: Following treatment, the Kara and Gokalan score decreased from 3 to 0. The changes in the ratios were 29% and 50%, respectively. The visual field defect due to edema in the left eye was also repaired. Conclusion: This study suggests that Korean medical treatment could be an effective option for treating eyelid edema following craniotomy.

• Korean Journal of Acupuncture
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• v.39 no.3
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• pp.107-113
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• 2022

Gastrocnemius muscle partial rupture is a common muscle injury. This case is report on a patient with a gastrocnemius muscle partial rupture who was continuously observed with ultrasonography while receiving Korean medicine treatment. Acupuncture, pharmacoacupuncture, herbal medicine, physical therapy and rehabilitation treatment were performed on a patient diagnosed with gastrocnemius partial rupture. The improvement of symptoms was evaluated using Numeric Rating Scale (NRS), Range of Motion (ROM) of ankle, circumference of calf and size of hematoma by using ultrasonography. NRS decreased more than 90%, ROM of ankle joint gradually improved, calf circumference improved, and hematoma reduced by more than 90% when measured by ultrasonography. In this study, gastrocnemius muscle partial rupture was observed with ultrasonography, and it is considered that the Korean medical treatment is useful for gastrocnemius muscle partial rupture.

• The Journal of Churna Manual Medicine for Spine and Nerves
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• v.14 no.2
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• pp.101-111
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• 2019

Objectives : The purpose of this study was to report five patients with a sternum fracture after a traffic accident who improved with a combination of Korean medicine treatments. Methods : We collected data of traffic accident patients with a sternum fracture who were admitted to Dae-Jeon Jaseng Korean Medicine Hospital from March 2019 to September 2019. We observed five cases of patients treated with acupuncture, pharmacoacupuncture, herbal medicine, and Korean physical therapy. We measured the validity of the treatments using the Numeric Rating Scale (NRS) and European Quality of Life-5 Dimension (EQ-5D) at admission, at two weeks, and on the discharge date of hospitalization. Results : Following treatment using a combination of the above mentioned methods, the general overall condition of the patients had significantly improved. Furthermore, the NRS and EQ-5D scores were numerically better. Conclusions : After the combination of Korean medicine treatments, results from five patients with a sternum fracture after a traffic accident suggested that the treatments were effective. However, the number of subjects was insufficient and individual efficacy was not measured in this study. Therefore, further studies are needed on this topic.

• The Journal of Churna Manual Medicine for Spine and Nerves
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• v.14 no.2
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• pp.113-122
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• 2019

Objectives : The purpose of this clinical study was to evaluate the effect of spinal decompression with Korean medicine treatment on the herniation of an intervertebral disc (HIVD) in a patient after fusion surgery of a cervical segment. Methods : A single patient was treated with spinal decompression, acupuncture, pharmacoacupuncture, and herbal medication. We measured the Numerical Rating Scale (NRS), Neck Disability Index (NDI), European Quality of Life-5 Dimension (EQ-5D), Cervical Range of Motion (cervical ROM) and the Beck Depression Inventory (BDI) score to evaluate the treatment effects. Results : The patient's post neck pain & pain in both arms improved significantly as suggested by the scores on the NRS, NDI, EQ5D, cervical ROM and BDI. Conclusions : Thus, spinal decompression, including Korean medicine treatment, could be taken into consideration for HIVD patients after fusion surgery.

• The Journal of Internal Korean Medicine
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• v.39 no.5
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• pp.994-1003
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• 2018

Objective: The aim of this study was to report a clinical case suggesting the potential effects of traditional Korean medicine for the treatment of sporadic spinocerebellar ataxia in a patient with herniated intervertebral lumbar discs. Methods: The patient was treated with a series of Korean medicine treatments including the herbal medicine Zhenganxifeng-tang-gagam, acupuncture, pharmacoacupuncture, and electroacupuncture along with herniated intervertebral lumbar disc treatments. Results: Improvements of Numeric rating scale (NRS) and European Quality of Life-5 Dimensions (EQ-5D) score were observed after the treatment. Conclusion: Traditional Korean medicine has potential benefits for sporadic spinocerebellar ataxia patients with herniated intervertebral lumbar discs.

• Korean Journal of Acupuncture
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• v.35 no.4
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• pp.239-246
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• 2018

Objective : This case study reports the therapeutic effect of Korean Medicine (KM) treatments including CS(care special pain) and BV(bee venom) pharmacopuncture on herniated intervertebral disc(HIVD) of lumbar spine(L-spine). Methods : Two patients diagnosed with HIVD of L-spine were treated with CS and BV pharmacopuncture on GV3 and EX-B2, acupuncture, cupping, and herbal medicine. The Numeric Rating Scale(NRS), the Oswestry low back pain Disablility Index(ODI) and the Roland Morris Disability Questionnaire(RMDQ) scores were evaluated before and after treatment for comparison. Results : Low back pain(LBP) and radiating pain was improved with a decrease in patients' NRS, ODI and RMDQ scores. Conclusion : These results suggest that KM treatments including combined CS and BV pharmacopuncture could be an effective treatment on patients with HIVD of L-Spine.