• 대한임상독성학회지
• /
• 제6권2호
• /
• pp.83-90
• /
• 2008

Organophosphate (OP) pesticides are the most common source of human toxicity globally, causing high mortality and morbidity despite the availability of atropine as a specific antidote and oximes to reactivate acetylcholinesterase. The primary toxicity mechanism is inhibition of acetylcholinesterase (AchE), resulting in accumulation of the neurotransmitter, acetylcholine, and abnormal stimulation of acetylcholine receptors. Thus, the symptoms (muscarinic, nicotinic, and central nervous system) result from cholinergic overactivity because of AchE inhibition. OP can also cause rhabdomyolysis, pancreatitis, parotitis, and hepatitis. OP therapy includes decontamination, supportive therapy, and the use of specific antidotes such as atropine and oximes. However, there has been a paucity of controlled trials in humans. Here we evaluated the literature for advances in therapeutic strategies for acute OP poisoning over the last 10 years.

• 대한임상독성학회지
• /
• 제19권1호
• /
• pp.59-63
• /
• 2021

Copper sulfate is widely used as a fungicide and pesticide. Acute copper sulfate poisoning is rare but potentially lethal in severe cases. Copper sulfate can lead to cellular damage of red blood cells, hepatocytes, and myocytes. Toxic effects include intravascular hemolysis, acute tubular necrosis and, rhabdomyolysis. A 76-year-old man presented with vomiting and epigastric pain. He had ingested a copper-containing fungicide (about 13.5 g of copper sulfate) while attempting suicide 2 hours prior to presentation. From day 3 at the hospital, laboratory findings suggesting intravascular hemolysis were noted with increased serum creatinine level. He was treated with a chelating agent, dimercaptosuccinic acid (succimer). His anemia and acute kidney injury gradually resolved with a 19-day regimen of succimer. Our case suggests that succimer can be used for copper sulfate poisoning when other chelating agents are not available.

• 농촌의학ㆍ지역보건
• /
• 제29권2호
• /
• pp.265-285
• /
• 2004

이 연구는 농약의 노출에 의해 중추신경 증상이 발생할 수 있으며, 장기간의 농약노출로 인해 중추신경계 영향이 있을 것이라는 가설을 검정하기 위해 농약 누적노출을 추정하였으며, 농약 노출 관련 요인에 따라 신경독성증상 호소의 차이를 보았다. 연구결과는 다음과 같다. 지난 1년 동안 농약살포시간은 과수농민 69.6시간, 밭농민 41.1시간, 축산농업인 25.8시간으로 통계적으로 유의한 차이가 있었으며, 누적노출지수는 과수농민 119.5g, 밭농민 63.9g, 축산농업인 23.7g으로 통계적으로 유의한 차이가 있었다(p<0.01). 누적노출지수에 의해 분류하면, 과수농민은 고노출군, 밭농민은 중간노출군. 축산농민은 저노출군에 해당하였다. 과거 농약중독 경험률은 과수농민 40.7%, 밭농민 35.1%, 축산농민 23.8%로 통계적으로 유의한 차이가 있었으며 (p<0.001), 지난 3개월 동안 농약중독 증상 경험률은 과수농민 67.2%, 밭농민 55.3%, 축산농민 20.5% 순으로 통계 적으로 유의한 차이가 있었다(p<0.001). 신경독성 자각증상의 총점과 6개 이상 증상을 호소하는 경우는 대조군 및 축산농민에 비해 밭농민 및 과수농민에서 유의하게 증가하였다(p<0.001). 연령, 교육수준, 성, 흡연, 음주를 보정한 상태에서도 6개 이상 신경독성 증상 발생의 교차 비는 비노출군에 비해 과수농민이 3.08(95% CI 1.50-6.30)배, 누적노출지수가 75% 이상 높은 군이 2.75(958% CI 1.12-6.78) 배, 과거 농약중독 경험이 있는 경우 1.97(95% CI 1.21-3.20)배, 현재 농약중독증상을 경험한 경우 정상군에 비해 경도 중독군 3.03(95% CI 1.47-6.22)배, 중등도 중독군이 6.34(95% CI 3.03-13.25)배 높게 나타났다. 이상의 결과로 볼 때, 신경독성증상의 발생에 일관되게 농약노출과 관련된 요인이 유의하게 나타나고, 농약노출이 높은 것으로 평가된 과수농민에서 중추신경계 증상 호소가 유의하게 녹게 나타나 만성 농약노출에 의해 중추신경계 영향이 발생할 가능성이 제기된다.

• 한국양봉학회지
• /
• 제32권4호
• /
• pp.295-302
• /
• 2017

Avoidance behavior is an important life history strategy to survive hazardous environment. The experiment was conducted to detect the avoidance tendency of the honeybee Apis mellifera against commonly used pesticides in apple production. Choice test given only 50% sucrose solution and pesticide-mixed sucrose solution as food estimated the avoidance in laboratory. Most of the acaricides and fungicides tested were shown avoided. Among insecticides, honeybee showed strong avoidance to cyhexatine, carbosulfan and fenpyroximate but low to diflubenzuron, tebufenpyrad, and acrinathrin. Avoidance behavior to neonicotinoid insecticides showed bifurcated; highly avoided from thiacloprid, acetamiprid while less avoided from imidacloprid, thiamethoxam and dinotefuran. From the field study, abamectin, fenthion, amitraz and acequinocyl showed highly avoided while fungicide of fenarimol, acaricides of acrinathrin and phosphamidon, IGR insecticide of diflubenzuron, neonicotinoid insecticide of imidacloprid, and carbamate insecticide of carbaryl showed less avoidance in the field. These results partly explained high bee poisoning from carbaryl in apple flowering period, and neonicotinoids during season.

• 로봇학회논문지
• /
• 제15권2호
• /
• pp.115-123
• /
• 2020

Farmers using conventional sprayer system are exposed to pesticide poisoning and soil pollution due to pesticide application. In order to reduce this problem, the effective sprayer system is required. In this paper, we propose development of intelligent sprayer system using tree recognition. This intelligent sprayer system consists of an image recognition module, a remote control, a sprayer system, an air blower, and a control module. It is possible to spray pesticides automatically and manually through remote control using cameras and controls. We conducted a total of four experiments in tree recognition experiment, test of attachment and water sensitive papers, measurement of pesticide consumption, and measurement of worker exposure. The test results showed that the consumption of pesticides could be reduced while giving the same effect as conventional controls.

• 농촌의학ㆍ지역보건
• /
• 제22권1호
• /
• pp.35-41
• /
• 1997

본 조사는 농민들의 농약사용실태와 농약사용으로 인해 야기되는 건강문제를 파악하므로써 이에 대한 예방대책과 개선방법 마련을 목적으로 보건진료소 관할지역내 거주하는 279가구중 100가구를 무작위추출하여 가구주를 대상으로 면접 설문조사한 결과 다음과 같은 결과를 얻었다. 농약의 종류를 선택할 때 과거의 경험에 의존하는 경우가 43.0%, 농약판매소의 권장으로 36.0%로 나타났다. 농약사용시 안전수칙에 대한 교육을 받은 대상자는 전체의 90%이며, 교육받은 기관은 농촌지도소 87.8% 보건진료소 84.4% 농약판매소 53.3% 농협 41.1% 순이었다. 교육을 받은 대상자보다 교육을 받지 않은 대상자의 농약중독 경험이 80.0%로 더 높았다. 교육후 지식이나 태도의 변화에 도움이 되었다가 78,9%로 나타났다. 안전수칙 10개항목 중 6가지이상 지킨다 76%, 그 이하가 24%로 나타났으며 6가지 이상 이행한 대상자의 중독경험은 63.2%로 5가지 이하 이행한 대상자의 중독경험 83.3%보다 낮았다. 이 중 사전에 설명서를 매번 읽는다는 25%, 가끔 읽는다 58%, 전혀 읽지 않는다 17%로 나타났으며 매번 읽는 경우가 가끔 읽거나 전혀 안읽는 경우의 중독경험(70.0%) 보다 64.4%로 낮았다. 안전수칙 불이행시 가장 흔히 경험한 신체증상으로 두통 80.9%, 현기증 73.5%, 피부질환 64.7%, 구토 41.2% 순이었다. 농약중독경험은 68.0%에서 나타났으며 60세이상 노인층에서 88.9%의 높은 중독경험을 보였다. 1회 농약 살포시간은 2시간 이내 64.0%, 2시간 이상 살포자 36%이며, 2시간 이상 농약살포후 중독경험은 77.8%였다. 보호장비 착용과 중독경험은 92.0%가 완전한 복장을 갖추지 않았고 완전한 보호장비를 착용한 경우도 62.5% 중독경험을 한 것으로 나타났다. 농약의 보관은 주로 창고나 헛간등에 보관하거나 자물쇠 없는 보관함에 관리하고 있었다. 농약사고의 원인중 보관불량으로 노인, 유아가 잘못 먹거나 만취에 의한 오음, 농약사용후의 관리불량이 전체의 21.9%를 차지하는 것으로 볼 때 불의의 사고를 예방하기 위해서 농약은 자물쇠 있는 보관함의필요성이 요구된다.

• 농약과학회지
• /
• 제5권4호
• /
• pp.57-61
• /
• 2001

영농에서 노동력 절감을 위해 $2{\sim}3종$ 농약을 혼용하여 살포하는 것은 흔한 농약살포 방법이다. 과수 재배시 널리 사용되고있는 4종 살충제의 상호혼합 및 혼용이 인체에 미치는 영향을 구명하고 안전성을 확보할 목적으로 급성독성시험, 유기인계 및 카바메이트계 농약의 주 저해효소인 콜린에스테라제의 활성에 미치는 영향을 평가하였다. 포스팜액제, 디디브이피 유제, 피레스 유제 및 푸라치오카브 유제의 단제 및 혼합제에 대한 급성독성 및 콜린에스트라제의 활성에 미치는 영향을 시험한 결과 포스팜 액제 및 디디브이피 유제의 급성경구독성 $LD_{50}$은 랫드에서 각각 30 mg/kg, 93 mg/kg로 고독성이었으며 나머지는 보통독성이었다. 혼합에 의한 급성경구 및 경피독성 시험결과, $LD_{50}$이 이론치보다 $0.29{\sim}1.0$ 배정도 낮은 상승독성이 발현되었다. 혼용에 의한 급성경구독성 시험결과 포스팜+디디브이피 조합의 경우, $LD_{50}$이 16 mg/kg로 맹독성 농약으로 구분되었으며, 그 외의 조합은 모두 고독성 농약으로 구분되었다. 급성경피독성시험의 경우도 경구와 동일한 결과로 독성발현이 전체적으로 상승되었다. 농약의 혼합에 의한 혈장내 cholinesterase 의 $ID_{50}$의 변화는 약제처리 30분에는 이론치보다 현저한 효소억제가 인정되었으나, 60분에는 이론치와 큰 차이가 없었다.

• 대한임상독성학회지
• /
• 제14권2호
• /
• pp.83-91
• /
• 2016

Purpose: This study was conducted to investigate the incidence, associated factors and clinical impact of hyperamylasemia in self-poisoning patients. Methods: This study was based on a toxicology case registry of patients treated from 2009 to 2013 at a tertiary care university hospital. We retrospectively investigated the demographics, clinical variables, laboratory variables and intoxicants. Hyperamylasemia was defined as an elevation in serum amylase level to above the upper normal limit within 24 hours after admission. We analyzed the predisposing factors and clinical outcomes of patients in the hyperamylasemia group. Results: Hyperamylasemia was identified in 49 (13.3%) of the 369 patients. Using multivariate logistic regression, the odds ratios for HA were 3.384 (95% confidence interval, 1.142-8.013, p=0.014), 3.261 (95% confidence interval, 1.163-9.143, p=0.025) and 0.351 (95% confidence interval, 0.154-0.802, p=0.013) for pesticides, multi-drug use and sedatives, respectively. In the hyperamylasemia group, the peak amylase levels during 72 hours were correlated with the peak lipase levels (r=0.469, p=0.002) and peak aspartate aminotransferase levels (r=0.352, p=0.013). Finally, none of these patients had confirmed acute pancreatitis. Conclusion: Hyperamylasemia occurred rarely in these self-poisoning patients, and pesticide and multi-drug use were independent predictors of hyperamylasemia. Peak amylase levels were correlated with the peak lipase and aspartate aminotransferase levels.

• 대한수의학회지
• /
• 제48권2호
• /
• pp.131-137
• /
• 2008

Pesticides are extensively used for the control of crop pests in agriculture and forestry. Organophosphate (OP) and carbamate pesticides are especially effective for the control of a variety of harmful insects. However, these cholinesterase inhibitors are also dangerous to non-target organisms (wildlife and other animals) because of their high acute toxicity. Most poisonings by pesticides occur as a result of misuse or accidental exposure, but intentional killing of unwanted animals also occurs. At the request of a local autonomous entity, we investigated wild bird poisonings by pesticides from 2003 to 2007. The 207 suspicious samples of pesticide poisoning based on the necropsy were analyzed by GC/NPD, GC/FPD, or GC/MSD. We looked for trends in the identification of pesticides in wild birds thought to have died from poisoning. Pesticides were determined in 59% of the total samples analyzed. Phosphamidon and monochrotophos were the most common pesticides identified, which amounted to 77% of the subtotal. Other OP and carbamate pesticides were also found in various concentrations from dead wild birds. The determined rates of pesticides were as high as 86% and 76% in 2003 and 2006, respectively, during an outbreak of avian influenza in Korea.

• 대한임상독성학회지
• /
• 제7권2호
• /
• pp.83-89
• /
• 2009

Purpose: Rhabdomyolysis is one of the most important complications of pesticide intoxication. It affects a patient's clinical prognosis and can cause acute renal failure. It is important that patients diagnosed with pesticide intoxication receive an accurate initial diagnosis and proper treatment to prevent significant complications. This study's objective was to investigate and confirm related factors causing acute renal failure by verifying clinical observations and laboratory findings collected following pesticide intoxication. Methods: A retrospective analysis was made of 734 patients who presenting to our emergency medical center after ingesting pesticides between January 2006 and December 2008, Of these, 513 patients were selected for the study. Two hundred and twenty-one patients were excluded because of paraquat intoxication, age (if under 18), or chronic renal failure. Seventy-four patients were diagnosed with rhabdomyolysis, based on serum creatinine phosphokinase levels were > 1,000U/L. Acute renal failure was diagnosed when creatinine levels were > 2.0 mg/dL. Results: Among the 74 patients diagnosed with rhabdomyolysis, 26 (35.1%) experienced acute renal failure. The most meaningful related factor in the prediction of acute renal failure was initial arterial pH and creatinine level. Conclusion: Initial arterial pH and creatinine level are predictors of complications such as acute renal failure in patients with rhabdomyolysis.