• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1993년도 한국자동제어학술회의논문집(국내학술편); Seoul National University, Seoul; 20-22 Oct. 1993
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• pp.330-335
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• 1993

This paper presents an efficient solution for a class of forbidden state problems by introducing a cyclic timed controlled marked graphs (TCMG's), a special class of timed controlled Petri nets (TCPN's) as a model of a class of discrete event systems (DES's). The state feedback control is synthesized, which is maximally permissive while guaranteeing the forbidden states will be avoided. The practical applications or tire theoretical results for an automated guided vehicle (ACV) coordination problem in a flexible manufacturing facility is illustrated.

• 대한가정학회지
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• 제41권8호
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• pp.123-137
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• 2003

The purpose or this study was to examine the effect or maternal parenting experience, mediated by maternal depression, marital conflict, and parenting behavior, on school children's maladjustment. The theoretical model was specified and estimated. Subject of this study consisted of 637 mothers having elementary students(from 5th to 6th grade) drawn from 4 elementary schools in Cheong-ju city. Maternal parenting experience in childhood had an indirect effect on school children's maladjustment mediated by maternal depression. Maternal permissive parenting experience had more strong relationship with maternal depression rather than authoritative parenting behavior. Maternal depression, marital conflict, parenting behavior were directly effected on school children's maladjustment. Maternal depression were significantly effected on children's maladjustment indirectly mediated by marital conflict and parenting behavior Maternal depression was the most important factor predicting marital conflict, parenting behavior, and school children's Maladjustment.

• 한국지역사회생활과학회지
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• 제17권4호
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• pp.127-135
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• 2006

This study investigated differences of opinion between youth and their parents about having permission to date. Opinions on youth dating permission was gathered from 150 adolescents and their parents. The results were as follows: first, for adolescents there were significant differences of opinion about youth dating permission depending on gender, age, scholastic record, and birth order, but for parents, the difference related to the gender and age of adolescents. Second, the result indicated that adolescents had a greater acceptance of dating permission than their parents, expressing a generational difference. Third, where the scholastic record of subjects was low, where subjects were non-eldest siblings, and where the parents' level of youth dating permission was high, the level of youth dating permission was higher. A main predictor of youth's level of dating permission was the level of the parents about youth dating.

• Biomolecules & Therapeutics
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• 제22권4호
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• pp.308-313
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• 2014

Activator protein-1 (AP-1) is an inducible transcription factor that contributes to the generation of chronic inflammation in response to oxidative and electrophilic stress. Previous studies have demonstrated that the PI3K/Akt1 pathway plays an important role in the transcriptional regulation of AP-1 expression. Although the histone post-translational modifications (PTMs) are assumed to affect the AP-1 transcriptional regulation by the PI3K/Akt pathway, the detailed mechanisms are completely unknown. In the present study, we show that heterochromatin 1 gamma ($HP1{\gamma}$) plays a negative role in TPA-induced c-Jun and c-Fos expression. We show that TPA-induced Akt1 directly phosphorylates $HP1{\gamma}$, abrogates its suppressive function and increases the interaction between histone H3 and 14-3-$3{\varepsilon}$. Collectively, these our data illustrate that the activation of PI3K/Akt pathway may play a permissive role in the recruitment of histone readers or other coactivators on the chromatin, thereby affecting the degree of AP-1 transcription.

• 한국식물생명공학회:학술대회논문집
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• 한국식물생명공학회 2005년도 추계학술대회 및 한일 식물생명공학 심포지엄
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• pp.197-197
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• 2005

• 아동학회지
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• 제29권2호
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• pp.33-56
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• 2008

This study examined effects on children's emotional expressiveness and regulation strategies or maternal attitudes and emotional expressiveness. Participants were 180 children(88 girls) age 3-5, their mothers, and 20 teachers. Results showed boys used more aggressive and girls used more positive coping strategies. Younger children used more aggressive and non-expressive strategies. When mothers had more Permissive and Accepting attitudes, children used more positive coping strategies. When mothers had more Restrictive or Controlling attitudes, children used more aggressive strategies. When mothers expressed positive emotions, children used fewer aggressive and venting strategies. When mothers expressed negative emotions, children used more aggressive and fewer positive coping and non-expressive strategies. Negative maternal emotional expressiveness was an especially influential factor on children's emotional regulation strategies.

• 대한가정학회지
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• 제42권3호
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• pp.159-178
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• 2004

The purpose of this study was to investigate the effect of sexual messages in the media on adolescents' attitudes and behaviors toward sex. Subjects of this study consisted of 488 high school students in Cheong-ju City. The findings of this study were as follows; First, sexual messages in the media influenced-adolescents' attitudes toward sex. The more exposure to sexual messages adolescents had more liberal and permissive attitude toward sex. Secondly, sexual messages in the media also effected adolescents' behaviors toward sex, as well. The less sexual messages that they were exposed to, they displayed less sexual relations and behavior. In particular, the number of sexual materials in mass media, variety of sexual messages, and types of school were significant factors in predicting adolescents' sexual intercourse. The research suggested that sexual messages in the media definitely had an effect on adolescents' attitudes and behaviors toward sex. Therefore, it should be encouraged to take advantage of the television V chip and screening software for computers to reduce inappropriate access for adolescents.

• Journal of Microbiology
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• 제35권3호
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• pp.228-233
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• 1997

The MTF1 gene of Saccharomyces cerevisiae encodes a 43 kDa MITOCHONDRIAL RNA polymerase specificity factor which recognizes mitochondrial promoters to initiate correct transcription. To better understand structure-function of the MTF1 gene as well as the transcription mechanism of mitochondrial RNA polymerase, two cold-sensitive alleles of the MTF1 mutation were isolated by plasmid shuffling method after PCR-based random mutagenesis of the MTF1 gene. The mutation sites were analyzed by nucleotide sequencing. These cs phenotype mtf1 mutants were respiration competent on the nonfermentible glycerol medium at the permissive temperature, but incompetent at 13.deg.C. The cs phenotype allele of the MTF1, yJH147, encoded an L146P replacement. The other cs allele, yJH148, contained K179E and K214M double replacements. Mutations in both alleles were in a region of Mtflp which is located between domains with amino acid sequence similarities to conserved regions 2 and 3 of bacterial s factors.

• IMMUNE NETWORK
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• 제20권3호
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• pp.24.1-24.14
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• 2020

Eosinophils are terminally differentiated cytotoxic effector cells that have a role in parasitic infections and allergy by releasing their granule-derived cytotoxic proteins. However, an increasing number of recent observations indicate that eosinophils are not only associated with the pathogenesis of a wide range of diseases, but also contribute to the maintenance of homeostatic responses in previously underappreciated diverse tissues, such as the gastrointestinal (GI) tract and adipose tissue. In this review, we describe biological characteristics of eosinophils, as their developmental properties, permissive proliferation and survival, degranulation activity, and migration properties enable them to distribute to both homeostatic and inflamed tissues. We describe pathologic aspects of eosinophils with a role in asthma and in various GI diseases, including eosinophilic GI disorders, inflammatory bowel disease, and radiation-induced enteropathy. Finally, we discuss the beneficial role of eosinophils, which contribute to the resolution of pathogenic conditions and to the modulation of homeostatic biologic responses.

• 미생물학회지
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• 제27권3호
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• pp.176-180
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• 1989

E. coli의 $tRNA^{phe}$내에는 세 개의 psiudouridine 염기들이 존재한다. 이 $tRNA^{phe}$내의 pseudouridine 염기들의 기능을 연구하기 위하여 부위특이적 돌연변이를 이용하여 $tRNA^{phe}$ 유전자의 염기를 다른 염기로 치환시켰다. E. coli $tRNA^{phe}$ 유전자들 중 하나인 phe W 유전자내에서 32번에 해당하는 T 염기를 C 염기로 39번 T 염기를 C 염기로 Kunkel이 개발한 부위특이적 돌연변이 방법을 사용하여 각각 치환시켰다. DNA 염기서열을 결정함으로써 돌연변이체를 확인하였으며, 이들 돌연변이 유전자를 함유한 재조합 플라스미드를 이용하여 돌연변이된 phe W 유전자들의 E. Coli NP37($pheS^{-ts}$)에 대한 complementation 활성을 조사하였다. 32번 위치가 변이된 pheW 유전자 뿐만아니라 39번 위치가 변이된 phe W 유전자를 함유한 E. coh NP37들은 모두 non-permissive temperature에서 자라지 못하였다. 이 결과는 변이된 pheW 유전자들이 E. coli NP37을 complementation 할 수 없으며, 또 pseudouridine 염기들이 생체내에서 E. coli $tRNA^{phe}$의 활성에 필수적이라는 것을 의미한다.