• Pediatric Infection and Vaccine
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• v.4 no.2
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• pp.288-292
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• 1997

Malaria is a febrile disease caused by protozoan parasites, genus Plasmodium. In Korea., indigenous malaria has been believed to be eradicated by 1984, and, thereafter, all of the reported cases were imported malaria. But since the first case report of re-emerging indigenous malaria in 1993, increasing number of cases were reported reaching more than 350 cases in 1996. However, indigenous malaria in children has not been reported yet. We experienced two cases of indigenous malaria in sisters who were 7 and 5 years old, respectively. Elder sister was presented with periodic fever, splenomegaly and mild headache. She had been to Guam before 4 months of the onset of symptoms. Younger sister was suffered from fever and splenomegaly and has not been abroad. They were diagnosed by examination of peripheral blood smear to be infected with Plasmodium vivax and were treated with hydroxychloroquine and primaquine successfully. These cases are believed to be first re-emerging cases of indigenous malaria in children, and malaria should be included in the differential diagnosis of unexplained febrile children.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2021.10a
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• pp.474-477
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• 2021

Recently, in order to prevent the proliferation of COVID-19, which began in earnest in 2020, an increasing number of places have been measuring the temperature and required to wear a mask. However, as wearing a mask and checking the temperature are typically measured directly by a person or by a single individual positioned in front of the machine, standards may vary based on the person's manual measurement method, wasting workforce. While standing in front of a device often measures the maximum temperature of the face, the standard of fever is also unclear. Both approaches can create bottleneck situations when checking large numbers of people. Furthermore, it is unable to conduct periodic measurements and tracking because the measuring machines are generally put only at the entrance. Thus, this study suggests a method for preventing the spread of infectious diseases by automatically identifying and displaying unmasked people and those with fever in real-time using a general camera, a thermal imaging camera, and an artificial intelligence algorithm.

• Journal of Periodontal and Implant Science
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• v.45 no.2
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• pp.76-80
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• 2015

Purpose: Methimazole is an anti-thyroid drug that can cause life-threatening neutropenia in rare situations. The aim of this case report is to describe a set of oral complications associated with methimazole-induced neutropenia and the healing of the gingiva after proper treatment. Methods: A 31-year-old female patient hospitalized for systemic symptoms of sore throat and fever and showing extensive gingival necrosis with pain was referred to the Department of Periodontics from the Department of Endocrinology. Methimazole-induced neutropenia was diagnosed based on blood test results and her medical history. Methimazole was discontinued and a range of treatments was administered, including the injection of granulocyte colony stimulating factor. Results: After systemic treatment, the gingiva began to heal as the neutrophil count increased. Approximately one year later, the gingiva had returned to a normal appearance. Twenty-one months after treatment, sequestra of the alveolar bone that had broken through the gingiva were removed. Periodic supportive periodontal treatment has been continued uneventfully. Conclusions: The oral manifestations of gingival necrosis and ulcerations, in combination with systemic symptoms such as fever and sore throat, are the critical signs presented in the early stages of drug-induced neutropenia. Therefore, dentists need to be aware of these oral complications in order to make an accurate diagnosis and to ensure that prompt medical intervention is provided.

• Journal of Yeungnam Medical Science
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• v.40 no.3
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• pp.283-288
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• 2023

Severe chronic neutropenia is classified as severe congenital, cyclic, autoimmune, or idiopathic. However, there is a lot of uncertainty regarding the diagnosis of severe congenital neutropenia (SCN) and chronic idiopathic neutropenia, and this uncertainty affects further evaluations and treatments. A 20-year-old man presented with fever and knee abrasions after a bicycle accident. On admission, his initial absolute neutrophil count (ANC) was 30/µL. He had no medical history of persistent severe neutropenia with periodic oscillation of ANC. Although his fever resolved after appropriate antibiotic therapy, ANC remained at 80/µL. Bone marrow (BM) aspiration and biopsy were performed, and a BM smear showed myeloid maturation arrest. Moreover, genetic mutation test results showed a heterozygous missense variant in exon 4 of the neutrophil elastase ELANE: c597+1G>C (pV190-F199del). The patient was diagnosed with SCN. After discharge, we routinely checked his ANC level and monitored any signs of infection with minimum use of granulocyte colony-stimulating factor (G-CSF), considering its potential risk of leukemic transformation. Considering that SCN can be fatal, timely diagnosis and appropriate management with G-CSF are essential. We report the case of a patient with SCN caused by ELANE mutation who had atypical clinical manifestations. For a more accurate diagnosis and treatment of severe chronic neutropenia, further studies are needed to elucidate the various clinical features of ELANE.

• Journal of Veterinary Clinics
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• v.14 no.2
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• pp.301-307
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• 1997

These studies were performed to provide some basic informations for developing an automatic system in dairy farming cattle in order that the farmers may easily and automatically detect the maintenance of pregnancy and the fact of abortion of the pregnant cows and also to find out the diseased animals with fever. As a method of automatical detection of the maintenance of pregnancy or the fact of abortion, weighing the pregnant cows was conducted from one month-pregnancy to the term using a digital balance. From the first to the 3rd month of pregnancy the body weight of dairy cows was slowly increased (less than 2% per month), then, relatively high increase (3.4% -4.3% per month) from the fourth to the seventh month followed by decrease (3.3%) in the 8th month and very low increase (0.8-0.9%) from the 9th month to the term were shown, resulting in increase of 128.8 kg (25.05%) of body weight to be compared with the first weight. More than 107, increase of body weight to be compared with the first month-weight was denoted from the 61th month of pregnancy and more than 20% increase from the 7th or the 8th month of pregnancy as wells consequently it was presumed that detection of the maintenance of pregnancy is possible from the 4th or the 5th month of pregnancy. It was possible to diagnose a cow aborted at the 6th month by continual weighing the cow from the 1st month of pregnancy. The calved cows showed considerably higher decrease of body weight even in the third week after parturition (p<0.01)to be compared with the body weight near to the term (81.8-102.0 kg, 14-16% decrease). During the same period of 8months, the pregnant cows gained 127.4 kg (24.78% increase), whereas the non-pregnant cows gained 33.0 kg (0.71% increase) to be compared with the first weight showing considerably higher increase of body weight gain in the pregnant cows than the non-pregnant cows (p<0.01). The statistics of body temperatures of dairy cattle were collected from three clinics including the Teaching Hospital of Chonbuk University and the diseases were classified simply by the major symptoms manifested, denoting the highest temperature in respiratory disease ($39.8{\circ}C$) and the lowest in alimentary disease ($39.6{\circ} C$). These informations of body temperatures were expected to be of value for early and automatical detection of the diseased animals with fever when automatic machinery would be established. The results of periodic weighing the body weight of pregnant cows while milking were also expected to be of great use for the farmers to detect the maintenance of pregnancy and the fact of abortion when the automatic system is established in the near future.

• Korean Journal of Veterinary Service
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• v.25 no.1
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• pp.75-86
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• 2002

Outbreaks from September 1999 to July 2000 of blackleg in 4 milking and fatting cattle farms in the vicinity of Munkyong(northwestern part of Gyeongbuk province) were investigated biochemical characteristics of isolates and were surveyed epidemiological works during the period of 2 months from August to September 2000. Clostridium chauvoei, the etiological agent of blackleg is a serious pathogen of cattle and sheep causing fever, depression and lameness with high mortality in growing phase of 6 to 18 months old mainly beef cattle. Biochemical and cultural properties of 4 isolated Cl chauvoei were identical to those of reported results and isolates were susceptible to ampicillin, bacitracin, chlorarnphenicol, cephalothin, ciprofloxacin, erythromycin, norfloxacin, penicillin, and tetracycline, while they were resistant to amikacin, colistin, gentamicin, kanamycin, neomycin, streptomycin and trimethoprim-sulfamethoxazole. In the results of epidemiological survey, outbreak farms that concentrated region of milking or fatting cattle in each sites were so close contact within a radius of about 1km that they are separated only by wire fence or shrub harrier and flies, rodents, wild cats and birds could have the chance to move around between those farms. The origin of the outbreak blackleg were uncertain, but the transmission between farms were mainly through the movement of farm personnel, vehicles which were struck the feces or manures from farm and other mechanical factors such as flies, rodents and birds furthermore occurred 4 farms were not vaccinated. In conclusion, a periodic disinfection, vaccination and quarantine prevention are ideal methods of damage reduction by blackleg.

• Pediatric Infection and Vaccine
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• v.10 no.2
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• pp.200-207
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• 2003

Purpose : Malaria is known to have been eradicated for a few decades through persistent national health program in South Korea. However, malaria caused by Plasmodium vivax has started to reappear incidiously among military personnel near to DMZ since 1993. After then, the number of malarial cases have been increased abruptly year by year. We analyzed the children of indigenous malaria who were diagnosed by peripheral blood smear and malarial antibody test with regards to epidemiologic and clinical manifestations. Methods : The study 13 cases below 15 years of age, who were confirmed as vivax malaria during from January 2000 to August 2003. We retrospectively analyzed epidemiologic data, clinical manifestations, laboratory findings and therapeutic responses. Results : All of 13 cases were indigenous and tested positive for Plasmodium vivax. Of 13 patients, 9 were male and 4 were female. Mean age of onset was $9.5{\pm}3.6$ years old. Ilsan(n=9) was the most prevalent area, the most patients(n=11) were presented in summer (from June to August). A characteristic feature of periodic 3 day fever in patients with P.vivax infection was reported in only 2 among 13 cases. Thrombocytopenia was most prominent findings, which was accompanied by 12 of 13 patients and pancytopenia was appeared in 3 patients on this study. The therapeutic responses of hydroxycholoquine were very good in all cases, and abnormal laboratory findings were recovered and no relapse during follow-up period. Conclusion : Vivax malaria is indigenous in Korea near to DMZ, but recently endemic area seemed to be extended southward. Plasmodium vivax is the cause of indigenous malaria of children. As for children with high fever accompanying thrombocytopenia in endemic area of Korea, malaria must be included in differential diagnosis whether the type of fewer is periodic 3 day fever or not. Malaria antibody test is helpful as a screening test for malaria.

• Korean Journal of Oriental Medicine
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• v.16 no.3
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• pp.53-66
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• 2010

This study focuses on the contents about the Urinalysis which is the most representative one of the Tibetan medicine. Also, this study compares it with the Urinalysis of Traditional Korean medicine. This study focuses on the simple history, the theoretical system, the diagnosis and the urinalysis mainly based on the documents related to the Tibetan medicine. Also, through the comparison with the contents of textbook of Traditional Korean Medicine and the urinalysis shown in the Dongeuibogam(東醫寶鑑) which is the representative Korean medical book, the difference between Tibetan Medicine and Traditional Korean Medicine will be observed. The contents related about the urinalysis of the Tibetan medicine are more specific than those of Traditional Korean Medicine. By observing the color, scent, vapor and sediment of one's urine together with periodic changes more thoroughly, it is possible to find out the cause of a certain disease. However, Traditional Korean Medicine examines the medical conditions mainly based on the state of discharge and fever, showing a clear difference. The Tibetan medicine has an extremely specific type of urinalysis in comparison with that of Traditional Korean Medicine. It is the only characteristic of the Tibet medicine, which cannot be found in any other traditional medicine. By applying the viewpoint of the doctor who diagnoses the patient by measuring his or her pulse, it is possible to make the diagnosing process more specific and accurate. It is expected that the follow-up study will be continuously executed with the introduction of the system for the urinalysis of the Tibetan medicine to Traditional Korean medicine.

• Journal of Oriental Neuropsychiatry
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• v.21 no.4
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• pp.21-39
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• 2010

Objectives : This study was to investigate the characteristics of the heart rate variability(HRV), types of insomnia and accompanying symptoms of 175 insomnia patients. Methods : For this study we carried out HRV, Inbody of 175 patients with insomnia who have come to Dongeui oriental hospital of Dongeui university from the period of Janaury 2008 to September 2010. We studied the association of the insomnia patients' age and gender with HRV, accompanying symptoms and the types of insomnia. The information of the accompanying symptoms and types of insomnia was based on each patients' progress note. Results : l. There was no significant differences in the characteristics of HRV between male and female. 2. The most frequent symptom shown among the insmonia patents' was headache(41.14%). 3. Comparing the symptoms between the gender, female patients had more dry mouth, alternative periodic chill and fever, and hot flush symptoms than the male patients. 4. Comparing the symptoms between the age groups(divided in two), the lower age group (20~59) had more dizziness and constipation symptoms than the higher age group (over 60). 5. Comparing the types of insomma between the age group, the higher age group (over 60) had more termination insomnia. 6. The types of insomnia of the entire insomnia patients were onset insomnia (73.1%), maintenance insomnia(20.6%), termination insomma(l7.1 %), shallow sleep (52.6%), listed by order of frequency. 7. The patients who takes hypnotics had more anorexia symptoms than the patients who doesn't take hypnotics. 8. There was no visible differences of the average fractal portrait between male and female. The age group of 20~30yrs. had the highest average fractal portrait, and the age group of 30~59yrs. the second highest, and the age group over 60yrs. the lowest. 9. The average of the regulation reserves of the autonomic nervous system(B2) - was lower than the regulation level of the ANS at the present (Bl). 10. When compared the priority of the function of the ANS, it showed that the proportion of HF($38.61{\pm}29.19%$)was the most, and than VLF($30.65{\pm}23.36%$), LF($20.04{\pm}19.13%$) the least. 11. The average of the compensation level of the central nervous system at present(Cl) - was lower than the compensation reserves of the CNS(C2). 12. The average of the control reserves of the cerebrum(D2) - was lower than the control level of the cerebrum at the present (Dl). 13. There was no visible differences between different sexes and ages in pulse rate. 14. The abdomen fat ratio above the line of the insomnia patients was 77.97% in male and 93.1% in female. Both sexes showed that insomnia patients had more abdomen fat that the standard, and female patients had more abd. fat than male patients. Conclusions : This study shows that the HRV of insomnia patients had no significant differences between gender. Fractal portrait, HF, LF and VLF of the insomnia patients are in inverse proportion to the age. The study of the Body Component Analysis showed that female had more abdomen fat than male, and both gender showed more abdomen fat than the standard. When looked into the accompanying symptoms of the insomnia patients, the symptoms show differences according to gender, age and hypnotics taking, as shown as below. In the entire patients, Headache was the most accompanying symptom. Female had more dry mouth, alternative periodic chill and fever, and hot flush symptoms than male. Higher age groups had more dizziness and constipation as accompanying symptoms than lower age groups. Patients who takes hypnotics had more anorexia than those who dont.

• Journal of Veterinary Clinics
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• v.21 no.4
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• pp.402-405
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• 2004

A 5-year-old Rottweiler neutered female dog was presented with signs of mandibular and popliteal lymphadenopathy, erosion in mucocutaneous junction of muzzle and lips, multiple papules and nodules in right rear limb and neck, and alopecia in right thorax. There was no further clinical sign except anorexia, sporadic fever and ocular hyperemia. She hadn't shown any response to carprofen prescribed by local veterinarian. Hematological abnormalities included mild anemia and severe lymphocytosis. On serum biochemical profile, only elevated AST level was noticed. On cytological examination, there was an evidence of mild bacterial infection which seemed to occur secondarily. Three sites were biopsied that included muzzle, upper lip and right thoracic region. Histopathologically, multifocal confluent pyogranulomatous dermatitis, scattered granulomatous inflammation in subcutis and severe septal panniculitis were observed. Special stainings(Gram, Acid-fast, PAS, Giemsa) were performed to reveal that a dog was negative for any organism. Finally, sterile pyogranuloma/granuloma syndrome (SPGS) was diagnosed. The treatment was initiated with predinsolone and enrofloxacin. The condition was successfully resolved after 4 weeks of treatment. This good response suggests that SPGS may be immune-mediated disease of its pathogenesis and this drug combination may be a viable therapeutic option for dogs suffering from SPGS. Also, this article reports a case of SPGS in Rottweiller for the first time.