• Microbiology and Biotechnology Letters
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• v.21 no.4
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• pp.354-365
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• 1993

A novel control method with automatic tuning of PID controller parameters has been developed for efficient regulation of dissolved oxygen concentration in fed-batch fermentations of Escherichia coli. Agitation speed and oxygen partial pressure in the inlet gas stream were chosen to be the manipulated variables. A heuristic reasoning allowed improved tuning decisions from the supervision of control performance indices and it coule obviate the needs for process assumptions or disturbance patterns. The control input consisted of feedback and feedforword parts. The feedback part was determined by PID control and the feedforward part is determined from the feed rate. The proportional gain was updated on-line by a set of heuristics rules based on the supervision of three performance indices. These indices were output error covariance, the average value of output error, and input covariance, which were calculated on-line using a moving window. The integral and derivative time constants were determined from the period of output response. The specific growth rate was maintained at a low level to avoid acetic acid accumulation and thus to achieve a high cell density. The specific growthe rate was estimated from the carbon dioxide evolution rate. In fed-batch fermentation, the simutaneous control of dissolved oxygen concentration (at 0.2; fraction of saturated value) and specific growth rate (at 0.25$hr^{-1}$) was satisfactory for the entire culture period in spite of the changes in the feed rate and the switching of control input.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.32 no.4
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• pp.43-52
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• 2004

In this paper, the performance of the KOMPSAT-1 orbit determination (OD) accuracy at the ground station was analyzed by using the flight data. The Bayesian least squares estimation was used for the orbit determination and the assessment of the orbit accuracy was evaluated based on orbit overlap comparisons. We also compared the result from OD using GPS navigation solutions with NORAD TLE and the result from OD using range data. Furthermore, the effect of observation type and OBT drift on the accuracy was investigated. As a consequence, It is shown that the OD accuracy using only GPS position data is on the order of 5m RMS (Root Mean Square) with 4 hrs arc overlap for the 30hr arc and the GPS velocity data is not proper as a observation for the OD due to its inferior quality. The significant deterioration of the accuracy due to the critical clock bias was not founded by means of the comparison of OD result from other observations.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.14 no.2
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• pp.409-414
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• 2010

Latest personnel management Jobs with the existing payroll of a simple task rather than piecemeal, combined with the company's strategy, emerged as an important business management information system in e-HRM is an increasing need. In this paper, designed by e-HRM personnel-management Management Information System through the personnel costs and improve capabilities, performance-based assessment of the personnel was established, the staff of the opinions it easier to improve service through improved worker satisfaction. Also on the web, individuals, departments, and the company's performance and to be able to share your goals with an interactive interface to a more transparent process of HR royalty customers without having to focus only on financial indicators, financial, internal process perspective to manage the balance execution of the company's strategy can be used as a tool.

• Nuclear Engineering and Technology
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• v.55 no.10
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• pp.3822-3830
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• 2023

The large-area Compton camera (LACC), featuring significantly high detection sensitivity, was developed for high-speed localization of gamma-ray sources. Due to the high gamma-ray interaction event rate induced by the high sensitivity, however, the multiplexer-based data acquisition system (DAQ) rapidly saturated, leading to deteriorated energy and imaging resolution at event rates higher than 4.7 × 10³ s^-1. In the present study, a new simultaneous multi-channel DAQ was developed to improve the energy and imaging resolution of the LACC even under high event rate conditions (10⁴-10⁶ s^-1). The performance of the DAQ was evaluated with several point sources under different event rate conditions. The results indicated that the new DAQ offers significantly better performance than the existing DAQ over the entire energy and event rate ranges. Especially, the new DAQ showed high energy resolution under very high event rate conditions, i.e., 6.9% and 8.6% (for 662 keV) at 1.3 × 10⁵ and 1.2 × 10⁶ s^-1, respectively. Furthermore, the new DAQ successfully acquired Compton images under those event rates, i.e., imaging resolutions of 13.8° and 19.3° at 8.7 × 10⁴ and 10⁶ s^-1, which correspond to 1.8 and 73 μSv/hr or about 18 and 730 times the background level, respectively.

• Journal of Nutrition and Health
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• v.36 no.7
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• pp.711-719
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• 2003

The effects of taurine, carnitine or glutamine supplementation on endurance exercise performance along with related fatigue factors were evaluated in male college students in the Department of Physical Education, who's maximal oxygen consumption rates (VO$_2$max) were equivalent to those of endurance athletes. Twenty four subjects were randomly divided into 4 groups (n=6), and given placebo, taurine (4 g/day), carnitine (4 g/day), or glutamine (4 g/day) tablets for 2 weeks. Subjects could run 6.9 min or 9.0 min longer until exhausted on a treadmill at the intensity of 75% VO$_2$max following taurine or camitine supplementation for 2 weeks, respectively, compared to the value measured prior to each supplementation. Glutamine or placebo supplementation did not improve the endurance exercise performance based on the running time until exhausted on a treadmill. Serum lactate concentrations measured 1 hr after the initiation of the endurance exercise, as well as at all-out state tended to be decreased by taurine, carnitine, or glutamine supplementation, and were significantly lowered (43% decrease) by carnitine supplementation (p < 0.05). Taurine supplementation significantly reduced the serum inorganic phosphorus concentration measured at all-out state (14% decrease, p < 0.05), while carnitine supplementation significantly lowered the resting state serum inorganic phosphorus level (20% decrease, p < 0.05). Taurine (32% reduction) or carnitine (23% reduction) supplementation significantly decreased serum ammonia concentration measured at all-out state (p < 0.05). From these results, 4 g/day of taurine or carnitine supplementation appears to improve the endurance exercise performance and related human fatigue factors.

• Korean Journal of Food Science and Technology
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• v.25 no.4
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• pp.391-394
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• 1993

For the automation of Tackjoo fermentation, a sensor measurable gas production during brewing and a controller were built. The performance tests were carried out at 10 litter Tackjoo fermentor, The sensor was consisted of a transparent acryl cell for bubble formation and photo-interrupter for the detection of bubbles of 0.018ml size. The fermentation controller was fabricated with a single chip microcomputer (MC68705R3) and provided with both the monitoring module of temperature measurement and the valve controling device for the cooling water circulation in coil type heat exchanger. The operation programs were developed and systemized in ROM. With this computer system, the gas production amount and rate were acquired during the Tackjoo fermentation. The fermentation curve based on the gas production rate showed a good agreement with that of alcohol concentration. The maximum rate of gas production was found after 24 hr at $30^{\circ}C$. The correlation equation between the gas production and alcohol concentration was established and used as the control algorithm of the fermentation.

• Journal of Biomedical Engineering Research
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• v.37 no.2
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• pp.61-67
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• 2016

This paper presented a method for random forest based the arrhythmia classification using both heart rate (HR) and heart rate variability (HRV) features. We analyzed the MIT-BIH arrhythmia database which contains half-hour ECG recorded from 48 subjects. This study included not only the linear features but also non-linear features for the improvement of classification performance. We classified abnormal ECG using mean_NN (mean of heart rate), SD1/SD2 (geometrical feature of poincare HRV plot), SE (spectral entropy), pNN100 (percentage of a heart rate longer than 100 ms) affecting accurate classification among combined of linear and nonlinear features. We compared our proposed method with Neural Networks to evaluate the accuracy of the algorithm. When we used the features extracted from the HRV as an input variable for classifier, random forest used only the most contributed variable for classification unlike the neural networks. The characteristics of random forest enable the dimensionality reduction of the input variables, increase a efficiency of classifier and can be obtained faster, 11.1% higher accuracy than the neural networks.

• Atmosphere
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• v.31 no.2
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• pp.185-198
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• 2021

In this study, we examined a spatial downscaling method based on Gradient and Inverse Distance Squared (GIDS) weighting to produce high-resolution grid data from a numerical weather prediction model over Korean Peninsula with complex terrain. The GIDS is a simple and effective geostatistical downscaling method using horizontal distance gradients and an elevation. The predicted meteorological variables (e.g., temperature and 3-hr accumulated rainfall amount) from the Limited-area ENsemble prediction System (LENS; horizontal grid spacing of 3 km) are used for the GIDS to produce a higher horizontal resolution (1.5 km) data set. The obtained results were compared to those from the bilinear interpolation. The GIDS effectively produced high-resolution gridded data for temperature with the continuous spatial distribution and high dependence on topography. The results showed a better agreement with the observation by increasing a searching radius from 10 to 30 km. However, the GIDS showed relatively lower performance for the precipitation variable. Although the GIDS has a significant efficiency in producing a higher resolution gridded temperature data, it requires further study to be applied for rainfall events.

• Journal of Korean Society on Water Environment
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• v.27 no.3
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• pp.342-348
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• 2011

A hydrodynamic separator using natural free energy provided by bridge was operated for the treatment of stormwater runoff. The separator was automatically controlled by using electronic valve which is connected with pressure meter. Normally the separator was opened during dry days, but it was closed after the capture of first flush. The results indicated that the average pressure and the flow rate were directly affected by the rainfall intensity. The pressure was more than 3 meters as the rainfall intensity was above 5 mm/hr. The percent volume of underflow decreased as the pressure and flow rate increased, but the percent volume of overflow showed an opposite behavior. The concentration of total suspended solids (TSS) in underflow increased as a function of increasing pressure while it decreased in overflow. The TSS separation efficiency was evaluated based on mass balance. It ranged from 30% to 90% with the pressure ranging from 2 to 10 meters, and it was proportional to pressure and flow rate. The analysis of water balance indicated that around 13% of total runoff was captured by the separator as a first flush, and this runoff was separated as underflow and overflow with the respective percent volume of 29% and 71%. The pollutants budget was also examined based on mass balance. The results showed that the percent of TSS, $COD_{cr}$, TN and TP in underflow were 73%, 59%, 7.6% and 49%, respectively.

• Journal of Pharmaceutical Investigation
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• v.39 no.6
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• pp.457-463
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• 2009

The purpose of the present study was to evaluate the bioequivalence of meloxicam capsule, $Mobic^{TM}$ capsule( Boehringer Ingelheim Ltd., Korea) as a reference drug and $Meloxifen^{TM}$ capsule (Kukje Pharma Ind. Co., Ltd., Korea) as a test drug, according to the guidelines of Korea Food and Drug Administration(KFDA). Thirty two healthy male Korean volunteers received capsule containing meloxicam 7.5 mg in a $2{\times}2$ crossover study. There was a one-week above washout period between the doses. Plasma concentrations of meloxicam were monitored for over a period of 72 hr after administration by using a high performance liquid chromatography-tandem mass spectrometer(LC-MS/MS). $AUC_t$(the area under the plasma concentration-time curve from time zero to 72 hr), $C_{max}$(maximum plasma drug concentration) and $T_{max}$(time to reach $C_{max}$) were complied from the plasma concentration-time data. Analysis of variance(ANOVA) test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$ and $C_{max}$. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Meloxifen^{TM}/Mobic^{TM}$ were log 0.8605-log 0.9847 and log 0.9765-log 1.1503, respectively. These values were within the acceptable bioequivalence intervals of log 0.80-log 1.25, recommended by KFDA. In all of these results, we concluded that $Meloxifen^{TM}$ capsule was bioequivalent to $Mobic^{TM}$ capsule, based on the rate and extent of absorption.