• Archives of Pharmacal Research
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• v.24 no.1
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• pp.44-50
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• 2001

To search for cytotoxic components from Allium victoriallis , MTT assays on each extract and an isolated component, gitogenin 3-O-lycotetroside, were performed against cancer cell lines. Cytotoxicities of most extract were shown to be comparatively weak, though $IC_50$ values of $CHCl_3$fraction was found to be <31.3-368.4 $\mu\textrm{g}/ml$. From the incubated methanol extract at $36^{\circ}C, eleven kinds of organosulfuric flavours were predictable by CG-MS performance. The most abundant peak was revealed to be 2-vinyl-4H-1,3-dithiin(1) by its mass spectrum. Further, this extract showed significant cytotoxicities toward cancer cell lies. Silica gel column chromatography of the n-butanol fraction led to the isolation of gitogenin 3-O-lycotetroside (3) along with astragalin (4) and kaempferol 3, 4'-di-O-$\beta$-D-glycoside (5). This steroidal saponin exhibited significant cytotoxic activities ($IC_50$, 6.51-36.5 $\mu\textrm{g}/ml$) over several cancer cell lines. When compound 3 was incubated for 24 h with human intestinal bacteria, a major metabolite was produced and then isolated by silica gel column chromatography. By examining parent and prominent ion peak in FAB-MS spectrum of the metabolite, the structure was speculated not to be any of prosapogenins of 3, suggesting that spiroketal ring were labile to the bacterial reaction. These suggest that disulfides produced secondarily are the antitumor principles.

• Journal of the Microelectronics and Packaging Society
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• v.12 no.4 s.37
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• pp.323-330
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• 2005

We fabricate PIN PD (Positive Intrinsic Negative Photo-Diode) for CWDM optical repeater and optical transmission system, and analyze theoretically the characteristics to verify the capability of device fabricated. Furthermore, we integrate CWDM filter into PD package to enhance the cost and the performance when compared to the conventional system, in which CWDM filter and PD package are linked by optical fusion splicing. The integrated CWDM PD is fabricated by three steps as follows: CWDM filter design, PD packaging, and product assembly and test. The results of measurement for PD fabricated reveal 0.5 dB bandwidth of 17 nm, isolation over 60 dB at transmission port and over 20 dB at reflection port. Also, the IMD3 for wireless communication is over 63 dBc, and the responsivity of PD presents over 0.9 A/W for 20 samples of the total 23 PD. The total insertion loss reduces about 0.4${\~}$0.7 dB due to the integrated assembly of CWDM and PD.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.22 no.5
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• pp.538-544
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• 2011

This paper presents a compact single balanced diode mixer fabricated using a 0.1 ${\mu}M$ GaAs p-HEMT commercial process for an E-band frequency up/down converter. This mixer includes a LO balun employing a Marchand balun with a good RF performance. In order to improve the port-to-port isolation, a high pass filter and a low pass filter are include in this mixer at the RF and IF ports, respectively. The fabricated mixer with a very compact size of 0.58 mm2(0.85 mm${\times}$0.68 mm) exhibits a conversion loss of 8～12 dB and an input P1dB of 1～5 dBm at the LO power of 10 dBm from 71～86 GHz.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.41 no.10
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• pp.915-921
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• 2017

Recently, studies to reduce vibration and noise of automobiles have been actively conducted. However, previous studies did not concentrate on the optimization of the mount system with passive or active mounts. This study analytically studies an active mounting system with three active structural paths between source and receiver and the feasibility has been verified. Active mounting system has a coupled structure of piezoelectric stack actuators and passive mounts. A dynamic model of the whole system is prepared and the control force and phase of the stack actuators in each path are determined to target full isolation of each path. Its performance on vibration attenuation is investigated and based on it, optimized combinations of passive and active paths for the best attenuation are presented.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.44 no.5
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• pp.478-483
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• 2011

An antimicrobial material was purified from the acidified whole body extract of the jellyfish Nemopilema nomurai by using C18 reversed phase and cation-exchange high performance liquid chromatography (HPLC). Whole body extract and the purified compound (JAP-1) showed potent antimicrobial activities against a wide range of microorganisms including Escherichia coli D31, Bacillus subtilis, Streptococcus iniae and Candida albicans, without significant hemolytic activity. Treatment of JAP-1 with trypsin completely abolished all antibacterial activity against Bacillus subtilis, suggesting that JAP-1 is likely to be a proteinaceous antibiotic. The molecular weight of JAP-1 was determined to be 680.10 Da by MALDI-TOF mass spectroscopy.

• Journal of Broadcast Engineering
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• v.13 no.3
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• pp.365-379
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• 2008

In this paper we consider technological requirements of the on-channel repeater to broadcast the terrestrial digital multimedia broadcasting (T-DMB) signals using single frequency networks (SFN) and propose the configuration and implementation method of the equalization on-channel repeater (OCR) that meet such requirements. The proposed equalization OCR not only has short time delay, but shows high output power and good quality of output signal by removing a feedback signal due to incomplete antenna isolation and multipath signal existing between the main transmitter and the OCR. In addition, computer simulations and laboratory tests results are provided to figure out performance of the proposed equalization OCR.

• The Journal of Korean Institute for Practical Engineering Education
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• v.2 no.2
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• pp.74-82
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• 2010

As the basic knowledge during designing most moving mechanical structures, vibration engineering is a subject teaching the theory on vibration control and isolation, which also cultivating the ability of analyze variety of vibration problems. However, vibration engineering is more difficult to understand than other dynamics courses in mechanical field, so the development of educational equipments in order to help understanding physical theory of vibration is really necessary. So in this paper we could see the effect after doing simple experiment process using the educational vibration equipment with multiple function, students could easily understand physical theory of vibration. The educational vibration equipment with multiple function and its application range are introduced, which could performance four kinds of typical vibration phenomenon: vibration of multidegree of freedom system, vibration of beam, vibration of beam, and vibration of plate. Finally, assessments of response and improvement plan are proposed through a survey.

• Korean Journal of Food Science and Technology
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• v.31 no.3
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• pp.848-854
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• 1999

Inhibitory compounds of angiotensin converting enzyme (ACE) were separated from Doenjang (traditional Korean fermented soybean paste). Water extracts from Doenjang which showed ACE inhibitory activity were separated with gel permeation chromatography (GPC), in which two fractions with high ACE inhibitory activities were obtained. The first fraction from GPC was further isolated by semi-preparative reverse phase preparative-HPLC (high performance liquid chromatography) and 2-dimensional electrophoresis/thin layer chromatography (TLC). The purified spot had molecular weight of 759 daltons and ninhydrin-positive non-peptide. The second fraction from GPC was also further isolated by semi-preparative reverse phase HPLC and $NH_2-column$ HPLC. One fraction with high ACE inhibitory activity was purified and characterized. Molecular weight of this fraction by LC-MS was 272.34 daltons. The active fraction was identified as Arg-Pro with ACE $IC_{50}$ of $92\;{\mu}M$.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.35 no.6
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• pp.599-607
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• 2011

In this paper, a reaction-force compensation system for an XY linear motion stage, without an additional external isolation structure or extra motors, is developed. This system consists of a movable magnet track, a spring, a dummy weight, and a dedicated sensor module that measures the relative positions of the movable magnet track with respect to the motor coil. The reaction force compensation system is modeled, and simulations are carried out to optimize design parameters such as the moving distance of the magnet track, the transmission force, the dummy weight, and the allowed size of the mechanism. An XY linear motion stage is built, incorporating the reaction force compensation system, and the performance of the system is verified experimentally. For acceleration and deceleration values of 10 m/$s^2$, 85% of the reaction force is absorbed by the reaction force compensation system.

• Journal of Biosystems Engineering
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• v.27 no.6
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• pp.537-546
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• 2002

In this study an automatic soil hardness measuring system mountable on agricultural tractors was developed to improve the accuracy of manual soil hardness testers by a constant penetrating rate, right direction of the cone-penetrometer and the isolation of vibration from the operator. This was necessary to supply similar experimental condition for performance test of new model and comparative experiment. The results of the study are summaried as follows; 1. The system consisted of a sensing part of soil hardness, a driving part of the measuring system and an attaching part between the tractor and the measuring system. 2. The allowable limit value of the system developed was set to 392N to protect from breaking the serve motor and the coupling used in this system. 3. The driving shaft penetrated into soil by 0.3m to measure soil hardness. The soil hardness was measured at the depth of 0.3m from the soil surface but the penetrating work was stopped and the driving shaft was pulled out to protect the system when the value of the soil hardness was too big on foreign substances like stones or straws. 4. Two values measured by automatic measuring system developed in this research and manual penetrometer were compared by statistics hypothesis testing method. When two people measured the soil hardness at the depth of 0.1 and 0.15m by manual cone penetrometer, there was no relationship between two values by two people but the values at the same depths by automatic measuring system developed showed similarity. The automatic system, therefore, developed in this research was proper for measuring soil hardness.