• Title/Summary/Keyword: Performance Enhanced Model

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Knowledge based Genetic Algorithm for the Prediction of Peptides binding to HLA alleles common in Koreans (지식기반 유전자알고리즘을 이용한 한국인 빈발 HLA 대립유전자에 대한 결합 펩타이드 예측)

  • Cho, Yeon-Jin;Oh, Heung-Bum;Kim, Hyeon-Cheol
    • Journal of Internet Computing and Services
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    • v.13 no.4
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    • pp.45-52
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    • 2012
  • T cells induce immune responses and thereby eliminate infected micro-organisms when peptides from the microbial proteins are bound to HLAs in the host cell surfaces, It is known that the more stable the binding of peptide to HLA is, the stronger the T cell response gets to remove more effectively the source of infection. Accordingly, if peptides (HLA binder) which can be bound stably to a certain HLA are found, those peptieds are utilized to the development of peptide vaccine to prevent infectious diseases or even to cancer. However, HLA is highly polymorphic so that HLA has a large number of alleles with some frequencies even in one population. Therefore, it is very inefficient to find the peptides stably bound to a number of HLAs by testing random possible peptides for all the various alleles frequent in the population. In order to solve this problem, computational methods have recently been developed to predict peptides which are stably bound to a certain HLA. These methods could markedly decrease the number of candidate peptides to be examined by biological experiments. Accordingly, this paper not only introduces a method of machine learning to predict peptides binding to an HLA, but also suggests a new prediction model so called 'knowledge-based genetic algorithm' that has never been tried for HLA binding peptide prediction. Although based on genetic algorithm (GA). it showed more enhanced performance than GA by incorporating expert knowledge in the process of the algorithm. Furthermore, it could extract rules predicting the binding peptide of the HLA alleles common in Koreans.

Spatialization of Unstructured Document Information Using AI (AI를 활용한 비정형 문서정보의 공간정보화)

  • Sang-Won YOON;Jeong-Woo PARK;Kwang-Woo NAM
    • Journal of the Korean Association of Geographic Information Studies
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    • v.26 no.3
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    • pp.37-51
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    • 2023
  • Spatial information is essential for interpreting urban phenomena. Methodologies for spatializing urban information, especially when it lacks location details, have been consistently developed. Typical methods include Geocoding using structured address information or place names, spatial integration with existing geospatial data, and manual tasks utilizing reference data. However, a vast number of documents produced by administrative agencies have not been deeply dealt with due to their unstructured nature, even when there's demand for spatialization. This research utilizes the natural language processing model BERT to spatialize public documents related to urban planning. It focuses on extracting sentence elements containing addresses from documents and converting them into structured data. The study used 18 years of urban planning public announcement documents as training data to train the BERT model and enhanced its performance by manually adjusting its hyperparameters. After training, the test results showed accuracy rates of 96.6% for classifying urban planning facilities, 98.5% for address recognition, and 93.1% for address cleaning. When mapping the result data on GIS, it was possible to effectively display the change history related to specific urban planning facilities. This research provides a deep understanding of the spatial context of urban planning documents, and it is hoped that through this, stakeholders can make more effective decisions.

Preoperative Prediction for Early Recurrence Can Be as Accurate as Postoperative Assessment in Single Hepatocellular Carcinoma Patients

  • Dong Ik Cha;Kyung Mi Jang;Seong Hyun Kim;Young Kon Kim;Honsoul Kim;Soo Hyun Ahn
    • Korean Journal of Radiology
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    • v.21 no.4
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    • pp.402-412
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    • 2020
  • Objective: To evaluate the performance of predicting early recurrence using preoperative factors only in comparison with using both pre-/postoperative factors. Materials and Methods: We retrospectively reviewed 549 patients who had undergone curative resection for single hepatcellular carcinoma (HCC) within Milan criteria. Multivariable analysis was performed to identify pre-/postoperative high-risk factors of early recurrence after hepatic resection for HCC. Two prediction models for early HCC recurrence determined by stepwise variable selection methods based on Akaike information criterion were built, either based on preoperative factors alone or both pre-/postoperative factors. Area under the curve (AUC) for each receiver operating characteristic curve of the two models was calculated, and the two curves were compared for non-inferiority testing. The predictive models of early HCC recurrence were internally validated by bootstrap resampling method. Results: Multivariable analysis on preoperative factors alone identified aspartate aminotransferase/platelet ratio index (OR, 1.632; 95% CI, 1.056-2.522; p = 0.027), tumor size (OR, 1.025; 95% CI, 0.002-1.049; p = 0.031), arterial rim enhancement of the tumor (OR, 2.350; 95% CI, 1.297-4.260; p = 0.005), and presence of nonhypervascular hepatobiliary hypointense nodules (OR, 1.983; 95% CI, 1.049-3.750; p = 0.035) on gadoxetic acid-enhanced magnetic resonance imaging as significant factors. After adding postoperative histopathologic factors, presence of microvascular invasion (OR, 1.868; 95% CI, 1.155-3.022; p = 0.011) became an additional significant factor, while tumor size became insignificant (p = 0.119). Comparison of the AUCs of the two models showed that the prediction model built on preoperative factors alone was not inferior to that including both pre-/postoperative factors {AUC for preoperative factors only, 0.673 (95% confidence interval [CI], 0.623-0.723) vs. AUC after adding postoperative factors, 0.691 (95% CI, 0.639-0.744); p = 0.0013}. Bootstrap resampling method showed that both the models were valid. Conclusion: Risk stratification solely based on preoperative imaging and laboratory factors was not inferior to that based on postoperative histopathologic risk factors in predicting early recurrence after curative resection in within Milan criteria single HCC patients.

Recent Progress in Air-Conditioning and Refrigeration Research : A Review of Papers Published in the Korean Journal of Air-Conditioning and Refrigeration Engineering in 2012 (설비공학 분야의 최근 연구 동향 : 2012년 학회지 논문에 대한 종합적 고찰)

  • Han, Hwataik;Lee, Dae-Young;Kim, Sa Ryang;Kim, Hyun-Jung;Choi, Jong Min;Park, Jun-Seok;Kim, Sumin
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.25 no.6
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    • pp.346-361
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    • 2013
  • This article reviews the papers published in the Korean Journal of Air-Conditioning and Refrigeration Engineering during 2012. It is intended to understand the status of current research in the areas of heating, cooling, ventilation, sanitation, and indoor environments of buildings and plant facilities. The conclusions are as follows : (1) The research works on thermal and fluid engineering have been reviewed as groups of fluid machinery, pipes and valves, fuel cells and power plants, ground-coupled heat pumps, and general heat and mass transfer systems. Research issues are mainly focused on new and renewable energy systems, such as fuel cells, ocean thermal energy conversion power plants, and ground-coupled heat pump systems. (2) Research works on the heat transfer area have been reviewed in the categories of heat transfer characteristics, pool boiling and condensing heat transfer, and industrial heat exchangers. Researches on heat transfer characteristics included the results for natural convection in a square enclosure with two hot circular cylinders, non-uniform grooved tube considering tube expansion, single-tube annular baffle system, broadcasting LED light with ion wind generator, mechanical property and microstructure of SA213 P92 boiler pipe steel, and flat plate using multiple tripping wires. In the area of pool boiling and condensing heat transfer, researches on the design of a micro-channel heat exchanger for a heat pump, numerical simulation of a heat pump evaporator considering the pressure drop in the distributor and capillary tubes, critical heat flux on a thermoexcel-E enhanced surface, and the performance of a fin-and-tube condenser with non-uniform air distribution and different tube types were actively carried out. In the area of industrial heat exchangers, researches on a plate heat exchanger type dehumidifier, fin-tube heat exchanger, an electric circuit transient analogy model in a vertical closed loop ground heat exchanger, heat transfer characteristics of a double skin window for plant factory, a regenerative heat exchanger depending on its porous structure, and various types of plate heat exchangers were performed. (3) In the field of refrigeration, various studies were executed to improve refrigeration system performance, and to evaluate the applicability of alternative refrigerants and new components. Various topics were presented in the area of refrigeration cycle. Research issues mainly focused on the enhancement of the system performance. In the alternative refrigerant area, studies on CO2, R32/R152a mixture, and R1234yf were performed. Studies on the design and performance analysis of various compressors and evaporator were executed. (4) In building mechanical system research fields, twenty-nine studies were conducted to achieve effective design of mechanical systems, and also to maximize the energy efficiency of buildings. The topics of the studies included heating and cooling, HVAC system, ventilation, renewable energy systems, and lighting systems in buildings. New designs and performance tests using numerical methods and experiments provide useful information and key data, which can improve the energy efficiency of buildings. (5) In the fields of the architectural environment, studies for various purposes, such as indoor environment, building energy, and renewable energy were performed. In particular, building energy-related researches and renewable energy systems have been mainly studied, reflecting interests in global climate change, and efforts to reduce building energy consumption by government and architectural specialists. In addition, many researches have been conducted regarding indoor environments.

A Dynamic Queue Manager for Optimizing the Resource and Performance of Mass-call based IN Services in Joint Wired and Wireless Networks (유무선 통합 망에서 대량호 지능망 서비스의 성능 및 자원 최적화를 위한 동적 큐 관리자)

  • 최한옥;안순신
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.25 no.5B
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    • pp.942-955
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    • 2000
  • This paper proposes enhanced designs of global service logic and information flow for the mass-call based IN service, which increase call completion rates and optimize the resource in joint wired and wireless networks. In order to hanve this logic implemented, we design a Dynamic Queue Manager(DQM) applied to the call queuing service feature in the Service Control Point(SCP). In order to apply this logic to wireless service subscribers as well as wired service subscribers, the service registration flags between the Home Location Register(HLR) and the SCP are managed to notify the DQM of the corresponding service subscribers’ mobility. Hence, we present a dynamic queue management mechanism, which dynamically manages the service group and the queue size based on M/M/c/K queueing model as the wireless subscribers roam the service groups due to their mobility characteristics. In order to determine the queue size allocated by the DQM, we simulator and analyze the relationship between the number of the subscriber’s terminals and the drop rate by considering the service increment rate. The appropriate waiting time in the queue as required is simulated according to the above relationship. Moreover, we design and implement the DQM that includes internal service logic interacting with SIBs(Service Independent building Blocks) and its data structure.

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Studies on Behavior Characteristics of Retrofitted Cut-and-Cover Underground Station Using Centrifuge Test Results (원심모형실험을 이용한 내진 보강된 개착식 지하역사의 거동특성 연구)

  • Kim, Jin-Ho;Yi, Na-Hyun;Lee, Hoo-Seok
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.21 no.2
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    • pp.24-33
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    • 2017
  • Domestic urban railway underground station structures, which were built in the 1970s ad 1980s, had been constructed as Cut-and-Cover construction system without seismic design. Because the trends of earthquake occurrence is constantly increasing all over the world as well as the Korean Peninsula, massive human casualties and severe properties and structures damage might be occurred in an non-retrofitted underground station during an earthquake above a certain scale. Therefore, to evaluate the retrofit effect and soil-structure interaction of seismic retrofitted underground station, a centrifugal shaking table test with enhanced stiffness on its structural main member are carried out on 1/60 scaled model using the Kobe and Northridge earthquakes. The seismic retrofitted members, which are columns, side walls, and slabs, are evaluated to comparing with existing non-retrofitted centrifuge test results Also, to simulate the scaled ground using variation of shear velocity according to site conditions such as ground depth and density, resonant column test is performed. From the test results, the relative displacement behavior between ground and structures shows comparatively similar in ground, but is increased on ground surface. The seismic retrofit effects were measured using relative displacements and moment behavior of column and side walls rather than slabs. Additionally, earthquake wave can be used to main design factor due to large structural deformation on Kobe earthquake wave than Norhridge earthquake wave.

Evaluating Proper CO2 Concentrations in CA Storage of Fuji Apple using CFD Analysis (CFD 해석을 통한 후지 사과 CA 저장고 내의 적정 CO2 농도 조성 검토)

  • Lee, Sang-Ik;Hong, Se-Woon;Choi, Won;Kim, Rack-woo;Lee, In-bok
    • Journal of The Korean Society of Agricultural Engineers
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    • v.60 no.3
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    • pp.71-81
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    • 2018
  • $CO_2$ concentration has a significant effect on quality of cold-stored apples. High indoor $CO_2$ concentrations above 10,000 ppm cause the browning of apples and result in economic loss for farmers. The purpose of this study is to evaluate $CO_2$ concentrations and their distribution in a controlled atmosphere (CA) storage and provide better structural designs to improve the $CO_2$ environment using computational fluid dynamics (CFD) simulations. The CFD model was developed for a real CA storage for apples and applied to investigate the effect of changing the inlet and outlet locations and the aspect ratio of the floor of the CA storage on the spatial distributions of $CO_2$ concentration and the browning of the apples. The lowest $CO_2$ concentrations in existing CA storage with a high aspect ratio of the floor were achieved from the combination of the inlet located at the top of the right side and the outlet located at the bottom of the left side. In modified CA storage with a low aspect ratio, the combination of the inlet and outlet located at top and bottom of left side respectively achieved the lowest $CO_2$ concentrations. The proposed case enhanced the storage performance by reducing total browned apples by 3.6% in storage duration of 210 days. This study is expected to reduce the browning damages of apples in CA storage, and thus greatly prevent economic losses.

Optimization Design in Time Domain on Impulse GPIR System (임펄스 GPIR시스템의 시간영역 최적화 설계)

  • Kim, Kwan-Ho;Park, Young-Jin;Yoon, Young-Joong
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.46 no.3
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    • pp.32-39
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    • 2009
  • In this paper, system optimization design technique of an impulse ground penetrating image radar (GPIR) in time domain is proposed to improve depth resolution of the system. For the purpose, time domain analysis method of key components such as impulse generator and UWB antenna is explained and by simulation, parameters of each component are determined. In particular, by standardizing the impulse signal, spectrum efficiency of a radiated impulse signal is improved and a U-shaped planar dipole antenna for a UWB antenna is developed. By equipping a parabolic metal reflector with the proposed antenna, external noise is prevented and the ability of radiating an input impulse into ground is improved. In addition, to remove ringing effect of the propose antenna which causes serious degradation of the system performance, resistors are loaded at the edge of the antenna and then Tx and Rx UWB antennas are optimized by simulation in time domain. For images of targets buried under the ground migration technique is applied and influence of tough ground surface on distortion of received impulse signals is reduced using technique of noise and signal distortion reduction in time domain and its time resolution is enhanced. To verify the design optimization procedure, a prototype of an GPIR and an artificial test field are made. Measurement results show that the resolution of the system designed is as good as that of a theoretical model.

Modeling Study on a Circulatory Hollow-Fiber Membrane Absorber for $CO_{2}$ Separation (이산화탄소 분리를 위한 순환식 중공사 막흡수기에 관한 모델링 연구)

  • Chun, Myung-Suk;Lee, Kew-Ho
    • Membrane Journal
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    • v.5 no.1
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    • pp.35-43
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    • 1995
  • For several years lots of attempts have been made to establish the liquid membrane-based techniques for separations of gas mixtures especially containing carbon dioxide. A more effective system to separate $CO_{2}$ from flue gases, a circulatory hollow-fiber membrane absorber(HFMA) consisting of absorption and desorption modules with vacuum mode, has been considered in this study. Gas-liquid mass transfer has been modeled on a membrane module with non-wetted hollow-fibers in the laminar flow regime. The influence of an absorbent flow rate on the separation performance of the circulatory HFMA can be predicted quantitatively by obtaining the $CO_{2}$ concentration profile in a tube side. The system of $CO_{2}/N_{2}$ binary gas mixture has been studied using pure water as an(inert) absorbent. As the absorbent flow rate is increased, the permeation flux(i.e., defined as permeation rate/membrane contact area) also increases. The enhanced selectivity compared to the previous results, on the other hand, shows the decreasing behavior. It has been found obviously that the permeation flux depends on the variations of pressure in gas phase of desorption module. From an accurate comparison with the results of conventional flat sheet membrane module, the advantageous permeability of this circulatory HFMA can be clearly ascertained as expected. Our efforts to the theoretical model will provide the basic analysis on the circulatory HFMA technique for a better design and process.

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Psychobiotic Effects of Multi-Strain Probiotics Originated from Thai Fermented Foods in a Rat Model

  • Luang-In, Vijitra;Katisart, Teeraporn;Konsue, Ampa;Nudmamud-Thanoi, Sutisa;Narbad, Arjan;Saengha, Worachot;Wangkahart, Eakapol;Pumriw, Supaporn;Samappito, Wannee;Ma, Nyuk Ling
    • Food Science of Animal Resources
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    • v.40 no.6
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    • pp.1014-1032
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    • 2020
  • This work aimed to investigate the psychobiotic effects of six bacterial strains on the mind and behavior of male Wistar rats. The probiotic (PRO) group (n=7) were rats pre-treated with antibiotics for 7 days followed by 14-day probiotic administration, antibiotics (ANT) group (n=7) were rats treated with antibiotics for 21 days without probiotics. The control (CON) group (n=7) were rats that received sham treatment for 21 days. The six bacterial strains with probiotic properties were mostly isolated from Thai fermented foods; Pedicoccus pentosaceus WS11, Lactobacillus plantarum SK321, L. fermentum SK324, L. brevis TRBC 3003, Bifidobacterium adolescentis TBRC 7154 and Lactococcus lactis subsp. lactis TBRC 375. The probiotics were freeze-dried into powder (6×109 CFU/5 g) and administered to the PRO group via oral gavage. Behavioral tests were performed. The PRO group displayed significantly reduced anxiety level and increased locomotor function using a marble burying test and open field test, respectively and significantly improved short-term memory performance using a novel object recognition test. Antibiotics significantly reduced microbial counts in rat feces in the ANT group by 100 fold compared to the PRO group. Probiotics significantly enhanced antioxidant enzymatic and non-enzymatic defenses in rat brains as assessed using catalase activity and ferric reducing antioxidant power assay, respectively. Probiotics also showed neuroprotective effects with less pyknotic cells and lower frequency of vacuolization in cerebral cortex. This multi-strain probiotic formulation from Thai fermented foods may offer a potential to develop psychobiotic-rich functional foods to modulate human mind and behaviors.