• Journal of Genetic Medicine
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• v.13 no.1
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• pp.20-25
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• 2016

Purpose: Xeroderma pigmentosum (XP) is rare autosomal recessive genetic disorder of DNA repair in which the ability to repair damage caused by ultraviolet light is deficient. We reported the first molecularly confirmed Korean patient of XP by targeted exome sequencing. The prevalence of XP included all subtype and carrier frequency of XP-A the using public data were estimated for the first time in South Korea. Materials and Methods: We described a 4-year-old Korean girl with clinical diagnosis of XP. We performed targeted exome sequencing in the patient for genetic confirmation considering disease genetic heterogeneity and for differential diagnosis. We verified a carrier frequency of c.390-1G>C in XPA gene known as mutational hot spot using Korean Reference Genome Data Base. We estimated the period prevalence of all subtypes of XP based on claims data of the Health Insurance Review and Assessment Service in South Korea. Results: We identified homozygous splicing mutation of XPA (c.390-1G>C) in the patient. The carrier frequency of risk for XPA (c.390-1G>C) was relatively high 1.608 e-03 (allele count 2/1244). The prevalence of XP in South Korea was 0.3 per million people. Conclusion: We expect that c.390-1G>C is hot spot for the mutation of XPA and possible founder variant in South Korea. However, the prevalence in South Korea was extremely low compared with Western countries and Japan.

• Fire Science and Engineering
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• v.5 no.1
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• pp.5-14
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• 1991

Fire Protection System is facilities that Control the fire by mechanic means. Buildings Over a Certain Scale is required this system. As the small from the fire extinguisher as the large to the sprinkler system of automatic fire extinguishing equipment the kinds are various. With the development of architecture technique while modern higher buildings are increased. As fire is a first product that human make, it performed many profits and services for our mankind. Sometimes as it Is profitable fire or harmful fire, it takes charge of human's life culture. Therefore fire protection system is facilities that control the latter fire by mechanic means Building over a certain scale is required this system. As the small from the fire extinguisher as the large to the sprinkler system of automatic fire extinguishing equipment, the kinds are various. With the development of architecture technique while modern higher buildings are increased high level and fire prevent facilities aren't reached to that level. The object of this study is present the problem which appear from the analysis of place standard for fire protection facility. This study described as a following order. First, We are going to look history of the fire protection system and change course of that with the year and facility. Second. We say the frame system and special nature of the foreign fire prevent Act. Third. We understand the control reality of fire protection system. Fourth. We took out the merit of foreign fire prevent law and the problem of our current domestic system. The placing standard of proper fire protection facilities that be presented from this study are followed next. 1) We have to reinforce sprinkler system placing standard for the fire extinguishing and check the spread of fire. 2) We must to be ruled the standard for keeping fire prevention system that are received reality and people's idea. 3) We should prepare lawful basis which can be place fire prevention center. 4) We have to correct the standard of use count about complex building without mainuse and we take increase the real effectiveness of this. 5) We ought to match the use of current fire prevention act and the use of architecture law.

• Journal of Veterinary Clinics
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• v.26 no.3
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• pp.282-285
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• 2009

A 10-year-old Paint horse was presented with gradual changes in behavior, characterized as stallion-like including aggressiveness towards people and other horse. The abnormal right ovary was detected via transrectal ultrasonography and rectal palpation. A complete blood count and biochemical panel values were within reference ranges. The hormone analysis revealed increased testosterone 46.00 pg/mL and inhibin 0.856 ng/mL, and progesterone concentration consistent with absence of luteal tissue 1.2 ng/mL more than normal values. The purpose of the study reported was to describe a ovariectomy of enlarged ovary by using the diagonal paramedian approach. This method is useful to minimize surgical exposure and hemorrhage. This ovary was confirmed fibroma by histological examination post operation. Behavior problems and the hormone values were alleviated after surgery, and clinical signs of complication were not showed.

• Korean Journal of Community Nutrition
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• v.11 no.6
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• pp.779-784
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• 2006

Several studies about hospital malnutrition have been reported that about more than 40% of hospitalized patients are having nutritional risk factors and hospital malnutrition presents a high prevalence. People in a more severe nutritional status ended up with a longer length of hospital stay and higher hospital cost. Nutrition screening tools identify individuals who are malnourished or at risk of becoming malnourished and who may benefit from nutritional support. For the early detection and treatment of malnourished hospital patients , few valid screening instruments fur Koreans exist. Therefore, the aim of this study was to develop a simple, reliable and valid malnutrition screening tool that could be used at hospital admission to identify adult patients at risk of malnutrition using medical electrical record data. Two hundred and one patients of the university affiliated medical center were assessed on nutritional status and classified as well nourished, moderately or severely malnourished by a Patient-Generated subjective global assessment (PG-SGA) being chosen as the 'gold standard' for defining malnutrition. The combination of nutrition screening questions with the highest sensitivity and specificity at prediction PG-SGA was termed the nutrition screening index (NSI). Odd ratio, and binary logistic regression were used to predict the best nutritional status predictors. Based on regression coefficient score, albumin less than 3.5 g/dl, body mass index (BMI) less than $18.5kg/m^2$, total lymphocyte count less than 900 and age over 65 were determined as the best set of NSI. By using best nutritional predictors receiver operating characteristic curve with the area under the curve, sensitivity and 1-specificity were analyzed to determine the best optimal cut-off point to decide normal or abnormal in nutritional status. Therefore simple and beneficial NSI was developed for identifying patients with severe malnutrition. Using NSI, nutritional information of the severe malnutrition patient should be shared with physicians and they should be cared for by clinical dietitians to improve their nutritional status.

• Proceedings of the Korea Contents Association Conference
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• 2008.05a
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• pp.170-175
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• 2008

Kimchi is Korean traditional culinary culture and one of the most representative, Korean cultural archetypes which reflect Korean sentiment and culture. Further, its virtue as a food has drawn attention from all over the world. One thing that you can count as the most important thing in successful cultural content is creative material. Kimchi is a life cultural content with universal quality which is shared with mankind in its culinary culture and originality generated from Korean people and its history. The rich cultural factors of Kimchi, in mental and material aspects, can be a platform for successful content which is globally competitive. Contents of Kimchi culture, which can be applied to various cultural business, has been developed on the basis of its colorful cultural factors. And with the cases used as standards, OSMU type cultural content development process of cultural archetype was suggested. This study was intended to suggest Korean cultural archetype's possibility to be developed into a life cultural content and tried to help building cultural content development process of Korean life cultural archetype.

• Proceedings of the Ginseng society Conference
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• 2002.10a
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• pp.385-391
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• 2002

Panax ginseng (family- Araliaceae) is a native plant of Korea and has been used for past several years among oriental people. To evaluate the radioprotective potential of P. ginseng on the formation of giant cells in the testis of Swiss albino mice, the animals were divided into four groups: -(I)-Only vehicle was administered. (II)P. ginseng treated group: -The animals received 10 mg/kg body weight P. ginseng root extract (in DDW) i.p. continuously for 30 days. (III) Irradiated group: -The animals were exposed to 8 Gy gamma radiation at the dose rate of 1.69 Gy/min at the distance of 80 ems. (IV) Combined treatment group: -Animals were given P. ginseng extract for four days and on fourth day they were irradiated to 8 Gy gamma radiation after 30 minute of extract administration. The animals of these three groups were autopsied on day 1,3, 7, 14 and 30 days. In ginseng treated group, active spermatogenesis was observed without any toxic effect. Histopathological studies of irradiated group (II) revealed reduction in germ cell count, loss of sperms and formation of multinucleated giant cells on day 7th. These giant cells were formed by round nuclei of early or late spermatids. In combination group (III), although germinal epithelium was still disorganized with loss of cells in few tubules, but no giant cell formation was observed. In order to know the mechanism of radioprotection of ginseng, LPO and GSH were estimated. It was observed that pretreated irradiated animals showed inhibition of LPO and increase in GSH. Thus the present study suggests ginseng protects male gonads. This may be attributed to the inhibition of LPO and increase synthesis of GSH byginseng.

• The Journal of the Korea institute of electronic communication sciences
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• v.13 no.6
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• pp.1263-1268
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• 2018

In this paper, a video analysis is proposed to implement video surveillance system with deep learning object detection and probabilistic data association filter for tracking multiple objects, and suggests its implementation using GPU. The proposed video analysis technique involves object detection and object tracking sequentially. The deep learning network architecture uses ResNet for object detection and applies probabilistic data association filter for multiple objects tracking. The proposed video analysis technique can be used to detect intruders illegally trespassing any restricted area or to count the number of people entering a specified area. As a results of simulations and experiments, 48 channels of videos can be analyzed at a speed of about 27 fps and real-time video analysis is possible through RTSP protocol.

• Journal of the Society of Disaster Information
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• v.17 no.3
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• pp.521-534
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• 2021

Purpose: In this paper, we propose an indoor positioning scheme based on pedestrian dead reckoning using inertial measurement unit. By minimizing the effects of the orientation error of smart-phone, the more accurate estimation for the direction, the step count, and the stride can be achieved. Method: The effectiveness and the performance of the proposed scheme is evaluated by experiments, and it is compared with the conventional scheme in the same conditions. Result: The results showed that the positioning error of the proposed scheme was 0.76m, while that of the conventional scheme was 1.84m. Conclusion: Sine most people carry his/her own smart-phone, the proposed scheme can be helpful to recognize where he/she was and was heading when the fast evacuation is needed in indoors.

• The Journal of Internal Korean Medicine
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• v.42 no.2
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• pp.175-183
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• 2021

Diabetes mellitus, commonly known as diabetes, comprises a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. Diabetes is classified into type 1 diabetes and type 2 diabetes, and the incidence and prevalence of diabetes, mostly type 2, have increased remarkably in recent decades. A diagnosis of type 2 diabetes is greatly influenced by heredity, and it is important to prevent diabetes in people with a family history by improving lifestyle and environmental factors. Controlling overeating, obesity, lack of exercise, and stress is effective to prevent diabetes. The patient in this case report had impaired fasting glucose and mild hyperlipidemia. The patient experienced improvements in these sequelae after the administration of herbal medicine (Yangkyuksanwha-tang) for 12 weeks and the implementation of a plant-based diet. The complete blood count, XXXX, fasting blood sugar, HbA1c, insulin, and C-peptide levels were measured, and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and HOMA-β were calculated according to the FBS and fasting insulin levels. Total cholesterol, triglyceride, FBS, and HbA1c levels all decreased after 12 weeks compared with baseline measures. There was no change in the insulin secretory ability; the C-peptide level did not change as a result of β-cell function; and the HOMA-β level reflected an improved insulin secretory ability.

• Spatial Information Research
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• v.22 no.4
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• pp.67-76
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• 2014

Recently, through the development of IT and mobile technology, spatial information plays a role of infrastructure of the people life and the national economy. Many kinds of applications including SNS and social commerce is to leverage the spatial information for their services. In the case of domestic, spatial open platform that can provide national spatial data infrastructure services in a stable manner has been released. And many people have been interested to the open platform services. However, the open platform currently has many difficulties to analyze its service status and load in real time, because it does not hold a real-time monitoring system. Therefore, we propose a method that can analyze the real-time service status of the open platform using the analysis of the web server log information. In particular, we propose the results of the analysis as follows: amount of data transferred, network bandwidth, number of visitors, hit count, contents usage, and connection path. We think the results presented in this study is insufficient to understand the perfect service status of the open platform. However, it is expected to be utilized as the basic data for understanding of the service status and for system expansion of the open platform, every year.