• IMMUNE NETWORK
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• 제21권3호
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• pp.18.1-18.13
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• 2021

TLR signaling is critical for broad scale immune recognition of pathogens and/or danger molecules. TLRs are particularly important for the activation and the maturation of cells comprising the innate immune response. In recent years it has become apparent that several different TLRs regulate the function of lymphocytes as well, albeit to a lesser degree compared to innate immunity. TLR2 heterodimerizes with either TLR1 or TLR6 to broadly recognize bacterial lipopeptides as well as several danger-associated molecular patterns. In general, TLR2 signaling promotes immune cell activation leading to tissue inflammation, which is advantageous for combating an infection. Conversely, inappropriate or dysfunctional TLR2 signaling leading to an overactive inflammatory response could be detrimental during sterile inflammation and autoimmune disease. This review will highlight and discuss recent research advances linking TLR2 engagement to autoimmune inflammation.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1998년도 추계학술대회 논문집 학회본부 C
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• pp.941-943
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• 1998

Exploitation of equipment with cross linked polyethylene (XLPE) insulation requires its condition monitoring and diagnostic. Traditionally diagnostics of insulation is carried out by means of partial discharge detection. Many researchers have developed a lot of methods to identify the defect by the PD form. However, such identification of a defect, for example, void, inclusion or treeing, does not say about its danger from a point of view of full insulation gap breakdown and insulation construction failure. The information about the form and size of formed upon high voltage treeing is necessary for prediction of the remained resource of XLPE insulation. For this purpose we carry out experimental research for determination of the dependencies between PD characteristics in XLPE upon time and three dimension PD patterns of corresponding treeing. The investigations were carried out by means of electrical measurement of PD current and simultaneous optical recording of treeing image. Test results show that the PD patterns can be applied for detecting tree growth well.

• Journal of information and communication convergence engineering
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• 제7권1호
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• pp.7-12
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• 2009

The advanced computer network and Internet technology enables connectivity of computers through an open network environment. Despite the growing numbers of security threats to networks, most intrusion detection identifies security attacks mainly by detecting misuse using a set of rules based on past hacking patterns. This pattern matching has a high rate of false positives and can not detect new hacking patterns, making it vulnerable to previously unidentified attack patterns and variations in attack and increasing false negatives. Intrusion detection and prevention technologies are thus required. We proposed a network based hybrid Probe Intrusion Detection model using Fuzzy cognitive maps (PIDuF) that detects intrusion by DoS (DDoS and PDoS) attack detection using packet analysis. A DoS attack typically appears as a probe and SYN flooding attack. SYN flooding using FCM model captures and analyzes packet information to detect SYN flooding attacks. Using the result of decision module analysis, which used FCM, the decision module measures the degree of danger of the DoS and trains the response module to deal with attacks. For the performance evaluation, the "IDS Evaluation Data Set" created by MIT was used. From the simulation we obtained the max-average true positive rate of 97.064% and the max-average false negative rate of 2.936%. The true positive error rate of the PIDuF is similar to that of Bernhard's true positive error rate.

• Biomolecules & Therapeutics
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• 제31권4호
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• pp.395-401
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• 2023

Innate immunity is a first line defence system in the body which is for sensing signals of danger such as pathogenic microbes or host-derived signals of cellular stress. Pattern recognition receptors (PRR's), which present in the cell memebrane, are suspect the infection through pathogen-associated molecular patterns (PAMP), and activate innate immunity with response to promote inflammation via inflammatory cells such as macrophages and neutrophils, and cytokines. Inflammasome are protein complexes which are part of innate immunity in inflammation to remove pathogens and repair damaged tissues. What is the important role of inflammation in disease? In this review, we are focused on the action mechanism of NLRP3 inflammasome in inflammatory diseases such as asthma, atopic dermatitis, and sepsis.

• Molecules and Cells
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• 제44권11호
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• pp.830-842
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• 2021

When perceiving microbe-associated molecular patterns (MAMPs) or plant-derived damage-associated molecular patterns (DAMPs), plants alter their root growth and development by displaying a reduction in the root length and the formation of root hairs and lateral roots. The exogenous application of a MAMP peptide, flg22, was shown to affect root growth by suppressing meristem activity. In addition to MAMPs, the DAMP peptide PEP1 suppresses root growth while also promoting root hair formation. However, the question of whether and how these elicitor peptides affect the development of the vascular system in the root has not been explored. The cellular receptors of PEP1, PEPR1 and PEPR2 are highly expressed in the root vascular system, while the receptors of flg22 (FLS2) and elf18 (EFR) are not. Consistent with the expression patterns of PEP1 receptors, we found that exogenously applied PEP1 has a strong impact on the division of stele cells, leading to a reduction of these cells. We also observed the alteration in the number and organization of cells that differentiate into xylem vessels. These PEP1-mediated developmental changes appear to be linked to the blockage of symplastic connections triggered by PEP1. PEP1 dramatically disrupts the symplastic movement of free green fluorescence protein (GFP) from phloem sieve elements to neighboring cells in the root meristem, leading to the deposition of a high level of callose between cells. Taken together, our first survey of PEP1-mediated vascular tissue development provides new insights into the PEP1 function as a regulator of cellular reprogramming in the Arabidopsis root vascular system.

• 한국재난정보학회 논문집
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• 제18권3호
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• pp.495-506
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• 2022

연구목적: 일반적으로, 사람들은 일상생활 속에서 자신이 어떻게, 어디서 걷는지 등에 대해 많은 관심을 기울이지 않는 경향이 있다. 하지만, 심각한 화재나 지진이 일어났을 때, 사람들은 가능한 한 빨리 위험지역에서 벗어나려고 노력한다. 만일 사람들이 비상상황에서 의사결정 이론에 근거하여 탈출하게 된다면, 사상 자는 크게 줄어들게 될 것이다. 본 연구는 심리학적인 관점과 인지과학의 관점으로 인간의 행동을 보다 구체적으로 이해하고자 한다. 연구방법: 본 연구에서는 유튜브, CCTV 등에서 얻은 비상상황에서의 영상자료를 수집하여 상황별 사람들의 보행 특성을 분류하였다. 연구결과: 비상상황에서의 보행자의 속도나 방향 전환이 평상시와 전혀 다른 특징을 가지는 것으로 나타났다. 재난 발생 시 탈출 방향이 주로 한 방향이기 때문에, 방향전환이 적으며, 평균 보행속도가 상대적으로 높은 것으로 나타났다. 분석결과, 평상시에서의 인간의 행동은 살면서 학습한 습관에 기반하지만 비상 상황의 경우, 원초적인 본능에 기반하는 것으로 나타났다. 결론 : 본 연구에서 활용된 방법론과 연구 결과는 비상상황에서 사람들의 보행 행태에 대한 시뮬레이션과 분석에 활용 될 수 있을것으로 판단된다.

• IMMUNE NETWORK
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• 제8권1호
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• pp.1-6
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• 2008

Apoptosis signal-regulating kinase 1 (ASK1), a mitogen- activated protein kinase kinase kinase, plays pivotal roles in stress responses. In addition, ASK1 has emerged as a key regulator of immune responses elicited by pathogen-associated molecular patterns (PAMPs) and endogenous danger signals. Recent studies have demonstrated that reactive oxygen species (ROS)-dependent activation of ASK1 is required for LPS-stimulated cytokine production as well as extracellular ATP-induced apoptosis in immune cells. The mechanism of ROS-dependent regulation of ASK1 activity by thioredoxin and TRAFs has been well characterized. In this review, we focus on the molecular details of the activation of ASK1 and its involvement in innate immunity.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 1999년도 춘계학술발표논문집 논문집
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• pp.221-230
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• 1999

Automobile horn's psychoacoustic characteristic and significance as a anturalistic signal of danger makes it a valuable auditory stimulus to study such psychophysiological responses as startle, orienting and defense reactions. However, comparison and differentiation of physiological responses to commercially available horns is a complicated task due to small contrast of technical features of horns and influence of such processes as habituation on physiological outcome with increased number of auditory stimulation trials. In the study on 10 college students we performed comparative analysis of tonic and phasic reactivity of physiological responses mediated by autonomic nervous system in order to identify role of habituation and decrement of autonomic responsivity, as well as possibility o differentiate subjectively most and least preferred and subjectively more appropriate horns according to physiological manifestations. It was showed that electrodermal and cardiovascular reactivity have concurrent patterns of adaptation to repeated stimulation, namely skin conductance variables habituated, cardiac reactivity failed to show signs of habituation, while vascular component of response were facilitated demonstrating marked sensitization. Differentiation of Physiological responses to horns with respect to their subjective rating scores was possible, however electrodermal reactivity was effective only at the first block of trials, while phasic and tonic cardiovascular reactivity differentiate responses during whole course of experiment. There are discussed possible autonomic mechanisms involved in mediation of observed results.

• 한국위성정보통신학회논문지
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• 제10권4호
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• pp.77-82
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• 2015

본 논문은 빅 데이터 분석을 이용하여 산악 안전사고를 예방하기 위하여 사고 예측 모델을 제시하였다. 산악 안전사고의 축적된 데이터를 파악하기 쉽게 그래프로 나타내었다. 사고가 발생하는 패턴을 알기 위하여 산악 안전사고 발생 건수의 연도별 분석, 연간 월별 사고 발생 건수, 요일별, 시간대별 분석을 수행하였다. 나타낸 그래프를 이용하여 산악 안전사고의 영향을 미치는 변수들을 가중치 모델링을 통하여 사고 예측 모델을 구성하였다. 산악 지역의 사고 다발 구역에 제시한 모델을 적용하여 예측 모델의 성능을 검정하였다.

• 한국안전학회지
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• 제13권1호
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• pp.98-104
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• 1998

Recently, industrial accidents have occurred in various patterns due to the diversity of industries and the integration of facilities. Especially, the major accidents affect broad area and result in huge loss of lives and properties. Domestic researches on techniques for keeping away from such hazardous danger have been actively performed but their activities are limited in some institutes and universities. In advanced countries, integrated management systems like Seveso Directive of EU and OSHA(Occupational Safety and Health Act) of U.S.A. have been legislated along with the systematic research activities. In Korea, the integrated safety management systems called SMS(Safety Management System) and PSM(Process Safety Management) have been applied to major industries. These systems made chemical industries manage the process safety information by collecting and arranging safety data by themselves. In order to implement the system successfully, it is urgently required to prepare a tool for searching and accumulating process safety data systematically. In this study, a computerized prototype of Risk Assessment System which is essential to SMS and PSM was developed as a main system and data base as subsystem to handle safety information.