• 대한기계학회:학술대회논문집
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• 대한기계학회 2003년도 춘계학술대회
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• pp.1065-1068
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• 2003

The nano imprint process is one of the next generation lithography has been mentioned as one of major nanoreplication techniques because it is simple process, low cost, high replication fidelity and relatively high throughput. This process requires a surface contact between a template with patterns and a wafer on a stage. After contact, the vertical moving the template to the wafer causes some directional motions of the stage. Thus the stage must move according to the motions of the template to avoid the damage of the transferred patterns on the wafer. This study is to develop the wafer stage with a passive compliance to overcome the damage. This stage is designed with the concept like that it has a monolithic, symmetry and planar 6-DOF mechanism.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2003년도 춘계학술대회 논문집
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• pp.624-627
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• 2003

Microcontact printing (uCP) of alkanethiols on gold was the first representative of soft-lithography processes. This is an attempt to enhance the accuracy of classical to a precision comparable with optical lithography, creating a low-cost, large-area, and high-resolution patterning process. Microcontact printing relies on replication of a pattered PDMS stamp from a master to form an elastic stamp that can be inked with a SAM solution(monolayer -forming ink) using either immersion inking or contact inking. The inked PDMS stamp is then used to print a pattern that selectively protects the gold substrate during the subsequent etch.

• 대한음성학회:학술대회논문집
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• 대한음성학회 2003년도 10월 학술대회지
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• pp.101-104
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• 2003

In this paper, speech quality is improved by removing abrupt noise intervals and then substituting the gaps with estimates of the previous speech waveform. An abrupt noise detection signal has been proposed as a prediction error signal by utilizing LP coefficients of the previous frame. Abrupt noise intervals are estimated by using spectral energy. After removing estimated noise intervals, we applied several waveform substitution techniques such as zero substitution, previous frame repetition, pattern matching, and pitch waveform replication. To prove the validity of our algorithm, the LPC spectral distortion test and the recognition test are executed and, the results show that the speech quality is fairly well improved.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2007년도 추계학술대회 논문집
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• pp.71-77
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• 2007

The surface of railway wheel tread in wheel-rail system can not be free from wear because of various circumstance such as railway condition, maintenance condition, weather condition, characteristics of wheel surface's geometrical shape, and vehicle suspension's structural characteristics etc. Therefore, the research on wear reduction and maintenance method are very important to ensure the safety of railway vehicle, to improve car comfort and to decrease maintenance cost. In this study, the wear rates of railway wheel have been periodically measured in terms of the running distance of Electrical Multiple Unit which have been currently operated and the microstructure transformation of wheel tread using replication method have been performed. The results show that the relations between the flange wear and tread microstructure are depended on running distance and it will supply basic data on wheel maintenance.

• 정보저장시스템학회논문집
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• 제1권2호
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• pp.192-196
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• 2005

In this paper, we investigated the possibility of replicating patterned media by nano-injection molding process with a metallic nano-stamper. The original nano-master was fabricated by E-beam lithography and ICP etching process. The metallic nano-stamper was fabricated using a nanoimprint lithography and nano-electroforming process. The nano-patterned substrate was replicated using a nano-injection molding process without additional etching process. In nano-injection molding process, since the solidified layer, generated during the polymer filling, deteriorates transcribability of nano patterns by preventing the polymer melt from filling the nano cavities, an injection-mold system was constructed to actively control the stamper surface temperature using MEMS heater and sensors. The replicated polymeric patterns using nano-injection molding process were as small as 50 nm in diameter, 150 nm in pitch, and 50 nm in depth. The replicated polymeric patterns can be applied to high density patterned media.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2005년도 춘계학술대회 논문집
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• pp.60-63
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• 2005

In this paper, we investigated the possibility of replicating patterned media by nano-injection molding process with a metallic nano-stamper. The original nano-master was fabricated by E-beam lithography and ICP etching process. The metallic nano-stamper was fabricated using a nanoimprint lithography and nano-electroforming process. Finally, the nano-patterned substrate was replicated using a nano-injection molding process without additional etching process. The replicated patterns using nano-injection molding process were as small as 50 nm in diameter, 150 nm in pitch, and 50 nm in depth.

• Design & Manufacturing
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• 제17권3호
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• pp.8-14
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• 2023

In this study, basic research was conducted on manufacturing technology of thick-walled light guide a component that controls the light source of automobile lamps. As a preliminary study for manufacturing the final injection molded parts, a model for analyzing the influence of micro patterns on light guides is presented. The optical characteristics of the light guide were analyzed according to the change of the curvature radius of the micro-optical pattern, and the injection molding characteristics of the light guide according to the change of injection molding conditions were analytically evaluated. It was confirmed that the luminance uniformity improves as the R value decreases for changes in the micro-pattern R value, but it was confirmed that there are technical limitations in actual injection mold core processing and high-replication injection molding. Injection molding analysis showed that cooling channel design is very important compared to general injection molding due to thick-wall characteristics and thickness variation. It was also confirmed that the cooling channel has a great influence on the cycle time and birefringence result due to residual stress. As a result of analyzing the influence of filling time, holding condition, and cooling on shrinkage, it was found that the cooling water temperature has a significant effect on the shrinkage of ultra-fine light guide parts, and the holding condition also has a significant effect.

• 한국보건간호학회지
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• 제12권2호
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• pp.107-121
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• 1998

The purpose of this study was to test the revised Health Promotion Model of Pender and to determine the factors to promote health behavior for adolescents' smoking behavior. The subjects of the study was 783 boys of 4 high school students. among 39. schools locating in Daejeon metropolitan city. The data was collected from July 1st to 15th. 1997 by school health nurse The research tool were HPLP of Walker. Pender. General self-efficacy scale of Sherer. control scale was measured by subconcept of hardiness scale of Pollock. and perceived barrier. perceived benefit. activity-related-affect tool were made by researcher via literature review The data were analyzed by SAS program using frequency. t-test. ANOVA. Schefee test. regression. The results were as follows 1. The mean of total health promoting behavior was $2.27\pm.35$. Among sub domain of health promoting behavior, the highest score was interpersonal support$(2.72\pm.60)$. and the lowest was health responsibility $(1.58\pm.44)$. 2. There were statistically significant difference in total health promoting behavior according to religion. parenting style. school performance. girl friend. father's smoking of individual characteristics. 3. The socioeconomic status. smoking, parent pattern. family structure of individual characteristics and experience domain associated with perceived benefit. perceived barrier. activity-related affect. interpersonal influence of behavior-specific cognition and affect domain. The perceived barrier. self-efficacy. girl friend and father's smoking of interpersonal influence. and control explained $25.8\%$ of variance of health promoting behavior. From above results school health nurse has to emphasize on health responsibility for health promotion of adolescent. But they couldn't intervene for parent pattern. socioeconomic status. family structure of individual characteristics and experience domain. it could be possible for school health nurse to promote health of adolescents through improving perceived barrier. also develop program to increase self-efficacy and through parent health class for fathers. Above results point to the importance of including parents in smoking prevention effort targeting adolescents. Because increasing control also promotes health of adolescents. it should be studied further about the specific measure. To verify the variables for increasing the fitness of health promoting model. it needs further replication of the research.

• 대한의생명과학회지
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• 제13권3호
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• pp.239-244
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• 2007

Hoxc8 is one of the homeotic developmental control genes regulating the expression of many downstream target genes, through which animal body pattern is established during embryonic development. In previous proteomics analysis, proliferating cell nuclear antigen (PCNA) which is also known as cyclin, has been implied to be regulated by Hoxc8 in F9 murine embryonic teratocarcinoma cell. When the 5' upstream region of PCNA was analyzed, it turned out to contain 20 Hox core binding sites (ATTA) in about 1.17 kbp (kilo base pairs) region ($-520{\sim}-1690$). In order to test whether this region is responsible for Hoxc8 regulation, the upstream 2.3 kbp fragment of PCNA was amplified through PCR and then cloned into the pGL3 basic vector containing a luciferase gene as a reporter. When the luciferase activity was measured in the presence of effector plasmid (pcDNA : c8) expressing murine Hoxc8, the PCNA promoter driven reporter activity was reduced. To confirm whether this reduction is due to the Hoxc8 protein, the siRNA against Hoxc8 (5'-GUA UCA GAC CUU GGA ACU A-3' and 5'-UAG UUC CAA GGU CUG AUA C-3') was prepared. Interestingly enough, siRNA treatment up regulated the luciferase activity which was down regulated by Hoxc8, indicating that Hoxc8 indeed regulates the expression of PCNA, in particular, down regulation in NIN3T3 cells. These results altogether indicate that Hoxc8 might orchestrate the pattern formation by regulating PCNA which is one of the important proteins involved in several processes such as DNA replication and methylation, chromatin remodeling, cell cycle regulation, differentiation, as well as programmed cell death.

• BMB Reports
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• 제40권5호
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• pp.814-824
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• 2007

Liver cirrhosis (LC) is defined as comprising diffuse fibrosis and regenerating nodules of the liver. The biochemical and anatomical dysfunction in LC results from both reduced liver cell number and portal vascular derangement. Although several studies have investigated dysregulated genes in cirrhotic nodules, little is known about the genes implicated in the pathophysiologic change of LC or about their relationship with the degree of decompensation. Here, we applied cDNA microarray analysis using 38 HBsAg-positive LC specimens to identify the genes dysregulated in HBV-associated LC and to evaluate their relation to disease severity. Among 1063 known cancer- and apoptosis-related genes, we identified 104 genes that were significantly up- (44) or down- (60) regulated in LC. Interestingly, this subset of 104 genes was characteristically correlated with the degree of decompensation, called the Pugh-Child classification (20 Pugh-Child A, 10 Pugh-Child B, and 8 Pugh-Child C). Patient samples from Pugh-Child C exhibited a distinct pattern of gene expression relative to those of Pugh-Child A and B. Especially in Pugh-Child C, genes encoding hepatic proteins and metabolizing enzymes were significantly down-regulated, while genes encoding various molecules related to cell replication were up-regulated. Our results suggest that subsets of genes in liver cells correspond to the pathophysiologic change of LC according to disease severity and possibly to hepatocarcinogenesis.