• Communications for Statistical Applications and Methods
• /
• 제25권5호
• /
• pp.559-568
• /
• 2018

Gene classification can involve complex order-restricted inference. Examining gene expression pattern across groups with order-restriction makes standard statistical inference ineffective and thus, requires different methods. For this problem, Roy's union-intersection principle has some merit. The M-estimator adjusting for outlier arrays in a microarray study produces a robust test statistic with distribution-insensitive clustering of genes. The M-estimator in conjunction with a union-intersection principle provides a nonstandard robust procedure. By exact permutation distribution theory, a conditionally distribution-free test based on the proposed test statistic generates corresponding p-values in a small sample size setup. We apply a false discovery rate (FDR) as a multiple testing procedure to p-values in simulated data and real microarray data. FDR procedure for proposed test statistics controls the FDR at all levels of ${\alpha}$ and ${\pi}_0$ (the proportion of true null); however, the FDR procedure for test statistics based upon normal theory (ANOVA) fails to control FDR.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 1997년도 하계학술대회 논문집 A
• /
• pp.260-263
• /
• 1997

In this paper, we describe the mechanical strain effects on the critical current density of HTS (BSCCO) pancake-type-magnet. Firstly the strain of pancake coil is calculated in terms of coil length, which is also a function of angle, and then the critical current density degradation due to strain is calculated along the coil. We assumed that the critical current density degradation pattern is same with that of $Nb_{3}Sn$. We also modelled the effects of magnetic field on the critical curent degradation, and the results are compared with those with null magnetic field.

• ETRI Journal
• /
• 제16권2호
• /
• pp.27-41
• /
• 1994

A new mathematical model to predict the beam pointing instability of a nonconservative two-body satellite system in spinning injection mode has been developed by using Newton-Euler and projection methods. Since the on-axis and null axis of the omni antenna with toroidal pattern beam form a right angle, wobbling of the antenna on-axis is measured by determining the Euler angles which represent the orientation of the satellite's spin axis. Because of the complexity of the system which is a time varying, nonstationary, nonlinear dynamical system, a numerical method is used for the analysis. Computer simulation results present the effects of the mass distribution and internal mass motion on the antenna beam pointing.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권5호
• /
• pp.2765-2769
• /
• 2013

Background: A close association between patterns identified by magnifying narrow-band imaging (M-NBI) and histological type has been described. M-NBI patterns were also recently reported to be related to the mucin phenotype; however, detials remain unclear. Materials and Methods: We investigated the cellular differentiation of gastric cancer lesions, along with their mucosal distribution observed by M-NBI. Ninety-seven depressed-type early gastric cancer lesions (74 differentiated and 23 undifferentiated adenocarcinomas) were visualized by M-NBI. Findings were divided into 4 patterns based on abnormal microvascular architecture: a chain loop pattern (CLP), a fine network pattern (FNP), a corkscrew pattern (CSP), and an unclassified pattern. Mucin phenotypes were judged as gastric (G-type), intestinal (I-type), mixed gastric and intestinal (M-type), and null (N-type) based on 4 markers (MAC5AC, MUC6, MUC2, and CD10). The relationship of each pattern of microvascular architecture with organoid differentiation indicated by cancer cell differentiation and its distribution in each histological type of early gastric cancer was investigated. Results: All CLP and FNP lesions were differentiated. The cancer cell distribution showed organoid differentiation in 84.2% (16/19) and 61.1% (22/36) of the two types of lesions, respectively, and there was a significant difference from the unclassified pattern with organoid differentiation (p<0.001). Almost all (94.7%; 18/19) CSP lesions were undifferentiated, and organoid differentiation was observed in 72.2% (13/18). There was a significant difference from the unclassified pattern with organoid differentiation (p<0.05). Conclusions: Cellular differentiation and distribution are associated with microvascular architecture observed by M-NBI.

• 한국전자파학회논문지
• /
• 제21권8호
• /
• pp.886-892
• /
• 2010

본 논문에서는 epsilon negative(ENG) 영차 공진과 $TM_{010}$-모드를 결합하여 넓은 대역폭을 갖고, 지향성 방사 패턴을 갖는 하이브리드 안테나를 제안한다. ENG 영차 공진을 얻기 위해 버섯 구조를 이용하였고, $TM_{010}$ 모드를 얻기 위해 패치 안테나를 이용하였다. 이 두 개의 안테나 사이에 갭을 주어 하나의 동축 선로 급전 구조로 두 개의 안테나를 결합하였다. ENG ZOR 주파수는 4 GHz, $TM_{010}$의 주파수는 3.9 GHz로 설계하였다. 두 주파수가 근접해 있기 때문에 이중 공진을 형성할 수 있고, 따라서 대역폭을 확장시킬 수가 있다. ENG ZOR 안테나는 전방향성의 방사 패턴을 갖지만, ENG ZOR 주파수와 $TM_{010}$의 주파수가 매우 근접해 있기 때문에 전방향성의 방사 패턴의 널 부분을 $TM_{010}$ 모드 방사가 보상해줄 수 있어 제안된 안테나는 지향성 방사 패턴을 갖는다. 제안된 안테나는 버섯 구조의 단위 셀을 각각 4개, 3개, 2개로 줄여나가면서 3가지 종류로 설계하여 특성을 분석하였다. 각각의 제안된 안테나는 비대역폭 $4.29{\sim}4.95 %$, 이득 3.16~5.57 dBi, 효율 62.4~94.2 %의 특성을 가지고 있다.

• 수산경영론집
• /
• 제40권1호
• /
• pp.51-74
• /
• 2009

The purpose of this study is to ascertain that how the futures market of the Japanese frozen shrimp that is the only fisheries asset all over the world can be efficient. Accordingly, this paper examines efficiency and information flow of the Japanese frozen shrimp market using data from Kansai Commodities Exchange frozen shrimp futures closing prices and spot prices. And then this paper estimates a forward price model using that data. From the model, risk premium is estimated and we could also analyse the future information flow into the futures market which reveals future spot prices. This thesis reached to conclusions as follows: First, the null of zero risk premium is rejected and the value of that is negative. Second, the time pattern of information flow into the futures market is that most of the information on future price arrives within a week and for the last week, most of relevant information is already incorporated. The result of this study contrasts with that of Stockman(1978) about currency futures market of U.S.

• 한국인지과학회:학술대회논문집
• /
• 한국인지과학회 2002년도 춘계학술대회
• /
• pp.111-116
• /
• 2002

The regularity effect for printed word recognition and naming depends on ambiguities between single letters (small grain-size) and their phonemic values. As a given word is repeated and becomes more familiar, letter-aggregate size (grain-size) is predicted to increase, thereby decreasing the ambiguity between spelling pattern and phonological representation and, therefore, decreasing the regularity effect. Lexical decision and naming tasks studied the effect of repetition on the regularity effect for words. The familiarity of a word from was manipulated by presenting low and high frequency words as well as by presenting half the stimuli in mixed upper- and lowercase letters (an unfamiliar form) and half in uniform case. In lexical decision, the regularity effect was initially strong for low frequency words but became null after two presentations; in naming it was also initially strong but was merely reduced (although still substantial) after three repetitions. Mixed case words were recognized and named more slowly and tended to show stronger regularity effects. The results were consistent with the primary hypothesis that familiar word forms are read faster because they are processed at a larger grain-size, which requires fewer operations to achieve lexical selection. Results are discussed in terms of a neurobiological model of word recognition based on brain imaging studies.

• BMB Reports
• /
• 제49권8호
• /
• pp.443-448
• /
• 2016

The arginylation branch of the N-end rule pathway is a ubiquitin-mediated proteolytic system in which post-translational conjugation of Arg by ATE1-encoded Arg-tRNA-protein transferase to N-terminal Asp, Glu, or oxidized Cys residues generates essential degradation signals. Here, we characterized the ATE1^−/− mice and identified the essential role of N-terminal arginylation in neural tube development. ATE1-null mice showed severe intracerebral hemorrhages and cystic space near the neural tubes. Expression of ATE1 was prominent in the developing brain and spinal cord, and this pattern overlapped with the migration path of neural stem cells. The ATE1^−/− brain showed defective G-protein signaling. Finally, we observed reduced mitosis in ATE1^−/− neuroepithelium and a significantly higher nitric oxide concentration in the ATE1^−/− brain. Our results strongly suggest that the crucial role of ATE1 in neural tube development is directly related to proper turn-over of the RGS4 protein, which participate in the oxygen-sensing mechanism in the cells.

• Molecules and Cells
• /
• 제38권5호
• /
• pp.426-431
• /
• 2015

Odin has been implicated in the downstream signaling pathway of receptor tyrosine kinases, such as the epidermal growth factor and Eph receptors. However, the physiologically relevant function of Odin needs to be further determined. In this study, we used Odin heterozygous mice to analyze the Odin expression pattern; the targeted allele contained a ${\beta}$-geo gene trap vector inserted into the 14t intron of the Odin gene. Interestingly, we found that Odin was exclusively expressed in ependymal cells along the brain ventricles. In particular, Odin was highly expressed in the subcommissural organ, a small ependymal glandular tissue. However, we did not observe any morphological abnormalities in the brain ventricles or ependymal cells of Odin null-mutant mice. We also generated BAC transgenic mice that expressed the PTB-deleted Odin (dPTB) after a floxed GFP-STOP cassette was excised by tissue-specific Cre expression. Strikingly, Odin-dPTB expression played a causative role in the development of the hydrocephalic phenotype, primarily in the midbrain. In addition, Odin-dPTB expression disrupted proper development of the subcommissural organ and interfered with ependymal cell maturation in the cerebral aqueduct. Taken together, our findings strongly suggest that Odin plays a role in the differentiation of ependymal cells during early postnatal brain development.

• 한국컴퓨터정보학회논문지
• /
• 제15권5호
• /
• pp.75-81
• /
• 2010

적응 배열 안테나 시스템은 간섭신호 방향으로 영점을 형성하여 표적신호를 추정한다. 그러나 적응 배열 안테나 시스템에 상관성 간섭신호가 입사된다면 표적신호를 간섭신호로 간주하여 시스템의 성능이 급격히 감소되고, 지향 오차에 민감하여 주빔이 표적신호의 입사방향을 지향하지 못한다. 본 논문에서는 고차제한조건과 지향오차수정방법을 결합하여 빔형성 알고리즘을 제안하였다. 그리고 제안한 알고리즘으로 자유도 손실을 최소화하고 간섭신호와 지향오차를 감소시켰다. 모의실험을 이용하여 제안 알고리즘과 기존 알고리즘의 성능을 비교 분석하였다. 본 논문에서 제안한 알고리즘은 신호 입사각을 정확히 추정하지만 기존의 알고리즘은 약 $0.8^{\circ}$의 오차가 발생하였다.