• Journal of Dental Anesthesia and Pain Medicine
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• 제24권3호
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• pp.145-159
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• 2024

Dental injections are routinely performed and can result in pain and anxiety in patients. This systematic review aimed to evaluate the efficacy of photobiomodulation therapy (PBMT) in dental injections for pain management in patients undergoing dental treatment. Indexed databases, including PubMed, EMBASE, Scopus, ISI Web of Knowledge, and Cochrane Library, were electronically searched without a time limit up to February 2024. A risk of bias evaluation was performed using the Cochrane tool. A preliminary investigation using electronic and manual methods yielded 4,920,881 manuscripts. Based on the eligibility requirements, 13 randomized control trials (RCTs) were included. Self-assessed pain was determined using the visual analog scale, Face, Legs, Activity, Cry, Controllability scale, or Wong-Baker face pain scale. Eight RCTs demonstrated a notable decrease in needle pain in patients undergoing dental needle injections using PBMT. Based on current evidence, PBMT may help reduce needle pain related to dental anesthesia. Further standardized studies are needed to assess the significance of PBMT for postoperative pain in patients undergoing dental injections.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제35권2호
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• pp.107-118
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• 2024

Objectives: This study aims to extract and summarize the literature on the mental health status of patients with monkeypox. Methods: This review was carried out according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using different databases and publishers such as Scopus, Sage, ScienceDirect, PubMed, BMJ, Wiley Online Library, Wolters Kluwer OVID-SP, and Google Scholar. The literature review was based on monkeypox and mental health. The year of publication was 2021-2023, during the monkeypox disease period. Data were extracted from opinions, editorials, empirical studies, and surveys. Results: Based on the literature related to the mental status of patients with monkeypox, the following themes and subthemes were identified: anxiety and depression, self-harm and suicidal tendencies, neuropsychiatric symptoms, mental health, social stigma, sex workers, vaccination, and stress-related diseases. Conclusion: A review of monkeypox virus infection studies reveals that 25%-50% of patients experience anxiety and depression due to isolation, boredom, and loneliness. Factors such as infected people, a lack of competence among healthcare professionals, and shame over physical symptoms exacerbate mental insults. The implications of society include increased self-harm, suicide, low productivity, fear of stigmatization, and transmission of infection.

• 한국임상약학회지
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• 제34권3호
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• pp.141-154
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• 2024

Background: As preexisting comorbidities are risk factors for Coronavirus Disease 19 (COVID-19), improved tools are needed for screening or diagnosing COVID-19 in clinical practice. Difficulties of including vulnerable patient data may create data imbalance and hinder the provision of well-performing prediction tools, such as artificial intelligence (AI) models. Thus, we systematically reviewed studies on AI prognosis prediction in patients infected with COVID-19 and existing comorbidities, including cancer, to investigate model performance and predictors dependent on patient data. PubMed and Cochrane Library databases were searched. This study included research meeting the criteria of using AI to predict outcomes in COVID-19 patients, whether they had cancer or not. Preprints, abstracts, reviews, and animal studies were excluded from the analysis. Majority of non-cancer studies (54.55 percent) showed an area under the curve (AUC) of >0.90 for AI models, whereas 30.77 percent of cancer studies showed the same result. For predicting mortality (3.85 percent), severity (8.33 percent), and hospitalization (14.29 percent), only cancer studies showed AUC values between 0.50 and 0.69. The distribution of comorbidity data varied more in non-cancer studies than in cancer studies but age was indicated as the primary predictor in all studies. Non-cancer studies with more balanced datasets of comorbidities showed higher AUC values than cancer studies. Based on the current findings, dataset balancing is essential for improving AI performance in predicting COVID-19 in patients with comorbidities, especially considering age.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7847-7852
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• 2015

Purpose: Research carried out with gynecologic cancer patients using CAM was reviewed to provide a source for discussing which CAM method is used for which purpose, patients' perceptions on the effects/side effects occurred during/after using CAM and their sources of information regarding CAM. Materials and Methods: This literature review was carried out for the period between January 2000 and March 2015 using Scopus, Dynamed, Med-Line, Science Dırect, Ulakbim, Research Starters, Ebscohost, Cinahl Complete, Academic Onefile, Directory of Open Access Journals, BMJ Online Journals (2007-2009), Ovid, Oxford Journal, Proquest Hospital Collection, Springer-Kluwer Link, Taylor & Francis, Up To Date, Web Of Science (Citation Index), Wiley Cochrane-Evidence Base, Wiley Online Library, and Pub-Med search databases with "complementary and alternative medicine, gynecologic cancer" as keywords. After searching through these results, a total of 12 full length papers in English were included. Results: CAM use in gynecologic cancer patients was discussed in 8 studies and CAM use in breast and gynecologic cancer patients in 4. It was determined that the frequency of CAM use varies between 40.3% and 94.7%. As the CAM method, herbal medicines, vitamins/minerals were used most frequently in 8 of the studies. When the reasons why gynecologic cancer patients use CAM are examined, it is determined that they generally use to strengthen the immune system, reduce the side effects of cancer treatment and for physical and psychological relaxation. In this review, most of the gynecologic cancer patients perceived use of CAM as beneficial. Conclusions: In order that the patients obtain adequate reliable information about CAM and avoid practices which may harm the efficiency of medical treatment, it is recommended that "Healthcare Professionals" develop a common language.

• 대한한방부인과학회지
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• 제35권3호
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• pp.122-136
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• 2022

Objectives: The aim of this study is to investigate Heart Rate Variability (HRV) characteristics of patients with primary dysmenorrhea at the menstrual phase. Methods: 7 databases (Pubmed, Cochrane library, CNKI, RISS, KISS, OASIS, ScienceON) were searched for eligible studies published before 2021 December. The studies comparing HRV between patients with primary dysmenorrhea and controls were included. A random-effects model was used to evaluate differences of HRV parameters between patients with primary dysmenorrhea and controls. Results: 4 articles were included in this review based on inclusion and exclusion criteria. SDNN (Standard deviation of NN intervals), RMSSD (Square root of the mean squared difference of successive NN intervals), mean PR (Mean of pulse rate), LF (Low frequency), HF (High frequency), was the most frequently used as HRV parameters. RMSSD was significantly lower in patients with primary dysmenorrhea than controls. There was no statistically significant difference of other HRV parameters between patients with primary dysmenorrhea and controls. Conclusions: This study suggests that parasympathetic activity and overall functions of autonomic nervous system might be decreased in patients with primary dysmenorrhea at the menstrual phase. In the future, well-designed clinical studies using HRV and additional meta-analysis should be conducted to obtain a wealth of information about HRV characteristics of patients with primary dysmenorrhea.

• 한국산학기술학회논문지
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• 제21권8호
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• pp.429-439
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• 2020

본 연구의 목적은 메타분석을 통해 가상현실 프로그램이 뇌졸중 환자의 상지기능에 미치는 효과크기를 알아보고자 한다. 데이터베이스는 한국교육학술정보원(RISS), 한국학술정보(KISS), 국립중앙도서관, 한국학술지인용색인(KCI), 국가과학기술정보센터(NDSL)를 활용하였다. 2010년 1월부터 2019년 6월까지 가상현실 프로그램을 실시한 선행연구들을 조사하였다. 본 연구는 PICO(Patient, Intervention, Comparison, Outcome, PICO)기준에 의거하여 최종 14편을 선정하여 메타분석을 실시하였다. 질 평가도구로 RCT(Randomized Control Trials) 연구는 RoB(Risk of Bias) 도구, NRCT(Non-Randomized Control Trials) 연구는 RoBANS(Risk of Bias Assessment tool for Non-randomised Study) 도구를 사용하였다. 선정된 각 연구들의 효과크기를 산출하기 위해 CMA 3.0프로그램을 사용하였다. 추가적으로 하위집단분석과 메타회귀분석 및 출판편의 분석을 실시하였다. 가상현실 프로그램이 상지기능에 대한 전체 효과크기는 Hedges's=0.390 (95 % CI: 0.192~0.587)으로 확인되었다(p<.05). 가상현실 프로그램은 뇌졸중 환자의 상지기능에 긍정적인 영향을 미친다. 따라서, 4차 산업에 발맞추어 뇌졸중 환자를 위한 다양한 가상현실 프로그램과 산학 협력 기술 개발이 요구된다. 향후 가상현실 프로그램에 대한 RCT연구들과 세부적인 상지기능에 대한 연구가 질적 및 양적으로 확보되어야 할 것이다.

• 재활치료과학
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• 제5권2호
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• pp.57-69
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• 2016

목적: 본 연구는 뇌졸중 환자를 대상으로 사용한 가속도계 연구를 고찰하여 뇌졸중 환자의 일상생활활동평가 도구로 가속도계가 유용하게 활용될 수 있는 지 알아보고자 하였다. 연구방법: 2014년 2월부터 3월까지 PubMed, EMBASE, Cochrane Library 데이터베이스를 통해 제공되는 논문들을 수집하였다. 총 331 개의 연구가 검색되었으며 최종 13개의 논문을 선정하였다 결과: 선정된 13편의 연구에서는 급성기, 아급성기, 만성기의 뇌졸중 환자를 대상으로 하였다. 평가에 사용한 가속도계의 종류로는 단축, 이축, 삼축 가속도계, 활동모니터가 있었으며, 20Hz 미만 혹은 이상의 진동수를 설정하고 1개에서 3개 이상을 사용하였다. 또한 가속도계는 일상생활의 상지 및 하지활동 및 움직임을 측정하기 위해서 사용되었으며, 일상생활의 상지 과제를 통해 움직임을 분석할 때는 주로 손목, 팔에, 하지의 움직임은 허리, 넓적다리, 복사뼈에 부착하여 분석하였다. 측정활동은 주로 상지과제 활동, 걷기 활동 이였으며, 측정활동에 따라 부착부위도 다양하였다. 측정변수로는 총 활동 수, 대상자 움직임의 속도, 양측 움직임 비율, 동작분석이 있었으며, 결과로는 모든 연구에서 중재 전, 후 가속도계로 측정한 변수와 기존의 다른 평가도구와의 유의한 상관관계를 보고하였다. 결론: 본 연구를 통해 작업치료사가 뇌졸중 환자의 일상생활활동을 객관적으로 평가할 때 가속도계가 유용하게 활용될 수 있다는 것을 증명하였다. 더 나아가 국내 작업치료 연구를 통해 가속도계가 임상 및 지역사회에서 다양한 방법으로 활용될 수 있기를 기대해 본다.

• 대한물리치료과학회지
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• 제18권2호
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• pp.1-8
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• 2011

Background: The purpose of this study was to systematic review the effect of exercise programs for chronic low back pain patients. We needs systematic development of low back pain exercise program to reduce economic cost further doing great service to public health promotion. Methods: We searched to the effects of exercise programs for chronic low back pain patients by Dankook University electronic library databases of DBPIA, KSI KISS, CINAHL, MEDLINE and PEDro combined with a hand search of papers published in relevant journals. Any type of study relevant to the topic published during time period from 1970 to 2007 was included. Results: The literature search identified 30 studies. 1.Performing the flexion exercise increased abdominal muscle activity but acute herniated intervertebral disc should be avoided. 2.The general lumbar extension exercise used lumbar extension machine and the muscle power increases, significant probability the change. 3.The spinal segments exercise for the patients offered significant efficacy and appeared to be a reasonable therapeutic option. 4.Spinal stabilization exercises appear to improve trunk endurance and balance to patients with chronic low back pain. This exercise programs had effective decrease pain and disability. Conclusion: The review suggests that although the exercise programs for chronic low back pain patients, and we expected the efficacy of the exercise programs for chronic low back pain patients used in this study should be further investigated in a long period study and objective outcomes.

• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.3917-3921
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• 2016

Background: The association between calcium channel blockers (CCBs) and survival in cancer patients remains unclear and the results of related studies are conflicting. The objective of the study was to investigate the association between calcium channel blockers (CCBs) use and survival in cancer patients. Materials and Methods: We searched PubMed, EMBASE, Web of Science and Cochrane Library for studies published before January 2016 with the terms related to CCBs and survival in cancer patients. The information was reviewed and extracted by two evaluators independently. Data of publications was extracted and calculated into hazard ratios (HRs) for overall survival (OS). Statistical analysis was performed by using Review Manager 5.3. Results: There were 11 studies included in our meta-analysis. Analysis of all studies showed that CCBs use was not associated with survival in cancer patients (HR=1.07; 95% CI: 0.91-1.25; P=0.42). No association between CCBs use and overall survival in cancer patients was existed whether in Asian (HR=1.18, 95% CI: 0.72-1.93; P=0.52) or Caucasian population (HR=1.03, 95% CI: 0.89-1.20; P=0.66). Conclusions: There is no evidence that CCBs use is associated with a better or worse outcome of survival in cancer patients.

• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.2369-2374
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• 2014

Background and Aim: Selumetinib is a promising and interesting targeted therapy agent as it may reverse radioiodine uptake in patients with radioiodine-refractory differentiated thyroid cancer. We conduct this metaanalysis to compare the efficacy and safety of selumetinib with current therapies in patients with advanced cancer. Methods: An electronic search was conducted using PubMed/ Medicine, EMBASE and Cochrane library databases. Statistical analyses were carried out using either random-effects or fixed-effects models according to the heterogeneity of eligible studies. Results: Six eligible trials involved 601 patients were identified. Compared with current therapies, treatment schedules with selumetinib did not improve progression free survival (hazard ratio, 0.91; 95%CI 0.70-1.17, P= 0.448), but did identify better clinical benefits (odds ratio, 1.24; 95%CI 0.69-2.24, P = 0.472) and less disease progression (hazard ratio, 0.72; 95%CI 0.51-1.00, P = 0.052) though its impact was not statistically significant. Sub-group analysis resulted in significantly improved progression free survival (hazard ratio, 0.61; 95%CI 0.49-0.57, P = 0.00), clinical benefits (odds ratio, 3.04; 95%CI 1.60-5.77, P = 0.001) and reduced disease progression (hazard ratio, 0.35; 95%CI 0.18-0.67, P = 0.001) in patients administrated selumetinib. Dermatitis acneiform (risk ratio, 9.775; 95%CI 3.143-30.395, P = 0.00) and peripheral edema (risk ratio, 2.371; 95%CI 1.690-3.327, P = 0.00) are the most frequently observed adverse effects associated with selumetinib. Conclusions: Compared with current chemotherapy, selumetinib has modest clinical activity as monotherapy in patients with advanced cancer, but combinations of selumetinib with cytotoxic agents in patients with BRAF or KRAS mutations hold great promise for cancer treatment. Dermatitis acneiform and peripheral edema are the most frequently observed adverse effects in patients with selumetinib.