• 한방안이비인후피부과학회지
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• 제30권3호
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• pp.46-61
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• 2017

Objectives : Allergic contact dermatitis(ACD) is a type IV delayed hypersensitivity reaction that results from cumulative exposures and subsequent sensitization to an environmental chemical. Lonicerae Caulis(LC) can clear away heat and relieve toxin, disperse wind and heat, dredge the channel. The present study was designed to investigate the effects of LC on allergic contact dermatitis(ACD) induced by 2,4-dinitrochlorobenzene(DNCB) in mice. Methods : In this experiment, the effects of LC on changes in body weights, ear and dorsum skin thicknesses, ear weights, clinical aspects on the dorsum skin, histopathological changes, spleen/body ratio, cytokines were investigated. In addition, the effects on proliferations of splenocytes were also investigated in vitro and vivo study. Results : LC spread(SPR) group and LC spread and administered(SPR+ADM) group showed diminished ear thicknesses. In SPR+ADM group, ear weights were lowered significantly compared to contact dermatitis control(CTL) group. LC treatment diminished erythema, desquamation and keratosis which were induced by repeated painting of DNCB. In histopathological observation, spongiosis and edema were diminished in SPR and SPR+ADM group. In cytokines, SPR+ADM group were increased in IL-10, and SPR and SPR+ADM group were decreased in TNF-${\alpha}$ compared with control group. Conclusions : These data suggest that LC can decrease symptoms of ACD, then LC is useful to treat patient with ACD.

• 치위생과학회지
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• 제15권2호
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• pp.238-245
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• 2015

본 연구는 지각과민처치제에 항균 물질을 첨가하여 항균실험 및 지각과민처치제의 세포독성실험을 실시하여 다음과 같은 결과를 얻었다. 항균실험에서는 Micro Prime은 항균 약물의 농도가 높을수록 항균력도 높게 나타나 각 그룹간의 항균 범위는 통계적인 유의차를 나타내었다(p<0.05). Hurri Seal에서는 gallic acid 항균 약물 농도가 높을수록 항균력이 높게 나타났지만(p<0.05), tetracycline을 함유한 desensitizer에서는 농도가 높을수록 항균효과는 떨어지는 것으로 나타났다(p<0.05). 또한 chlorhexidine과 cetylpyridinium chloride에서는 대조군에서만 차이를 나타내고(p<0.05), 각 실험군에서 차이를 나타내지 않았다. 세포독성도를 평가한 결과 Micro Prime은 미약한 세포독성을 나타냈으며, Hurri Sea은 심한 세포독성을 나타냈다. 이상의 연구결과로 지각과민처치제에 항균물질을 첨가할 경우 우수한 항균력이 나타났기 때문에 지각과민 환자의 동통을 줄여 줄 것으로 사료되며 항균성을 가진 지각과민처치제로 사용이 가능할 것으로 판단된다.

• Radiation Oncology Journal
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• 제36권4호
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• pp.304-316
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• 2018

Purpose: The indication of elective neck treatment (ENT) for clinically N0 (cN0) paranasal sinus (PNS) carcinoma remains unclear. We aimed to investigate different treatment outcomes regarding ENT and propose optimal recommendations for ENT. Materials and Methods: We identified patients with cN0 PNS carcinoma who underwent curative-intent treatment between 1992 and 2015. Survival outcomes and pattern of failure were compared between patients who received ENT and those who did not. We sought to identify significant patient or pathologic factors regarding treatment outcomes. Results: Among 124 patients meeting the inclusion criteria, 40 (32%) received ENT ('ENT (+) group') and 84 (68%) did not ('ENT (-) group'). With a median follow-up of 54 months, the 5-year overall survival (OS) was 67%, and the 5-year progression-free survival (PFS) was 45%. There was no significant difference between the ENT (+) and ENT (-) groups regarding OS (p = 0.67) and PFS (p = 0.50). Neither group showed a significantly different pattern of failure, including regional failure (p = 0.91). There was no specific benefit, even in the subgroups analysis by tumor site, histologic type, and T stage. Nevertheless, patients who ever had regional and/or distant failure showed significantly worse prognosis. Conclusion: ENT did not significantly affect the survival outcome or pattern of failure in patients with cN0 PNS carcinomas, showing that ENT should not be generalized in this group. However, further discussion on the optimal strategy for ENT should continue because of the non-negligible regional failure rates and significantly worse prognosis after regional failure events.

• Journal of Microbiology
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• 제43권6호
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• pp.546-554
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• 2005

We assessed the genetic relations and epidemiological links among bloodstream isolates of Candida albicans, which were obtained from a university hospital over a period of five years. The 54 bloodstream isolates from the 38 patients yielded 14 different karyotypes, 29 different patterns after digestion with SfiI (REAG-S), and 31 different patterns after digestion with BssHII (REAG-B) when analyzed using three different pulsed-field gel electrophoresis (PFGE) typing methods. In 11 patients with serial blood stream isolates, all strains from each patient had the same PFGE pattern. The dendrograms for all of the strains revealed that the distribution of similarity values ranged from 0.70 to 1.0 in the REAG-S patterns, and from 0.35 to 1.0 in the REAG-B patterns. Overall, the combination of the three different PFGE methods identified 31 distinct types, reflecting the results obtained using the REAG-B alone different. different Five PFGE types were shared among 22 isolates from 12 patients. These types of strains were more frequently associated with central venous catheter-related fungemia than the other 26 type strains $(92\%\;versus\;31\%;\;P<0.005)$. Of five PFGE types, four isolates were determined to be epidemiologically related: each of these types was primarily from two or three patients who had been hospitalized concurrently within the same intensive care unit. Our results suggest that the REAG-B constitutes perhaps the most useful PFGE method for investigating C. albicans candidemia and also shows that a relatively high proportion of C. albicans candidemia may be associated with exogenous acquisition of clonal strains.

• 대한한의학방제학회지
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• 제22권2호
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• pp.1-13
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• 2014

Objectives : ShangHanLun is a clinical guideline, and its core is in the part of Six-meridian Diseases. In recent philological sutdies, independent textual analysis of Shanghanlun is essential to define the scope of research. Methods : By the textual study, I defined the Shanghanlun clinic model. And I researched about medical range of Shanghanlun, and relations between Shanghanlun and JinGuiYaoLue, and between Shanghanlun and Huangdineijing. Results : In six topic sentences, the word '-之爲' means 'a process'. In provisions following topic sentences, the word '者' means 'a person'. So Shanghanlun is describing processing factors of Six-meridian Diseases and related human changes with clinical therapy. In the philological studies, meaning of '傷寒' was possibly just the 3rd provision of the greater yang disease part. Practically Shanghanlun's study range is over the concept of Cold damage today. Additionally Jinguiyaolue deals diseases, but Shanghanlun deals human. Gangpyeong-Shanghanlun's phrases can be separated into five part, and oldest part is independent of Huangdineijing. Conclusions : So we need to set a new and independent clinic model of Shanghanlun to verify it. The Shanghanlun's clinic model has a 3 steps. 1st step is to find 6 type defined symptoms, which act as processing factors of Six-meridian Diseases. 2nd step is to confirm a human changes after a Disease appeared. 3rd step is to treat a patient as a provision suggests. Philologically Shanghanlun's clinic range is not limited by the word '傷寒'. And many concepts in Shanghanlun should be independent of Huangdineijing.

• 대한한의학회지
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• 제36권1호
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• pp.33-44
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• 2015

Objectives: The aim of this study was to understand the characteristics of herbal-drug-associated adverse events (AEs) reported in the internet newspaper articles and to take a countermeasure against the safety issue of herbal drugs. Methods: We searched the internet newspaper articles published from 2010 to 2014 in the 3 major portal sites in Korea, NAVER, DAUM, and GOOGLE. Search terms were the Korean words equivalent of 'herbal drug' and 'side effects'. Informations on the type and characteristics of suspected herbal drugs, AEs, and the patient records were extracted from the articles reporting the herbal-drug-associated AE occurred in Korea. Results: From 8,806 articles, a total of 36 AEs were found. The most frequently reported age group was 20s, and women outnumbered men. Obesity was the most common cause of administration. Doctors of Korean medicine clinic were the most commonly referred prescribers and purchasing route (11 cases). The most frequently mentioned medicinal herb was Ephedra sinica (7 cases) and the most commonly reported AEs were abdominal pain (8 cases), dizziness (6 cases), diarrhea (5 cases), and vomiting (5 cases) were followed in order. Ten cases were judged as serious AEs, and the others were not. Conclusions: Current customers demand health care providers to offer them sufficient information on the safety of herbal drugs. To satisfy their requirements, physicians of Korean medicine should be able to explain, predict, prepare, recognize, and deal with the herbal-drug-associated AEs. We propose an establishment of pharmacovigilance system for herbal medicine, in which doctors of Korean medicine are participated as important personnel, to collect and analyze the related AEs and offer credible information on the safety of herbal drug.

• 대한한의학회지
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• 제30권1호
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• pp.26-39
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• 2009

Objectives: Pulse energy values recorded with an add-pres sure-type pulse apparatus were correlated with Sasang constitutional syndromes in order to match pulse energy values with Sasang prescriptions. Methods: The pulse energy values were measured with Daeyo Pulse Apparatus at the Gwan pulse point of both wrists. Prescriptions were divided into two major categories of interior syndromes or exterior syndromes, and categorized according to major component herbs specific to each of the four Sasang constitutions, and the relationship between the pulse energy and each groups divided by their prescription was studied. Results: About 10% of all people had nonmal pulse energy values. 10% had values over normal range, and $70\sim80%$ had lower values than normal. The normal range of pulse energy was regarded as being between 450 and 700. Conclusions: 1. For patients of the Soeum constitution, prescriptions without Panax ginseng is suitable for patients with high pulse energy, and prescriptions containing Panax ginseng are suitable for patients who have lower pulse energy. 2. All prescriptions for the Soyang constitution containing Rehmannia radix preparata or Comus officinalis are suitable for patients who have lower pulse energy, and prescriptions containing Rehmannia radix or Gypsum fibrosum are applicable to patients with pulse energy values higher than normal. 3. Most prescriptions for the Taeum constitution containing Semen coicis or Semen castaneae are suitable for patients with lower pulse energy, and prescriptions containing Radix puerariae or Radix et rhizoma rhei can be prescribed for patients who have lower pulse energy levels. 4. The Taeyang constitutional prescription Ogapijangcuck-tang is suitable for patients who have higher pulse energy levels and Mihudeungsikjang-tang is better for patients with lower than normal pulse values. As described above, the pulse energy level of each patient can be matched with a specific Sasang constitutional prescription. If this relationship is taken into consideration with other conventional symptoms, it can be helpful in diagnosis, improving efficacy of treatment, and be used as objective evidence.

• 한국콘텐츠학회논문지
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• 제10권12호
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• pp.1-9
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• 2010

당뇨병은 대사질환의 일종으로 고혈당을 특징으로 하며, 고혈당으로 인하여 여러 증상 및 징후와 합병증을 유발하여 삶의 질을 급격히 저하시킨다. 당뇨병의 예방 및 치료를 위해서는 식이, 운동, 약물 처방 등이 있지만 무엇보다도 체계적인 식단 관리가 필수적이다. 본 논문에서는 체계적인 당뇨병 관리를 위해서 스마트폰 기반의 개인 맞춤형 식단 관리 시스템을 제안한다. 현재 대부분의 당뇨병 환자의 식단 서비스는 영양사나 의사의 주관적인 판단으로 식단을 처방하며 상황 및 개인의 선호도는 반영 되지 않는다. 제안하는 시스템은 당뇨식단을 계절, 날씨, 시간, 선호도에 맞추어 제공한다. 특히, 스마트 폰 서비스로 구현하여 언제 어디서나 장소에 제한받지 않고 사용자에게 레시피 및 개인화된 식단을 제공하며, 사용자의 간단한 조작만으로도 손쉽게 식단 변경이 가능하다.

• The Korean Journal of Pain
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• 제2권1호
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• pp.57-60
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• 1989

The Melkersson-Rosenthal (M-R) syndrome consists of a triad of (1) recurrent peripheral facial nerve paralysis which develops alternately on both sides of face, (2) non-inflammatory facial edema, and (3) fissuring of tongue. A 59 years old female patient developed the left facial palsy on September, 1988. Right facial palsy developed continuously 2 months later after the spontaneous remission of left facial palsy. On February, 1989, we have found out M-R syndrome which accompanied with migraine type of intermittent headache, and hypertension in one attack of cerebral stroke several years ago, there were no diabetes mellitus, pulmonary tuberculosis and brain tumor in clinical studies. Although the causes of this syndrome were not noted, we performed the stellate ganglion block and transcutaneous electrical nerve stimulation for treatment of the palsy, but the clinical effectiveness of these were not satisfactory.

• 임상간호연구
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• 제20권1호
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• pp.134-145
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• 2014

Purpose: The purpose of this study was to develop and apply a video dietary instruction program for hemodialysis patients to understand dietary compliance as well as the effect on the physiological indicator. Methods: This is a quasi-experimental study of a nonequivalent control group pre-post test design. Data were collected from August 6, 2012 to January 10, 2013. Twenty patients were assigned to an experimental group and twenty-one patients were assigned to a control group. A video dietary instruction program was developed and applied only to the experimental group once a week for a total of 8 weeks. Dietary compliance and physiological indicators were subsequently measured. Results: Dietary compliance was improved in both groups over time. There was no significant change in the physiological indicator value in both groups, indicating that there was no correlation between the treatment type and time. Conclusion: The video dietary instruction program could not make a statistically significant change on the physiological indicator value of the experimental group; however, this change was maintained within the allowable limits. Therefore, the video dietary instruction program can be utilized continuously as a standardized nursing intervention program in order to maintain the dietary compliance of hemodialysis patients.