• Health Policy and Management
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• v.9 no.3
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• pp.70-94
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• 1999

This paper was performed for a cost-effectiveness analysis of pharmacologic treatment of hypercholesterolemia. Agents modeled were cholestyramine, gemfibrozil. bezafibrate, lovastatin, pravastatin, simvastatin. Pharmacologic effectiveness was estimated by regression from reported clinical trials. Pharmacologic effects were expressed as the percent change of blood cholesterol level. Cost estimates included patients' travel expenses and time loss as well as resource consumption in the health care sector. Bezafibrate was the most efficient agent for reducing total cholesterol levels, having an cost over 1 year of ￦31.400 per percent reduction in total cholesterol. Simvastatin (10mg/d) was also efficient(￦33,100 per percent reduction). Chole styramine(8g/d) was least efficient at ￦90,200. For low-density lipoprotein cholesterol. simvastatin(10mg/d) was most efficient, at ￦23,200 per percent reduction, followed by lovastatin(20mg/d) at ￦28,000. Gemfibrozil was least efficient at ￦77,800 per percent reduction. For high-density lipoprotein cholesterol. bezafibrate(400mg/d) was most efficient at ￦39,300 per percent increase of high-density lipoprotein cholesterol. Cholestyramine was least efficient at ￦514,700. Analyses combining low-density lipoprotein cholesterol and high-density cholesterol effects suggest that bezafibrate(600mg/d) and simvastatin (10mg/d) were most efficient for reducing cardiovascular risk. The cost-effectiveness analysis results show that both simvastatin and bezafibrate could be efficient treatment. Simvastatin provide more effective treatment at higher cost, whereas bezafibrate is more cost-effective, as it may be less effective, at lower cost. Therefore, clinicians should choose reasonable treatment according to the patient's needs This pharmacoeconimc analysis will provide a guideline for efficient pharmacologic treatment and also be reference data for pricing new drugs.

• Journal of Korean Neurosurgical Society
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• v.40 no.4
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• pp.256-261
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• 2006

Objective : The goal of this study was to establish the benefit and prognostic factors of lumbar medial branch block[MBB] for low back pain. Methods : A retrospective analysis was based on the data obtained from 281 patients with low back pain, who visited our hospital between January 2001 and November 2004. Pain relief was evaluated at 2 weeks, 1 month and 3 months. The authors analyzed the results of MBB according to the patient's age, sex, symptom duration, pathologic condition, and presence of radiating pain. Results : Two hundred eighty one patients had sprain [151]. lumbar fracture [27], spinal stenosis [50], herniated lumbar disc [24] acute post-operative pain [8], and chronic post-operative pain [21] with success rate of 63.6%, 59.3%, 26.0%, 25.0%, 87.5% and 42.9%, respectively. The effects of MBB in sprain, lumbar fracture, and acute post-operative pain were significantly better than those in stenosis, herniated lumbar disc and chronic post-operative pain patients. The patients in young age group [<60 years], with short symptom duration [<6 months] and without radiating pain showed good response to lumbar MBB. Conclusion : The lumbar MBB appears to be safe and effective for low back pain in certain selected patients. Good prognostic factors were low back pain without surgical conditions and radiating pain, with short symptom duration [<6 months], and in relatively young age [<60 years] group.

• Women's Health Nursing
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• v.11 no.1
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• pp.67-76
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• 2005

Purpose: This study was to identify the influence of sexual behavior, body image, social support, and other characteristics on sexual satisfaction in patients with breast cancer according to their participation in a support group. Method: Data was collected by self-report questionnaires. Participants included 63 patients attending a support group and 76 patients who did not participate in the support group. The questionnaire sections consisted of sexual satisfaction, sexual behavior, body image, social support and information on general characteristics, disease-related characteristics, and sexual life-related characteristics. Result: There was no statistically significant difference in sexual behavior, body image and sexual satisfaction between the two groups. Social support scores were significantly higher in the support group. Sexual satisfaction was positively related with sexual behavior, post-op change of sexual intercourse frequency, body image, and patient's education level, and negatively related to age in the support group. Sexual satisfaction was positively related with sexual behavior, social support and body image in the non support group. Sexual behavior is predictable 37.0% of sexual satisfaction in the support group. Sexual behavior, body image, and social support is predictable for 38.0% of the sexual satisfaction in non support group participants. Conclusion: Implications point to the need for the development and implementation of programs that focus specifically on sexual life issues for breast cancer patients, as well as further research measuring the effects of such intervention programs. Continuous education and counseling through participation in support groups can contribute to promote and affirm a healthy sexual life for patients with breast cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.6
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• pp.2675-2679
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• 2012

Introduction: Annually a considerable number of people die because of breast cancer, a common disease among women also in Iran. Identifying risk factors and susceptible people can lead to prevention or at least early diagnosis. Among susceptibility risks, 5-10% of patients have a family history predisposing factor which can influence the risk of incidence among the family. Having a registry program can be a more practical way to screen high risk families for preventive planning. Method: Based on inclusion criteria, a questionnaire was prepared and after a pilot study on a small number of patients, actual data were collected on 400 patients and processed in SPSS 16.0. Results: Totally, 28.2%of the patients were younger than 40 years old and 36.8% had the included criteria for familial breast cancer (FBC). 102 patient's samples could be compared for receptor presentation. Similar to other studies, the number of triple negative breast cancers increased as the age decreased. Conclusion: The high percentage of patients with FBC among 400 cases in this study demonstrates that in order to design an infrastructural diagnostic protocol and screening of patients with FBC, a precise survey related to frequency and founder mutations of FBC is needed nationwide.

• The Journal of Korean Medicine
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• v.38 no.1
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• pp.93-111
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• 2017

Objectives: The aim of this study is to make evidence-based data for developing a traditional Korean medicine clinical practice guideline for acute bronchitis. Methods: We searched 3 international databases(PubMed, EMBASE, CENTRAL) and 7 domestic databases (KoreaMed, Kmbase, NDSL, KISS, KISTI, OASIS, KoreaTK) to identify randomized controlled trials (RCTs) of acute bronchitis using medicine in recent 10 years. The chosen trials were analyzed by their study design, age range, intervention group, control group, primary and second outcome measure, inclusion and exclusion of participants and adverse events. Results: 15 RCTs are finally included in this study and most of their medications are herbal medicine. For diagnosis and outcome measure of acute bronchitis, Bronchitis Severity Score(BSS) was mostly used. Other measurements eligible are coughing fits, quality of life scale, sputum viscosity, change of individual symptoms and patient's satisfaction. Test duration was for average 7days and safety assessment was held by recording adverse events. Except for anti-inflammatory and antibiotic trials, all medications are found to be effective and well-tolerated. General risk of bias of chosen trials is evaluated low. Conclusions: A well designed clinical trials for traditional Korean medicine of acute bronchitis is needed and this study is expected to make it available.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.8
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• pp.3850-3857
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• 2013

This study aims to examine the effect of the program by identifying changes in oral health behaviors, oral health knowledge, the Patient Hygiene Performance(PHP) index and others after performing oral health promotion program on children in community children's centers to develop persistent and more effective program. The final analysis subjects were 27 children. According to the examination results of dental plaque score, the PHP index score was reduced from 3.42 to 2.43 before and six month after the tooth brushing education, respectively, indicating the effect of oral health promotion program(p<0.001). The data of this paper can be used oral health promotion programs development based on the social ecological model.

• Journal of Korean Neurosurgical Society
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• v.40 no.2
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• pp.74-78
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• 2006

Objective : We examined the incidence of fenestration in the proximal segment of the anterior cerebral artery[ACA] and reviewed its clinical significance. Methods : Cerebral angiography was performed in 843 patients and magnetic resonance angiography[MRA] in 1,787; all patients had, or were suspected to have, cerebrovascular disease. We subsequently reviewed the angiography and MRA data. Results : Fourteen patients [six men and eight women, $35{\sim}81$ years of age, median age = 67 years] had proximal ACA fenestrations. Three of the 843 patients [0.36%] undergoing cerebral angiography had fenestrations of proximal ACA as did eleven of the 1,787 MRA patients [0.62%]. Seven fenestrations were located on the right side and seven fenestrations were located on the left side. The fenestrated ACA in one patient was associated with a saccular aneurysm at its proximal end. None of the 120 patients who underwent both conventional cerebral angiography and cranial MRA showed fenestration of proximal ACA. Conclusion : Although fenestration of ACA has little clinical significance, knowledge and recognition of this condition is important in the interpretation of cerebral images, especially during neurosurgical procedures.

• Journal of Chest Surgery
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• v.29 no.3
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• pp.360-364
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• 1996

Chylothorax is denned by extravasation of the milky fluid to pleural cavity from the thoracic duct or it's main branches due to operative trauma, congenital lesions, diagnostic procedures, tumor, etc. Another rare cause is diffuse pulmonary Iymphangiomatosis which is uncommon and not well charact rized. We experienced a case of the bilateral chylothorax caused by the diffuse pulmonary Iymphangiomatosis. The patient was at years old girl with symptoms of coughing and febrile sensation, and the chest radiographs showed bilateral pleural effusion and interstitial infiltrates. The laboratory data of the pleural effusion was identified as chile. Uncontrollable with closed tube thoracostomy, division of tHe thoracic duct and biopsy were decided. Biopsy showed anastomosing endothelial lined spaces along the pulmonary Iymphatic routes especially in pleural and interlobar septum, and smooth muscle at the proliferative interstitium of the Iymphatic duct was observed. Postoperatively, chylothorax was controlled with several trial of chemical pleurodesis. Af'leer discharge from the hospital, she was well for ten months follow up.

• The Journal of Korean Society for School & Community Health Education
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• v.13 no.2
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• pp.107-118
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• 2012

Backgrounds: In order to prevent dental injuries that often occur in child and adolescent, it is intended to investigate and assess actual state of the injury development, present epidemiological background, and consider and discuss for preparing preventive means against the injury development. Purpose: It was attempted to understand major features of dental injuries developing in child and adolescent and indentify high risk factors of dental injuries in child and adolescent. Methods: In this study, 523 cases of computerized data collected as disease entities of dental injuries among 1-18 years old patient visiting S university hospital located in Seoul in 2009 were analyzed and following results were obtained. Results: It was found that the ratio of dental injuries by genders in child and adolescent was 66.14% of male and 33.86% of female. It was shown also that causes of dental injuries by ages were more in order of falling, bumping, chewing, traffic accident, sports, violence, and crash. In addition places where dental injuries occur by ages were home in less than 5 year old group, park, playground, and play yard in 6-11 year old group, park, playground, and play yard also in 12-14 year old group, and stairs, road, and outdoor places such as mountain climbing, beach, and camping in 15-18 year old group. It was found that time rages when dental injuries in child and adolescent often develop were 15-19 o'clock for falling, 15-19 o'clock for crash, 15-19 o'clock for bumping, 19-03 o'clock for violence, 15-19 o'clock for traffic accident, 15-19 o'clock for sports activity, and 15-19 o'clock for chewing. Conclusion: Background of dental injury inducing factors are very complicated and diversified, so deep study and analysis are required for its prediction. Therefore, it seems necessary to identify risk factors by phases such as before, at, and after accident, establish strategies to reduce injury development, and develop and utilize necessary programs.

• Journal of Korean Neurosurgical Society
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• v.50 no.3
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• pp.191-194
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• 2011

Objective : The aim of this study was to analyze the treatment outcome of patients with vein of Galen aneurysmal malformations (VGM). Methods : Clinical and angiographic data of six consecutive patients with VGM were retrospectively reviewed. VGMs were angiographically classified by Yasargil's method. Treatment outcomes were evaluated. Results : Mean age at initial treatment was $4.4{\pm}5.7$ months. Angiographic types of VGMs were type II in two patients and type III in four. Three patients had cardiac symptoms and the others were asymptomatic. Two patients were treated with transvenous embolization, three with transarterial embolization, and one was managed conservatively. Two patients died due to venous hypertension few days after transvenous approach. Of three patients who were transarterially embolized, one was completely occluded with Onyx and two were incompletely occluded. During the follow-up period (range, one to six years) two of three patients treated with transarterial approach were asymptomatic and the other showed mild symptoms. One patient who was managed conservatively showed normal performance. Conclusion : Transarterial embolization of VGMs may be better than transvenous approach in terms of the treatment outcome and complication. Further studies are needed because of the rarity of the disease and rapid advancement of endovascular techniques.