• Korean Journal of Clinical Pharmacy
• /
• v.7 no.1
• /
• pp.17-21
• /
• 1997

Cefaclor is a second generation cephalosporin antibiotic that shows a potent antibacterial activity against both Gram-positive and Gram-negative bacteria, when it is orally administered. Due to its patent expiration, a number of generic drugs have been marketed, but not yet elucidated to ensure therapeutic equivalence. In this study, cefaclor capsules manufactured by Chong Kun Dang were bioequivallently assessed by comparing with $Ceclor^{TM}$ introduced originally by Daewoong Lilly. A total of 16 healthy male volunteers were evaluated in a randomized crossover manner with a 2-week washout period. Concentrations of cefaclor in plasma were measured upto 6 hours following a single oral administration of two capsules (500 mg of cefaclor) by high-performance liquid chromatography with UV detection. Although the plasma concentration at 6 hours was not detected, the computed half-life of cefaclor was approximately 0.5 hours. The area under the concentration-vs-time curve from 0 to 4 hours $(AUC_{0-4h})$ was calculated by the trapezoidal summation method. The differences in mean values of $AUC_{0-4h}$, peak plasma concentration $(C_{max})$, and time to peak concentration $(T_{max})$ between the two products were $4.63\%,\;1.84\%,\;and\3.28\%$, respectively. The least significant differences at $\alpha4= 0.05 for $AUC_{0-4h},\;C_{max},\;and\;T_{max}\;were\;6,53\%,\;4.05\%,\;and\;6.47\%$, respectively. In conclusion, the test drug was bioequivalent with the reference drug.

• Communications for Statistical Applications and Methods
• /
• v.18 no.4
• /
• pp.507-516
• /
• 2011

Comparative studies on generalized binomial models (Moon, 2003; Ng, 1989; Paul, 1985; Kupper and Haseman, 1978; Griffiths, 1973) are restrictive in that the models compared are rather limited and MSE of the estimates is the only measure considered for the model adequacy. This paper is aimed to report simulation results which provide possible guidelines for selecting a proper model. We examine Pearson type of goodness-of-fit statistic to its degrees of freedom and AIC for the overall model quality. MSE and Bias of the individual estimates are also considered as the component fit measures. Performance of some models varies widely for a certain range of the parameter space while most of the models are quite competent. Our evaluation shows that the Extended Beta-Binomial model (Prentice, 1986) turns out to be particularly favorable in the point that it provides consistently excellent fit almost all over the values of the intra-class correlation coefficient and the probability of success.

• Journal of Korean Society of Steel Construction
• /
• v.25 no.5
• /
• pp.543-553
• /
• 2013

As the deep deck plate has the shape of open cross section, It can cause structural problems such as bending torsions due to instability of the section. There are a number of fasteners types which are frequently used on light gage steel diaphragms such as bolts, rivets, welds, and screws. In this study, the structural capacity of the self drilling screw connection between the deep deck and the reinforced cap plate was evaluated by experimental variables such as the arrangement method, numbers of screw, pitch of screw, and head plate thickness.

• Journal of KIISE:Software and Applications
• /
• v.36 no.10
• /
• pp.861-873
• /
• 2009

There are many reasons that fail to get appropriate information in information retrieval. Allomorph is one of the reasons for search failure due to keyword mismatch. This research proposes a method to construct alternative word candidates automatically in order to minimize search failure due to keyword mismatch. Assuming that two words have similar meaning if they have similar co-occurrence words, the proposed method uses the concept of concentration, association word set, cosine similarity between association word sets and a filtering technique using confidence. Performance of the proposed method is evaluated using a manually extracted alternative list. Evaluation results show that the proposed method outperforms the context window overlapping in precision and recall.

• Asian Journal of Turfgrass Science
• /
• v.20 no.1
• /
• pp.1-10
• /
• 2006

This study was carried out to develope new zoysiagrass cultivar 'Millock'(Patent registration No. : 10-2005-0110051). Artificial selfing of collected line of MJ8 was conducted to develope F1 plant (MJ8S). Among the inbred progenies, MJ8S-9 (Millock) showed superior performance in color, density, and rust resistance. 'Millock' showed genetically dark green color, with medium-textured leaf ($4.2{\pm}0.44$ mm), short internode length ($3.5{\pm}0.28$ cm), and wide leaf angle ($52.5{\pm}10.8$ degree). Height to the lowest leaf blade of this cultivar was $1.9{\pm}0.91$ cm, which may allow low mowing height. 'Millock' has a yellowish green stolen. Also, specific bands with primer number OPB 8 by RAPD analysis can be used for a cultivar identification.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.39 no.2
• /
• pp.64-71
• /
• 2016

Recently, nanotechnology has grown as one of the leading science technology along with other converging technologies such as biology, information, medicine etc., bringing the continuous investment of the government in nano-related field. However, it is difficult to measure and evaluate the performance of the national research and development programs because of the multidimensional character of the expected outcomes. This study aims to measuring efficiency of the national nanotechnology research and development programs using DEA model. The decision making units are nine nano-related ministries including the Ministry of Science, ICT and Future Planning. The input variables are total expenditure, number of the programs and average expenditure per program. The output variables are science, technology and economic indicator, and the combination of these outputs are respectively measured as seven different DEA cases. The Ministry of Science, ICT and Future was the first efficient ministry in total technical efficiency. Ministry of Agriculture, Food and Rural Affairs and the Ministry of Food and Drug Safety were efficient in pure technical efficiency, when the Ministry of Commerce Industry and Energy took the first in the scale efficiency. The program efficiency was affected by organizational characteristics such as the institution's scale, the concentration of the research paper or the patent, technology transfer or the commercialization. The result of this study could be utilized in development of the policy in the nanotechnology and the related field. Furthermore, it could be applied for the modification of expenditure management or the adjustment of the research and development programs' input and output scale for each ministry.

• International Journal of Highway Engineering
• /
• v.20 no.1
• /
• pp.77-85
• /
• 2018

PURPOSES : The purpose of this study was to develop an urgent road-repair system and perform a field applicability test, as well as discover the optimum mix design for machine applications compared to the optimum mix design for lab applications. METHODS : According to reviews of the patent and developed equipment, self-propelled and mix-in-place equipment types are suitable for urgent pavement repair, e.g., potholes and cracks. The machine-application mix design was revised based on the optimum lab-test mix design, and the field application of a spray-injection system was performed on the job site. The mixture from the machine application and lab application was subjected to a wet-track abrasion test and a wheel-tracking test to calibrate the machine application. RESULTS and CONCLUSIONS : This study showed that the binder content could differ for the lab application and the machine application in the same setting. Based on the wet-track abrasion test result, the binder contents of the machine application exceeded the binder contents of the lab application by 1-1.5% on the same setting value. Moreover, the maximum dynamic stability value for the machine application showed 1% lower binder contents than the maximum lab-application value. Collectively, the results of the two different tests showed that the different sizes and operating methods of the machine and lab applications could affect the mix designs. Further studies will be performed to verify the bonding strength and monitor the field application.

• Journal of the Korean Society for Precision Engineering
• /
• v.16 no.6
• /
• pp.52-57
• /
• 1999

Funtional metal prototypes are often required in numerous industrial applications. These components are typically needed in the early stage of a project to determine form, fit and function. Recent R/P(Rapid Prototyping) part are made of soft materials such as plastics, wax, paper, these master models cannot be employed durable test in real harsh working environment. Parts by direct metal rapid tooling method, such as laser sintering, by now are hard to get net shape, pores of the green parts of powder casting method must be infiltrated to get proper strength as tool, and new type of 3D direct tooling system combining fabrication welding arc and cutting process is reported by song etc. But a system which can build directly 3D parts of high performance functional material as metal part would need long period of system development, massive investment and other serious obstacles, such as patent. In this paper, through the rapid tooling process as silicon rubber molding using R/P master model, and fabricate wax pattern in that silicon rubber mold using vacuum casting method, then we tranlsated the wax patterns to numerous metal prototypes by new investment casting process combined conventional investment casting with rapid pototyping & rapid tooling process. with this wax-injection-mold-free investment casting, we developed new investment casting process of fabricating numerous functional metal prototypes from one master model, combined 3-D CAD, R/P and conventional investment casting and tried to expect net shape measuring total dimension shrinkage from R/P part to metal part.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
• /
• v.19 no.2
• /
• pp.55-62
• /
• 2005

There are many risk factors of electrical shock caused by a minimum of protective devices, loose working environments, deterioration of installations at temporary power installations of construction sites. An insulation cover for instrument transformer(MOF) used in 22.9[kV] class power receiving system hasn't shown good performance in terms of electrical safety because of short clearance between insulation cover and each input and output wire junction part. The insulation cover is easily moved by outside environment as wind or rain because of different size between insulation cover and busing, also can be leaded to breakdown by tracking. Therefore, we have proposed the insulation cover which effectively can prevent from electrical disaster in this paper, and a utility model patent had been registered already. To decrease the electric field concentrated on specific part, we had roundly designed the shape of insulation cover and the clearance between cover and live part was adjusted to be longer than the existing thing. The proposed insulation cover was evaluated by using the electric field solution program.

• Korean journal of communication and information
• /
• v.36
• /
• pp.231-253
• /
• 2006

Based on the development of IT(information technology), the explosive diffusion and growth of the new media and services in Korea has attracted keen international attention. The construction of IT infrastructure driven by the proactive social informatization policy of the government has also been spectacular. Korea has persistently pursued strong 'new media-informatization policy' with three main objectives in mind: 1)Industrial-economic value creation; 2)socio-cultural value creation; and 3)building of the knowledge society-knowledge state. But its consequence is rather paradoxical. While its performance is excellent in terms of quantity growth of industry and technology, quality development of society, culture and knowledge creation is lagging far behind. This paradoxical outcome originates, not from any simple policy error, but from a structural problem inherent in new media-informatization policy in Korea which has long been captured by developmentalism. In order for Korea to harvest the reward of strong new media-informatization infrastructure, it needs to institute a policy structure based on a knowledge IT strategy such as research and development of core and patent technologies, design and production of quality contents, networking knowledge bases of society, etc.