• Journal of Chest Surgery
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• 제29권1호
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• pp.32-37
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• 1996

Between May 1991 and September 1995, 7 patients underwent surgical repair of ventricular septal defect (VSD) complicated with myocardial infarction in Asan Medical Center. The patients included two male and five female. The ages of patients were ranged from 54 years to 76 years with a mean of 65 years. The sites of postinfarction ventricular septal defect were consist of anterior septal defect in 6 patients and anteroposterior septal defect in 1 patient. Preoperative 2D-echocardiography & angiography were performed in all patients in order to measure ventricular function and evaluate the extent of coronary artery disease. The operations were delayed till mean 24 $\pm$ 12days after myocardial infarction. All patients underwent infarctectomy and Teflon patch closures through the area of the left ventricle infarction or aneurysm in the anterior or apical aspect of postinfarction ventricular septal defect. The ventricular septal defect repaired simultaneously with coronary artery b pass graft in 3 patients, with ventricular aneurysmectomy in 5 patients, and with left ventricular thrombectomy in 1 patient. Patch fixation in the left side of interventricular septum by tracts-septal interrupted pledget suture reduced the recurrence rate of VSD. There were 2 postoperative complications : One with pneumonia, 1 patient with the skin necrosis of left thigh. There was ilo early death. The 6 patients except for one emigrant were followed up postoperatively between 3 and 63 months(mean .28 months), without any sequelae and late death. They are in New York Heart Association functional class I-II.

• Journal of Korean Society of Coastal and Ocean Engineers
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• 제11권4호
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• pp.201-215
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• 1999

Field measurements were made for long- and short-period waves and current velocities at the harbor mouth using pressure-type wave gauges and a current meter, respectively, at the Gamcheon Harbor which has a rectangular shape with a narrow entrance. The measured pressure data were subjected to spectral analyses after removing tidal effects by applying trend removal and high-pass filtering. For the band averaging of the raw spectra, in order to obtain good resolution over the entire frequency, instead of a constant band width, variable band widths were used, which gradually increase as marching from the lowest frequency towards higher frequencies. The Helmholtz resonance mode at the Gamcheon Harbor shows the relative amplification ratio of 9.2 at the wave period of 31.7 minutes, which is quite large compared with those at the harbors located on the east coast of Korea. The second and the third resonance period was 10.3 and 5.4 minute, respectively. On the other hand, the analysis of every 24 hours data shows that during storms the spectral densities are very large compared to those during calm seas and also the second and third resonances are predominant.

• Journal of Environmental Impact Assessment
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• 제26권1호
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• pp.11-26
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• 2017

Approximate empirical equations obtained by measuring overall noise levels at different distances have been used to evaluate environmental influence of the railway noise though the accurate prediction of noise levels is important. In this paper, a noise prediction model considering the frequency characteristics of noise sources and propagation was suggested to improve the accuracy of noise prediction. The railway noise source was assorted into track, wheel, traction and aerodynamic components and they were characterized with the source strength and speed coefficient at each octave-band frequency. Correction terms for the acoustic roughness and the track/bridge condition were introduced. The sound attenuation from a source to a receiver was calculated taking account of the geometrical divergence, atmospheric absorption, ground effect, diffraction at obstacles and directivity of source by applying ISO 9613-2. For obtaining the source strength and speed coefficients, the results of rolling noise model, numerical analysis and measurements of pass-by noise were analyzed. We compared the predicted and measured noise levels in various vehicles and tracks, and verified the accuracy of the present model. It is found that the present model gives less error than the conventional one, so that it can be applied to make the accurate prediction of railway noise effect and establish its countermeasures efficiently.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• 제23권3호
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• pp.293-301
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• 2005

In case of the roads that pass the mountain area, the cut sections or the tunnels are constructed. And In winter season it appears sunshine few in the specific segment, the shade is continued last and the freezing sections occur. So, the attention is necessary in traffic safety. This study was to evaluate the influence of sunshine and surface freezing sections expected in route plans of roads using GIS and makes alternative ideas in road stability security. After selecting 29 km sections of Donghae highway and creating a 3 dimensional terrain surface through the digital conversion of design plan data, it reflects the road alignment data of the same coordinates and a 3 dimensional road modeling is created. It set shadow time of road surface for the solar trace in the winter solstice in 20 minute interval. Shade areas are displayed and inputed in polygon data by manual vertorizing. Graphic and attribute data of this shade section is constructed in geodatabase of ArcCatalog. And it extracted the freezing section using intersect fuction of the GIS spatial analysis. By analyzing the winter meteorological data of temperature, rainfall, snowfall, humidity, and etc. and grasping dangerous freezing section of the road surface effectively, it will be able to make alternative ideas of the preliminary stability evaluation reflected in basic design.

• Journal of the Korean Society of Marine Environment & Safety
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• 제13권4호
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• pp.71-78
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• 2007

Towing vessels have carried out the important role and service in the maritime industry construction, such as port and sea bridge construction, fairway dredging and sea reclamation etc. Furthermore, tugboat takes the largest portion in number of vessel at the domestic registry and barges as big as the general merchant vessel, which are getting specialized and larger, are in operation. In spite of the increase of marine accidents under this situation, there has been no proper measure for the safe navigation of tugboat in the aspect of a nation. This paper aims to propose the measure for the safe navigation of tugboat according to the frequent marine accident of tugboat with sea bridge. Therefore, we show an example of the sailing schedule and operation checklist based on the analysis of statistics and precedent of marine accident and the investigation of the actual operation state of tugboat in the aspect of a contract of carriage and a personnel setup, which should be checked by the operator of tugboat, to pass through sea bridge safely and propose the safe traffic supporting system based on electronic chart system to improve the safe navigation of tugboat.

• Journal of the Korean Society of Marine Environment & Safety
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• 제26권6호
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• pp.606-614
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• 2020

The administrative ship, Chuja-ho, is the only mode of transportation between manned islands in the Chuja-do, Jeju. Chuja-ho is a 25-year-old age, which is identified to pass the persisting period (25 years) for public ships, and there is an urgent need for a replacement. The residents of the island are also requesting that the new administrative ship be outfitted with medical functions because there is no sea transportation system for medical emergencies in Chuja-do. The purpose of this study is to examine the required functions of a new administrative ship outfitted with medical functions and to suggest a conceptual design. In order to review the necessity of an emergency patient transport system, user requirements were surveyed and analyzed, and the ship's condition assessed by ship experts who carried out an on-site survey and analysis of ship survey data. Thereafter, a conceptual design for a new administrative ship with medical functions was presented. The results of this study can be used during a review of a new budget plan and for basic ship designs during the replacement project by the local government. It is also expected to improve the safety and medical environment of Chuja-do residents.

• Journal of Pharmaceutical Investigation
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• 제35권4호
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• pp.295-301
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• 2005

Famciclovir is an oral prodrug of the antiherpesvirus nucleoside analogue, penciclovir. In human, famciclovir is orally well absorbed and then undergoes extensive first pass metabolism to penciclovir and essentially no parent compound is recovered from plasma or urine. The purpose of the present study was to evaluate the bioequivalence of two famciclovir tablets, $Famvir^{TM}$ tablet 250 mg (Novartis Korea Ltd.) and Famcivir (Hanmi Pharmaceutical Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of famciclovir from the two famciclovir formulations in vitro was tested using KP VIII Apparatus II method with water. Twenty six healthy male subjects, $24.19{\pm}2.08$ years in age and $71.55{\pm}6.89$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After a single tablet containing 250 mg as famciclovir was orally administered, blood samples were taken at predetermined time intervals and the concentrations of penciclovir in serum were determined using HPLC with UV detector. The dissolution profiles of two formulations were similar at water. In addition, the pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the reference drug, $Famvir^{TM}$ tablet 250 mg, were -2.93, -8.02 and 10.47% for $AUC_t$, $C_{max}$ and $T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log0.8 to log1.25 (e.g., $log0.92{\sim}log1.01$ and $log0.85{\sim}log1.00$ for $AUC_t$ and $C_{max}$, respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Famcivir was bioequivalent to $Famvir^{TM}$ tablet 250 mg.

• Journal of Pharmaceutical Investigation
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• 제38권3호
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• pp.199-205
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• 2008

Famciclovir, 9-(4-hydroxy-3-hydroxymethylbut-1-yl) guanine, is an oral prodrug of the antiherpesvirus nucleoside analogue, penciclovir. In human, famciclovir is orally well absorbed and then undergoes extensive first pass metabolism to penciclovir and essentially no parent compound is recovered from plasma or urine. The purpose of the present study was to evaluate the bioequivalence of two famciclovir tablets, Famvir tablet 750 mg (Novartis Korea Ltd.) and Famcivir tablet 750 mg (Hanmi Pharmaceutical. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of famciclovir from the two famciclovir formulations in vitro was tested using KP VIII Apparatus II method with water. Twenty six healthy male subjects, $23.38{\pm}1.72$ years in age and $68.59{\pm}7.84\;kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After a single tablet containing 750 mg as famciclovir was orally administered, blood samples were taken at predetermined time intervals and the concentrations of penciclovir in serum were determined using HPLC with UV detector. The dissolution profiles of two formulations ere similar at water. The pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the reference drug, $Famvir^{(R)}$ tablet 750 mg, were -0.53%, 1.12% and -24.82% for $AUC_t$, $C_{max}$ and $T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., $log\;0.9569{\sim}log\;1.0423$ and $log\;0.8763{\sim}log\;1.2136$ for $AUC_t$ and $C_{max}$, respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Famcivir tablet 750 mg was bioequivalent to Famvir tablet 750 mg.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• 제5권2호
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• pp.155-169
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• 2007

A transport container for a 500 kCi tritium storage vessel was developed, which could be used for the transport of metal tritide from Wolsong TRF facility to a disposal site. The structural, thermal, shielding, and confinement analyses were performed for the container in a view of Type B. As a result of structural analysis, the developed container sustained its integrity under normal and accidental conditions. The maximum temperature increase of the inner storage vessel by radiation was evaluated at $134.8^{\circ}C at room temperature. In $800^{\circ}C$ fire test, The thermal barrier of container sustained the inner vessel at $405^{\circ}C after 30 min, which temperature was allowable for the container integrity since maximum design temperature of inner vessel was $550^{\circ}C. In the evaluation of the shielding, the activity of radiation was nearly zero on the outer surface of inner vessel. Consequently the transport container for a 500 kCi tritium was evaluated to pass all the safety tests including accidental condition, so it was concluded that the designed transport container is proper to be used.

• Korean Journal of Fisheries and Aquatic Sciences
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• 제13권4호
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• pp.195-206
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• 1980

Fish were grown in a water recycling rearing system consisting of a filter system, of which the area is about $30\;m^2$ and the volume of filter gravels is about $15\;m^3$, 6 rearing and 2 supplementary tans about $7\;m^2$ of surface area each. The results for 180 days from April 18 to October 14,1980 are summarized as following: One rearing tank was used for main experiment stocked with an equal number, and weight of each Israeli strain and $F_1$, hybrid between this strain and Korean local strain of common carp. Gross total production was 461 kg with a net production of 395 kg, and the Israeli strain grew to about 8 times initial weight and the hybrid about 6 times. Based on an analysis of results of the above mentioned main experiment and the other miscellaneous fish grown in the remaining tanks, it was considered to be feasible to implement a commercial production in this system by improving parts of the system and adding a number of the units. A special problem seems to be an adoption of more effective aeration device when fish loading increases. A solid waste removal system was deviced by use of by-pass flow ana this system worked very efficiently in view of supply water economy. A serious problem encountered in this experiment was heavy outbreaks of the gill-fluke, Dactylogyrus sp. which was relatively easily eradicated with Dipterex or DDVP treatment in the first trials, but later on strains which were resistant to any of these chemicals appeared.