• Title/Summary/Keyword: Particulate matter 2.5

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Particulate matter induces ferroptosis by accumulating iron and dysregulating the antioxidant system

  • Minkyung Park;Young-Lai Cho;Yumin Choi;Jeong-Ki Min;Young-Jun Park;Sung-Jin Yoon;Dae-Soo Kim;Mi-Young Son;Su Wol Chung;Heedoo Lee;Seon-Jin Lee
    • BMB Reports
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    • v.56 no.2
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    • pp.96-101
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    • 2023
  • Particulate matter is an air pollutant composed of various components, and has adverse effects on the human body. Particulate matter is known to induce cell death by generating an imbalance in the antioxidant system; however, the underlying mechanism has not been elucidated. In the present study, we demonstrated the cytotoxic effects of the size and composition of particulate matter on small intestine cells. We found that particulate matter 2.5 (PM2.5) with extraction ion (EI) components (PM2.5 EI), is more cytotoxic than PM containing only polycyclic aromatic hydrocarbons (PAHs). Additionally, PM-induced cell death is characteristic of ferroptosis, and includes iron accumulation, lipid peroxidation, and reactive oxygen species (ROS) generation. Furthermore, ferroptosis inhibitor as liproxstatin-1 and iron-chelator as deferiprone attenuated cell mortality, lipid peroxidation, iron accumulation, and ROS production after PM2.5 EI treatment in human small intestinal cells. These results suggest that PM2.5 EI may increase ferroptotic-cell death by iron accumulation and ROS generation, and offer a potential therapeutic clue for inflammatory bowel diseases in human small intestinal cells.

Evaluation of genotoxic potentials in diesel exhaust particulate matter with the Ames test, the comet assay and the micronucleus assay

  • Kim, Soung-Ho;Lee, Do-Han;Han, Kyu-Tae;Oh, Seung-Min;Chung, Kyu-Hyuck
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.165.1-165.1
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    • 2003
  • This research was designed to examine the presence of mutagenic/carcinogenic compounds in airborne pollutants in diesel particulate matter using an integrated biological approach. Respirable air borne particulate matter (PM2.5: <2.5mm) was collected from diesel engine exhaust using a high-volume sampler equipped with a cascade impactor. (omitted)

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A study on the Factors Affecting Behavior for Particulate Matter among Adolescents (청소년의 미세먼지 행위에 영향을 미치는 요인)

  • Ha, Young-Sun;Park, Yong-Kyung
    • Journal of the Korea Convergence Society
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    • v.11 no.11
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    • pp.393-403
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    • 2020
  • This study was aimed to investigate the factors influencing particulate matter behavior of particulate matter knowledge, particulate matter attitude among adolescents. A descriptive study design was used. Participants were 218 high school students in D city. The data were collected from May 13 to 24 2019. Collected data were analyzed by t-test, one-way ANOVA, Pearson's correlation coefficient, multiple regression using SPSS WIN 18.0 program. Results: The influential factor for particulate matter behavior was particulate matter attitude (β=0.52, p<.001). It was found that particulate matter education experience (β=0.08, p=.157), academic background of father (β=0.08, p=.288), academic background of mother (β=0.05, p=.463), particulate matter knowledge (β=-0.05, p=.415), residence with (β=-0.09, p=.126), school record (β=-0.02, p=.710) had no significant effect on teacher efficacy. In order to develop a program to increase the particulate matter behavior for youth, it is necessary to prepare a plan to improve the attitude of particulate matter.

Evaluation on the Expected Purification Efficiency of Air Ion and Analysis on the Generated Amount of Negative Air Ions by Plants for the Purification of Particulate Matter in Air (지표대기 미세먼지 정화를 위한 식물체 음이온 발생량 분석 및 음이온의 미세먼지 기대정화지수 평가)

  • Oh, Deuk-Kyun;Ju, Jin-Hee
    • Journal of Environmental Science International
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    • v.29 no.6
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    • pp.623-631
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    • 2020
  • This study analyzes the effect of negative air ions on the concentration of airborne particulate matter and evaluates the expected purification efficiency of open spaces for particulate matter by investigating the amount of negative air ions generated by plants. This study establishes a negative air ion generation treatment environment, plant environment, and control environment to measure the purification efficiency of particulate matter under the conditions of each, analyzing the expected purification efficiency by designing a particulate matter purification model. Results show that the amount of generated negative air ion according to environment was negative air ion generation treatment environment > plant environment > control environment; this order also applies to the particulate matter purification efficiency. Moreover, it took 65 min for the negative ion generation treatment environment, 90 min for the plant environment, and 240 min for the control environment to reach the standard expected purification efficiency of particulate matter concentration of 960 mg/㎥ for PM10. For PM2.5, with the designated maximum concentration of 700 mg/㎥, it took 60 min for the negative ion generation treatment environment, 80 min for the plant environment, and more than 240 min for the control environment. Based on these results, the expected purification efficiency compared to the control environment was quadrupled in the negative ion generation treatment environment and tripled in the plant environment on average.

A Study on the Distribution Characteristics and Countermeasures of Concentrations of Ambient PM10 and PM2.5 in Yangju, South Korea

  • Dohun Lim;Yoonjin Lee
    • Economic and Environmental Geology
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    • v.55 no.6
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    • pp.701-716
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    • 2022
  • This study investigated the distribution behaviors of PM2.5 and PM10 at two air quality monitoring sites, Go-eup (GO) and Backseokeup (BS), located in Yangju City, South Korea. The amounts of emissions sources of pollutants were analyzed based on the Clean Air Policy Support System (CAPSS), and the contribution rates of neighboring cities were enumerated in Yangju. Yangju has a geological basin structure, and it is a city with mixed urban and rural characteristics. The emission concentration of particulate matter was affected by geological and seasonal factors for all sites observed in this study. Therefore, these factors should be considered when establishing policies related to particulate matter. Because the official GO and BS station sites in Yangju are both situated in the southern part of the city, the representativeness of both stations was checked using correlation analysis for the measurement of PM2.5 and PM10 by considering two more sites-those of Bongyang-dong (BY) and the Gumjun (GJ) industrial complex. The data included discharge amounts for business types 4 and 5, which were not sufficiently considered in the CAPSS estimates. Because the 4 and 5 types of businesses represent over 92.6% of businesses in this city, they are workplaces in Yangju that have a significant effect on the total air pollutant emission. These types of businesses should be re-inspected as the main discharge sources in industry, and basic data accumulation should be carried out. Moreover, to manage the emission of particulate matter, attainable countermeasures for the main sources of these emissions should be prepared in a prioritized fashion; such countermeasures include prohibition of backyard burning, supervision of charcoal kilns, and management of livestock excretions and fugitive dust in construction sites and on roads. The contribution rates by neighboring cities was enumerated between 6.3% and 10.9% for PM2.5. Cooperation policies are thought to be required with neighboring cites to reduce particulate matter.

The Relationship between Particular Matter Reduction and Space Shielding Rate in Urban Neighborhood Park (도시근린공원 미세먼지(PM)저감과 공간차폐율과의 관계 - 대구광역시 수성구 근린공원을 중심으로 -)

  • Koo, Min-Ah
    • Journal of the Korean Institute of Landscape Architecture
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    • v.47 no.6
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    • pp.67-77
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    • 2019
  • The purpose of this study is to analyze how much particulate matter at the center of the urban park is reduced compared to the entrance of the park, where the particulate matter problem is serious. It also endeavored to analyze the relationship between the space closure rate and particulate matter reduction rate in the center of the park through the collection and analysis of experimental data. Seven flat land type urban neighborhood parks in Suseong-gu, Daegu were measured at the same place for three days. The research results are as follows. First, the center of the urban neighborhood park had an average temperature 1.05℃ lower than at the entrance and an average humidity of 2.57% higher. Second, the rate of fine dust reduction was PM1- 17.09%, PM2.5- 17.65%, PM10- 14.99%. As for the reduction rate of particulate matter, the smaller the size of the park, the greater the reduction rate. In addition, the reduction rate at the center of the park was lower on days when particulate matter concentration based on the weather reports was low. The higher the concentration at the park entrance, the higher the reduction rate was. Third, a higher the rate of space closures at the center of the park resulted in a higher effect of particulate matter reduction. Noting this, the relationship between particulate matter reduction and the space closure rate in urban neighborhood parks was clearly shown. We hope to be the basis for more extensive experimental data collection.

Characteristics of Particle Size Distributions Generated in the Vicinity of Building Blasting Demolition Sites (발파해체현장에서 발생하는 순간분진의 입경분포 특성)

  • Lee, Kyoung-Hee;Kim, Hyo-Jin;Park, Chan-Gyu;Ko, Kwang-Baik
    • Journal of Environmental Science International
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    • v.18 no.1
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    • pp.41-47
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    • 2009
  • In building demolition work, major dust-generating activities are blasting concrete and rock. The aim of this study was to find the characteristic of particle size of dusts which were generated during building demolition work using explosion. The DustMate of the Turnkey-Instruments Ltd. was used for particulate size-selective sampling of the four sites. TSP(Total Suspended Particle), PM10(Particle Matter $10{\mu}m$), PM2.5(Particle Matter $2.5{\mu}m$), and PM1.0(Particle Matter $1.0{\mu}m$) were measured during building demolition work using explosion. The large particulate (higher than the diameter $10{\mu}m$) showed to be higher than 50%. The particulate ranged from $10{\mu}m\;to\;2.5{\mu}m$ showed about 30-40%. PM2.5 was not scarcely detected in the samples collected for building demolition work using explosion. We conclude that the dust generated during building demolition work using explosion has not most respirable particulate.

Analysis of 119 dispatch for patients with cardio-cerebrovascular and respiratory diseases according to particulate matter (미세먼지 농도에 따른 심·뇌혈관계 및 호흡기계 환자의 119 구급 출동 분석)

  • Koo, Ji-Yeon;Cho, Keun-Ja
    • The Korean Journal of Emergency Medical Services
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    • v.24 no.1
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    • pp.37-55
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    • 2020
  • Purpose: The purpose of this study was to provide basic data for improving the response capacity of 119 EMS systems by analyzing the effects of particulate matter on cardio-cerebrovascular and respiratory symptoms in the pre-hospital stage. Methods: We examined 46,389 patients who transferred to the hospital with complaints of cardiopulmonary arrest and cardio-cerebrovascular and respiratory symptoms by 119 ambulances in Incheon from 2016 to 2018. Results: The probability of 119 emergency dispatch for patients with cardiopulmonary arrest increased 2.8-4.0% from the day of symptom onset until two days before hospital presentation as particulate matter 10㎛ or less in diameter(PM10) increased by 10㎍/㎥ (OR=1.028; 95% CI=1.014-1.041, p=0.000, lag 0), (OR=1.040; 95% CI=1.024-1.056, p=0.000, lag 1), (OR=1.032; 95% CI=1.016-1.049, p=0.000, lag 2). Meanwhile, emergency dispatch increased 3.6-6.1% for PM2.5 in creased by 10㎍/㎥ (OR=1.046; 95% CI=1.024-1.068, p=0.000, lag 0), (OR=1.061; 95% CI=1.035-1.088, p=.000, lag 1), and (OR=1.036; 95% CI=1.010-1.063, p=0.006, lag 2). Conclusion: Emergency medical technicians (EMTs) who respond to 119 calls should rapidly and accurately evaluate patients and provide professional emergency care by identifying the characteristics of the vulnerable groups relative to particulate matter size. To prevent the occurrence and exacerbation of symptoms caused by particulate matter, EMTs should be prepared and equipped with a response system for high particulate matter in the EMS system.

Association between ambient particulate matter levels and hypertension: results from the Korean Genome and Epidemiology Study

  • Sewhan Na;Jong-Tae Park;Seungbeom Kim;Jinwoo Han;Saemi Jung;Kyeongmin Kwak
    • Annals of Occupational and Environmental Medicine
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    • v.35
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    • pp.51.1-51.15
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    • 2023
  • Background: Recently, there has been increasing worldwide concern about outdoor air pollution, especially particulate matter (PM), which has been extensively researched for its harmful effects on the respiratory system. However, sufficient research on its effects on cardiovascular diseases, such as hypertension, remains lacking. In this study, we examine the associations between PM levels and hypertension and hypothesize that higher PM concentrations are associated with elevated blood pressure. Methods: A total of 133,935 adults aged ≥ 40 years who participated in the Korean Genome and Epidemiology Study were analyzed. Multiple linear regression analyses were conducted to investigate the short- (1-14 days), medium- (1 and 3 months), and long-term (1 and 2 years) impacts of PM on blood pressure. Logistic regression analyses were conducted to evaluate the medium- and long-term effects of PM on blood pressure elevation after adjusting for sex, age, body mass index, health-related lifestyle behaviors, and geographic areas. Results: Using multiple linear regression analyses, both crude and adjusted models generated positive estimates, indicating an association with increased blood pressure, with all results being statistically significant, with the exception of PM levels over the long-term period (1 and 2 years) in non-hypertensive participants. In the logistic regression analyses on non-hypertensive participants, moderate PM10 (particulate matter with diameters < 10 ㎛) and PM2.5 (particulate matter with diameters < 2.5 ㎛) levels over the long-term period and all high PM10 and PM2.5 levels were statistically significant after adjusting for various covariates. Notably, high PM2.5 levels of the 1 year exhibited the highest odds ratio of 1.23 (95% confidence interval: 1.19-1.28) after adjustment. Conclusions: These findings suggest that both short- and long-term exposure to PM is associated with blood pressure elevation.

A Study on Green Space Location Selection to Reduce Particulate Matter by Projecting Distributions of Emission Source and Vulnerable Groups - focusing on Seongdong-gu, Seoul - (미세먼지 배출원과 취약계층 분포 추정을 통한 미세먼지 저감 녹지 입지 선정 연구 - 서울시 성동구를 대상으로 -)

  • Shin, Ye-Eun;Park, Jin-Sil;Kim, Su-Yeon;Lee, Sang-Woo;An, Kyung-Jin
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.24 no.1
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    • pp.53-68
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    • 2021
  • The study aims to propose a locating method of green space for reducing Particulate Matter (PM) in ambient air in conjunction with its source traces and vulnerable groups. In order to carry out the aims and purposes, a literature review was conducted to derive indicators of vulnerable area to PM. Based on the developed indicators, the vulnerable areas and green spaces creation strategies for each cluster were developed for the case of Seongdong-gu, Seoul. As a result, six indicators for vulnerability analysis were came out including the vulnerable groups (children's facilities, old people's facilities), emission sources (air pollutant emission workplaces, roads), and environmental indicators (particulate matter concentration, NDVI). According to the six selected indicators, the target area was divided into 39 hexagons and analyzed to result the most vulnerable areas to particulate matter. As a result of comprehensive vulnerability analysis, the Seongsu-dong area was found to be the most vulnerable to particulate matter, and 5 clusters were derived through k-means cluster analysis. Cluster 1 was analyzed as areas that most vulnerable to particulate matter as a result of the comprehensive analysis, therefore urgent need to create green spaces to reduce particulate matter. Cluster 2 was areas that mostly belonged to the Han River. Cluster 3 corresponds to the largest number of hexagons, and since many vulnerable groups are distributed, it was analyzed as a cluster that required the creation of a green spaces to reduce particulate matter, focusing on facilities for vulnerable groups. Three hexagons are included in cluster 4, and the cluster has many roads and lacks vegetation in common. Cluster 5 has a lot of green spaces and is generally distributed with fewer vulnerable groups and emission sources; however, it has a high level of particulate matter concentration. In a situation where various green spaces creation projects for reducing particulate are being implemented, it is necessary to consider the vulnerable groups and emission sources and to present green space creation strategies for each space characteristic in order to increase the effectiveness of such projects. Therefore, this study is regarded as meaningful in suggesting a method for selecting a green area for reducing PM.