• Title/Summary/Keyword: Particle rearrangement

Search Result 27, Processing Time 0.025 seconds

Synthesis of Reconstituted High Density Lipoprotein (rHDL) Containing apoA-I and apoC-III: the Functional Role of apoC-III in rHDL

  • Cho, Kyung-Hyun
    • Molecules and Cells
    • /
    • v.27 no.3
    • /
    • pp.291-297
    • /
    • 2009
  • Apolipoprotein (apo) C-III is a marker protein of triacylglycerol (TG)-rich lipoproteins and high-density lipoproteins (HDL), and has been proposed as a risk factor of coronary heart disease. To compare the physiologic role of reconstituted HDL (rHDL) with or without apoC-III, we synthesized rHDL with molar ratios of apoA-I:apoC-III of 1:0, 1:0.5, 1:1, and 1:2. Increasing the apoC-III content in rHDL produced smaller rHDL particles with a lower number of apoA-I molecules. Furthermore, increasing the molar ratio of apoC-III in rHDL enhanced the surfactant-like properties and the ability to lyse dimyristoyl phosphatidylcholine. Furthermore, rHDL containing apoC-III was found to be more resistant to particle rearrangement in the presence of low-density lipoprotein (LDL) than rHDL that contained apoA-I alone. In addition, the lecithin:cholesterol acyltransferase (LCAT) activation ability was reduced as the apoC-III content of the rHDL increased; however, the CE transfer ability was not decreased by the increase of apoC-III. Finally, rHDL containing apoC-III aggravated the production of MDA in cell culture media, which led to increased cellular uptake of LDL. Thus, the addition of apoC-III to rHDL induced changes in the structural and functional properties of the rHDL, especially in particle size and rearrangement and LCAT activation. These alterations may lead to beneficial functions of HDL, which is involved in anti-atherogenic properties in the circulation.

Particle Behavior and Deformation During Compaction of Al Powder Using MPFEM (다입자유한요소법을 이용한 Al분말 압축공정에서 입자의 거동과 변형에 관한 연구)

  • Lee, Kyung-Hun;Lee, Jung-Min;Kim, Byung-Min
    • Transactions of the Korean Society of Mechanical Engineers A
    • /
    • v.34 no.4
    • /
    • pp.383-390
    • /
    • 2010
  • This paper describes multiparticle finite element model (MPFEM)-based powder compaction simulations performed to demonstrate the densification of compacted aluminum powders. A 2D MPFEM was used to explore the densification of a collection of aluminum particles with different average particle sizes under various ram speeds. Individual particles are discretized using a finite element mesh for a detailed description of contact mechanics. Porous aluminum powders with average particle sizes of $20\;{\mu}m$ and $3\;{\mu}m$ were compressed uniaxially at ram speeds of 5, 15, 30, and 60 mm/min by using an MTS servo-hydraulic tester. The slow ram speed was of great advantage to powder densification in low compaction force due to sufficient particle rearrangement. Owing to a decrease in the average particle size of aluminum, the compaction force increased.

Effect of Cyclic Drying-Wetting on Compressive Strength of Decomposed Granite Soils (습윤-건조 반복작용으로 인한 화강풍화토의 압축강도 특성 변화 연구)

  • Yoo, Chung-Sik
    • Journal of the Korean Geosynthetics Society
    • /
    • v.10 no.4
    • /
    • pp.19-28
    • /
    • 2011
  • This paper presents the results of an investigation into the effect of cyclic wetting-drying on the compressive strength characteristics of decomposed granite soils. A series of plane strain compression (PSC) tests were performed on test specimens with varying fine contents under different wetting-drying cycles to investigate the change in compressive strength under the process of wetting-drying cycles. The effect of wetting-drying cycles on the structural particle rearrangement at a micro-scale level was also examined using scanning electron microscope (SEM) tests. It was shown that the soil containing larger fines showed more significant decrease in compressive strength compared with the soils with less fines. Also found was that the wetting-drying cycle did not have significant effect on the particle arrangement.

Effects of Particle Size of Alumina on Densification Behavior in ZTA (ZTA 제조시 알루미나 입자크기가 치밀화 거동에 미치는 영향)

  • Chae, Jihoon;Cho, Bumrae
    • Korean Journal of Materials Research
    • /
    • v.23 no.4
    • /
    • pp.250-254
    • /
    • 2013
  • In order to increase the toughness of ZTA(zirconia toughened alumina) ceramics, the present study focused on rearrangement and densification of particles according to the particle size of the parent material. When rough alumina was used for production of ZTA, densification behavior was observed in the specimen sintered at a temperature over $1550^{\circ}C$. However, it was found that the densification behavior was occurred in the specimen sintered at $1450^{\circ}C$ when fine alumina powder was used. High relative density exceeding 98% was obtained when fine alumina powder was mixed with 15 wt% of 3Y-TZP and sintered at $1600^{\circ}C$. Also, a hardness of 1820.2 Hv was obtained when a specimen containing 10 wt% of 3Y-TZP was sintered at $1600^{\circ}C$. In the case of 3Y-TZP containing rough alumina powder that had been sintered the hardness value was around 1720.3 Hv. It was predicted that an improved toughening effect in ZTA could be achieved by using finer alumina powder as the parent material.

A Change of Porewater Pressure under Particle Crushing of Carbonate Sand of Sabkha Layer (Sabkha층 탄산질 모래의 입자파쇄에 따른 간극수압 변화)

  • Kim, Seok-Ju;Yi, Chang-Tok;Ji, Won-Baek;Han, Heui-Soo
    • Journal of the Korean Geotechnical Society
    • /
    • v.30 no.2
    • /
    • pp.19-32
    • /
    • 2014
  • Carbonate sand of Sabkha layer in the middle east was made of deposition of shell fragments and it consisted of porous particles containing inner void. Generally, at yield stress the soil structure begins to break down, so the porewater pressure and the settlement are increased rapidly. In carbonate sand, unlike quartz sand if particle crushing happens, the inner voids are exposed and porewater pressure can be decreased under yield stress. Porewater pressure can be determined as the sum of excess porewater pressure due to increase of relative density, inner void expose of particle under particle crushing stress and rearrangement of crushed particle fragments. The porewater pressure can be negative value in case of greater amount of inner void expose, so if particle crushing is bigger, the porewater pressure value is smaller. The negative value zone of porewater pressure from triaxial test result means particle crushing effect is bigger than outer void decrease effect and the particle crushing effect dominant zone size was 1.50∼3.46% from triaxial test result of Sabkha layer.

Sunroof Buffeting Flowfield Visualization Using Particle Image Velocimetry (PIV 유동장 가시화 기법을 이용한 썬루프 드론소음 연구)

  • Shin, Seong-Ryong;Kim, Dong-Bum;Kook, Hyung-Seok
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
    • /
    • 2007.11a
    • /
    • pp.1104-1108
    • /
    • 2007
  • Automobile sunroof buffeting is the tonal noise of low frequency around 20Hz. It occurs due to the acoustic feedback process between the shear layer detached from the leading edge of sunroof opening and the Helmholtz resonator-like property of a car cabin. In this paper, PIV visualization technique is applied to the unsteady flow field around sunroof opening of an SUV in the full-scale automotive wind tunnel in order to find out buffeting mechanism. A phase-marking PIV measurement method, in which image and sound pressure are recorded simultaneously, and a phase-rearrangement post-processing program were developed for capturing noise-related velocity fields without expensive synchronization systems. Through this study, some characteristics of the real-car sunroof shear layers under various deflector conditions were identified and these results can provide insights into the noise reduction mechanism of the tube-type deflector.

  • PDF

Fundamental Aspects of Resistance Sintering under Ultrahigh Pressure Consolidation

  • Zhou, Zhangjian;Kim, Ji-Soon;Yum, Young-Jin
    • Journal of Powder Materials
    • /
    • v.19 no.1
    • /
    • pp.19-24
    • /
    • 2012
  • The consolidation results of fine tungsten powders, W-Cu composite and W/Cu FGM by using a novel method combining resistance sintering with ultra high pressure have been reviewed. The densification effects of the consolidation parameters, including pressure, input power and sintering time, have been investigated. The sintering mechanism of this method was quite different from other sintering methods. Particle rearrangement, sliding, distortion and crushing due to the ultra high pressure are the dominant mehanisms at the initial stage, then the dominant sintering mechanisms are transient arc-fused processes controlled by the input power.

Effects of Media Breakage on Infiltration Characteristics in Stormwater Management System (강우유출수 처리시설 침투특성에 대한 필터여재 파쇄의 영향)

  • Segismundo, Ezequiel Q.;Koo, Bon-Hong;Kim, Lee-Hyung;Lee, Byung-Sik
    • Journal of the Korean Geotechnical Society
    • /
    • v.32 no.2
    • /
    • pp.31-41
    • /
    • 2016
  • For sand and zeolite filter media in stormwater BMPs, media breakage effects on infiltration were investigated. Compaction effort and infiltration force were mainly examined for breakage sources. The 1-D column infiltration tests for un-compacted and compacted media filters were conducted to investigate the breakage effect on infiltration. As a result, the following findings were deduced: 1) particle breakage due to filtration forces was found to be relatively minimal; 2) un-compacted media had lesser amount of crushed particles and permeability fluctuations compared to compacted media; 3) even without the presence of suspended solids in the influent, reduction in permeability was found, which resulted from rearrangement and re-entrainment of media particle itself; 4) only media particle breakage resistance is considered, sand was revealed to have better performance compared to zeolite media.

Effects of Secondary Forming Process on Mechanical Properties of $SiC_p$/Al Composites Fabricated by Squeeze Casting (용탕단조법에 의하여 제조한 $SiC_p$/Al 복합재료의 2차 성형공정이 기계적 성질에 미치는 영향)

  • Seo, Y.H;Kang, C.G
    • Transactions of the Korean Society of Mechanical Engineers A
    • /
    • v.20 no.11
    • /
    • pp.3474-3490
    • /
    • 1996
  • A metal matrix composites(MMCs) for A16061 reinforced with silicon carbide particles is fabricated by melt-stirring method. The primary products of MMCs billets are prepared by volume fractions 5 vol% to 20 vol% and particle size $13\mu m$ to $22\mu m$.This paper will be made to examine the microstructure and mechanical properties of fabricated $SiC_p$/Al 6061 composite by melt-stirring and squeeze casting method. The MMC billets is extruded at $500^{\circ}C$ under the constant extrusion velocity $V_e$=2mm/min using curved shape die. Extrusion force, particle rearrangement, micro structure and mechanical properties of extruded composites will be investigated. The mechanical properties of primary billets manufactured by melt-stirring and squeeze casting method will be compared with extrusion specimen. The effect of volume fraction and size of the reinforcements will be studied. The increase in uniformity of particle dispersion is the major reason for an improvement in reliability due to hot extrusion with optimal shape die. Experimental Young's modulus and 0.2% offset yield strength for the extruded MMCs will be compared with theretical values calculated by the Eshelby method. A method will be proposed for the prediction of Young's modulus and yield strength in $SiC_p$ reinforced MMCs.

Effects of Co-doping on Densification of Gd-doped CeO2 Ceramics and Adhesion Characteristics on a Yttrium Stabilized Zirconia Substrate

  • Lee, Ho-Young;Kang, Bo-Kyung;Lee, Ho-Chang;Heo, Young-Woo;Kim, Jeong-Joo;Lee, Joon-Hyung
    • Journal of the Korean Ceramic Society
    • /
    • v.55 no.6
    • /
    • pp.576-580
    • /
    • 2018
  • In this study, a small amount of CoO was added to commercial Gd-doped $CeO_2$ (GDC) powder. The CoO addition greatly enhanced sinterability at low temperatures, i.e., more than 98% of relative density was achieved at $1,000^{\circ}C$. When GDC/8YSZ (8 mol% yttrium stabilized zirconia) bilayers were sintered, Co-doped GDC showed excellent adhesion to the YSZ electrolyte. Transmission electron microscope (TEM) analysis showed that there were no traces of liquid films at the grain boundaries of GDC, whereas liquid films were observed in the Co-doped GDC sample. Because liquid films facilitate particle rearrangement and migration during sintering, mechanical stresses at the interface of a bilayer, which are developed based on different densification rates between the layers, might be reduced. In spite of $Co^{2+}$ doping in GDC, the electrical conductivity was not significantly changed, relative to GDC.