• Journal of Ginseng Research
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• v.18 no.1
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• pp.53-59
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• 1994

To develop the methodology of the quantitative analysis of saponin in ginseng milk, conditions of the saponin extraction were optimized using the fractional factorial design with 3 variables and 3 levels by a RSM computer program. The extraction of saponin increased with an increase in extraction temperature up to $90^{\circ}C$ and then decreased significantly at $100^{\circ}C$. Extraction time affected the saponin yield in a similar trend. On the other hand, decreasing cooling temperature increased the amount of the saponin extracted. Recovery yield of the saponin from ginseng milk varied from 70.0% to 92.9%. The optimum extraction temperature, time and cooling temperature determined by partial differentiation of the model equation were $86^{\circ}C$, 2.83 hrs and $4^{\circ}C$, respectively. Key words Ginseng milk, saponin, response surface methodology.

• 제어로봇시스템학회:학술대회논문집
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• 1998.10a
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• pp.289-294
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• 1998

The distributed-parameter structures expressed with the partial differential equations are considered as the infinite-dimensional dynamic system. For implementation of a controller in multivariate systems, it is necessary to derive the state-space reduced order model. By the eigensystem realization algorithm, we can yield tile subspace system with the Markov parameters derived from the measured frequency response function by the inverse discrete Fourier transformation. We also review the necessary conditions for the convergence of the approximation system and the error bounds in terms of the singular values of Markov-parameter matrices. To determine the natural frequencies and modal damping ratios, the modal coordinate transformation is applied to the realization system. The vibration test for a smart structure is performed to provide the records of frequency response functions used in the subspace system realization.

• The Korean Journal of Physiology and Pharmacology
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• v.2 no.1
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• pp.77-84
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• 1998

Ureteral obstruction causes increase in renal blood flow (RBF) and partial impairment of the autoregulation of RBF. Although increased renal prostaglandin production is responsible for the former, it is not clear whether or not it is also responsible for the latter. Therefore, we investigated the role which prostaglandins play in the autoregulation of RBF during an ureteral pressure elevation (40 $cmH_2O$). Since the major mechanism of RBF autoregulation is the tubuloglomerular feedback, studying the interaction between ureteral pressure and RBF autoregulation may reveal the role of prostaglandin in tubuloglomerular feedback. To pursue the purpose, six anesthetized dogs were prepared for the measurements of RBF, mean sytemic and renal arterial pressure (RAP) and the manipulation of ureteral pressure. The autoregulation curves were determined during both control and elevation of the ureteral pressure, before and after the pretreatment with indomethacin, a cyclooxygenase inhibitor. The desired ureteral pressure was achieved by vertically elevating the water-filled reservoir connected to the ureteral catheter to 40 cm above the kidney level. In response to the elevation of the ureteral pressure, RBF increased from $170{\pm}8 ml{\cdot}min^{-1}\;to\;189{\pm}8$, and the systemic arterial pressure didn't change significantly. During spontaneous urine flow, RBF autoregulation was abolished when RAP was reduced to $59{\pm}3$ mmHg. On the other hand, during the ureteral pressure elevation, the autoregulation curves shifted upward and rightward from control, and the pressure when RBF autoregulation was abolished was $74{\pm}3$ mmHg. The pretreatment of the dogs with indomethacin failed to affect the lower limit of RBF autoregulaion during both control ($63{\pm}5$ mmHg) and the elevated ureteral pressure ($77{\pm}5$ mmHg). Since RBF failed to increase in response to the elevated ureteral pressure, RBF autoregulation curves obtained during the elevated ureteral pressure shifted only rightward from indomethacin control. The results indicate that the increased intrarenal level of prostaglandin or prostaglandin-induced vasodilation does not appear to bear any relation to the reduction in the autoregulatory capacity during partial ureteral obstruction. It seems that the partial impairment of the autoregulation during acute ureteral obstruction is due to the consumption of tubuloglomerular feedback mechanism at spontaneous RAP and that prostaglandin is neither mediator nor effector of tubuloglomerular feedback mechanism.

• Journal of Broadcast Engineering
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• v.7 no.2
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• pp.145-152
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• 2002

As the number of digital images available to users is exponentially growing due to the rapid development of digital technology, content-based image retrieval (CBIR) has been one of the most active research areas. A variety of image retrieval methods have been proposed, where, given an input query image, the images that are similar to the input are retrieved from an image database based on low-level features such as colors and textures. However, most of the existing retrieval methods did not consider the case when an input query image is a part of a whole image in the database due to the high complexity involved in partial matching. In this paper, we present an efficient method for partial image matching by using the histogram distribution relationships between query image and whole image. The proposed approach consists of two steps: the first step prunes the search space and the second step performs block-based retrieval using partial image matching to rank images in candidate set. The experimental results demonstrate the feasibility of the proposed algorithm after assuming that the response tune of the system is very high while retrieving only by using partial image matching without Pruning the search space.

• International Journal of Concrete Structures and Materials
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• v.11 no.1
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• pp.135-149
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• 2017

The prediction of the actual ultimate capacity of confined concrete columns requires partial confinement utilization under eccentric loading. This is attributed to the reduction in compression zone compared to columns under pure axial compression. Modern codes and standards are introducing the need to perform extreme event analysis under static loads. There has been a number of studies that focused on the analysis and testing of concentric columns. On the other hand, the augmentation of compressive strength due to partial confinement has not been treated before. The higher eccentricity causes smaller confined concrete region in compression yielding smaller increase in strength of concrete. Accordingly, the ultimate eccentric confined strength is gradually reduced from the fully confined value $f_{cc}$ (at zero eccentricity) to the unconfined value $f^{\prime}_c$ (at infinite eccentricity) as a function of the ratio of compression area to total area of each eccentricity. This approach is used to implement an adaptive Mander model for analyzing eccentrically loaded columns. Generalization of the 3D moment of area approach is implemented based on proportional loading, fiber model and the secant stiffness approach, in an incremental-iterative numerical procedure to achieve the equilibrium path of $P-{\varepsilon}$ and $M-{\varphi}$ response up to failure. This numerical analysis is adapted to assess the confining effect in rectangular columns confined with conventional lateral steel. This analysis is validated against experimental data found in the literature showing good correlation to the partial confinement model while rendering the full confinement treatment unsafe.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.29 no.8
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• pp.98-103
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• 2015

Power plant is that very high reliability when industrial and economic impact on the overall electric power system is required, it is essential to improve the reliability, especially the fault prediction diagnosis. Since an accident caused by the partial discharge in the power plant is above state has a faster response characteristic than the other indications in the case of any, the partial discharge generated in the power plant immediately detect the deterioration of insulation due to the accident of the power plant and the non-drawn It should prevent or reduce. Partial Discharge Measuring Systems for UHV SF6 Gas Insulated Switchgear and power transformer on site installed has some probability of abnormal recognition in case of non-flexible deal with on site noise. Many methode to eliminate these kinds of noises, UHF Detection System is chosen as purchase description in Korea, but this system having a bandwidth between 500MHz 1.5GHz wide band. Initial install periods(about 20 years ago), this band had no strong signal source, but in these days this wide band have strong signals, such as LTE. So, module described in this paper is designed as simultaneously use with wide and narrow band for solve this noise problem, and introduce this system.

• Smart Structures and Systems
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• v.9 no.3
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• pp.231-251
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• 2012

The stochastic optimal control for a piezoelectric spherically symmetric shell subjected to stochastic boundary perturbations is constructed, analyzed and evaluated. The stochastic optimal control problem on the boundary stress output reduction of the piezoelectric shell subjected to stochastic boundary displacement perturbations is presented. The electric potential integral as a function of displacement is obtained to convert the differential equations for the piezoelectric shell with electrical and mechanical coupling into the equation only for displacement. The displacement transformation is constructed to convert the stochastic boundary conditions into homogeneous ones, and the transformed displacement is expanded in space to convert further the partial differential equation for displacement into ordinary differential equations by using the Galerkin method. Then the stochastic optimal control problem of the piezoelectric shell in partial differential equations is transformed into that of the multi-degree-of-freedom system. The optimal control law for electric potential is determined according to the stochastic dynamical programming principle. The frequency-response function matrix, power spectral density matrix and correlation function matrix of the controlled system response are derived based on the theory of random vibration. The expressions of mean-square stress, displacement and electric potential of the controlled piezoelectric shell are finally obtained to evaluate the control effectiveness. Numerical results are given to illustrate the high relative reduction in the root-mean-square boundary stress of the piezoelectric shell subjected to stochastic boundary displacement perturbations by the optimal electric potential control.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.5
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• pp.2093-2098
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• 2015

In patients with multiple myeloma (MM), once-weekly intravenous injection or twice-weekly subcutaneous injection (SC) of bortezomib has been proven to offer non-inferior efficacy to standard twice-weekly intravenous administration, with an improved safety profile. However, whether once-weekly SC bortezomib can further reduce the incidence rate of peripheral neuropathy (PN) and not compromise the efficacy remains to be investigated. 25 patients of MM treated with once-weekly SC bortezomib were reviewed in this study. The median treatment cycles were 4 (range, 2-9 cycles). Complete response (CR) rate was 52%, ${\geq}$very good partial response (VGPR) rate was 72%, and ${\geq}$partial response (PR) rate was 84%. 1-year and 2-year PFS rate was 63.0% and 34.3%, respectively, and 2-year OS rate was 100%. Any grade of PN was reported in 9 patients (36.0%), with 7 patients (28.0%) had grade 1 PN, and 2 patients (8.0%) had grade 2 PN. No patients reported grade 3/4 PN in this cohort. In conclusion, once-weekly subcutaneous administration of bortezomib offers excellent efficacy with a further improved safety profile, especially with regard to PN. It needs to be validated in future prospective randomized trials.

• Journal of Yeungnam Medical Science
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• v.32 no.2
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• pp.85-89
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• 2015

Background: We examined the usefulness of urine osmolality, as a predictive factor in the treatment of monosymptomatic nocturnal enuresis (NE) with combination therapy of imipramine and desmopressin. Methods: From May 2014 to April 2015, 59 monosymptomatic NE patients participated in this study. Early morning urine osmolality was measured at 1 week and 1 day before combination therapy of imipramine and desmopressin, and at 1 week and 2 weeks after therapy. The response to combination therapy was evaluated at 3 months after treatment. The mean period of combination therapy was $6.4{\pm}4.2weeks$. Therapeutic response was classified as complete (0-1 wet night/week), partial (over 50% reduction of night) and non-responders (less than 50% reduction of night). Results: The cumulative rate of the complete and partial responders was 76.3%. Among the 3 groups, the statistically lowest value of pre-treatment urine osmolality was observed in the complete responder group (p<0.001). Urine osmolality increased in all groups after treatment, however, statistically the greatest difference between pre and post-treatment urine osmolality was observed in the complete responder group (p=0.024). No serious side effects were observed. Conclusion: Early morning urine osmolality and change of urine osmolality between pre and post-treatment have predictive values in the response to combined imipramine and desmopressin for treatment of monosymptomatic NE.

• The Korean journal of helicobacter and upper gastrointestinal research
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• v.18 no.4
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• pp.264-270
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• 2018

Gastrointestinal stromal tumor (GIST) is a mesenchymal tumor derived from Cajal cells originating from the myotonic plexus. The expression of tyrosine kinase (KIT) membrane receptors that are active on KIT is inhibited by the KIT inhibitor imatinib mesylate. GISTs are resistant to conventional chemotherapy, and radiation therapy is not significantly beneficial for GISTs. With the development of imatinib mesylate, approximately 81.6% of patients with advanced and metastatic GIST exhibit an effect above the stabilization response, thereby increasing the survival time. However, imatinib mesylate alone is unlikely to cure metastatic GISTs. Even with a partial or stable response, imatinib mesylate may be used for a longer time period. However, resection of grossly visible lesions should be considered for patients with a stable response during surgical treatment. In this study, we present a case of GIST with liver metastasis after imatinib mesylate treatment, which was followed up without recurrence after partial resection.