• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제33권5호
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• pp.554-558
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• 2007

저자 등은 좌측 이하부에 발생한 기무라씨병을 가진 19세의 남환에 대하여 표층 이하선 절제술을 동반한 종양 절제술과 함께 방사선 치료를 시행하였다. 수술 후 약 6년 9개월 경과 관찰 한 결과 현재까지 특기할만한 후유증 및 합병증과 재발 소견 혹은 증상은 보이지 않았기에 문헌 고찰과 함께 보고하는 바이며, 이후에도 지속적인 경과관찰을 요하리라 사료된다.

• Journal of Oral Medicine and Pain
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• 제38권2호
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• pp.121-136
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• 2013

구강 내에 발생되는 질환의 대부분은 타액의 영향을 받는다. 타액분비에 영향을 주는 요소 중에서 스트레스에 광범위하게 노출되어 있는 현대인들에게 나타나는 타액분비장애는 매우 중요한 문제로 대두되고 있는데, 스트레스가 타액선에 미치는 영향에 관해서는 자율신경에 의한 반응에 대하여만 알려져 있고 세포수준의 미시적 변화에 대한 연구는 미흡한 실정이다. 이에 본 연구에서는 구속 스트레스 조건하에서 타액선 세포의 변화를 광학현미경과 전자현미경을 이용하여 구조적인 변화를 관찰하였고, 세포자사와 간접적으로 관련이 있다고 알려진 clusterin를 이용하여 백서 이하선의 변화를 관찰하고자 하였다. 실험재료로는 웅성백서 18마리를 사용하였으며, 정상대조군 2마리, 실험대조군 2마리, 실험군 14마리를 배정하였고, 실험 대조군과 실험군은 매일 2시간씩 restraint cone을 사용하여 구속스트레스를 부여하였다. 이들은 각 군별로 즉일(실험대조군), 1일, 2일, 3일, 4일, 5일, 6일, 7일에 각각 2마리씩 희생한 후 이하선 조직을 절취하여 전자현미경검사와 clusterin 단백질 검색을 위한 면역조직화학검사를 시행 한 바 다음과 같은 결과를 얻었다. 1. 광학현미경 하에서, 백서의 이하선은 구속스트레스에 의하여, 스트레스가 반복됨에 따라 선포세포, 선포엽간 조직, 선포간 결체조직이 변성되어, 선포 간 이개 현상이 나타났으며, 실험 4일 후에는 선포 내에 공포가 관찰되었고 많은 수의 선조관이 관찰되었다. 2. 전자현미경 하에서, 백서의 이하선은 구속스트레스에 의하여, 선포세포 내의 층판상 구조인 rER이 실험 3일 후에 부종이 시작되기 시작하였으며, 4일 후에 심화되었고, 5일 후에는 심하게 부종되어 변성된 상이 관찰되었다. 3. 백서의 이하선에서 clusterin은 구속스트레스에 의하여, 선조관의 세포질에서 소실되었고, 개재관에서는 3일 후까지는 미약하게, 4일 후에는 매우 증가되었다가, 실험 5일 후부터는 점차 감소되는 양상을 보였다.

• Tuberculosis and Respiratory Diseases
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• 제51권4호
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• pp.386-389
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• 2001

An endobronchial metastasis is defined as a subsegmental or a more proximal central bronchial metastasis of a nonpulmonary neoplasm in the bronchoscopically visible range. However, the frequencies of endobronchial metastasis range from 2 to 50% of pulmonary metastases from extrathoracic neoplasms by a different definition of an endobronchial metastasis. Primary neoplasms of an endobronchial metastasis including breast cancer, colon cancer, renal cell carcinoma, and ovarian cancer are relatively common. However, an endobronchial metastasis arising from thyroid cancer, parotid gland tumor, bone tumor, bladder cancer, and stomach cancer has only rarely been reported in the literature. Here we report a case of an endobrochial metastases from a hepatocellular carcinoma.

• 한국방사선학회논문지
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• 제10권8호
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• pp.577-582
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• 2016

본 연구는 MR Sialography 검사 시 사용되는 타액분비촉진제를, 새로운 고체 자극제로 대체하더라도 신호강도는 차이가 없다는 것을 증명함으로써, 기존 액체 자극제의 사용으로 인해 발생되는 문제점을 개선하고자 하였다. 연구방법은 2016년 1월부터 동년 8월까지 타액선 질환이 없는 60명을 대상으로, 액체 자극제와 고체 자극제를 적용한 그룹으로 나누어 각각 영상을 획득한 후, 자극제의 종류에 따른 이하선 관의 신호강도를 비교 평가하였다. 연구결과, 기존의 액체 자극제($59.42{\pm}15.74$)에 비해 새로운 고체 자극제($61.80{\pm}13.99$)를 사용했을 경우 신호강도는 4.01%(2.38) 증가하였으나, 통계적으로 유의한 차이를 보이지 않았다. 결론적으로 자극제의 종류에 따른 신호강도는 차이가 없음으로 새로운 고체 자극제를 사용하면 기존의 액체 자극제의 사용으로 인해 발생되는 여러 가지 문제점을 개선할 수 있다.

• Journal of Acupuncture Research
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• 제17권4호
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• pp.180-187
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• 2000

By process of treatment for a case which diagnosed as glossopharyngeal neuralgia and admitted from the 4th, August, 2000 to the 1st, September, 2000, the results are as follows. Method & Resuits : This patient was diagnosed as Flaring up of Heart-fire(心火上炎), medicated Gamichengsimyeonja-eum(JiaWeiQingXinLianZi-Yin) and acupunture therapy was taken on proximal acupoints of right throat and parotid and distal acupoints inciuding Yuji(L10, 魚際), Taixi(K6,太谿), Zhaohai(K3, 照海), Hegu(LI4, 合谷) and Taichong(Liv3, 太衝). And negative therapy was taken on some pressure points of Jianzhongshu(SI15, 肩中兪) Jianjing(G21, 肩井) and Futu(LI18, 扶突). As a result, the patient's paroxysmal megalgia was improved. Conclusion : I consider that idiopathic pain diseases including glossopharyngeal neuralgia can improved by Oriental-Western collaborative medical treatment and continuous research must be accumulated subsequently.

• 대한한의학회지
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• 제29권4호
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• pp.171-179
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• 2008

Objective: Bufonis Venenum is the traditional Korean medicine Chan Su, which is obtained from the skin and parotid venom gland of the toads. It has been used for myocardial diseases, inflammation diseases, pain relief, cancer and others. The main components of BV are cinobufotoxin, cinobufalin, bufalin and others. Of these, bufalin, the major active ingredient of BV, has been reported to induce apoptosis and to possess anti-tumor effects. There was no report of anti-tumor screening of BV on hepatic cancer and which signaling pathway can be involved. In order to examine the effect of BV on hepatic cancer and the related signaling pathway with BV-induced apoptosis, human Hep G2 cells were used. Methods: Analysis of apoptosis was confirmed by MTT assay. BV decreased cell viability in a dose and duration dependent manner. To observe which signaling molecules will be activated by BV, phosphorylation of MAPK (p38, ERK, JNK), caspase 8 and caspase 9 were examined by Western blot analysis. Results: The phosphorylation levels of p38 started to increase at 5 min after addition of 5 ${\mu}g$/ml of BV and sustained to increase until 48 hours. The phosphorylation levels of other MAPK (ERK and JNK), caspase 8 and caspase 9 increased in a time-dependent manner. These imply that BV may activate different signaling pathways, MAPK, caspase 8 and caspase 9. These results propose that BV may induce apoptosis on Hep G2 cells through the activation of MAPK, caspase 8 and caspase 9.

• 대한소아치과학회지
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• 제23권2호
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• pp.415-427
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• 1996

As a part of host factors of dental caries, saliva has been well known for its important role in relation to dental caries. The studies on its physical and chemical characteristics on development and progress of dental caries has been conducted. Recently, various comparisons between saliva of caries-susceptable individuals and caries-free individuals has been done and the efforts to understand the mechanisms of salivary intervention of development and progress of dental caries is actively in progress. In this study, 15 children with rampant dental caries and 15 caries free children without any systemic diseases from the ages of 2 to 5 were chosen for the experiment and the whole saliva and parotid saliva from each individuals were collected and protein compositions were compared using polyacrylamide gel electrophoresis (PAGE). As results of this study, in parotid saliva, there was no difference in protein compositions between the rampant dental caries and the caries free children. While electrophoresis was done with the whole saliva, protein with 120 KDa was found in children with rampant dental caries. However, this protein was not found or unclear, if any for the caries free group. (Exceptionally, clear protein band was present for one person.) Protein compositions of whole saliva of rampant dental caries group was compared before and after the caries control and thick and clear protein bands of about 120 KDa were found in both cases. Protein compostions of caries free children and adults were identical. Quantitative analysis of protein was done for the rampant dental caries group and the control group and no significant difference was found. Taken all together, protein with molecular weight of 120 KDa, found in rampant dental caries group, was still present when the treatment for the dental caries was done so it can be assumed that this protein has no interrelation with the presence of active carious lesions during saliva collecting. It can also be presumed that this specific salivary protein with the molecular weight of 120 KDa found in rampant dental caries group has effect on development and progress of dental caries. Identification on this protein with the molecular-weight of 120 KDa and the role of this protein against dental caries remain to be solved.

• Pediatric Infection and Vaccine
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• 제21권3호
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• pp.214-218
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• 2014

가와사키병은 일반적으로 특징적인 증상 또는 검사 기준에 근거하여 진단한다. 그러나 가와사키병의 전형적인 증상 없이, 드문 동반 증상으로 먼저 발현하는 경우에 가와사키병의 진단은 어렵다. 저자들은 일측 이하선염으로 발현한 가와사키병 1례를 경험하였다. 23개월 여아가 갑자기 발열과 일측 이하선의 부종과 압통이 있어 화농 이하선염으로 추정 진단받고 항생제로 치료받았으나 발열과 증상이 호전되지 않았다. 발열 8일째에 발진과 비화농성 결막충혈, 관상동맥 이상 등 가와사키병의 증상이 나타나기 시작하여 정맥주사용 면역글로불린과 salicylate를 투약받은 뒤 모든 증상이 호전되었다. 본 증례를 통해, 일측 이하선염은 가와사키병에서 매우 드물게 발생하는 증상이지만, 항생제 치료에도 호전이 없는 경우에, 반드시 가와사키병의 가능성을 고려하여야겠다.

• 대한약침학회지
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• 제4권2호
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• pp.35-47
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• 2001

Objectives : Through the literatures on the effets of Bufonis Venenum, we are finding out the clinical possibility and revealing the more effective to intractable diseases. Methods : We investigated the literatures of Oriental Medicine and experimental reports about Bufonis Venenum. Results : 1. Bufonis Venenum is made of bufonidae bufo bufo gargarizans cantor or bufo melanostictus schneider of white serum which secreted from parotid gland or dermato gland, and it is dried for using. 2. In oriental medicine, Bufonis Venenum has been mainly used on the tumors, cacanthrax and dermatic disease, and then it has been clinically used on infantile athrepsia, tetanus, sore throat, toothache, and so on. 3. The pharmacological effects of Bufonis Venenum are cardiotonic, respiration stimulation, depressor or vasopressor, topical anesthcsia, hallucination, striped muscle stimulation, antiasthmatic, antibacterial, antiinflammatory, anticancer, diuretic, immuno effects, etc. 4. Bufonis Venenum is largely divided in ether binding steroid compound, hydroxyl steroid compound, carboxyl or aldehyde steroid compound, indole compound, and adrenaline, cholesterole, etc. 5. Symptoms of Bufonis Venenum poisoning in digestive system are vommitig, abdominal pain, diarrhea, dehydration, in circulatory system are palpitation, shock, bradycardia, in nervous system are vertigo, somnolentia, muscle-tendon reflex weakness, and critical conditions to tissue necrosis and heart attack. 6. Ways to treat Bufonis Venenum poisoning include gastric irrigation with $0.2~0.5\%$ potassium permanganate fluid and atropine $0.5{\sim}1.0mg$ subcutaneous injection. From the chinese book of Bon Cho Gang Moke(本草綱目), if white serum of Bufonis Venenum enter the eyes, it happens the edema and pain. And then washed the eyes by juice of Lithospermi Radix(紫草) that the edema is removed. Conclusions and Discussion : The results from above literary studies show that prescriptions and Aqua-acupuncture of Bufonis Venenum could be clinically used to sedative, anticonvulsant, antibacterial, antiinflammatory, anticancer and topical ataralgesia. However it is expected that pharmacological and side effects of Bufonis Venenum are further studied.

• Imaging Science in Dentistry
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• 제51권2호
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• pp.129-136
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• 2021

Purpose: This study investigated the effects of 1 year of training on imaging diagnosis, using static ultrasonography (US) salivary gland images of Sjögren syndrome patients. Materials and Methods: This study involved 3 inexperienced radiologists with different levels of experience, who received training 1 or 2 days a week under the supervision of experienced radiologists. The training program included collecting patient histories and performing physical and imaging examinations for various maxillofacial diseases. The 3 radiologists (observers A, B, and C) evaluated 400 static US images of salivary glands twice at a 1-year interval. To compare their performance, 2 experienced radiologists evaluated the same images. Diagnostic performance was compared between the 2 evaluations using the area under the receiver operating characteristic curve (AUC). Results: Observer A, who was participating in the training program for the second year, exhibited no significant difference in AUC between the first and second evaluations, with results consistently comparable to those of experienced radiologists. After 1 year of training, observer B showed significantly higher AUCs than before training. The diagnostic performance of observer B reached the level of experienced radiologists for parotid gland assessment, but differed for submandibular gland assessment. For observer C, who did not complete the training, there was no significant difference in the AUC between the first and second evaluations, both of which showed significant differences from those of the experienced radiologists. Conclusion: These preliminary results suggest that the training program effectively helped inexperienced radiologists reach the level of experienced radiologists for US examinations.