• 보건교육건강증진학회지
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• 제30권5호
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• pp.139-151
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• 2013

Objectives: This study investigated how income, duration of illness, social stigma, quality of sleeping, ADL and social participation related to Parkinson's disease(PD) predict depression in a conceptual model based on the International Classification of Functioning(ICF) model. Methods: The sample included 206 adults with idiopathic Parkinson's disease(IPD) attending D university hospital in B Metro-politan City. A structured questionnaire was used and conducted face-to-face interviews. The collected data were analyzed for fitness, using the AMOS 18.0 program. Results: A path analysis showed that the overall model provided empirical evidence for linkages in the ICF model. Depression was manifested by significant direct effects of social stigma(${\beta}=.20$, p<.001), quality of sleeping(${\beta}=-.40$, p<.001), ADL(${\beta}=-.20$, p<.01), and social participation(${\beta}=-.12$, p<.05), indirect effects including income(p<.05), duration of illness(p<.05). These variables explained 45.9% of variance in the prediction model. Conclusions: This model may help nurses to collect and assess information to develop intervention program for depression.

• Journal of Korean Biological Nursing Science
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• 제21권3호
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• pp.199-206
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• 2019

Purpose: The purpose of this paper was to verify effects of the team approach rehabilitation program on balance, gait, and muscle strength of lower extremities of elderly people with Parkinson's disease. Method: Subjects of this paper were 40 elderly people with Parkinson's disease, 20 control and experimental groups respectively, who could walk independently and were less than the 2.5 Hoehn &Yahr stage. The team approach rehabilitation program was applied to the experimental group for 12 weeks. Results: There was significant decrease in second at timed up &go test (p= .008), but no significant difference in reach length at functional reach test (p= .201) with partial improvement of balance. There was no significant difference in second at 10-meter walk test (p= .070), but showed tendency of improvement of gait. And number of times at 30s-chair stand test, indicating muscle strength on lower extremities, increased significantly (p= .029), Conclusion: The team approach rehabilitation program has demonstrated its effectiveness on improving balance, and muscle strength of lower extremities for the elderly with Parkinson's disease.

• 대한한의학회지
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• 제26권2호
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• pp.176-181
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• 2005

Objectives: This study was designed to evaluate the effect of moxibustion on UPDRS and heart rate variability of patients with Parkinson's disease. Methods: Subjects were voluntarily recruited through newspapers and internet. All subjects were confirmed as showing idiopathic Parkinson's disease by a neurologist. Moxibustion therapy was performed 5 times a week by the patient's family at home and once a week by an oriental medical doctor in hospital. Moxibustion points were GV20, CV12, ST36, BL18, and BL20. Intensity was up to pain threshold to prevent patients getting burned. The patient's symptoms were assessed before and after 8 weeks of treatment by unified Parkinson's disease rating scale (UPDRS). Heart rate variability was measured for 5 minutes before and after the treatments. Results: Total UPDRS scores were significantly improved after 8 weeks compared to pre-treatment (p<0.05). There were significant decrease of mean heart rates (p<0.05) and increase of SDNN and TP (p<0.05) after 8 weeks' moxibustion treatments. There were no significant changes in other components of heart rate variability. Conclusions: This study suggests that moxibustion treatments can be applicable to improve not only symptoms but also heart rate variability in the patients with idiopathic Parkinson's disease.

• 한국운동역학회지
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• 제19권2호
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• pp.257-264
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• 2009

본 연구의 목적은 파킨슨 환자들에게 일상생활 속에서 빈번히 수행되는 방향전환 동작 중에 작용하는 하지의 운동학 및 근육의 활동을 규명하는데 있다. 호엔야르 $1.5{\sim}4$척도의 60대 파킨슨 환자 7명이 본 실험에 참여하였다. 실험실 바닥에 직선($0^{\circ}$) 및 방향전환($60^{\circ}$, $90^{\circ}$, $120^{\circ}$) 보행로를 만들었다. 보행로에 5cm 넓이의 검은색 접착테이프를 붙여 놓아, 그 경로를 따라 무작위 순서로 지나가도록 하였다. 하지의 운동학적 변인을 측정하기 위해 해당부실에 21개의 마커를 부착하였으며, 근전도 변인을 측정하기 위해 우측 하지의 장내전근, 중둔근, 대둔근, 대퇴이두근, 대퇴직근, 비복근, 전경골근에 전극을 부착하였다. 방향전환 각도별(4수준: $0^{\circ}$, $60^{\circ}$, $90^{\circ}$, $120^{\circ}$)로 얻은 하지의 운동학 및 근전도 변인의 차이를 규명하기 위하여 반복이 있는 일원 변량 분석을 실시하였다. 파킨슨 환자들은 방향전환시 활보장과 보간을 감소시키는 것으로 나타났으며, 하지에 작용하는 근육활동에는 차이가 없는 것으로 나타났다.

• 음성과학
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• 제12권2호
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• pp.59-72
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• 2005

The purpose of this study was to investigate the effects of rhythm therapy program on MPT(Maximum Phonation Time) and acoustic parameters in patients with Parkinson's disease. The therapy program utilized 5 Korean traditional rhythms: jinngyang, jungmori, jungjungmori, jajinmori, and semachi. The therapy consisted of counseling regarding vocal hygiene and actual therapy procedures. Six subjects with Parkinson's disease participated in the study; 3 subjects in experimental group and the other 3 subjects in control group. The pre- and post- acoustic analyses were performed in both groups. The results of this study were as follows; 1) MPT was significantly increased in the experimental group, 2) mono-pitch was significantly improved in the experimental group, 3) mono-loudness was significantly improved in the experimental group, and finally, HNR was significantly increased in the experimental group compared to the control group.

• ETRI Journal
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• 제39권6호
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• pp.851-858
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• 2017

Parkinson's disease is a growing and chronic movement disorder, and its diagnosis is difficult especially at the initial stages. In this paper, movement characteristics extracted by a computer using multilayer back propagation neural network mapping are converted to the symptoms of this disease. Then, modulation of three classifiers of C4.5, k-nearest neighbors, and support vector machine with majority voting are applied to support experts in diagnosing the disease. The purpose of this study is to choose appropriate characteristics and increase the accuracy of the diagnosis. Experiments were performed to demonstrate the improvement of Parkinson's disease diagnosis using this method.

• Journal of Acupuncture Research
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• 제36권2호
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• pp.113-117
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• 2019

Parkinson's disease (PD) is a neurodegenerative disease, where treatment with medication may lead to gastrointestinal (GI) symptoms. The objective of this case study was to investigate the effectiveness of Korean medicine (KM) in treating PD with drug-induced GI dysfunction. A 70-year-old female participant was diagnosed with PD in 2010 and drug-induced gastritis in 2016. Her major symptoms were related to GI, PD, and overall feeling of weakness. She was treated with KM including pharmacopuncture, acupuncture, moxibustion, and herbal medicines, in combination with Western medicines during 46 days of in-patient care. This study showed an improvement in symptoms and scores on the GI symptom scale, Unified Parkinson's disease rating scale, Hoehn and Yahr staging, Berg balance scale, PD quality of life, and stress index at discharge. This case demonstrated that the symptoms of drug-induced GI dysfunctions in PD was improved by treatment with KM.

• 한국임상약학회지
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• 제25권4호
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• pp.254-263
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• 2015

Objectives: The present study assessed the prevalence of the potentially inappropriate medication (PIM) use in Korean elderly patients with Parkinson's disease. In addition, this study examined risk factors that affect PIM use. Method: A retrospective, observational study was conducted using Korean National Health Insurance claims database of 2009. PIM use in Parkinson's disease patients aged 65 years or older was examined based on 2012 Beers Criteria. Multivariable logistic regression was conducted to identify risk factors for PIM use. Results: Among 5,277 elderly patients with Parkinson's disease, 88.9% of patients used PIM(s) at least once. The average number of PIM items used per patient was 4.2. PIM use ratio, the proportion of total amount of PIMs to all medications per patient, was 12.6%. Frequently used PIM therapeutic classes were benzodiazepines (32.7%), first-generation antihistamines (19.2%), and prokinetics (17.5%). Individual PIMs most commonly used included chlorpheniramine (11.4%), levosulpiride (10.9%), diazepam (9.0%), and alprazolam (7.6%). Women (odds ratio [OR] 1.14, 95% confidence interval [CI] 1.11-1.16), medical aid (OR 1.18, 95% CI 1.15-1.21), and long-term facilities (OR 2.43, 95% CI 2.22-2.65) were shown to be risk factors associated with PIM use. Of particular, wide variation in PIM use was associated with the types of healthcare facility. Conclusion: The PIM prevalence was very high in elderly Parkinson's disease patients. Nationally effective and systematic efforts to identify and prevent PIM use should be made to ensure patient safety and to improve quality of care in the elderly.

• 동의신경정신과학회지
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• 제23권1호
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• pp.129-143
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• 2012

Objectives : To evaluate the neuroprotective effects of the essential oil from Sohaphwangwon (SH), a Chinese traditional medicinal prescription in a Parkinson's disease mouse model. Methods : 1. The neuroprotective effect of SH on primary neuronal cells was examined by using 1-methyl-4-phenylpyridinium ion (MPP+). 2. The neuroprotective effect of SH was examined in a Parkinson's disease mouse model. C57BL/6 mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30 mg/kg/day), intraperitoneal (i.p.) for 5 days. SH inhalation was applied before MPTP treatment for 7 days and continued until 12 days after the first MPTP treatment. 3. To find out the intracellular target signal molecule(s) regarding the neuroprotective effect of SH essential oil, brain-derived neurotropic factor (BDNF) and synaptic protein SNAP25 were examined by Western blot analysis. Results : 1. MPP+ induced a concentration-dependent decrease in cell viability. However, in the presence of 3 and 5 ug/ml of SH, MPP+-induced cell death was significantly reduced. 2. SH inhalation in MPTP mice led to the restoration of behavioral impairment and rescued tyrosine hydroxylase (TH)-positive dopaminergic neurodegeneration. 3. In SH / MPTP mice, BDNF and SNAP25 increased. Conclusions : This experiment suggests that the neuroprotective effect of SH essential oil is mediated by the expression of BDNF. Furthermore, SH essential oil may serve as a potential preventive or therapeutic agent regarding Parkinson's disease.

• The Journal of Korean Physical Therapy
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• 제31권2호
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• pp.122-128
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• 2019

Purpose: This study examined the effects of sagittal spinopelvic alignment on the clinical parameters, motor symptoms, and respiratory function in patients with mild to moderate Parkinson's disease (PD). Methods: This study was a prospective assessment of treated patients (n=28, Hoehn and Yahr (H&Y) stage 2-3) in a PD center. Twenty-eight subjects ($68.5{\pm}5.7yrs$) participated in this study. The clinical and demographic parameters, including age, sex, symptoms duration, treatment duration, and H&Y stage, were collected. Kinematic analysis was conducted in the upright standing posture with a motion capture system. A pulmonary function test (PFT) was performed in the sitting position using a spirometer. The motor symptoms were assessed on part III of the movement disorder society sponsored version of the unified Parkinson's disease rating scale (MDS-UPDRS). SPSS 18.0 was used to analyze the collected data. Results: The exceeding 12 degrees group of the lower trunk showed significantly higher on the clinical parameters than the below 12 degrees group. In addition, the exceeding 12 degrees group of the lower trunk showed a significantly lower forced expiratory volume at one second (FEV1) / forced vital capacity (FVC) (%) and 25-75% forced mid-expiratory flow (FEF) (L/s) than in the below group. On the other hand, there was no difference in the upper trunk and the cervical pelvis between the groups. Conclusion: These findings suggest that the sagittal balance in the lower trunk is related to the clinical parameters and respiratory function, but not the motor symptoms in patients with mild to moderate PD.